>gi|57222253|ref|NP_001009557.1	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MDFSEHGEMLRQPSNSVPPQPSGGPVGATTNTKPENSK
-------PAPPPPP----------VNERKTFCPSENKPCDMEANKAYGTFKNTAP-G---
--PTFAGVNSAVRKDSVGKMDASTG---KATSDFMSNNQSAVRIAA--------------
EHNNSTGD-WTSMSQTTIILGTDGNTSVLP-GTVTGPPTDDTGRLFQDDDDDDGGDENK-
---ARGNWS-----NKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLGLAG
IPIFLLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNIIMCWTLYYLFA
SL------KETLPWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTTFCLSANVVG
NLSKLLNVTV-----D--NKTYVSPSEEYFKYNVL--H--------ISKGIEYPGDIRWP
LAACLFLAWLIVYASLAKGIKSSG-------------KVVYFTATFPYVVLVILLIRGVT
LPGAGSGILYFITP--------KWEKLNDAKVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHELKV-PIESVA-DEG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
VSDEF-PKY--L--RK--H-KPQFTLVCCLSF-FVLGFPMITESGMYMLQLVDTFAA-SY
SLVIIAIFELVGISYIYGLQRFCEDIEMMIGFQ-------------PNKF-------WRV
CWAFVTPTILTFILALSLYQ-WKVMTYED----YTYPNWSMVLGWLMVICSVIW-IPIMF
AIKMH----------------------------------LAPG-SLIERLKLVCS-----
-------------------------PQPDW---GPFLMKHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------NSLGL
KLPPKDFQLSAQYQ----------------------------------------------
----------------------------
>gi|40882479|gb|AAR96151.1|	Drosophila melanogaster
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MYTNSASDGDGGGDVCKHESIE------------------------------------
--------------MSKELGHTTSLQSSSPTTTDTS-----------NKQQLVKIEQLP-
---DRGSWS-----SKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAG
IPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFM
SM------RADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTT-----------QKV
CSVSALNIT---------SLELTGPVKEFWERRAL--Q--------ISHGIEEIGNIRWE
LAGTLLLVWILCYFCIWKGVKWTG-------------KVVYFTALFPYVLLTILLVRGIT
LPGALEGIKFYIIP--------NFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKF
TNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQR-PVADVA-ASG----------
------------PGLAFLVYPSAVLQLPGSPM-WSCLFFFMLLLIGLDSQFCTMEGFITA
IIDEW-PQL--L--RK--R-KEIFIAIVCALS-YLVGLTCITQGGMYIFQILDSYAVSGF
CLLWLIFFECVSISWCYGVDRFYDGIKDMIGYY-------------PTVW-------WKF
CWCVTTPAICLGVFFFNIVQ-WTPVKYLD----YSYPWWAHAFGWFTALSSMLY-IPLYM
FWLWK----------------------------------RTPG-ELSEKIRALVR-----
-------------------------IDEDV---TRLREKML---------REAYAKEI--
------------------------------------------------------------
------------------------------------------------------------
-------EFNSL------------------------------------------------
----------------------------
>gi|73977211|ref|XP_850903.1|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSGDTRSALGAHPGMASARGPVAPSSPEQVSHLP
EPPG--------------FFIRPFSERLPLF-----------------------------
--PLAESVPQVWRGAYDSSLLPHS------------------------------------
---------WARHGSTTAFLMVASLLSPQN-GAVPS--------------EATKRDQNL-
---KRGNWG-----NQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCG
IPLFFMELSFGQFASQGCLGVW-RISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFS
SM------THVLPWAYCNNPWNTPDC--AGVLDASNLTNGSRPA-------------ALP
GNLSHLLNH---------SLQRTSPSEEYWRLYVL--K--------LSDDIGNFGEVQLP
LLGCLGVSWVVVFLCLIRGVKSSG-------------KVVYFTATFPYVVLTILFVRGVT
LDGAFTGIMYYLTP--------QWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKF
HNNCYRDSIIISITNCATSVYAGFVIFSILGFMANHLGV-DVSRVA-DHG----------
------------PGLAFVAYPEALTLLPISPL-WSLLFFFMLILLGLGTQFCLLETLVTA
IVDEVGNEW--I--LQ--K-KTYVTLGVAVAG-FLLGVPLTSQAGIYWLLLMDNYAA-SF
SLVIISCIMCVSIMYIYGHRNYFQDIQMMLGFP-------------PPLF-------FQI
CWRFVSPAIIFFILIFTVIQ-YRPITYNH----YQYPGWAVAIGFLMALSSVIC-IPLYA
LFQLC----------------------------------RTDGDTLLQRLKNATK-----
-------------------------PSRDW---GPALLEHQ---------TGRYAPTI--
----PPS-----------------------------------------------------
-------------------------------------------------------PEDGL
EVQPLHPDKAQLPMVGSNGSRLQDSRI---------------------------------
----------------------------
>gi|67866500|gb|AAN52844.2|	Trichoplusia ni
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MALKTPTPGVG-----------------------------------------------
------------------------------------------------------------
---ERETWG-----KKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYCIMLVVGG
IPLFYMELALGQFHRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWALRFFFA
SF------TTMLPWTNCDNEWNTPACRPFEAIWESSANKSRVRQNS--------------
---SSTSLGS-----PP-TTPFTSAASEYFNRAIL--ELQ------GSEGLHDLGPIKWD
MALCLFAVYIICYFSLWKGISTSG-------------KVVWFTALFPYAVLLILLVRGIT
LPGSATGIQYYLSP--------NFEAITQPQVWVDAATQVFFSLGPGFGVLLAYASYNKY
HNNVYKDAILTSVINSATSFVAGFVIFSVLGYMAHTSGR-DIQDVA-TEG----------
------------PGLVFVVYPAAIATMPGSTF-WALIFFMMLLTLGLDSSFGGSEAIITA
LSDEF-PPI--G--RH----REIFVACLFTLY-FIVGLTSCTKGGFYFFQLLDRYAA-GY
SILVAVFFEAIAVSWIYGTERFCEDIRDMIGFR-------------PGLY-------WRV
CWRFVAPAFLLFITAYGLLD-WEPLRYEG----YVYPGWANVLGWAIAGSSVMC-IPTVA
IYKLI----------------------------------TAKG-SFVERLRLLTT-----
-------------------------PYADT---EGNGTVHNGMVVSESG-GVRLASTV--
---QTP------------------------------------------------------
-------------------------------------------------------TSQPP
TTPPLASAPALV------------------------------------------------
----------------------------
>gi|118404628|ref|NP_001072913.	Xenopus tropicalis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MDNKVPGAVSNGYCVPPTKPLM------------------------------------
-----------------------------------E-----------KEPKMEDGDMMI-
---ERGQWN-----NKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCG
IPVFFLETALGQYTSQGGVTAWRKICPLFEGIGYSSQVIVMLLNCYYIVVLAWALFYLFN
SF------TSELPWASCGHSWNTENCLDFYKGNSTHNVTLNGT-----------------
-----------------------SSVIEFWERRVL--R--------ISDGIDNIGGLHWE
LALCLLLAWIICYFCIWKGVKSTG-------------KVVYFTATFPYLMLIVLLIRGVS
LPGALTGIQFYLYP--------DLSRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKY
NNNCYRDCVALCFLNSGTSFVAGFAIFSILGFMAEEQGV-HISDVA-ESG----------
------------PGLAFIAYPRAVSMMPFSPL-WACFFFFMVILLGLDSQFVCVESLVTA
VVDMY-PTI--F--RKKNR-RELLILGVSMIS-FLVGLIMLTEGGMYVFQLFDYYAASGM
CLLFVAIFETLCVGWVYGADNFYDKVEHMIGYR-------------PTGI-------IKY
CWLFVTPAVCMATFLFSLVK-YTPLTYNK---HYVYPWWGDAIGWLLALSSMVC-IPLWV
GYKLS----------------------------------TIKG-SLMERFRQLTF-----
-------------------------PDPDL---PQK---------------TQCEPLS--
------------------------------------------------------------
------------------------------------------------------------
QTAQGTLLEESLC-----------------------------------------------
----------------------------
>gi|18029259|gb|AAL56437.1|	Oikopleura dioica
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MAKVKQQGLMNFQVKNELPNRMASAANDSFTEES-------
--SSEKVKLTRLREGFNFQTGNLS------------------------------------
--------------NSFIFISRDFSTDLSELRSLPG------------------------
----RQSWG-----NKIEFMLSMVGYAVGLGNIWRFPYLTYKNGGGAFLIPYLICLVLCG
LPIFLFEVALGQFCSQGPIKAF-NGVPIFKGIGYAMVAVSTIIGCYYNVIISYTLRYLFE
SFQ-AFS-TGELPWANCDNSWNDEKCMDVGRLNRCRSIQANGTLEV-----------PAM
CQLNHTNRE--------------APSQQYFENHIL--E--------MSDSIEDVGLPKAD
LVLYLAISYAILFICLAKGIQSTG-------------KAVYITSTFPYVVLTTLLIVGLT
KDGSLNGIKYFLTP--------EWERLKDMSVWKDAATQIFFSLSASWGGLITLASYNEF
DNNIVRDTLIVVLTNSATSIFAGLTIFSYLGFMAHSMGV-EVEDVA-RQG----------
------------PGLAFIAYPEALTQISTGSIVWSVLFFTMLLMLGLSTMFATMNTIITC
CSDAF-PQ---L--RK--R-QASFTAVLCVFL-FLLGIPMTTRAGLYILTLFDDFGG-SY
ALLVISVAEMVSICFIYGLDNFCSDIQIMIKRP-------------VGMF-------WRI
CWKFVSPVLLTAVFIAVLAN-WKVSTLGN----YVYPNWTNYPAVGLILFSVLF-IPLMA
IHHVI-----------------------------------KKG-----SIKAACE-----
-------------------------PTSHW---GPLNSENRL--------NTRYENRK--
HFTRDPHRFIDY------------------------------------------------
-------------------------------------------------------TSSGQ
TLLSSGASFVS-------------------------------------------------
----------------------------
>gi|66510350|ref|XP_394655.2|	Apis mellifera
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MVVTIINVTMQGY---------------------------------------------
---------WSRQ-------NEDKYSVANSQAPLQA-----------------GEDEHP-
---ERGTWT-----GKFDFLLSLLGYSVGLGNVWRFPYLCYSNGGGAFLIPFTVMLIIAG
LPLMFMELSLGQYASLGPVAAYKRFCPLLRGLGYGMVLVSSVVMLYYNLIIAWTLYYIFV
SVA-G---AGKLPWSKCEPAWSTEDCFMPEAAEACASQNMSYFKGKCLNSTQ-----MAS
MGLTLENIT---------SAIRRPPAEEYFNNHVL--G--------MSSGIEETGAIRPS
MAVNLLLAWIIVFLCLSKGVQSSG-------------KVVYFTALFPYVVLIALFIRGIL
LPGANEGILFYLTP--------DWKRLMSAKVWGDAAVQIFFALSPAWGGLITLSSYNKF
TNNCYKDSLIVAVSNIGTSFFAGFVIFSVIGFLAHELAV-PVASVV-DQG----------
------------AGLAFIVYPEVVARLPVAPV-WSLLFFVMLLTLGLDSQFALMETVTTA
ILDAF-PA---L--RN--Y-KLWVVLAAAVFG-YAGGIIFTTNAGMYWLQLMDKYAA-NW
SVLLIAIGECILVAWIYGADRFLDDVQQMIGPR-------------SRLWRFF----WTW
MWKVITPATLFFILFFNWVE-YEPLKYGV----YVYPKWADIVGWVVGMIPVLV-IVGLA
LSQLR-DRRRRSAYDDDDDDDDDLDNRPSYQRPGKGKTKKSNGKNVWWRAKMLLQ-----
-------------------------PTSDW---GPASRNPSTPSR-----TLTHTPSP--
----GPPGGYNSVRDTIVLVNGQPMMVQPS------------------------------
----------------------------------------------ST-------SGAAQ
KLPGPSILKNSSKTDLITSQQV--------------------------------------
----------------------------
>gi|144678874|gb|ABP01779.1|	Macaca fascicularis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------METTPLNSQKQLSACKDGEDCQENGVLQKVV
PTPGDKVESGQISNGYSAVPSPGAG-----------------------------------
-----------DDTRHSIPAATTTLVAELHQG----------------------------
---ERETWG-----KKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGG
IPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLIS
SF------TDQLPWTSCKNSWNTGNCTNYFS---EDNITWTLHST---------------
-----------------------SPAEEFYTRHVL--QIH------RSKGLQDLGGISWQ
LALCIMLIFTVIYFSIWKGVKTSG-------------KVVWVTATFPYIILSVLLVRGAT
LPGAWRGVLFYLKP--------NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKF
NNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNE-DVSEVAKDAG----------
------------PSLLFITYAEAIANMPASTF-FAIIFFLMLITLGLDSTFAGLEGVITA
VLDEF-PHI--W--AK--R-REWFVLAVVITC-FFGSLVTLTFGGAYVVKLLEEYAT-GP
AVLTVALIEAVAVSWFYGITQFCRDVKEMLGFS-------------PGWF-------WRI
CWVAISPLFLLFIICSFLMS-PPQLRLFQ----YNYPHWSIILGYCIGTSSFVC-IPTYI
AYRLI----------------------------------STPG-TFKERIIKSIT-----
-------------------------PET--------------------------------
------------------------------------------------------------
----------------------------------------------------------PT
EIPCGDVRLNAV------------------------------------------------
----------------------------
>gi|47230774|emb|CAF99967.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MRAKVFVPRRINLGKWTAAKPTGRLENAAPAA---
--PGSAAVNSAFRKDSAAHADP-------------------LRATA--------------
EQNNTPGT-WTAMSQTTIILGTDGNTSVQP-GTVTA-----------NDDDEEGGDENK-
---ARGNWS-----NKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLTMLGIAG
IPIFLLEVSLGQFASQGPVSVW-KCIPALQGCGIAMLIISVLIAIYYNIIMCWTLYYLFA
SL------KGSLPWANCRNDWNTVECKDKDMLLLDSCILRDRNSISVRNSSFCLSANALG
NLSKLLNVSA-----EG-NKSYVSPSEEYFKYNVL--H--------ISKGIEYPGDIRWP
LAGCLFLAWFIVYASLAKGIKSSG-------------KVVYFTATFPYVVLIILLIRGVT
LPGAFDGILYFITP--------KWEKLNDAKVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTIIVTCTNSATSIFAGFVIFSVIGFMAHELKV-PIEQVA-DEG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
VSDEF-PKY--L--RK--H-KALFTLACCISF-FILGFPMITENGMYMLQLVDTFAA-SY
SLVIIAIFELVGISYLYGLQRFCEDIEMMIGFQ-------------PNRF-------WRL
CWAFVTPTILTGILILSLYQ-WKVMTYED----YTYPTWSMVLGWLMVICSVIW-IPIMF
VIKMH----------------------------------LAPG-TIIERLKLVCS-----
-------------------------PQPDW---GPFLMKHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------NSLGL
KLPSKDLQLGS-------------------------------------------------
----------------------------
>gi|20384923|gb|AAM09083.1|	Schistosoma mansoni
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MTDRKAQDVDVCFLSDDHGMSI------------------------------------
----------------SQDGNPNKNTFLVPHQDGTG-----------NSGEVILVRQNPT
---ERGGWN-----GKLEFMMTCIGYAVGLGNVWRFPYLCFKNGGGAFLIPYTLMLALLG
LPLFFLEFAFGQFASLGPISVW-NISPLFKGIGYAMVFLSWLLNIYYQVVVAHCLYYFGV
SF------THTLPWTECNPAWSTPDCIDSNRMNYSNITYPK-------------------
-----------------------SPSEDYYFNQVL--K--------LSPGFEEFGAPGWE
LSLCLLSCWILCGLAVIKGVQSLG-------------KVSYFTSVFPYIMLTILLIRGAL
LPGSGAGVLYYLTP--------DFSRLTDPQVWADAATQIFFSLGCCNGGLITVSSYNKF
KNNCCRDAVIVAIINCATSVYAGFVIFSNLGFMAYQKNT-TIVEVA-SSG----------
------------PGLAFIVYPEAMTNMPLSSL-WSVLFFTMMLTLGFGSQFSILETTLSG
IQDEF-RRLGVH--LTERR-KIVFRISVCCLN-FFMGLPMVCAGGYYLVTIYDSVMS-GY
APLIVALSETVVITYVYGLKQFRCDIELMINER-------------PNWY-------WRI
CWLVFTPTICLLLIISVLTN-RIELKEMN----YSFPPWTYVLYHLLSAGTVLL-IVGWF
IYKYC----------------------------------SEGG---FLLLKEFLK-----
-------------------------PVHEW---GPADKKHRAEFISMIKSNESRINEAGG
NTYTSPIGGPNTIEGSQLQLGYGLNSSLKSGLAAAGVIDDTKFFQSKLNVAEKLTHAHTK
---EVVKRVVSNADISPANAVALLSASQTALAAVNSVALLGSQSLSGCIPGNTNIDTIGI
KLPEQFFISSDCDEMNESIKSTDQ------------------------------------
----------------------------
>gi|444010|emb|CAA54394.1|	Torpedo californica
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MATNGAKTPDGQISTELHDAPV------------------------------------
-----------SNDKPKTLVVKVQKTRKIP------------------------------
---EREKWG-----GRYDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFMTLIFAG
MPIFLLECSLGQYTSVGGLGIW-RLAPMFKGVGLAAAVLSFWLNIYYVVIIAWAIYYLYN
SF------TSELPWQSCGNSWNTDRCFSNYSMTNSTNLS---------------------
-----------------------SPIVEFWERNMH--Q--------LTDGLDQPGQIRAP
LAITLAIAWVLVYFCIWKGVSWTG-------------KVVYFSAIYPYIMLLTLFFRGVT
LPGAREGILFYITP--------DFRRLSDSEVWLDAATQIFFSYGLGLGSLVALGSYNKF
HNNVYRDSIIVCCINSTTSMFAGFVIFSIVGFMAHVTNR-PIADVA-ASG----------
------------PGLAFLAYPEAVTQLPISPL-WSILFFSMLLMLGIDSQFCTVEGFITA
LVDEF-PKL--L--RG--R-REIFIAMVCIVS-YLIGLSNITQGGLYVFKLFDYYSASGM
SLLFLVFFETVSISWCYGVNRFFVNIEEMVGHK-------------PCLW-------WKL
CWSFFTPIIVGGVFLFSAIQ-MKPLKMGS----YIFPKWGQGVGWFMALSSMML-IPGYM
GYMFL----------------------------------TSKG-SLKQRLRLMTQ-----
-------------------------PNEDM---KCRENGPE-------------------
------------------------------------------------------------
-------------------------------------------------------QTECG
NTPSDEAYM---------------------------------------------------
----------------------------
>gi|1171630|emb|CAA60635.1|	Torpedo marmorata
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MRAEKAIPIINGKPEDTMDIEA------------------------------------
---------------------SNVNLVRTNDKRMS-------------------------
---ERGHWN-----NKIEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVIFFIGCG
IPVFFLETALGQYTSEGGITCWRKICPLFEGIGYATQVIEAHLNMFYIIVLAWAIFYLFN
CF------TSELPWATCGHYWNTENCLEFQKLNSTNCNHTAVPNAT--------------
-----------------------SPVIEFWERRVL--G--------LSRGIEHIGRVRWE
LALCLLAAWIICYFCIWKGPKSTG-------------KVVYVTATFPYLMLLVLLIRGVT
LPGAAEGIKFYLYP--------DVSRLSDPQVWLDAGTQIFFSYAICLGCLTALGSYNPY
HNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAFEQGV-PIAEVA-ESG----------
------------PGLTFIAYPKAVTMMPLAPL-WAFLFFLMLIFLGLDSQFVCMESLVTA
IIDMY-PSI--F--RRGYR-REQLIFVIALAS-YLMGLVMVTEGGMYIFQLFDAYASSGM
CLLFVAIFECICIGWVYGGNRFYDNIEDMIGYR-------------PFVL-------IKW
CWIFITPGICAAIFIFFIVR-YQPLKYNN---VYVYPDWGYALGWALALSSMIC-IPLGF
IFKMW----------------------------------STEG-TFLEKIKKLTT-----
-------------------------PSADL---RRKGMGMSN--------MDTCCSTI--
---SDCDGK---------------------------------------------------
-------------------------------------------------------LKGDE
CIPAITEKETHF------------------------------------------------
----------------------------
>gi|114602772|ref|XP_527072.2|	Pan troglodytes
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MEEMVAERAGSVKWEEQVLLRRVIKRPVFLAPEPTASSLLAVPVALCAFQRV
TQKAEGFRREPPSPLAQGSPIRSSACGGARIPPPSVRQLSVWVSTRAQQCTLPQPRALRR
DRQGVRSALPALHARTRQTAAPASVPAPAGAREPRGQRRSGQRTIS----------RALA
LCAPGQLSPGHPLSKMKKLQGAHLRKPVTP-DLLMTPS--------DQGDVDLDVDFAA-
---DRGNWT-----GKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICG
IPLFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFA
SL------TSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCT--------------
----------------------VSPSEEYWSRYVL--HIQ------GSQGIGSPGEIRWN
LCLCLLLAWVIVFLCILKGVKSSG-------------KVVYFTATFPYLILLMLLVRGVT
LPGAWKGIQFYLTP--------QFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTF
HQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGV-PVDQVA-KAG----------
------------PGLAFVVYPQAMTMLPLSPF-WSFLFFFMLLTLGLDSQFAFLETIVTA
VTDEF-PYY--L--RP--K-KAVFSGLICVAM-YLMGLILTTDGGMYWLVLLDDYSA-SF
GLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFK-------------PGLY-------FRA
CWLFLSPATLLALLVYSIVK-YQPSEYGS----YRFPPWAELLGILMGLLSCLM-IPAGM
LVAVL----------------------------------REEG-SLWERLQQASR-----
-------------------------PAMDW---GPSLEENR---------TGMYVATLAG
SQSPKPLMVHMR------------------------------------------------
-------------------------------------------------------KYGGI
TSFENTAIEVDRETAEEEESMM--------------------------------------
----------------------------
>gi|109107067|ref|XP_001093080.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MPASAVAELWGYAQTLSLFRSN
IFGIPEDWGREQWNIVKGKEKTVDCSAPKEMNKQPANSPEAAAAQGHLDGPCAPRTSPEQ
ELPA---AAAPPPP----RVPRSASTGAQTFQSADARACEAERP-GVGSCKLSSPRA---
--QAASAALPDLREAQGAQAVPPPG--SSGPSNALHCKIHALRGPE--GDANVSVGKGTL
ERNNTPAVGWVNMSQSTVVLGTDGITSVLP-GSVAT----------VATQEDEQGDENK-
---ARGNWS-----SKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAG
LPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SF------VSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNL
TMVNFTSQA---------NKTFVSGSEEYFKYFVL--K--------ISAGIEYPGEIRWP
LAFCLFLAWVIVYASLAKGIKTSG-------------KVVYFTATFPYVVLVILLIRGVT
LPGAGAGIWYFITP--------KWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
ISDEF-PKY--L--RT--H-KPVFTLGCCICF-FIMGFPMITQGGIYMFQLVDTYAA-SY
ALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQ-------------PNIF-------WKV
CWAFVTPTILTVRILHVFLC-RQHLAYIS----WELVCWVVVQSW--VSCTGLWSTPMTF
VLLLH----------------------------------IVPD-KFAERLKLVCS-----
-------------------------PQPDW---GPFLAQHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPVKDLELGTQC-----------------------------------------------
----------------------------
>gi|108873744|gb|EAT37969.1|	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MNTQVTVLLTAPQAMSPASVYQRRNIE------------
--TGKLAKDPLVDGDCKNGVDGGV------------------------------------
-----------GGSGEEVSLAMTTLGQIKAASRKPG-----------HCLDLAESD----
---QRETWS-----GKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYCVMLLVGG
IPLFYMELALGQFNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFA
SF------TSQLPWTLCDNSWNTILCKPFEFGGPNKTAVAATVASVNG---------TFA
NTSIALSNE---------TVKFASAASEYFNRYIL--ELD------KSAGLHDLGTIKWD
MALCLLAVYLICYFSLWKGISTSG-------------KVVWFTALFPYAVLLILLVRGIT
LPGSADGIKYYLSP--------RFDMIEKPEVWVDAATQVFFSLGPGFGVLLAYASYNKY
HNNVYKDAILTSCINSATSFVAGFVIFSVLGYMAHASGQ-DIEDVA-TEG----------
------------PGLVFVVYPAAIATMPGSIF-WALIFFMMLLTLGLDSSFGGSEAIITA
LSDEF-PKI--G--RN----REIFVAGLFTLY-FFVGLASCTQGGFYFFQLLDRYAA-GY
SILIAVLFEAIAVSWIYGTKRFCDDIRDMIGFA-------------PGIY-------WRV
CWKFVAPLFLLFIIIYGLIG-YEPLSYED----YVYPTWANVLGWCIAGSSMIM-IPLMA
FYKLL----------------------------------VTPG-TLRQRFVILTT-----
-------------------------PWRDQ---QMS------------------------
------------------------------------------------------------
--------------------------------------------------------VNGV
MVEPAQVRLTNSDEGEEV------------------------------------------
----------------------------
>gi|50979138|ref|NP_001003311.1	Canis lupus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MATKEKLQCLKDFHKDILKPSP------------------------------------
-------------------------------GKSPG-----------TRPEDEAEGKPP-
---QREKWS-----SKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGG
LPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNIYYVIILAWATYYLFQ
SF------QSELPWAHCNHSWNTPQCMEDTMRKNKSLWITLSTK----------------
--------------------NFTSPVTEFWERNVL--S--------LSSGIDDPGSLKWD
LALCLLLVWLVCFFCIWKGVKSTG-------------KVVYFTATFPFAMLLVLLVRGLT
LPGAGAGIKFYLYP--------DISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKY
KYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGV-DIADVA-ESG----------
------------PGLAFIAYPKAVTMMPLPTF-WSILFFIMLLLLGLDSQFVEVEGQVTS
LVDLY-PSF--L--RKGFR-REIFIAFMCSIS-YLLGLSMVTEGGMYVFQLFDYYAASGV
CLLWVAFFECFVIAWIYGSDNLYDGIEDMIGYR-------------PGPW-------MKY
SWAVVTPVLCVGCFIFSLVK-YVPLTYNK---VYVYPTWAIGLGWSLALSSMMC-VPLVM
VIRLC----------------------------------QTEG-PFLVRLKYLLT-----
-------------------------PREPN---RWAVEREG---------ATPYSSRL--
------------------------------------------------------------
-------------------------------------------------------AVNGA
LMKPTHIIVETMM-----------------------------------------------
----------------------------
>gi|118091086|ref|XP_420906.2|	Gallus gallus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MPGELSGVLPAEPPRGEGSRSTGVLTLNERASRG
TGTPRNSPKLFFFLPKSKFSSGHDYTSQGDMNRQVMNSPETIPP-GPNEGAGVARISPEN
EPQN----TPLQPPAAMARLPRSLSNDYKTLLSEETKPNDLERT-KVGICKLSSTPV---
--QANSMLRRESAETFPYKQVAGAA--AAGQAVIPHCKIAALQSTD--GDANAALGKSTL
EQNNAKST-WVTLSQSTVVLGTDGNTSVLP-GRVEG----------VSTDEDDVGDENK-
---ARGNWS-----SKLDFILSMVGYAVGLGNVWRFPYLAFKNGGGAFLIPYLMMLALAG
IPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNIILCYTLFYLFA
SF------VPVLPWASCNNPWNTPDCKDKNKLLLDSCIISDHPKIQIKNSTFCMTAYPNL
TMVNFTSEG---------NKTFVSGSEEYFKYFVL--K--------ISAGIEYPGEIRWP
LALSLFLAWVIVYASLAKGIKSSG-------------KVVYFTATFPYVVLIILLIRGVT
LPGAGAGIWYFITP--------KWEKLIDAMVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANELKV-NIEAVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
VSDEF-PKY--L--RT--H-KALFTLGCCISF-FIMGFPMITQGGMYMLQLVDTYAA-SY
SLVIIAIFELVGVSYIYGLQRFCEDIEMMIGFQ-------------PSKF-------WRV
CWAFVTPTILTFILCFSFYQ-WEPMTYGA----YHYPGWSMVLGWLMLACSVIW-IPVMF
VIKMH----------------------------------LAPG-KFIERVKLVCS-----
-------------------------PQPDW---GPFLAKHR---------GERYMNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPVKDIELGTQC-----------------------------------------------
----------------------------
>gi|52783378|sp|Q761V0|SC6A5_MO	Mus musculus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MDCSAPKEMNKQPANILEAAVP-GHRDSPRAPRTSPEQ
DLPAEAPAATVQPP----RVPRSASTGAQTFQSADARACEAQQS-GVGFCNLSSPRA---
--QATSAALRDLSEGHSAQANPPSG--PAGAGNALHCKIPALRGPE--EDANVSVGKGTL
EHNNTPAVGWVNMSQSTVVLGTDGIASVLP-GSVAT----------TTIPEDEQGDENK-
---ARGNWS-----SKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAG
LPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SF------VSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNL
TMVNFTSQT---------NKTFVSGSEEYFKYFVL--K--------ISAGIEYPGEIRWP
LAFCLFLAWVIVYASLAKGIKSSG-------------KVVYFTATFPYVVLVILLIRGVT
LPGAGAGIWYFITP--------KWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
ISDEF-PKY--L--RT--H-KPVFTLGCCICF-FIMGFPMITQGGIYMFQLVDTYAA-SY
ALVIIAIFELVGISYVYGLQRFCEDIEMMIGFK-------------PNIF-------WKV
CWAFVTPTILTFILCFSFYQ-WEPMTYGS----YRYPNWSMVLGWLMLACSVIW-IPIMF
VIKMY----------------------------------LAPG-RFIERLKLVCS-----
-------------------------PQPDW---GPFLAQHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPVKDLELGTQC-----------------------------------------------
----------------------------
>gi|149728412|ref|XP_001489870.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MDPGTLPGTKDMISSLTEVIAYRRKTDGWMSLVRVSGANTICATL
ACLNVRPSNGPLQAAALDRPLPISSVASTAPQALGDPPLGLRQRRSPSPAAGLLAGQRRS
PRTVSPAAEPRRGGAERARRGPEPQRAGSPRRVEPSAAERSAAATP--------------
-----ESKEMATKEKLQCLKDFHKDILKPSPGKSPG-----------TRPEDEAEGKPP-
---QREKWS-----SKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGG
LPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNIYYIVILAWATYYLFQ
SF------QSELPWAHCNHSWNTPQCLEDTLRKNKSLWDSLNTS----------------
--------------------NFTSPVTEFWERNVL--S--------LSSGIDDPGSLKWD
LALCLLFVWLICFFCIWKGVKSTG-------------KVVYFTATFPFAMLLVLLIRGLT
LPGAGAGIKFYLYP--------DISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKY
KYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGV-DIADVA-ESG----------
------------PGLAFIAYPKAVTMMPLPTF-WSILFFIMLLLLGLDSQFVEVEGQITS
LVDLY-PSF--L--RKGFR-REIFIAFICSIS-YLLGLTMVTEGGMYVFQLFDYYAASGV
CLLWVAFFECFVIAWIYGSDNFYDGIEDMIGYR-------------PGPW-------MKY
SWAVVTPVLCVGCFIFSLVK-YIPLTYNK---VYMYPTWAIGLGWSLALSSMVC-VPLVV
VIRLC----------------------------------QTKG-PFLVRLKYLLT-----
-------------------------PREPN---RWAVEREG---------ATPYNSRR--
------------------------------------------------------------
-------------------------------------------------------AVNGA
LMKPSHILVETMM-----------------------------------------------
----------------------------
>gi|124245551|gb|AAZ08592.2|	Ostrinia nubilalis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MAGMPVLGNSVGPGELRDNSREASNRSPSSGSRRGSSPHRAQDSD
EGHKPD-LTNALPARRHHCDKDGYPEKVPTMASLSGSGVVTHTAPSYEEQRASPALLSRG
ASGTPGGRSVRDDGYCSASSTPRA------------------------------------
----------FDHKSTKGSVVTLSCYKKEPKIQIEEECIYSDSSKRVRTSSLKPGDPDD-
---GRETWG-----TGADFLLSIIGFAVDLANVWRFPYLCYRNGGGAFLIPYTLMLIFGA
VPLFYMELILGQYNRQGPITIW-KICPLFKGVGFCAVMVAFYVSFYYNVIIGWAFYFLVS
SA------RSELPWVHCDNAWNTDQCWDAARLNNTNRTEIPYQGPL--------------
--------------------SHFTPASEFFHRAVL--EMQ------HSEGLNDLGFPKWQ
LTVCLGLVYVTLYLSLFKGVKSSG-------------KVVWMTATMPYVVLSILLARGLL
LPGATRGIAYYLQP--------ELTRLKDTQVWVDAAVQIFYSVGAGFGVHLSYASYNTF
HNNCYRDCLVTTLVNCFTSFFSGFVIFTYLGFMSYKQGV-PISSVA-TEG----------
------------PGLVFQVYPEAVATLPGASL-WAMLFFFMLIMLGLDSGMGGLECVITG
LLDAA-RAS--G--AKHLR-REHFTFVVVCVS-FCVACINVTPGGIYMFHLLDTYAA-GI
SLLCSALFEAVAVSWFYGLKKFSDDVEEMLGFR-------------PGLY-------WRI
CWKFVSPTFIIGVVVFGLLY-QQPLVYQT----YTYPQWAVVLGWGLACSSILM-IPLVA
IYKFV----------------------------------MTPG-TCRQRVACCIS-----
-------------------------PESEH---EAI------------------------
------------------------------------------------------------
--------------------------------------------------------RGGA
PVTRFTWKHWLYV-----------------------------------------------
----------------------------
>gi|125982667|ref|XP_001355135.	Drosophila pseudoobscura
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MELKGV----------
--HQQNGTSNGTGAAGTEGESPPP------------------------------------
---------------------APAPATAEAAASLET-----------TTEKVDAEQQKT-
---ERTNWG-----NGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIG
KPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFATICIITYYSSLLALTLFYLFV
SF------QSVLPWSYCWEEW--MNCVDSRPQEDTDALLLSSSNVTNVT--------ALT
DTVKLQ-----------------SSSELYFLNVVIKEKMD------ISDGI---GDPDWK
LTLALFVSWVVIFLVIMRGVKSSG-------------KAAYFLALFPYVVLFILLVRAVT
LEGARDGIIFFLEP--------QWGELLNPTVWKNAVVQCFFSLAVGSGPIIMFASYNRF
DHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVV-RSG----------
------------TGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTI
LCDQF-KSW-----------KYWKVALATSICGFLMGLVYVTPGGQWILTLVDFYGG-TY
VVFILAIFELAGIVWIYGMQNFCDDVEFMCNRR-------------VSLY-------WRV
CWSFFTPVMMIVIFIYSMVT-IEPITYSE----QFFPEAGNVAGWLLFGIGAAQ-FPLWW
MWYIS---------------------------------HHREG-SLGQSFVASLR-----
-------------------------PSDKW---GPANPETKRQWVIFKN-EKAAQRAT--
------------------------------------------------------------
-------------------------------------------------------KKQSS
KMGAFWQKLGHFCGSNT-------------------------------------------
----------------------------
>gi|126723132|ref|NP_001075866.	Oryctolagus cuniculus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MAKKSAENGIYSVSGDEKKGPL------------------------------------
-----------------IAPGPDGAPAKGDGPAGLG--------------APGGCLAVP-
---PRETWT-----RQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGG
IPIFFLEISLGQFMKAGSINVW-NICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVK
SF------TTTLPWATCGHTWNTPDCVEIFR--HEDCANGSLANLT--------------
------CDQ---------LAERRSPVIEFWENKVL--R--------LSGGLEVPGALNSE
VTLCLLACWVLVYFCVWKGVKSTG-------------KIVYFTATFPYVVLVVLLVRGVL
LPGALDGIIYYLKP--------DWSKLRSPQVWIDAGTQIFFSYAIGLGALTALGSYNRF
NNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGV-HISKVA-ESG----------
------------PGLAFIAYPRAVTLMPVAPL-WAALFFFMLLLLGLDSQFVGVEGFITG
LLDLL-PASYYF--RF--Q-REISVALCCALC-FVIDLSMVQMAGMYVFQLFDYYSASGT
TLLWQAFWECVAVAWVYGADRFMDDIACMIGYR-------------PCPW-------MKW
CWSFFTPLVCMGIFIFNIVY-YKPLVYNK---TYVYPWWGEAMGWAFALSSMLC-VPLHL
LGCLL----------------------------------RAKG-TMAERWQHLTQ-----
-------------------------PV--W---GLHHLEYRAQ-------DADVRGLT--
------------------------------------------------------------
-------------------------------------------------------TLTPV
SESSKVVVVESVM-----------------------------------------------
----------------------------
>gi|89255269|dbj|BAE80716.1|	Crassostrea gigas
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MNDSKQNGYSSDGDPLS------------------------------------
-----------WKQQEAEALSSDDSATTSSEGPKMK------------------------
---RREVWA-----NKLDFLLACIGFSVGLGNVWRFPFLCYRNGGGAFLIPYFTAVLLGG
IPVFFLEVSLGQFMSEGGIGTW-KITPLFQGIGYACTIIVFLLNCEYNIILTWTFYYLFS
SF------NTVLPWSQGDNEWNSELCRNSSKMAASLMSNYSKMASSVVSKLND----TMT
TVAYTVATE---------NTTKCDPVTEFWESKVL--Q--------LSSGVDHAGTVKWD
LALCLLLAWIVVYGCIWKGIKSSG-------------KVMYFTATSPYILMLILLIRGVT
LDGAAEGLKFYLLP--------DWSKLQEAQVWVDAGTQIFFSYSISLGTLTALGSYNKF
RHNSYRDAMIFAGVNSFTSILAGLVIFSVLGFMAKQQGV-SVADVA-ESG----------
------------PGLAFIAYPTAVAQMPVAPL-WSVLFFVMIILLGLDSQFVGVEGFITA
CVDMY-PHY--L--RIGKR-REIFTGIVCFIC-FLIGLSMVTEGGMYVFQLFDYYSA-SR
IVLVVAFFECIVVAYIYGINRYYDNLEMMFGFR-------------IAPV-------MKI
CWMFVTPLFSLTIFIMGAIS-YSELTYKRKTYEYTYPSWAIGVGWMLALVSVIW-IPITF
FKRVI----------------------------------DAEG-SIAQRLMSTTR-----
-------------------------PILKR---HQLRQGEDLTKVVLDE-SCSFDPDDPI
LQGLDPRDE---------------------------------------------------
-------------------------------------------------------PLLAN
SVELQKIENSKRNETNGV------------------------------------------
----------------------------
>gi|62005843|dbj|BAD91313.1|	Mytilus galloprovincialis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MDEPKEDTTWISEKLPSKVDNPE------------------------------------
-----------VTSTDTTVTSSSGSDRLKPKLK---------------------------
---KREVWG-----KKIDFLLACVGFSVGLGNVWRFPFLCYRNGGGAFLIPYFIAVVVCG
IPCFFLEVCLGQFMAQGGVSAW-KITPLFQGIGFASAIIVFLLNCEYNIISSWSLYYLFS
SF------TAVLPWSHGNNEWNSENCTNLYKTNPVNSTISLLANVT-------------A
DVEDVISNL---------SKKLCDPVTEFWERKVL--N--------LSSGVDHPGAIKWD
LALCLLLAWIIVYFCIWKGIKSSG-------------KVMYFTATSPYIFMLILLIRGVT
LDGAELGLKYYLLP--------DWSKLRDPQVWVDAGTQIVFTYSLALGTLTALGSYNKF
HHNAFRDSIIFSCINSFTSLLAGLVIFSVLGFMAKRQGV-SIADVA-ESG----------
------------PGLAFIAYPEAVAQMPAAPF-WSVLFFVMILLLGLDSQFVGVEGFVTA
IVDYF-PNQ--L--RRGKR-REIFIGCVCIFC-FFIGLSMVTEGGMYVFQLFDYYAA-SR
IVLVMTFFECVVVAYIYGVNRFYDNLQMMFGYK-------------LSPFMSRLMKVMKY
MWAIFTPLFSMIIFIVGAIS-YSELDYKRKSLTYQYPSWAIGVGWILALSSVIW-VPIVF
IVRLL----------------------------------QTPG-TLRERFVITTM-----
-------------------------PRLQR---HQIREGEDMSKICVIDDEGEIESHIAT
SSNTEP------------------------------------------------------
-------------------------------------------------------TLLSY
SMEYEKFLQKDSNV----------------------------------------------
----------------------------
>gi|157058891|gb|ABV03173.1|	Xenopus laevis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MDYVNVVDGSKKTMNSPEGAAP-GLIGATGITNPTPDN
DLPL---QASNKLT----RLSQSTSNDSKLIAAGEPKACDLERSRVGGSCKMTTP-G---
--HSNFVLKRDSVEGCPAKNSSMAE--SNGQTNPMHCRIVPLQSAE--GDTNQGFGKNSL
EQNNAKGD-WVPISQSTVVLGTDGNTSVFP-GTLTG---------------DEEGDENK-
---ARGNWS-----NKLDFILSMVGYAVGLGNVWRFPYLAFKNGGGAFLIPYLTMLALAG
LPIFYLEVALGQFASQGPISVW-KAIPALQGCGIAMLIISVLIAIYYNIIMCYTIFYLFA
SL------VYVLPWASCNNPWNTPDCKDKDRLLLDSCIISSQPNIQIKNSTFCMTAYPNL
TMVNFTSHG---------NKSFVSGSEEYFKYNML--K--------ISAGIEYPGEIRWP
LVFCLFLAWIIVYASLAKGIKTSG-------------KVVYSTATFPYVVLVILLFRGVT
LPGAGDGIWWFIMP--------KWEKLMDATVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNLYRDTLIVTCINSATSIFAGFVIFSVIGFMAHILNV-DIEKVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
VSDEF-PKL--L--RT--H-KPLFTLVCCVAF-FIMGFPMITQGGIYMLQLVDNYAA-SY
SLVIIAIFELVGISYIYGLQRFCEDIEMMIGFQ-------------PSRF-------WKI
CWAFVTPTILTFILGFSFYQ-WEPMTYGS----YHYPSWSMVMGWLMLACSVIW-IPIMF
VIKMF----------------------------------LAPG-TFIERLKLVCS-----
-------------------------PQPDW---GPFLAKHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPPKDFELGTQC-----------------------------------------------
----------------------------
>gi|13549154|gb|AAK29670.1|AF35	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQ
ELPA---AAAPPPP----RVPRSASTGAQTFQSADARACEAERP-GVGSCKLSSPRA---
--QAASAALRDLREAQGAQASPPPG--SSGPGNALHCKIPSLRGPE--GDANVSVGKGTL
ERNNTPVVGWVNMSQSTVVLGTDGITSVLP-GSVAT----------VATQEDERGDENK-
---ARGNWS-----SKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAG
LPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SF------VSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNV
TMVNFTSQA---------NKTFVSGSEEYFKYFVL--K--------ISAGIEYPGEIRWP
LALCLFLAWVIVYASLAKGIKTSG-------------KVVYFTATFPYVVLVILLIRGVT
LPGAGAGIWYFITP--------KWEKLTNATVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
ISDEF-PKY--L--RT--H-KPVFTLGCCICF-FIMGFPMITQGGIYMFQLVDTYAA-SY
ALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQ-------------PNIF-------WKV
CWAFVTPTILTFILCFSFYQ-WEPMTYGS----YRYPNWSMVLGWLMLACSVIW-IPIMF
VIKMH----------------------------------LAPG-RFIERLKLACS-----
-------------------------PQPDW---GPFLAQHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPVKDLELGTQC-----------------------------------------------
----------------------------
>gi|126332504|ref|XP_001380033.	Monodelphis domestica
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MSDYSGPKDMNKQLANSLEAP---GNPEGSSVTRTSPEP
EPSS---ATPSQPP----RIAKSASNGIQTFLSEEAKSYESERT-KVGIC---SARA---
--PLDAASRQDSIEAHALQTIPPTGDPGPGPGNAQHCRIPALRGASVGEEESGSSGKGTL
ERNSTQAAGWINMSQSTVVLGTDGITSVLP-GSVTT----------TSTPEDDEGDENK-
---ARGNWS-----SKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAG
LPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SF------VSVLPWASCNNPWNTPDCKDKTKLLLDSCFVGDHPKIQIKNSTFCMTAYPNL
TMVNFTSQA---------NKTFVSGSEEYFKYFVL--K--------ISAGIEYPGEIRWP
LVVCLFLAWVIVYASLAKGIKTSG-------------KVVYFTATFPYVVLVILLIRGVT
LPGAGAGIWYFITP--------KWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
ISDEF-PKY--L--RT--H-KPVFTLGCCVCF-FIMGFPMITQGGIYMFQLVDTYAA-SY
ALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQ-------------PNIF-------WKV
CWAFVTPTILTFILCFSFYQ-WEPMTYGS----YRYPNWSMVLGWLMLACSVIW-IPIMF
VIKMH----------------------------------LAPG-KFIERLKLVCS-----
-------------------------PQPDW---GPFLARHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPVKDFELGTQC-----------------------------------------------
----------------------------
>gi|6714643|dbj|BAA89537.1|	Cyprinus carpio
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MAQKEKLQCLKDFHKDILKPSP------------------------------------
-------------------------------GKSPG-----------TRPEDEAEGKHP-
---QREKWA-----SKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGG
LPVFFLEVALGQFTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLFQ
CF------QPELPWASCNNKWNTENCIEDTLRKNKTLWGAVNAT----------------
--------------------NFTSPVTEFWERNVL--S--------ISDGIEDVGHVKWD
LALCLLAVWVICFFCIWKGVKSTG-------------KVVYVTATFPFVMLIVLLVRGVT
LPGAAEGIKFYLYP--------NLTRLGDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKY
KYNCYRDCLLLGGLNSATSFVSGFAIFSVLGFMAQEQGV-DIADVA-ESG----------
------------PGLAFIAYPKAVSMMPLPTF-WAILFFIMLLLLGLDSQFVEVEGQITS
LVDLY-PSF--L--RKGYR-REIFIAIVCFLS-YLLGLTMVTEGGMYVFQLFDYYAASGV
CLLWVAFFECIAVAWVYGADNFYDAIEEMIGYR-------------PNPW-------MKW
SWTVITPFLCVGCFIFSLVK-YTPLRYNK---VYEYPDWSIGVGWTLALASMIC-IPMVV
VIKII----------------------------------QSDG-PLIERIKAVAA-----
-------------------------PVRGG---ASSCPPEYQPK------SNELAQPL--
----DPN-----------------------------------------------------
-------------------------------------------------------WNGGL
TKPTHTIVETMM------------------------------------------------
----------------------------
>gi|157020163|gb|EAA04277.4|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MKCRKDAEPRDLAQGSTKNSIEGDALK----
--ELNGGAENGVGGDSEGTALAMT------------------------------------
---------------TIGQIKAKGRPGLLPRNGAGG----------GGGGELDDGE----
---ERETWS-----GKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYGIMLVVGG
IPLFYMELALGQFNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFA
SF------TDSLPWTHCSNAWNTVECKPFGYINSTAATVVNRTGVL-----------AAN
VTSTVSTIN---------DTKFASAASEYFNRYIL--ELD------KSEGIHDLGAIKWD
MALCLLAVYLICYFSLWKGISTSG-------------KVVWFTALFPYAVLLILLVRGIT
LPGSAEGILYYLRP--------NFDVIYNAEVWVDAATQVFFSLGPGFGVLLAYASYNKY
HNNVYKDALLTSLINSATSFIAGFVIFSVLGYMAHASGQ-SIQDVA-TEG----------
------------PGLVFVVYPAAIATMPGSIF-WALIFFMMLLTLGLDSSFGGSEAIITA
LSDEF-PKI--G--RN----REIFVAVLFSLY-FVVGLASCTQGGFYFFQLLDRYAA-GY
SILIAVFFEAIAVSWIYGTERFCNDIKDMIGFA-------------PGIY-------WRV
CWKFVAPLFLLFIIIYGLIG-HEPLSYED----YVYPSWANVLGWCIAGSSMIM-IPLMA
SYKLI----------------------------------VTPG-SLRQRFKILTT-----
-------------------------PWRDQ---QMA------------------------
------------------------------------------------------------
--------------------------------------------------------VNGV
SIEPAQVRLTHSDEGEEV------------------------------------------
----------------------------
>gi|149412619|ref|XP_001510332.	Ornithorhynchus anatinus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MT
PVTPDLLMTPSDQGDGDLEMDYSA------------------------------------
------------------------------------------------------------
---DRGNWT-----GKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFIMLAICG
IPIFFMELSLGQFSSLGPLAVW-KISPLFKGVGAGMLLIVSLVAIYYNMIIAYVLFYLFA
SL------TSDLPWQHCGNWWNTELCLDHHAMREANVALPLNLSGT--------------
----------------------VSPSEEYWSRYVL--HIQ------GSAGIGDPGGIRWN
LCLCLLLSWVIVFLCILKGVKSSG-------------KVVYFTATFPYVILLMLLVRGVT
LQGAWKGIRFYLTP--------QFEHLLSSKVSVESVQEIDWSLQ-DWGYGVGGGNPGIP
ALSVPRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGV-PVNQVA-KAG----------
------------PGLAFVVYPQAMTMLPLSPF-WSFLFFFMLLTLGLDSQFAFMETIVTA
VTDEF-PYY--L--RP--K-KAFFSGVLCVAM-FLMGLILTTDGGMYWLVLLDDYSA-GF
GLMVVVITSCLVVTRVYGIQRFCRDIHMMLGFK-------------PGFY-------FKA
CWACLSPVTMMALLVYSIVK-YQPSEYGN----YHFPFWAELLGILMGLLSCLM-IPAGM
VVAVL----------------------------------REEG-PLWERIRQASR-----
-------------------------PAMDW---GPSLEENR---------TGMYVATLAG
SQSPRPLMVHMR------------------------------------------------
-------------------------------------------------------KYGGI
TSYEHTAIEVDKEMEEEEESMM--------------------------------------
----------------------------
>gi|89243282|gb|ABD64799.1|	Drosophila virilis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MRCESYTLPIA------------------------------------
------------------------------------------------------------
--------------SKLDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYILTLFLAG
IPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFM
SM------RADVPWRTCNNWWNTINCVNQYERKNLHCWDKMINGTA-----------NKV
CSVAAANIS---------STELTDPVKEFWERRAL--Q--------ISSGIDEIGNIRWE
LAGTLLLVWILCYFCIWKGVKWTG-------------KVVYFTALFPYVLLTVLLIRGIT
LPGALEGIKFYIIP--------NFSKLSHSEVWIDAVTQIFFSYGLGLGTLVALGSYNKF
TNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQR-PVAEVA-ASGSYSAIQKYIY
QKYILIMQNIKSPGLAFLVYPSAVLQLPGSPM-WSCLFFFMLLLIGLDSQFCTMEGFITA
IIDEW-PQL--L--RK--R-KEIFIAIVCMLS-YLVGLTCITQGGMYIFQILDSYAVSGF
CLLWLIFFECVSISWCYGVDRFYDGIKDMIGYY-------------PTVW-------WKF
CWCVTTPAICLGVFFFNIVQ-WTPIKYLD----YSYPWWAHAFGWFTALSSMLY-IPAYM
FWLWK----------------------------------RTPG-DLCEKIRSIVR-----
-------------------------IDEDI---TRLREKMQ---------REAYAKEI--
------------------------------------------------------------
------------------------------------------------------------
-------EFNS-------------------------------------------------
----------------------------
>gi|156549479|ref|XP_001604321.	Nasonia vitripennis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MEVPSSEQRQQGQLAGATATPS------------------------------------
------------------ILNEDKYSVANSQAPLQA-----------------GEDEHP-
---ERGTWS-----GKFDFLLSLLGYSVGLGNVWRFPYLCYSNGGGAFLIPFTVMLIIAG
LPLMFMELSLGQYASLGPVAAYKRFCPLLRGLGYGMVMVSSVVMLYYNLIIAWTLFYMFA
SV------TGELPWSKCEEEWSTRECFMPEAALLCANQNMTYFKRECLNSSQ-----LAA
INFSPENLT---------SVIRKPPAEEYFNNHVL--R--------LSHGIEDTGSISPK
MAGCLFLAWVIVFLCLSKGVQSSG-------------KVVYFTALFPYVVLIALFIRGIM
LPGADEGILFYLTP--------DWKRLASAKVWGDAAVQIFFALSPAWGGLITLSSYNKF
TNNCYKDSLIVAVSNIGTSFFAGLVIFSVIGFLAHELDV-EVKSVV-DQG----------
------------AGLAFIVYPEVVSRLPVAPV-WSLLFFVMLLTLGLDSQFALMETVTTA
ILDGI-PA---L--RN--Y-KFWVVLACAVFG-YGGGLIFTTNAGMYWLQLMDKYAA-NW
SVLLIAISECILVAWVYGADRFLDDVQQMIGVR-------------GRCWRFF----WTW
MWKVVTPAALFFILFFNWVE-YEPLSYGT----YVYPRWADAVGWVVGLVPVLV-IVGLA
VVQLRVSKRPRSEYEDEEEEEND-------------ELRGSGNDSVWSRARKLLQ-----
-------------------------PTSDW---GPATRNPLTPSR-----TLPHTPSP--
----GPQCGYDSVRDTIVLVNGQPMTVQGATGGTGIPG----------------------
-------------------------------------------------------SGSSQ
KLPGPSILKNSSKTDLITSQQV--------------------------------------
----------------------------
>gi|22086693|gb|AAM90737.1|AF42	Salmo salar
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MAQKEKLQCLKDFHKDTLKPSP------------------------------------
-------------------------------GKSPG-----------TRPEDEAEGKPI-
---QREKWA-----SKLDFILSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYTIFLFGGG
LPVFFLEVALGQYTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLFQ
CF------QPELPWAKCNQPWNTDRCVEDTFRKNKTLMLAANIT----------------
--------------------NFTSPVTEFWERNVL--S--------ISSGIDDIGPLKWD
LALCLLAVWIVCFFCIWKGVKSTG-------------KVVYITATFPFVMLIVLLVRGVT
LPGASEGIKFYLYP--------NLTRLQDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKY
KYNCYRDCLLLGGLNSGTSFVSGFAIFSVLGFMAQEQGV-DIADVA-ESG----------
------------PGLAFIAYPKAVSMMPYPTF-WAILFFIMLLLLGLDSQFVEVEGQITS
LVDLY-PAA--L--RTGYR-REIFIAVMCCIS-YLLGLTMVTKGGMYVFQLFDYYAASGV
CLLWVAFFECIAVAWVYGADNFYDAIEDMIGYR-------------PNPW-------MKW
SWTFITPVLCAGCFIFSLVK-YKPLTYNK---VYEYPDWSIGLGWSLALASMIC-IPMVM
VIKIL----------------------------------QSDG-PLIERIKAVAA-----
-------------------------PVKGG---ASSRPKEYSVK------GSELTQPL--
----DPN-----------------------------------------------------
-------------------------------------------------------GNNGL
IKPTHTIVETMM------------------------------------------------
----------------------------
>gi|76657139|ref|XP_606459.2|	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MDCSAPKEMNKQPANSLEAAVPSGHHDGPCAPRTSPEQ
ELPA---ATAAPPP----RVPRSASTGAQTFHAADARACEAERPGGAGACKLSSLRS---
--PAASAALRDWSEAHGAQTAPPSG--GAGPGNALPCKITALRGLE--GDANVSVGKGTL
ERNNTPAVGWVNMSQSTVVLGTDGITSVLP-GSVAT----------AATQEDEQGDENK-
---ARGNWS-----SKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAG
LPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SF------VSVLPWGSCNNPWNTPECKDKTKLLLDSCVINDHPKIQIKNSTFCMTAYPNL
TMVNFTSQA---------NKTFVSGSEEYFKYFVL--K--------ISAGIEYPGEIRWP
LAFCLFLAWVIVYASLAKGIKTSG-------------KVVYFTATFPYVVLVILLIRGVT
LPGAGAGIWYFITP--------KWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
ISDEF-PKY--L--RT--H-KPVFTLGCCVCF-FIMGFPMITQGGIYMFQLVDTYAA-SY
ALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQ-------------PNIF-------WKV
CWAFVTPTILTFILCFSFYQ-WEPMTYGS----YRYPNWSMVLGWLMLACSVIW-IPIMF
VIKMH----------------------------------LAPG-RFIERLKLVCS-----
-------------------------PQPDW---GPFLAQHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPVKDLELGTQC-----------------------------------------------
----------------------------
>gi|42627863|ref|NP_976079.1|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MDCSAPKEMNKPPTNILEATVP-GHRDSPRAPRTSPEQ
DLPAAAPAAAVQPP----RVPRSASTGAQTFQSADARACEAQRP-GVGFCKLSSPQA---
--QATSAALRDLSEGHSAQANPPSG--AAGAGNALHCKIPALRGPE--EDENVSVAKGTL
EHNNTPPVGWVNMSQSTVVLGTDGIASVLP-GSVAT----------TTIPEDEQGDENK-
---ARGNWS-----SKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAG
LPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SF------VSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNL
TMVNFTSQA---------NKTFVSGSEEYFKYFVL--K--------ISAGIEYPGEIRWP
LPFCLFLAWVIVYASLAKGIKTSG-------------KVVYFTATFPYVVLVILLIRGVT
LPGAGAGIWYFITP--------KWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKF
HNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVA-DQG----------
------------PGIAFVVYPEALTRLPLSPF-WAIIFFLMLLTLGLDTMFATIETIVTS
ISDEF-PKY--L--RT--H-KPVFTLGCCICF-FIMGFPMITQGGIYMFQLVDTYAA-SY
ALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQ-------------PNIF-------WKV
CWAFVTPTILTFILCFSFYQ-WEPMTYGS----YRYPNWSMVLGWLMLACSVIW-IPIMF
VIKMY----------------------------------LAPG-RFIERLKLVCS-----
-------------------------PQPDW---GPFLAQHR---------GERYKNMI--
----DPLGT---------------------------------------------------
-------------------------------------------------------SSLGL
KLPVKDLELGTQC-----------------------------------------------
----------------------------
>gi|11191966|dbj|BAB18038.1|	Oreochromis mossambicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MK
EIMAQKEKLQCLKDFHKDTLKPSP------------------------------------
-------------------------------GKSPG-----------TRPEDEAEGKAP-
---QREKWA-----SKLDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGG
LPVFFLEVALGQYTSEGGITCWAKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLFQ
CF------QPELPWAKCKQPWNTEHCVEDTVRKNKTLWLAANAT----------------
--------------------NFTSPVTEFWERNVL--S--------ISTGIEDIGPLKWD
LALCLLAVWVICFFCIWKGVKSTG-------------KVVYITATFPFVMLIVLLVRGVT
LPGAREGIKFYLYP--------NVTRLQDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKY
KYNCYRDCLLLGGLNSGTSFVSGFAIFSVLGFMAQEQGV-DIADVA-ESG----------
------------PGLAFIAYPKAVSMMPLPTL-WAILFFIMLLLLGLDSQFVEVEGQITS
IVDLY-PAV--L--RKGYR-REIFIAVMCFMS-YLLGLAMVTKGGMYVFQLFDYYAASGV
CLLWVAFFECIAVAWVYGVDNFYDAVEDMIGYR-------------PNPW-------MKW
SWSIITPVLCMGCFVFSLVK-YKPLTYNK---VYEYPDWAIGLGWILALSSMIC-IPMVM
VIKIL----------------------------------QSEG-PLIERIKAVAA-----
-------------------------PAKSG---VSSRPKEYNLK------GSELTQPL--
----DPNG----------------------------------------------------
--------------------------------------------------------NNGL
IKPTHTIVETMM------------------------------------------------
----------------------------
>gi|115968599|ref|XP_001186423.	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MTILASTYILINVDVESLFTKQTAHLYQTLAYTKIRGSTGDPP
HNTDPKDSGPQVSNFGHTILTKTLLPQAAIFDQSDQLPILTDEDPAFSTSQKPSGAV---
--DPTQGKERIAVIAHDFSHDEDEVRAMKMDTFKNTQWSTFEKAGLVMICGRMDKTPEIQ
EKDWNSLVKFLEDASKSSPANASGMADRNHDSAATAPVANGLDEKELLNKKLEKESENKS
KQKSRGTWT-----SQLDFLLALIGASVGLGNVWRFPYLCYKNGGGAFLIPYFICLILGG
IPQLILEIGLGQWTNQAAVTAW-DICPIFKGLGGAGMFIQFFLDTYYIVIMAWALYYMFM
SF------TSKLPYSHCDNEWNTPCCLATGASSLDANETTTAMTSTEMSYDP-----TGT
PSWNLTDPC---------NGTTISSTVEFWDRKIL--QIH------LSDGIEQLGGINWQ
LLLCMFFAWFLCYLCICKGVKTSG-------------KVVYFTAPFPYILMTILLIRAVT
LEGAMDGIVYYLKP--------DISRLNDSQVWMDAATQIFFSYSLGQGVLIALGSYNKH
KHNFIRDALIFSVANTGTSLYSGFVIFAVLGFMAGQQGV-DVSVVA-KSG----------
------------PGLAFIAYPEAITQMPASTL-WAVLFFLCLLVLGIDSQFVGVEGFVAT
IVDLF-PNT--L--LKGHR-REIFCIFVCLFF-CIAGIPMCTYGGMYIFQLFDYYAASGF
VLLWVSMFESITIGWAYGGFRFMKNVTEMSGVKW------------ISPY-------MIT
AWIFLSPLFTFAIFIFSLVK-YKPLTYNN---TYVYPWWGYMIGWILALMTMLN-IPVFF
FYQLI---------------------------------FNAKG-NLIERWNILTT-----
-------------------------PYLPH---CRSDTV-----------NAPNVHVV--
----DPIFSNIELGHNNHADGEVIK-----------------------------------
-------------------------------------------------------NGHDA
DIPPPPYNESVGIQTYDATDSV--------------------------------------
----------------------------
>gi|13242271|ref|NP_077348.1|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MTAEQALPLGNGKAAEEARGSE------------------------------------
--------------ALGGGGGGAAGTREARDKAVH-------------------------
---ERGHWN-----NKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCG
IPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSN
CF------TTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNAT--------------
-----------------------SPVMEFWERRVL--A--------ISDGIEHIGNLRWE
LALCLLAAWTICYFCIWKGTKSTG-------------KVVYVTATFPYIMLLILLIRGVT
LPGASEGIKFYLYP--------DLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNY
NNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGV-PIAEVA-ESG----------
------------PGLAFIAYPKAVTMMPLSPL-WATLFFMMLIFLGLDSQFVCVESLVTA
VVDMY-PKV--F--RRGYR-RELLILALSIVS-YFLGLVMLTEGGMYIFQLFDSYAASGM
CLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYR-------------PLSL-------IKW
CWKVVTPGICAGIFIFFLVK-YKPLKYNN---VYTYPAWGYGIGWLMALSSMLC-IPLWI
FIKLW----------------------------------KTEG-TLPEKLQKLTV-----
-------------------------PSADLKMRGKLGASPRMVT------VNDCEAKV--
------------------------------------------------------------
--------------------------------------------------------KGDG
TISAITEKETHF------------------------------------------------
----------------------------
>gi|91093757|ref|XP_969586.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEPRAAAALQFNASRGHKMDAVPKRLKPEP
EEAEAGPRAPSPSFRRENSTRSLRSAYVGDAKTSSESGSHLSKP----------------
--LSDAASVRSWASVGMGSTDGRK------------------------------------
------------MIVRRVPTSPVELFNIVNPPTPPEEYLYDGESDDGSGDDEDSVYIKP-
---RRQTWS-----NKLQFVLACVGYSVGLGSVWRFPYLCYKSGGGVFLIPYAIIMIVCG
VPMLYMELSVGQYTGRGPIGALGHLCPLLKGTGLGSVVISFLMSTYYSVIIAYGIYYFFT
SF------KAKQPWEDCSHRWNTDECWVPGKSSPSIAKPNDSQ-----------------
-----------------------TPAEQFYDKKVL--Q--------IGDGIEDFDSLRWE
LVACLLCAWVMVYFAIWKSIKSSA-------------KVRYFTATLPFLLIIVFLAKSLT
LEGADKGMRYFFKP--------KFQLLLDAKVWVNAAAQTFNSMGIAFGSMISFASYSKY
NNNILHDTLAVSFVNAITSLLVGIFAFATIGNIASEQGT-SIEAVI-DDG----------
------------PGLIFVVYPQAMAKMPAAQL-WAVLFFFMLICLALNSQFAIVEVVVTS
IQDGF-PAW--I--KKHLMCHEVLVLIICVVS-LICGLPNVTQGGIYFFQLIDHYAA-SI
SIMYLAFFEVIAIAWFYGVTRLSKNVKTMTGRQ-------------PSLY-------FKF
CWLIATPLMIFSVWVFCMID-YESPTYNN--GEYHYPIWAIVIGWIISALSILC-IPIYM
VYVFM----------------------------------KSPGNTFMEKLKSSLKSDLLD
KCPKCEEFDCECVVKEGEIEPMLVMHKPDS---KDSNSTSVPFYIPLSRVPTVHKFDLEK
VAVQRPLFLNIDKVQRHKLDNSKEDVLKNS------------------------------
--------------------------------------------------------VQNG
TIPEEDRLQADDLASDSTNTEVQQEKDYSSHSNIHLVAADAANQLKTCEKGDGEVQANGG
ECDGAKE---------------------
