>gi|109484110|ref|XP_236715.4|	Rattus norvegicus
------------------------------------------------------------
-----------------MT---------LSPRIA--H---RGHLPLKPAKLDATALHDDT
SASSVPLSEACNHAVLACSPGIPEE----------------HYVSEAIED-APS-YRGHR
DACTITDVCNSTN-------LPEVEIISLLEEQLPHYKLRADTIY---GYDHDD----W-
---LHTPL-ISPDANIDLTTEQIEETLKYFL------L-CAERVGQMTK--TYNDIDAVT
RLLEE-----------------KERDLELAARIGQSLLKKNKTLTERNELL--EEQVEHI
REEVSQLRHELSMKDELLQ---FYTSAAEESEPESV---------------------CST
PL---K--RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEAC---QLKTETITYEEKE
QQLVND-------CVKELR----------------------------DANVQIASISEEL
AKKTEDAARQQEEITHLLS----QIVDLQKKAKSCAV-ENEELVQHLGAAKDAQRQLT--
-----AELR--------------------------------ELEDKYAECMEMLH--EAQ
EELKNLRNK--TMP--TSRRYHSL-------GLFP--MDSLAAEI--EGTMRKELQLEEP
ESPD----------------------------------ITHQKRVFETVRNVNQ-----V
VKQRSLTP----SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDV-SHVVLDNKTNS-I
LLETEAADLGNEEHNKKPGTPGTPGSHDLETALRRLS----LRRENYLSE---RRFFEEE
QERKLREL-AEKGELH--SGSLT----PTESIMSLGTHSRFSE-------FTGFSGMSFS
S-----RSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVV------TKGFRT
LDVDLDEVYCLNDFEED-------------------------DTGDHISLA-------GL
ATSTTI------------QHMETSAHHPGKCMSQTNSTF-TFTTCRILHPSDELTRVTPS
LNSAP--APSCSSTSHL-KSTPVATPCTPRRLSLAESFTNVRESTTTMSTSL--------
--------------GLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPRMAVIPSTPPN
SPMQTPS-ASPPSFEFKCTSPPY--NNFLASKPASSILRE-VREK---------------
---KHVRSSESQTDVSVSNLNLVDKVRR---FGVARVV---NSGRAHIPTLT-EDQGPLL
CGPTGPA--------------------HALVPG-GLVPEGLPLGCP------------SG
IRRNR------------------------------SFPTM---VGSSVQMRAPVILTSGI
LMGAKLPKQTSLR-----------------------------------------------
----------------------
>gi|125987247|ref|XP_001357386.	Drosophila pseudoobscura
------------------------------------------------------------
----------------------------------------------------MLSARLGA
NGGQMPLSPSAQATLSKHLPKLQTK----------------RLMQQATAAAAAPPKPQTC
DASCLTELCSSEN-------LPEVEIFSLLEEQIPKYKVRNDFLTNFSGYANED----W-
--FVPAPALPIPAEGLGLTKDQTRECLNYFL------L-CGNRVSQMTR--AYDDIEAVT
RLLEE-----------------KEKDLELTVQIGKELLTQNNALEARVTDL--EADLKSS
NDDRSQLLHELHKKNELIS---VLTNDADDG-----------------------------
--------TDTETPTMSKSITLDLLQRKVNSLLDENKSLKCEAT---QLAHQTDEVEEHE
RQLMAD-------IGAQLH----------------------------DANSQYDNLSLEC
ERQREENRLQHEQIVSLTA----RLAEAEMRLHQLTQ-DNDDHLSLLHVTKENQNALA--
-----LELV--------------------------------EFKQRYEEVLALLH--SAQ
DQLKQQRKR--SQPQARSSFLGGMGTSGAGGGMLM--PDSLKSELM-NSSLYSENSLDSG
ISGDSQRTDRISRMMMHMPGGMGSSGVGGGSIYAGSGVVPPYKRVFDTVRCAGK-----S
GNYMDSGN----VSMTTLGAMSMSSSSGPRMASMAYPAGSYYRGG--GNQSLGVKTLS-N
ESLNSQSDDGYP--AQPSGVPGAPGARELEAALKRLTPGEVLARRAMLSYAPIGTYNYDE
PTMHGGAG-ASNSNLP--LGVRT----P-DSIMSTGS-SRMSA-------SSNNMSASMT
H-----QWRLPEKLQIIKPMEGSQTLHHWSRLATPTLSGLLDERPGVT------IRGGRD
LEDLGMQIYTLSDVEED-------------------------------------------
----------------------VSEELPGKQFEAAGSTF-TYTTSVVMHPDDGFVNDLSF
LSQSQMSSRMASTS----TSRQPSCPATPR------AGLSRKNSCSTFSVNL--------
--------------GLAGMLNERGIKA----------VTPSALNTPAGPNF---------
SPTVTPC-NSPEGSPPRCQSPEP--LFGLLSSGADLIRRK-IVGD---------------
---LMLSHLERR---ALRSLNLIEKVES---IGLENII---SAQRGLGAGIANRSSSPMS
SGSLQSL------HTSSNSIVDDIHFDRAQIKG-VLHRGLKPKDTSTTTKAAAAAQQTDG
ASCSTGGTAPSTST---------------------SSETR---VKQMQRQKSRRQLKNG-
-MANQRPDLGTIGGGGGGRVRPDLGRVADSSGANKTSASRAAARREAAAARAEEEEAAPQ
TITQAFVGSVSSLLFGRKGGWL
>gi|114667384|ref|XP_001167883.	Pan troglodytes
------------------------------------------------------------
----------------------------MRPKRSGRCCAGSRLGPGDPAALTCAPSPSAS
PAPEPSAQPQARGTGQRAGSLAASG---------------SQFLSEARTGARPASEAGAK
AGARRPSAFSAIQ-------GDVRSMPDNSDAPWTRFVFQGPFGSRATGRGTGKAAGIW-
---------KTPASYVGRRPGVSGPERAAFIRELEEAL-CPNLPLPVKKI-TQEDVKVML
YLLEELLPPVWESVTYGMVLLQRERDLNTAARIGQSLVKQNSVLMEENSKL--EALLGSA
KEEILHLRHQVNLRDELLQ---LYSDSDEEDEDEEEEEEE-----EQEEEEAEEDQQCAH
PCDAPKLILQEALLHQHHCPQLEALQEKLRLLEEENHQLREEAS---QL----DTLEDEE
QMLILE-------CVEQFS----------------------------EASQQMAELSEVL
VLRLENYERQQQEVARLQA----QVLKLQQRCRMYGA-ETEKLQKQLASEKEIQMQLQEE
SVWVGSQLQ--------------------------------DLREKYMDCGGMLI--ETQ
EEVKTLRQQ--PPVSTGSATHYPYSVPL---ETLPGFQETLAEER--RTSLRR--MISDP
--------------------------------------VYFMERNYEMPR----------
-------------------------------------------GDT-------------S
SLRYDFRYSEDREQVQ-----G----------------------------------FEAE
EGLMLAAD-IMRGEDF------T----PAEELVP--------------------------
----------QEELGAAKKV--------------PAEEGVMEEAELVSEE----TEGWEE
VELELDEATRMNV-----------------------------------------------
--------------------------------------------------------VTSA
LEASG-------------------------------------------------------
-------------------------------------LGPSHLDMNYV------------
-------------------------LQQLANWQDAHYRRQ-LRWK---------------
------------------------------------------------------------
-----------------------------MLQK-SECPHG--------------------
-----------------------------------ALPAA---SRTSCRSSCR-------
------------------------------------------------------------
----------------------
>gi|33468583|emb|CAE30366.1|	Danio rerio
------------------------------------------------------------
----------------------------TYSGLFCVVINPYKNLPIYSENIIEM-YRGKK
RHEMPPHIYAISESAYRCMLQDRED----------------QSILCTGESGAGKTENTKK
VIQYLAHVASSHKGRKDHNIPPESPKAVKLQGELERQLLQANPILE--SFGNAK----TV
KNDNSSRFGKFIRINFDVTGYIVGANIETYL------L-EKSRAIRQAK--DERTFHVFY
QLLAG-----------------AGEHLR--SDLLLEGFNSYRFLSNGNIPIPGQQDKDNF
QETMEAMHIMSFNHEEILS---MLKV-------------------------------VSA
VLQFGNIVFKKERNTDQASMPENTAAQKLCHLLGMNVMEFTRAILSPRIKVGRDYVQKAQ
TKEQADFAVEALAKATYER--------------------------------LFRWLVHRI
NKALDRTKRQGASFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQ
REGIEWSFI--------------------------------DFGLDLQPCIDLIERPANP
PGVLALLDEECWFPKATDKTF----------------VDKLVQEQGTHGKFQKPRQLKDK
AD-------------------------------------------FCIIHYAGR-----V
DYKADEWLMKNMDPLN-------DNVATLLHQSTDKFVAELWKDVD-RIVGLDQVAGM-N
ETAFGAAYKTKKGMFRTVGQLYKESLTKLMATLRNTNP-NFVRCIIPNHE---KRAGKLE
PHLVLDQL-RCNGVLEGIRICRQ----GFPNRIVFQE---FRQ-------RYEILTPNAI
P-----KGFMDGKQACERMIRALELDPNLYRIGQSKIF----FRTGVLAH----LEEERD
LKITDIIIYFQSVCRGY-------------------------------------------
-------------LA---RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRLFTKVKPL
LQVTRQEEEMQAKDEELIKVKERQVKVENELVEMERKHQQLLEEKNILAEQLQAETELFA
EAEEMRARLVAKKQELEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQDLEE-QLDEEE
AARQKLQ-LEKVTAEAKIKKMEE--DILLLEDQNSKFLKE-KKLLEDRVGEMTSQLAEEE
EKAKNLGKVKNKQEM--MMVDLEERLKK---EEKTRQELEKAKRKLDAETTDLQDQIAEL
QAQIDEL------------------KIQLAKKE-EELQAVLARGDEEVAQKNNALKQLRE
LQAQLA-----------------------------ELQED---LESEKAARNKAEKLKRD
LSEELEALKTELEDTLDTTAAQQELRY---------------------------------
----------------------
>gi|40789028|dbj|BAA82994.2|	Homo sapiens
---------------------------------GSQAAWSYITHCASRTAHNLR------
----------------------------ICPNKQTQKTAEEGTGGWLCEVLPGLSSHGGS
LCSLKCLWSLCLHMALVFQFGQPVR-----------------------AQPLPGLCHGKL
IRTNACDVCNSTD-------LPEVEIISLLEEQLPHYKLRADTIY---GYDHDD----W-
---LHTPL-ISPDANIDLTTEQIEETLKYFL------L-CAERVGQMTK--TYNDIDAVT
RLLEE-----------------KERDLELAARIGQSLLKKNKTLTERNELL--EEQVEHI
REEVSQLRHELSMKDELLQ---FYTSAAEESEPESV---------------------CST
PL---K--RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEAS---QLKTETITYEEKE
QQLVND-------CVKELR----------------------------DANVQIASISEEL
AKKTEDAARQQEEITHLLS----QIVDLQKKAKACAV-ENEELVQHLGAAKDAQRQLT--
-----AELR--------------------------------ELEDKYAECMEMLH--EAQ
EELKNLRNK--TMPNTTSRRYHSL-------GLFP--MDSLAAEI--EGTMRKELQLEEA
ESPD----------------------------------ITHQKRVFETVRNINQ-----V
VKQRSLTP----SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDI-GNVVLDNKTNS-I
ILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLS----LRRENYLSE---RRFFEEE
QERKLQEL-AEKGELR--SGSLT----PTESIMSLGTHSRFSE-------FTGFSGMSFS
S-----RSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVV------TKGFRT
LDVDLDEVYCLNDFEED-------------------------DTGDHISLP-------RL
ATSTPV------------QHPETSAHHPGKCMSQTNSTF-TFTTCRILHPSDELTRVTPS
LNSAP--TPACGSTSHL-KSTPVATPCTPRRLSLAESFTNTRESTTTMSTSL--------
--------------GLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPKMAVIPSTPPN
SPMQTPT-SSPPSFEFKCTSPPY--DNFLASKPASSILRE-VREK---------------
----NVRSSESQTDVSVSNLNLVDKVRR---FGVAKVV---NSGRAHVPTLT-EEQGPLL
CGPPGPA--------------------PALVPR-GLVPEGLPLRCPTVTSAIGGLQLNSG
IRRNR------------------------------SFPTM---VGSSMQMKAPVTLTSGI
LMGAKLSKQTSLR-----------------------------------------------
----------------------
>gi|119888279|ref|XP_873117.2|	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
-------MSQSQDATFTAPMGEENL----------------M-------------NINHR
DSESITDVCSNED-------VPEVELVSLLEEQLPQYKLRVDSLF---LYENQD----W-
---TQSPH-QQQHASDTLSPVLAEETFRYMI------L-GTDRVEQMTK--TYNDIDMVT
HLLAE-----------------RDRDLELAARIGQALLKRNHALSEQNETL--EEQLGQA
FDQVNQLQHELSKKDELLR---IVSIASEESETDSS---------------------CST
PL---R--FNESFSLSQGLLQLDMLQEKLKELEEENMLLRSKAC---HIKTETITYEEKE
QQLVSD-------CVKELR----------------------------ETNAQMSRMTEEL
SGKSDELIRYQEEISSLLS----QIVDLQHKLKEHVI-EKEELRLHLQASKDAQRQLT--
-----MELH--------------------------------ELQDRNMECLGMLH--ESQ
EEIKELRSR--SSPAAHLYFSQPY-------GVFS--GESLAAEI--EGTMRKKLSLDEE
SSLFKQ--------------------------------KAQQKRVFDTVKAAND-----T
RGRSVPFP----ILLPIPGSNRSSVIMT----------AKPFES------GLEPTEGK-T
--TQKSNLEEDPGNIQKADQPGPSTESDLATALHRLS----LRRQNYLSE---KQFFAEE
WQRKIQVL-ADQKEEG--SGCGT----PTESLASL--YTDQSE-------ITDLSSASCL
------RGFMPEKLQIVKPLEGSQTLHQWQQLAQPNLGTILDPRPGVI------TKGFTQ
LP--KDAIYHLSDLEEDE------------------------EEGITFQVQQPLQVEQKT
SISQPVTGIFLPPMTSAGGPVTVATSNPGKCLSCTNSTF-TFTTCRILHPSD----ITQV
TPSSGFPSLSCASSGSSSSNTAMNSPAVSYRLSVGESITNRRDSTITFSSTV--------
--------------SLAKLLQERGISAKVYHSP----ISENPLLQP-LPRGLSTPSIPPN
SPSHSPC-PSPLPMEPRVHLS----ENFLASRPAETFLQE-MYGL---------------
------RPSRNPPDVGQLKMNLVDRLKR---LGIARVI---------------KTPEAQA
NGRSQKA--------------------ENGLQR----PNS-------AVYLNSGSNLLSG
LRRNQ------------------------------SLPVM---LGSFSTPVCTSSPKMDI
LKED--------------------------------------------------------
----------------------
>gi|149729022|ref|XP_001497664.	Equus caballus
-----------------------------MGKYGGTASQAEQTASAEASARRLVWLECRE
PLGKVDMDEGDDLPGAIHP---------TVPDSCSRTPDGSEHLPVKPAKLDATVLHDDT
LANSVPPSEGCSHAVLACGPGIPEE----------------HYVSEAVED-APS-CRGYR
DACTITDVCNSTD-------LPEVEIISLLEEQLPHYKLRADTIY---GYDHDD----W-
---LHTPL-ISPDANIDLTTEQIEETLKYFL------L-CAERVGQMTK--TYNDIDAVT
RLLEE-----------------KERDLELAARIGQSLLKKNKTLTERNELL--EEQVEHI
REEVSQLRHELSMKDELLQ---FYTSAAEESEPESV---------------------CST
PL---K--RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEAC---QLKTETITYEEKE
QQLVND-------CVKELR----------------------------DANVQIASISEEL
AKKTEDAARQQEEITHLLS----QIVDLQKKAKACTV-ENEELVQHLGAAKDAQRQLT--
-----AELR--------------------------------ELEDKYAECMEMLH--EAQ
EELKNLRNK--TVPNTTSRRYHSL-------GLFP--MDSLAAEI--EGTMRKELQLEEP
ESPD----------------------------------IAHQRRVFETVRNINQ-----V
VKQRSLTP----SPMNIPGSNQSSAVNSLLSSCVSTPRSSFYGSDV-GNVVLDNKTNS-I
ILEAESADLGNNERSKKPGTPGTPGSHDLETALRRLS----LRRENYLSE---RRFFEEE
QERKLREL-AEKGELL--SGSLT----PTESIMSLGTHSRFSE-------FTGFSGMSFS
S-----RSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVV------TKGFRT
LDVDLDEVYCLNDFEED-------------------------DTGDHISLP-------GL
ATSTPV------------QHPETSAHHPGKCMSQTNSTF-TFTTCRILHPSDELTRVTPS
LNSAP--TPACGSASHL-KSTPVATPCTPRRLSLAESFTNIRESTTTMSTSL--------
--------------GLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPRMTVIPSTPPN
SPMQTPM-SSPPSFEFKCTSPPY--DNFLASKPASSILRE-VREK---------------
---KNVRSSESQTDVSVSNLNLVDKVRR---FGVAKVV---NSGRAHVPTLT-EEQGPLL
CGPPGPA--------------------QALVPG-GLVPEGLPLGCPTVTSAIGGLQLNSG
IRRNR------------------------------SFPTM---VGSSMQMKAPVTLTSGI
LMGAKLPKQTSLR-----------------------------------------------
----------------------
>gi|73989842|ref|XP_542729.2|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
-------------MALVLQFGQPVR-----------------------AQPLPGLCQGRL
VQTNSCDVCNSTD-------LPEVEIISLLEEQLPHYKLRADTIY---GYDHDD----W-
---LHTPL-ISPDANIDLTTEQIEETLKYFL------L-CAERVGQMTK--TYNDIDAVT
RLLEE-----------------KERDLELAARIGQSLLKKNKTLTERNELL--EEQVEHI
REEVSQLRHELSMKDELLQ---FYTSAAEESEPESV---------------------CST
PL---K--RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEAC---QLKTETITYEEKE
QQLVND-------CVKELR----------------------------DANVQIASISEEL
AKKTEDAARQQEEITHLLS----QIVDLQKKAKACAV-ENEELVQHLGAAKDAQRQLT--
-----AELR--------------------------------ELEDKYAECMEMLH--EAQ
EELKNLRNK--TMPNTTSRRYHSL-------GLFP--MDSLAAEI--EGTMRKELQLEEP
ESPD----------------------------------IAHQKRVFETVRNINQ-----V
VKQRSLTP----SPMNIPGSNQSSAVNSLLSSCVSTPRSSFYGSDV-GNIVLDNKTNS-I
ILEAEAADLGSDERSKKPGTPGTPGSHDLETALRRLS----LRRENYLSE---RRFFEEE
QERKLREL-AEKGELL--SGSLT----PTESIMSLGTHSRFSE-------FTGFSGMSFS
S-----RSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVV------TKGFRT
LDVDLDEVYCLNDFEED-------------------------DTGDHISLP-------GL
ATSTPV------------QHPETSAHHPGKCMSQTNSTF-TFTTCRILHPSDELTRVTPS
LNSAP--TPACGSASHL-KSTPVATPCTPRRLSLAESFTNVRESTTTMSTSL--------
--------------GLVWLLKERGISAAVYDPQSWDRAARGSLLHSYTPRMAVIPSTPPN
SPMQTPT-SSPPSFEFKCTSPPY--DNFLASKPASSILRE-VREK---------------
---KNVRSSESQTDVSVSNLNLVDKVRR---FGVAKVV---NSGRAHVPTLT-EDQGPLL
CGPPGPA--------------------QALVPG-GLVPESLPLGCPTVTSAIGGLQLNSG
IRRNR------------------------------SFPTM---VGSSMQMKAPVTLTSGI
LMGAKLPKQTSLR-----------------------------------------------
----------------------
>gi|157107178|ref|XP_001649659.	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------V------L-CGNRVSQMTR--AYDDIDAVT
RLLEE-----------------KEKDLELTVQIGKELLTQNTHLENRVAEL--EQELKNT
NENLAQLAHELHQKNELIG---ILTNDVDDS-----------------------------
--------SENVTPTTSKSVNLELLQRKVKSLEDENKSLRSEAA---QLVQETDECEEQE
RRLMAD-------IANQLS----------------------------TANSEFDGLNLEL
ERLKEENRLQHEQIISLTG----RLSEAEIRLHQLTT-ENEEASSLLSITKENQNLLA--
-----GELS--------------------------------EFKARYQEVLNLLH--DAQ
EQLRRQRKR--SQPMARSTLIP---------GLTAPAPDSLQSELM-ETSLYSEHSLDSG
IASERG-------------GPLH---------------QPSYKKVFETVRSATR------
-------------ANPTGFSDGFSHLGSMTMSSSSQPRMAPYSGSSIYSTMYDSSLGGRS
FSRESLVSESEDGYPGAAQGPGAPGAKDLEAALKRLTPAEVLARRAMLQHAPAGTYSYDD
QP----------SGIP--LGCRT----P-DSIMSTG--------------SSGLSGMSSN
------QWRLPEKLQIVKPIEGSQTLHHWSRLATPTLSGLLEERPGVT------IRGGRG
LEDLGLQTYSLSDVEED-------------------------------------------
-----------------------AEEQPGKRFQSFGCTY-TFTNSTVMHPDDGTTAVTFS
LPPSQMSSQMASEC----PSRQPSAPSTPR------TGLSRRNSCSTFSVNL--------
--------------GLASMLNERGIKA----------VTPSALNTPAGPNF---------
SPTVTPC-NSPEGSPTRSMSPEPPLLSGLLASGADILRKK-FAVA-SSSSEMERPSRLTA
RNKLALSRLEKK---ALRSIKIMEKVES---MGVDNFM--PHAGHGISPLAL-HSSSALY
TSTVRGRTSSPMAQLTKGGLLIDKETIKAVLSR-GLSHDRNASSGSSDASGSSSVASGAY
ADSDSGTSSISGAVVKPTVLAKKVTTTEHKSAEGTPTPATAARLKQMQRQKSRRNLLNG-
ANGSQRPDLGTVN----GSSRPAGVRPDLGTVGGSNKSKSNNSKNEAAAAPVAPVPEQSR
SIGQSVYGTISSLLFGRKGGLL
>gi|91091378|ref|XP_973088.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
MQKNVKGRPRVR-AGRSVNIHDWEK-------------------------------QSEV
LENWNNELCSGES-------LPEVEIISLLEEQIPKYKLRADTLTKFGGYENQD----W-
--FIPSPALQIDEADLKLSPDQIRETLNYFL------L-CSNRVSQMTK--TYDDIEAVT
RLLEE-----------------KEKDLELTARIGKELLQANSKLENTIASL--ETDLKSA
LEKITQLSHEVQKKTELIQ---ILTNDMDESIFENG------------------------
---------------TSGRINLELMQKRMAGLEEENKALKSEYN---RLARDTETVEAKE
QMLLKD-------LTGQLT----------------------------CANTSMGFLEDEL
DRQKEENRFQHEQILTLQS----KLQDMEERLNKFMS-ENYELNGLLQITKDNQGSLA--
-----IELS--------------------------------EFKARYYEVESLLR--DTQ
EQLRKLRKK--QMPGARIAMFSSL-------GANTQPFDSLQSEL--EMSMHSELSTDSG
ISNSD---------------------------------IPQYKKVFETVRCASQNSLSSA
ESLGSLHSGLGGYASSTAGSGPRMSIRA-QTSDMRRSSGSIYSSSSLGYPSIDSTGHSDT
EFSQTDSDDGYPGGAQK-GIPGVPGAADLEAALKRLTPGEVLARRANLQH----------
-GPAFGGY-EGEGCVP--FGCRT----P-DSLMSTGSGNYM-------------------
------GWKLPEKLQIVKPIEGSQTLHQWAQLAQPTFGGLLEERPGVK------IRGGKE
LEEMGLESYGLSDLEED-------------------------------------------
----------------------EEYSNPGKIFDSLQPTY-TLTNSTVMHPDDG-TFVTPS
NRG----SRVASVCSSI-QNSPPQTPGQ----------LSRRNSCSTFSTTY--------
--------------GLAKILNERGIKA----------ATPSAFNTPNGANSFTPTATPCN
SPDGSPS-QS------RSESPEPFSFPQLILSSVPQFIKD-TVGG--------------G
AKKKMIKSKRSKPERAESLVGKIERIGITNLMGAPGALSI-SAGLYSRPALT-SPMAQLT
CLLPNPE---------------PHLGTKSLPNQ-RKPPSGLGVPGKPGSGALSKRLEQLN
SRKQRRGG---------------------------VTRSD---LGTVSTKKVPEPPEQTS
TLGTLSSLLFGRKGGLF-------------------------------------------
----------------------
>gi|110756450|ref|XP_001120451.	Apis mellifera
------------------------------------------------------------
-------------------------------------MNEFLDNCHSIEPTNDDVFKDKT
RIAEVAAATLCRLNSIMKQMKDWRDDRMKLRSNIWRLKLALRVAGRETDSSVHADPLIEQ
QKEEIKRLETTNR-------ELKKEIKLMEHNEYMKQLSKLDSILKEINNEIDK----LK
SNHVKRHYKIGDSEGLEYLNKIVE--LEAIIEEIQSAMNRLNRCSKGKSN-ESKDIEKLE
EFVGRVCHEI------------KQLEVIVVSSDRLSVFKRIDQLEESIVRL--KTELSNK
EAHMTDLDQELVDTDSMLKQKMVALQDARQEITILIQENKVLKEKTNVMEEKTSELQCEH
-----EDVKKELEQLQYVKHEANLTKKKLQNLQDDKEELLNEMQ---KIRDALNKKNEET
KIVLAE-------KNTMER----------------------------VFNVKIADLSKNL
QISSKENEKLQNKVNEL------ERMKYRREASNVEK-ENESARRLKDITEKMNNEIQ--
-----------------------------------------LLKVNLKISKEDFN--HAN
REIADLKIKLEHLSDEKTKLESSV-------AQLESKKEILVYQLG-AEKTTADERLKE-
--------------------------------------ITKLKSDYVELDVEKV-----N
LKMEK-------EQLNVNFTNLK---------------------------VEKEQIEK-S
LELVQSKCCTFENKIDK----YKYERNNLLEEVRNLK----VTKETLTIKLEETKSQLDG
TGDKIRQLEVENSKLHSDLNELTAKKTSLEQAFETREQTLLSENHDLATRVNKLEGENQM
L-----RNQLKESKTTNVELIKLKTEYDNVKLENTTQLDELRQCNEML------KEMNNE
LKMKLNEIHSEYRILEN-------------------------------------------
---------------------------QLKILELMNSTL----KKDKELLEKEYMNALQR
LRIERMEKEGITSGSES-VSTEQNEETEKGKFEKRPKKEKVPEKEVIKKLIM--------
--------------------ENESLKFEILNLRSQNYEIKTQLNQTKE-EIQRQKSNAVE
KKTNETT-IKPISNKLEI-------VNLYYKEINSYSSRG-LRNT---------------
---------EAVTHIDQSSLCLYEGMNRGSDIDIEKLLEIMNKLKVENIALR-MEVNSLR
CNLIINFSEDEKKKKELRIATDEIQALKSELKKLRDERESLRVKFNTTNAKLDLLESEKA
ALKNELYTIRNINSDFKQKISDLHSTYQKSKEKNLVFENC---IVKAIKKIEKYTLCDHM
QIKGNNELKVLLKKYISNEEILQSIEQRIDIETT--------------------------
----------------------
>gi|118785834|ref|XP_314926.3|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------V------L-CGNRVSQMTR--AYDDIDAVT
RLLEE-----------------KEKDLELTVQIGKELLAQNTHLENRVAEL--VQELKTT
NENRAQLSHELHQKIELIG---ILTNDADDT-----------------------------
--------SENVTPTASKSINLELLQRKVKQLEDENKSLRTETA---QLVKETDECEEQE
RRLMAD-------IANQLT----------------------------TANSEFDGLNLEL
ERLKEENRLQHEQIISLTG----RLADAEIRLHQLTS-ENEEASSLLSITKENQNLLA--
-----GELA--------------------------------EFKLRYQEVLNLLQ--EAQ
EQLRRQRKR--SQPLARSSLIPGIT------GMPAA-PDSLQSELM-ETSLYSEHSLDSG
IDSVRG-------------GIGGGGSMMGGMMTGSQQQVPAYRKVFETVRSASR------
-----ANPNGFSDSFSQLGSMTMSSSSQPRMAPGSSVYSTMYGGG--GGSSLGGRTYSRE
SLTADS-EDGYPGPAQ-TGIPGAPGAKDLEAALKRLTPAEVLARRAMLQHAPLGTYSYDE
QP----------AGIP--LGCRT----P-DSIMSTG--------------SSGLSGLSSS
SAAGNGQWRLPEKLQIVKPIEGSQTLHHWSRLATPTLSGLLEERPGVT------IRGGRG
LDELGLQTYSLSDVEED-------------------------------------------
---------------------EDTEDHPGKRFQSFGCTY-TYTNSTVLHPDDGTTAVTFS
LPPSQMSSQMTSEC----PTRQPTAPSTPR------SSLSRRNSCSTFSVNM--------
--------------GLASMLNERGIKA----------VTPSALNTPAGPNY---------
SPTVTPC-NSPDGSPTRSMSPEPPLLSGLLASTADILRKRFVASTGGQHSSADPADRPSR
IMTRNKVALSRLEKKALRSIKIMEKVES---IGLENIMLPPQHPPGISPLALHGTSALYT
AAASGRG---PQQQQADDLVTIDKETIKAVLTK-GLSHDSLKSMASSSGASSG---ISTA
MSFDSDSSSVASFDSEPRTKDTTSGASSAATNTNTASPTTAARLKQMQRQKSRRNLLNGA
NGGSQRPDLGTVNGSSRPGVRPDLGTVGSKATGKTGGNSSTGG--------TPAVKEESR
SLGQSVYGTISSLLFGRKGGLL
>gi|47216725|emb|CAG00999.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------SVY---LSDSQD----WV
VSPSGSPD-EGPVHHNAISPMLAEETFRYMI------L-SADRVEQMTK--TYNDMEVVT
QLLAE-----------------RDRDLELAARIGQSLLQRNHLLQERNEAL--EEQLTQA
VDQVHQLQHELSKKDELLR---MVASATEESETDSG---------------------VST
SL---QPVAPGATAAAAALSQLEFLRNKLQDLEEENLALRSEAC---QLKSDTITYEEKE
QQLVSD-------CVKELRKCDADFDAKQTPFFKTFPHLLLVAMGLGESNSQMVTLTDEL
SQKNEELLRHQEEIAQLLS----QIVELQHRVKELAL-EKEELRIHLQASKDAQRQLT--
-----AEVRDTFSDHTCRRSMQNIGNGKCAAMAPVRALQLNELADRNAECVEMLH--ESQ
EEIKELRSK--NAPSAGLRRHLSY-------GLYPMVRETLSGPML-RHSITSQRFMFKG
YVLITA-------------V------------------RSSHKRVFQTVRSVNA-----S
ASRSAA------ATSPIPGSGLSSLVMT----------AHLFQSVQ-GSVGLFSQTLM-P
LSVFRFLNLHLCREDLREGQPGPAGGNDLTRALHRLS----LRRQNFLCE---RQFFQAE
RERKLQAL-SDGDG----SGCSS----PAGSGISS--FSNLSE-------IS--LGSSIF
------KTFLPEKLQIVKPMEGSLTLHHWQQLAKPHLATILDPHPGVV------TKGFCP
LP--QDAIYHLSDMEEDEADDRSGVAVLEKGAAEEGKEEGDDEEEGGITFKSTTQGSARV
QLSPPT---LSQPAESCTPVTSHRSQQGKRCSKDKNDSFLVVQPLSSLLPARLFLPHSSF
SSSQT--SIMANTPSSM--RTGPSTPVTPCRLSLGDAFPPRRPLVHAR------------
--------------GLAKLVLERGISAQTSTE-----IPPSPKSTPQGPLLRLHPGTPPN
SPSQSPI-PSPVPTESR--KPPA--DNFLASRPAELFLQD-VYGLNLGRAPHPNLPSSSR
ENPGLSSPSATKAGPSPVSVGLVERLRR---LGFTKVL----------------------
-------------------------------QG-AETEAGTQRQDSATFVSAGGGSLLDG
LRRNQ------------------------------SLPAM---IGARAGKPSSTPAP---
------------------------------------------------------------
----------------------
>gi|126341608|ref|XP_001379011.	Monodelphis domestica
MASTSRNVHKGSSLDLFHDGSQQLCSFSLDPVKLKVGEELEKFSEAVALAPRPPLTTLRS
RPEVAHYCSRQVLPNPFKEFLCPEDLDLIPPAPSTGPPHGSLYIPVKPAKLDATALPTDI
LATTVPLPETCDHAVLACSPGIHEE----------------HYVSEALED-VPD-CRKYR
DACTITDVCNSTD-------LPEVEIISLLEEQLPHYKLRADTIY---GYDHDD----W-
---LHTPL-ISPDANIDLTTEQIEETLKYFL------L-CAERVGQMTK--TYNDIDAVT
RLLEE-----------------KERDLELAARIGQSLLKKNKTLTERNELL--EEQVDHI
REEVSQLRHELSMKDELLQ---FYTSAAEESEPESV---------------------CST
PL---K--RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEAC---QLKTETITYEEKE
QQLVND-------CVKELR----------------------------DANVQIASISEEL
AKKTEDASRQQEEITHLLS----QIVDLQKKAKACAV-ENEELVQHLGAAKDAQRQLT--
-----AELR--------------------------------ELEDKYAECMEMLH--EAQ
EELKNLRNK--SMPNTISRRYHSL-------GLFP--MDSLAAEI--EGSMRKELQMEEP
ESPD----------------------------------ITHQKRVFEAVRNINQ-----V
VKQRSLTP----SPMNIPGSNQSSAMNSIISSCVSTPRSSLYGGDI-TNIMIDNKTNS-I
ILETESSDTGNEDKNKKPGTPGTPGSHDLEIALRRLS----LRRENYLSE---RRFFEEE
QERKLREL-AEKGELH--SGSLT----PTESIMSLGTHSRFSE-------FTGFSGMSFS
S-----RSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVV------TKGFRT
LDVDLDEVYCLNDFEED-------------------------ETGD-ISYK-------GL
ATSLPV------------QHSETSAHHPGKCMSQTNSTF-TFTTCRILHPSDELTRVTPS
LNSAP--TPACGNSSNL-KSTPVGTPCTPRRLSLAESFTNLRESTTTMSTSL--------
--------------GLVWLLKERGISAAVYNPQSWDRASRGTLLNPYSPKMTVIPSTPPN
SPMQTPL-SSPPSFDFKCTSPPY--DNFLASKPASSILKE-VREK---------------
---KNIRNSESQTEVSVSNLNLVDKVKR---FGIAKVV---NSGRPHAPALT-EDQGPLL
CGPQGPT--------------------RAL------VPEGLPLGCPVVTSAIGGLQLNTG
IRRNR------------------------------SFPTM---VGSSMQMKAPVTLTSGI
LMGAKLPKQTSLR-----------------------------------------------
----------------------
>gi|148677214|gb|EDL09161.1|	Mus musculus
----------------------------ATGGRGRADNESEQRHRPRDRARRPRASCGFS
VSRTFWYTESPGGPSARLP---------LTPAAG--TPHGSGHLPLKPAKLDATALHDDT
SASSTPISEACSHAVLACGPGIPEE----------------YYVSEAVED-APS-YREHR
DACTITDVCNSTN-------LPEVEIISLLEEQLPHYKLRADTIY---GYDHDD----W-
---LHTPL-ISPDANIDLTTEQIEETLKYFL------L-CAERVGQMTK--TYNDIDAVT
RLLEE-----------------KERDLELAARIGQSLLKKNKTLTERNELL--EEQVEHI
REEVSQLRHELSMKDELLQ---FYTSAAEESEPESV---------------------CST
PL---K--RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEAC---QLKTETITYEEKE
QQLVND-------CVKELR----------------------------DANVQIASISEEL
AKKTEDAARQQEEITHLLS----QIVDLQKKAKSCAV-ENEELVQHLGAAKDAQRQLT--
-----AELR--------------------------------ELEDKYAECMEMLH--EAQ
EELKNLRNK--TMP--TSRRYHSL-------GLFP--MDSLAAEI--EGTMRKELQLEEL
ESPD----------------------------------ITHQKRVFETVRNVNQ-----V
VKQRSLTP----SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDV-SNVVLDNKTNS-I
LLETEAADLGNEDHNKKPGTPGTPGSHDLETALRRLS----LRRENYLSE---RRFFEEE
QERKLREL-AEKGELH--SGSLT----PTESIMSLGTHSRFSE-------FTGFSGMSFS
S-----RSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVV------TKGFRT
LDVDLDEVYCLNDFEED-------------------------DTGDHISLA-------GL
ATSTPI------------QHPETSAHHPGKCMSQTNSTF-TFTTCRILHPSDELTRVTPS
LNSAP--APACSSTSHL-KSTPVATPCTPRRLSLAESFTNVRESTTTMSTSL--------
--------------GLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPRMAVIPSTPPN
SPMQTPS-ASPPSFEFKCTSPPY--NNFLASKPASSILRE-VREK---------------
---RPVRSSESQTDVSVSNLNLVDKVRR---FGVARVV---NSGRARIPTLT-EEQGPLL
CGPTGPA--------------------QALVPG-GLVPEGLPLGCP------------SG
IRRNR------------------------------SFPTM---VGSSVQMRAPVILTSGI
LMGAKLPKQTSLR-----------------------------------------------
----------------------
>gi|118086149|ref|XP_418813.2|	Gallus gallus
----------------------------MSGTECQRAQKSFKLCEADSSKEKEFYFCQ--
----------------------------PDPVSSAGPPDGSLYNPLKPAKLDATDLHDCT
LAATVPPSELLNHAVQACDTGIHEE----------------HYVSEAVEDDVPD-CREYR
DACTITDVCNSTN-------LPEVEIISLLEEQLPHYKLRADTIY---GYDHDD----W-
---LHTPL-ISPDANIDLTTEQIEETLKYFL------L-CAERVGQMTK--TYNDIDAVT
RLLEE-----------------KERDLELAARIGQSLLKKNKSLTERNEFL--EEQVEHI
REEVSQLRHELSMKDELLQ---FYTSAAEESEPESI---------------------CST
PL---K--RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEAC---QLKTETITYEEKE
QQLVND-------CVKELR----------------------------DANIQIANISEEL
AKKTEDAARQQEEITHLLS----QIVDLQKKAKACAV-ENEELVQHLGAAKDAQRQLT--
-----AELR--------------------------------ELEDKYAECMEMLH--EAQ
EELKNLRNK--TMPNAVSRRYHSL-------GLFP--MDSLAAEI--EGSMRKELHLDEP
DSPD----------------------------------LAHQKRVFETVRNVNQ-----V
VKQRSMTP----SPMNIPGSNQSSAMNSLISSCISTPRSSFYGGDI-SNIVIDNKTNS-I
ILETDS-ENGNEDRMKKPGTPGTPGSSDLETALRRLS----LRRENYLSE---RKFFEEE
QERKLREL-AEKGELR--SGSIT----PTESIMSLGTHSRFSE-------FTGYSGMSIS
S-----RSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVV------TKGFRT
LDLDLDEVYCLNDYEED-------------------------ETGD-ISYK-------GL
TTSTPV------------QHTETSVPHPGKCMSQTNSTF-TFTTCRILHPSDELTRVTPS
LNAAP--TPACGSVSNL-KGTPVATPCTPRRLSLAESFTNLRESTTTMSTSL--------
--------------GLVWLLKERGISAAVYNPQSWDRASKGTLLNTYSPKMAIIPSTPPN
SPMQTPS-SSPPSFEFKCTSPPY--DNFLASKPASSILKE-VRNK---------------
---KNIRNSESQTDVSVSNLNLVDKVRR---FGIAKVV---SSGQVPTPPLT-DDQGPLV
CGAQGSG--------------------RALVPG-GLAPDTLPLGCPAVTSAIGGIQLNTG
IRRNR------------------------------SFPTM---VGSSMQMKGPTSLTSGI
LMGTKLPKQTSLR-----------------------------------------------
----------------------
>gi|109100572|ref|XP_001098295.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
-------MSQSQNAIFTSPTGEENL----------------M-------------NSSHR
DSESITDVCSNED-------LPEVELVSLLEEQLPQYRLKVDTLF---LYENQD----W-
---TQSAH-QQQHASDALSPVLAEETFRYMI------L-GTDRVEQMTK--TYNDIDMVT
HLLAE-----------------RDRDLELAARIGQALLKRNHVLSEQNESL--EEQLGQA
FDQVNQLQHELSKKDELLR---IVSIASEESETDSS---------------------CST
PL---R--FNESFSLSQGLLQLEMLQEKLKELEEENMALRSKAC---HIKTETVTYEEKE
QQLVSD-------CVKELR----------------------------ETNAQMSRMTEEL
SGKSDELIRYQEEISSLLS----QIVDLQHKLKEHVI-EKEELKLHLQASKDAQRQLT--
-----MELH--------------------------------ELQDRNMECLGMLH--ESQ
EEIKELRSR--SGPAAHLYFSQSY-------GAFT--GESLAAEI--EGTMRKKLSLDEE
SSLFKQ--------------------------------KAQQKRVFDTVRIAND-----T
RGRSISFP----ALLPIPGSNHSSVIMT----------AKPFES------GLQQTEDK-S
LLNQGSSSEEVAGSSQKMGQPGPSGDSDLATALHRLN----LRRQNYLSE---KQFFAEE
WQRKIQVL-ADQKEGV--SGCVT----PTESLVSL--CTNQSE-------ITDLSSASCL
------RGFMPEKLQIVKPLEGSQTLYHWQQLAQPNLGTILDPRPGVI------TKGFTQ
LP--RDTIYHISDLEEDE------------------------EEGITFQVQQPLQVEEKL
STSKPVTGIFLPPITSAGGPVTVATANPGKCLSCTNSTF-TFTTCRILHPSD----ITQV
TPSSGFPSLSCGSSGSSSSNTAVNSPALSYRLSIGESITNRRDSTTTFSSTM--------
--------------SLAKLLQERGISAKVYHSP----ISENPLQP--LPKSLAIPSTPPN
SPSHSPC-PSPLPFEPRVHLS----ENFLASRPAETFLQE-MYGL---------------
------RPSRNPPDVGQLKMNLVDRLKR---LGIARVV---------------KNPGAQE
NGRCQEA--------------------EIGLQK----PDS-------AVYLNSGSSLLGG
LRRNQ------------------------------SLPVI---MGSFAAPVCTSSPKMGV
LKED--------------------------------------------------------
----------------------
>gi|120431738|ref|NP_817084.2|	Homo sapiens
------------------------------------------------------------
----------------------------MRPKRLGRCCAGSRLGPGDPAALTCAPSPSAS
PAPEPSAQPQARGTGQRVGSRATSG---------------SQFLSEARTGARPASEAGAK
AGARRPSAFSAIQ-------GDVRSMPDNSDAPWTRFVFQGPFGSRATGRGTGKAAGIW-
---------KTPAAYVGRRPGVSGPERAAFIRELEEAL-CPNLPPPVKKI-TQEDVKVML
YLLEELLPPVWESVTYGMV-LQRERDLNTAARIGQSLVKQNSVLMEENSKL--EALLGSA
KEEILYLRHQVNLRDELLQ---LYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQCAH
PCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEAS---QL----DTLEDEE
QMLILE-------CVEQFS----------------------------EASQQMAELSEVL
VLRLENYERQQQEVARLQA----QVLKLQQRCRMYGA-ETEKLQKQLASEKEIQMQLQ--
------------------------------------------------------------
------EEE--TLP-----------------GF----QETLAEEL--RTSLRR--MISDP
--------------------------------------VYFMERNYEMPR----------
-------------------------------------------GDT-------------S
SLRYDFRYSEDREQVR-----G----------------------------------FEAE
EGLMLAAD-IMRGEDF------T----PAEEFVP--------------------------
----------QEELGAAKKV--------------PAEEGVMEEAELVSEE----TEGWEE
VELELDEATRMNV-----------------------------------------------
--------------------------------------------------------VTSA
LEASG-------------------------------------------------------
-------------------------------------LGPSHLDMNYV------------
-------------------------LQQLANWQDAHYRRQ-LRWK---------------
------------------------------------------------------------
-----------------------------MLQK-GECPHG--------------------
-----------------------------------ALPAA---SRTSCRSSCR-------
------------------------------------------------------------
----------------------
