>gi|126165309|ref|NP_001075175.	Gallus gallus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
NFQKVEKIG-------------EGTYGVVYKARN-KVTGEVVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDAS---SLGG-IALP
LIKSYLFQLLQ----------GLAFCHAHRVLHRDLKPQNLLINADGAIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL---GCIFAEMV-TRRALFPGDSE
IDQLFRIFRTLGTPDEAAWPGVTALPDYKP--SFPKWAR-QDLGKVVPP-----LDEEG-
---RKLLAQMLHYDPNKRISAKAALSHPFFRDVTRAVPHLRL------------------
----------------------------
>gi|2589145|dbj|BAA23218.1|	Hemicentrotus pulcherrimus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
DFTKIEKLG-------------EGTYGVVYKGRH-KRTGKIVALKKIRLESEEEGVPSTA
IREISLLKELYHPN-IVLLEDVLMEP-NRLYLVFEYLTMDLKKYMESL---KGKQ-MDPA
LVKSYLHQMVD----------GILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAF
GIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWSL---GCIFAEMV-TKRPLFHGDSE
IDQLFRIFRTLGTPTDEIWPGVTQLQDYKS--TFPMWTK-PNIKGAVKG-----MDEEG-
---LDLLEKMLIYDPAKRITAKASMRHPYFDNIPDLSDRLQPIRS---------------
----------------------------
>gi|156051638|ref|XP_001591780.	Sclerotinia sclerotiorum
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MDNKRHPS
SFQQLEKLG-------------EGTYATVFKGRN-RQTGELVALKEIHLDSE-EGTPSTA
IREISLMKELKHEN-IVSLHDVIHTE-NKLMLVFEHMDKDLKKYMDTS---GDRGALPPP
TIKSFMHQLLK----------GIDFCHQNRVLHRDLKPQNLLINMKGQLKLADFGLARAF
GIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSA---GCIMAEMY-TGRPLFPGTTN
EDQLVRIFRIMGTPSERTWPGISQFTEYKT--NFQMYAT-QDLRVILPQ-----IDAVG-
---IDLLQRMLQLRPELRISAHDALSHPWFNDLPGAMRRPQVQ------QGQMPMQRG--
--------------YAPQEVAQGGYQQY
>gi|73978991|ref|XP_532760.2|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MEEEERKGQAEPETVAPEAVPSVYSPPHATTD-----------------PTPRSQNTK
QLLSRASIG-------------EGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGVPSSA
LREICLLKELKHKN-IVRLHDVLHSD-KKLTLVFEFCDQDLKKYFDSC---NGD--LDPE
IVKSFLFQLLK----------GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF
GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA---GCIFAELANAGRPLFPGNDV
DDQLKRIFRLLGTPTEEQWPAMTKLPDYKP---YPMYPATTSLVNVVPK-----LNATG-
---RDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP------------------------
----------------------------
>gi|114670582|ref|XP_001149644.	Pan troglodytes
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MEAGGATGALGVGCKLPSAFC-----------------FPGSSVAMD
MFQKVEKIG-------------EGTYGVVYKAKN-RETGQLVALKKIRLDLEMEGVPSTA
IREISLLKELKHPN-IVRLLDVVHNE-RKLYLVFEFLSQDLKKYMDST---PGSE-LPLH
LIKSYLFQLLQ----------GVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAF
GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSI---GCIFAEMV-TRKALFPGDSE
IDQLFRIFRMLGTPSEDTWPGVTQLPDYKG--SFPKWTR-KGLEEIVPN-----LEPEG-
---RDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFHH-----------
----------------------------
>gi|2956719|emb|CAA12223.1|	Sphaerechinus granularis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MN
NFEKIEKIG-------------EGTYGVVYKAKD-LKSGKTVALKKIRLDTESEGVPSTA
IREIALLKELDHKN-IVKLHDVVHSD-KKLYLVFEFMNQDLKKYMDIA---PPSG-LPTA
LVKSYLQQLLH----------GIAFCHAHRVLHRDLKPQNLLIDADGHIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCRFYSTAVDIWSI---GCIFVEMI-TRRALFPGDSE
IDQLFRIFRTMGTPDEKLWPGVTSLPDYKT--SFPRWSP-QDFNKIVPM-----LSKDG-
---KDLLKCMLCYEPDKRISAKTALSHPYFKDVKLVPPPHLPT-----------------
----------------------------
>gi|146413753|ref|XP_001482847.	Pichia guilliermondii
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MTGSSS
QFQQLEKLG-------------EGTYATVYKGRN-RNTGALVALKEINLDSE-EGTPSTA
IREISLMKELDYEN-IVTLYDVIHTE-NKLTLVFEYMDKDLKRYMETN---GNNGALELH
VVKSFMFQLLK----------GIMFCHDNRVLHRDLKPQNLLINGKGELKLGDFGLARAF
GIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSA---GCIFAEMC-TGKPLFPGTTN
EDQLIKIFRLMGTPNERTWPGISSYANYKS--NWQIFVP-QDLRSLIPN-----LDSMG-
---LNLLSSLLQMRPDARITARQALHHPWFHEVSNPNPLLQHMSDPYQREYRPEQQQ---
----------------------------
>gi|126308701|ref|XP_001377434.	Monodelphis domestica
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MLRAGPLS-----------------LRQQLTGME
VFQKVEKIG-------------EGTYGVVYKARN-KQTGQLVALKKIRLDSETEGVPSTA
IREISLLKELKHPN-IVRLLDVVHSE-KKLYLVFEFLSQDLKKYMDSA---AATE-LPLH
LVKSYLFQLLQ----------GVNFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAF
GVPLRTYTHEVVTLWYRAPEILLGCKFYSTAVDVWSI---GCIFAEMV-TRRALFPGDSE
IDQLFRIFRTLGTPSEATWPGVTQLPDYKG--SFPKWTR-KSIEEIVPS-----LDPEG-
---KDLLMQLLQYDPNRRISAKAALTHHYFSTCKSCSAPRQCMLEHFCR-----------
----------------------------
>gi|17137070|ref|NP_477080.1|	Drosophila melanogaster
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MQ
KYDKMEKIG-------------EGTYGTVFKGRN-RDTMEIVALKRVRLDEDDEGVPSSA
LREICLLKELKHKN-IVRLIDVLHSD-KKLTLVFEHCDQDLKKYFDSL---NGE--IDMA
VCRSFMLQLLR----------GLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAF
GIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSA---GCILAELADAGRPLFPGSDV
LDQLMKIFRVLGTPNEDSWPGVSHLSDYVA---LPSFPAITSWSQLVPR-----LNSKG-
---RDLLQKLLICRPNQRISAEAAMQHPYFTDSSSSGH----------------------
----------------------------
>gi|149723546|ref|XP_001491953.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
-----------------MMLPKPGIYYFPWEVSAGQVPDGGTLRTFGRLCLYDMTQSRVT
LMAQHGSDQHQILVCTKLVEPFQAQVGSLYTVLGDLEHQKNGGSVVKARVLTCVEGMNLP
LLEQAIREQRMYQRERDNSHGTGREGRRPRLPSC-----------------FPGSSADMD
VFQKVEKIG-------------EGTYGVVYKAKN-KETGQLVALKKIRLDLETEGVPSTA
IREISLLKELKHPN-IVRLLDVVHSE-KKLYLVFEFLSQDLKKYMDST---PASE-LPTH
LVKSYLFQLLQ----------GVNFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAF
GVPLRTYTHEVVTLWYRAPEILLGSKFYSTAVDVWSI---GCIFAEMV-TRRALFPGDSE
IDQLFRIFRTLGTPTEATWPGVTQLPDYKG--SFPKWTR-KRLEEIVPN-----LQPEG-
---QDLLMQLLQYDPSRRISAKAALAQPYFSSTETSPAPRQCVLERFCR-----------
----------------------------
>gi|22122813|ref|NP_666351.1|	Mus musculus
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MAMPRNGSRL-
-------DIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSL
PADIRIPDGYLEKLQISSPPFDQPMSRRSRRASL-----------------SEIGFGKME
TYIKLEKLG-------------EGTYATVYKGRS-KLTENLVALKEIRLEHE-EGAPCTA
IREVSLLKDLKHAN-IVTLHDIVHTD-KSLTLVFEYLDKDLKQYMDDC---GNI--MSMH
NVKLFLYQILR----------GLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAK
SVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGV---GCIFFEMA-SGRPLFPGSTV
EDELHLIFRLLGTPSQETWPGVSSNDEFKNY-NFPKYKP-QPLINHAPR-----LDSEG-
---IELITKFLQYESKKRVPAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGF
RNSSYPETALS-----------------
>gi|52783216|sp|Q9HGY5|PHO85_CA	Candida albicans
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MTGSSS
QFQQLEKLG-------------EGTYATVYKGRN-RATGALVALKEISLDSE-EGTPSTA
IREISLMKELDHEN-IVTLYDVIHTE-NKLTLVFEYMDKDLKKYMEVH---GQQSALDLK
VVKSFMFQLLK----------GIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAF
GIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSA---GCIFAEMC-TGKPLFPGTAN
EDQLIKIFRLMGTPNERTWPGISQYTNYKN--NWQIFVP-QDLRLIVPN-----LDSMG-
---LNLLQSLLQMRPESRITARQALQHPWFHEITMPNA-VPQHLSDPYQQQQQQQQH---
---------------PHQPIIDQQY---
>gi|110761543|ref|XP_393450.3|	Apis mellifera
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MD
NFVKIEKIG-------------EGTYGVVYKAKD-KLTGKLVALKKIRLETESEGVPSTA
IREISLLRELTHPN-IVQLFDVVDGD-NHLYLVFEFLQQDLKKLLDSV---K-GG-LDQA
LVKSYLYQLLK----------AISFCHLHCILHRDLKPQNLLIDQEGHIKLADFGLARTF
GVPVRTYTHEIVTLWYRAPEILLGTKLYSNAVDVWSL---GCIFAEMA-TRRALFPGDSE
IDQLFRIFRTLGTPDENIWPGVSQLRDYTS--MFPRWEP-RPLDEVVPS-----FDSDA-
---KDLLLKLLTYDPNQRITAKKGLSHPYFNGVTLVPPPLPKKT----------------
----------------------------
>gi|18266682|ref|NP_543161.1|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MQ
KYEKLEKIG-------------EGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGVPSSA
LREICLLKELKHKN-IVRLHDVLHSD-KKLTLVFEFCDQDLKKYFDSC---NGD--LDPE
IVKSLLFQLLK----------GLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF
GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSA---GCIFAELANAGRPLFPGNDV
DDQLKRIFRLLGTPTEEQWPAMTKLPDYKP---YPMYPATTSLVNVVPK-----LNATG-
---RDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP------------------------
----------------------------
>gi|50304029|ref|XP_451964.1|	Kluyveromyces lactis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MSELT
NYKRLEKVG-------------EGTYGVVYKAVDLRHQNRVVAMKKIRLESEDEGVPSTA
IREISLLKELKDDN-IVRLYDIVHSDAHKLYLVFEFLDLDLKRYMESI---PKDQPLGGN
IIKKFMMQLCK----------GIAYCHAHRIIHRDLKPQNLLINRDGNLKLGDFGLARAF
GVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDVWSI---GCIFAEMC-NRKPLFSGDSE
IDQIFKIFRVLGTPNERTWPDIIYLPDFKT--TFPKWNR-RNLSEVIPS-----LDANG-
---IDLLDKLITYDPIHRISAKRAVQHPYFKEE---------------------------
----------------------------
>gi|157119359|ref|XP_001659377.	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MQ
KYEKLEKIG-------------EGTYGTVFKGKN-RDTLEIVALKRVRLDEDDEGVPSSA
LREICLLKELKHKN-IVRLYDVLHSD-KKLTLVFEHCDQDLKKYFDSL---NGE--IDPD
VVKSFMYQLLR----------GLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAF
GIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSA---GCIFAELANAGRPLFPGSDV
DDQLKRIFKLLGTPTEDTWPGITQLSDYKP---FPLYPPTTSWSQVVPR-----LNSKG-
---RDLLQKLLICRPTLRLSAEQAMAHPYFTEN---------------------------
----------------------------
>gi|70984850|ref|XP_747931.1|	Aspergillus fumigatus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MDYRNSYRTAEDSRSEYNNPASFSEIV
STLVSPKSFLFNNQRPKPSTQQTSITTRGNISSQ-----------------TMDKSQQPS
SFQQLEKLG-------------EGTYATVFKGRN-RQTGELVALKEIHLDSE-EGTPSTA
IREISLMKELKHES-IVSLYDVIHTE-NKLMLVFEYMDKDLKKYMDTR---GDRGQLDHA
TIKSFMHQLLK----------GIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAF
GIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSA---GCIMAELY-TGRPLFPGTTN
EDQLQKIFRLMGTPSERSWPGISQLPEYKP--NFHVYAT-QDLGLILPQ-----IDPLG-
---LDLLNRMLQLRPEMRISAADALQHPWFHDLPQLQAQLQQQ----QQQQQQQMAGG--
--------------YGGMVPPQQTY---
>gi|56118390|ref|NP_001008136.1	Xenopus tropicalis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
NFQKVEKIG-------------EGTYGVVYKARN-RETGEIVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLLDVIHTE-NKLYLVFEFLNQDLKKFMDGS---NISG-ISLA
LVKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINSEGAIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSL---GCIFAEMI-TRRALFPGDSE
IDQLFRIFRTLGTPDEVSWPGVTTMPDYKS--TFPKWVR-QDFSKVVPP-----LDDDG-
---RDLLAQMLQYDSNKRISAKAALTHAFFRDVSRPTPHLI-------------------
----------------------------
>gi|1345715|sp|P48963|CDK2_MESA	Mesocricetus auratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
NFQKVEKIG-------------EGTYGVVYKAKN-KLTGEVVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLLDVIHTE-NKLYLVFELLHQDLKKFMDAS---AVTG-IPLP
LIKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL---GCIFAEMV-TRRALFPGDSE
IDQLFRIFRTLGTPDEVVWPGVTSMPDYKP--SFPKWAR-QDFSKVVPP-----LDEDG-
---RSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------
----------------------------
>gi|5921709|sp|O55076|CDK2_CRIG	Cricetulus griseus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
NFQKVEKIG-------------EGTYGVVYKAKN-KLTGEVVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDAS---AVTG-IPLP
LIKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL---GCIFAEMV-TRRALFPGDSE
IDQLFRIFRTLGTPDEVVWPGVTSMPDYKP--SFPKWAR-QDFSKVVPP-----LDEDG-
---RSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------
----------------------------
>gi|156548656|ref|XP_001601962.	Nasonia vitripennis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MPSDCLASVKASFFAFSVEYLTSYSACAE-----------------SVKEQEVGT
RAKKYKKIG-------------EGTYGVVYKAKD-KITGKLVALKKIRLETESEGVPSTA
IREISLLKELTHEN-VIQLLDVVQGD-KYLYLVFEFLQQDLKKLLDSL---KTG--LSPQ
LVKSYLWQLLK----------AIAFCHVNRILHRDLKPQNLLVDQEGYLKLADFGLARSF
GVPVRTFTHEVVTLWYRAPEILLGTKLYSTAVDVWSL---GCIFAEMA-TKRALFPGDSE
IDQLFRIFRTLGTPDETVWPGVSQLQDYKS--MFPQWEA-TDLDEVVPM-----FDDKA-
---KDLLMKLLIYDPNMRITAKQALSHSYFEGVKLVPPPMPKKD----------------
----------------------------
>gi|50811836|ref|NP_998571.1|	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
SFQKVEKIG-------------EGTYGVVYKAKN-KVTGETVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLRDVIHTE-NKLYLVFEFLHQDLKRFMDST---SVSG-ISLP
LVKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL---GCIFAEMI-TRRALFPGDSE
IDQLFRIFRTLGTPDESIWPGVTSMPDYKP--SFPKWAR-QDLSKVVPP-----LDEDG-
---RDLLGQMLTYDPNKRISAKNALVHRFFRDVTMPVPPLRL------------------
----------------------------
>gi|109118320|ref|XP_001102502.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MD
VFQKVEKIG-------------EGTYGVVYKAKN-RETGQLVALKKIRLDLEMEGVPSTA
IREISLLKELKHPN-IVQLLDVVHNE-RKLYLVFEFLSQDLKKYMDST---PDSE-LPLH
LIKSYLFQLLQ----------GVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAF
GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSI---GCIFAEMVERGAPLFPGDSE
IDQLFRIFRMLGTPSEATWPGVTQLPDYKG--NFPKWTR-KGLGEIVPS-----LEPEG-
---RDLLMQLLQYDPSRRITAKTALAHPYFSSPEPSPAARQYVLQRFCR-----------
----------------------------
>gi|126138566|ref|XP_001385806.	Pichia stipitis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------TS
RFQQLEKLG-------------EGTYATVYKGRN-RSTGAFVALKEINLDSE-EGTPSTA
IREISLMKELDHEN-IVTLYDVIHTE-NKLTLVFEYMDKDLKRYMEVH---GNQGALDLK
IVKSFMFQLLK----------GIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAF
GIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSA---GCIFAEMC-TGKPLFPGTAN
DDQLIKIFRLMGTPNERTWPGISQYANYKS--NWQIFVP-QDLRLIVPN-----LDLMG-
---LNLLQSLLQMRPEARITARQALQHPWFHEITNPNPIVHHLGDPYQQQQQQQQQPVLD
QQYQ------------------------
>gi|13623189|gb|AAH06190.1|	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MDRMKKIKRQLS
MTLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSL-----------------SEIGFGKLE
TYIKLDKLG-------------EGTYATVYKGKS-KLTDNLVALKEIRLEHE-EGAPCTA
IREVSLLKDLKHAN-IVTLHDIIHTE-KSLTLVFEYLDKDLKQYLDDC---GNI--INMH
NVKLFLFQLLR----------GLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAK
SIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGV---GCIFYEMA-TGRPLFPGSTV
EEQLHFIFRILGTPTEETWPGILSNEEFKTY-NYPKYRA-EALLSHAPR-----LDSDG-
---ADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASL
RSSSMPDSGRPAFRVVDTEF--------
>gi|6166046|sp|Q63699|CDK2_RAT	Rattus rattus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
NFQKVEKIG-------------EGTYGVVYKAKN-KLTGEVVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDAS---ALTG-LPLP
LIKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL---GCIFAEMV-TRRALFPGDSE
IDQLFRIFRTLGTPDEVVWPGVTSMPDYKP--SFPKWAR-QDFSKVVPP-----LDEDG-
---RSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------
----------------------------
>gi|62460564|ref|NP_001014934.1	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
NFQKVEKIG-------------EGTYGVVYKAKN-KLTGEVVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDAS---ALTG-IPLP
LIKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINADGSIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL---GCIFAEMV-TRRALFPGDSE
IDQLFRIFRTLGTPDEVVWPGVTSMPDYKP--SFPKWAR-QDFSKVVPP-----LDEDG-
---RSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL------------------
----------------------------
>gi|147903705|ref|NP_001084120.	Xenopus laevis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
NFQKVEKIG-------------EGTYGVVYKARN-RETGEIVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLLDVIHTE-NKLYLVFEFLNQDLKKFMDRS---NISG-ISLA
LVKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINSDGAIKLADFGLARAF
GVPVRTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSL---GCIFAEMI-TRRALFPGDSE
IDQLFRIFRTLGTPDEVSWPGVTTMPDYKS--TFPKWIR-QDFSKVVPP-----LDEDG-
---RDLLAQMLQYDSNKRISAKVALTHPFFRDVSRPTPHLI-------------------
----------------------------
>gi|4808831|gb|AAD29956.1|AF116	Sporothrix schenckii
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MDGKRQLN
SFQQLEKLG-------------EGTYATVFKGRN-RHTGEFVALKEIHLDSE-EGTPSTA
IREISLMKELKHEN-IVALHDVIHTE-SKLMLVFEYMDGDLKKYMDTN---GERGALKPM
LIKSFMYQLLK----------GIDFCHQNRVLHRDLKPQNLLINGKGQLKLGDFGLARAF
GIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSV---GCIMAEMY-TGRPLFPGTTN
EDQMLRIFRIMGTPAEHNWPGISQFPEYKA--TAPRYAT-QDLRQILPQ-----IDATG-
---IDLLQRLLQLRPELRISAHDALQHPWFHDILQYQHCQQAAG----------------
----------------------------
>gi|83771497|dbj|BAE61629.1|	Aspergillus oryzae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MDKAQQPS
SFQQLEKLG-------------EGTYATVFKGRN-RQTGELVALKEIHLDSE-EGTPSTA
IREISLMKELKHES-IVSLYDVIHTE-NKLMLVFEYMDKDLKKYMDTR---GERGQLDQA
TIKSFMHQLLK----------GIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAF
GIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSA---GCIMAELY-TGRPLFPGTTN
EDQLQKIFRLMGTPSERSWPGISQLPEYKP--NFHVYAT-QDLGLILPQ-----IDPLG-
---LDLLNRMLQLRPEMRVSAHDALQHPWFHDLPQMQAQLQQQ--QQQQQQQQQQMSG--
--------------YGGMVTSQQAYQ--
>gi|1168865|sp|P43450|CDK2_CARA	Carassius auratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
SFQKVEKIG-------------EGTYGVVYKAKN-KVTGETVALKKIRLDTETEGVPSTA
IREISLLKELNHPN-IVKLHDVIHTE-NKLYLVFEFLHQDLKRFMDSS---TVTG-ISLP
LVKSYLFQLLQ----------GLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL---GCIFAEMI-TRKALFPGDSE
IDQLFRIFRTLGTPDESIWPGVTSMPDYKP--SFPKWAR-QDLSKVVPP-----LDEDG-
---RDLLGQMLIYDPNKRISAKNALVHRFFRDVTMPVPPLRL------------------
----------------------------
>gi|118786999|ref|XP_315787.3|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------RPQQPLTMQ
KYEKLEKIG-------------EGTYGTVFKGKN-RDTLEIVALKRVRLDEDDEGVPSSA
LREICLLKELKHKN-IVRLYDVLHSD-KKLTLVFEHCDQDLKKYFDSL---NGE--IDPD
VVKSFMYQLLR----------GLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAF
GIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSA---GCIFAELANAGRPLFPGSDV
DDQLKRIFKLLGTPEEENWPGITQLSDYKP---FPLYPPTTSWSQVVPR-----LNSKG-
---RDLLQKLLVCRPLLRLSAEQAMSHPYFTEN---------------------------
----------------------------
>gi|91086567|ref|XP_973039.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MIL-----------------LPESLSAMQ
KYEKLEKIG-------------EGTYGTVFKAKN-RETHEIVALKRVRLDDDDEGVPSSA
LREICLLKELKHKN-IVRLYDVLHSD-KKLTLVFEHCDQDLKKYFDSL---NGD--IDLD
VVKSFMYQLLR----------GLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAF
GIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSA---GCIFAELANAGRPLFPGSDV
DDQLRRIFKLLGTPTEETWSGMTQLPDYKP---FPLYQPNMSLSQVVPK-----LGNRG-
---RDLLQRLLVCNPMGRMSADDAMAHAYFSDLNPAIKNDRC------------------
----------------------------
>gi|3643645|gb|AAC42260.1|	Emericella nidulans
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MDKSQQPS
SFQQLEKLG-------------EGTYATVFKGRN-RQTGELVALKEIHLDSE-EGTPSTA
IREISLMKELKHES-IVSLYDVIHTE-NKLMLVFEYMDKDLKKYMDTR---GDRGQLDQA
TIKSFMHQLMS----------GIAFCHDNRVLHRDLKPQNLLINKKGQLKLGDFGLARAF
GIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSA---GCIMAELY-TGRPLFPGTTN
EDQLQKIFRLMGTPSERSWPGISQLPEYRA--NFHVYAT-QDLGLILPQ-----IDPLG-
---LDLLNRMLQLRPEMRIDAHGALQHPWFHDLPQLQAQLQQQ-----------QMAG--
--------------YGGMMPPQQAY---
>gi|121717671|ref|XP_001276120.	Aspergillus clavatus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MDKTQQPS
SFQQLEKLG-------------EGTYATVFKGRN-RQTGELVALKEIHLDSE-EGTPSTA
IREISLMKELKHES-IVSLYDVIHTE-NKLMLVFEYMDKDLKKYMDTR---GDRGQLDHA
TIKSFMHQLLK----------GIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAF
GIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSA---GCIMAELY-TGRPLFPGTTN
EDQLQKIFRLMGTPSERSWPGISQLPEYKP--NFHVYAT-QDLGLILPQ-----IDPLG-
---LDLLNRMLQLRPEMRISAADALQHPWFHDLPQLQAQLQQQHQQQQQQQQQQMAGG--
--------------YGGMVPPQQAY---
>gi|56753669|gb|AAW25037.1|	Schistosoma japonicum
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MTNQVVL
KYEKLEKIG-------------EGTYGKVYKARN-RETHEIVALKRVRLENDDEGIPSSA
FREICLLKELKHKN-IVRLFDVLLSD-SRLTIVFEYCDQDLKKYFDNC---NGE--IDQN
TVKLFMFQLLR----------GLQFCHSHNVLHRDLKPQNLLINDNGELKLADFGLARAY
GIPVRQYSAEVVTLWYRPPDVLLGAKLYTTSIDMWSA---GCIFAEMSNAGRPLFPGYDV
EDQLQRIFKLLGTPTESTWPSVVELPDYEP--FTVMYPRIMNWHHVVPK-----MSFRG-
---RDLLQQLVACNPVDRISADQALKHSYFESIL--------------------------
----------------------------
>gi|115702469|ref|XP_790847.2|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MN
NFEKIEKIG-------------EGTYGVVYKARD-LKSGKTVALKKIRLDTESEGVPSTA
IREIALLKELDHKN-IVKLHDVVHSD-KKLYLVFEFMNQDLKKYMDVA---PPSG-LPPG
LVKSYLHQLLQ----------GIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAF
GVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSL---GCIFVEMI-TRRALFPGDSE
IDQLFRIFRTMGTPDEKLWPGVTSLPDYKT--SFPRWTP-QDFTKIVPM-----LNKDG-
---KDLLKSMLCYEPDKRISAKTGLSHPYFKDVKMVPPPRLPT-----------------
----------------------------
>gi|149244914|ref|XP_001527000.	Lodderomyces elongisporus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MYRIETNVD-----------------KDMHINTHY
RFQQLEKLG-------------EGTYATVYKGRN-RATGALVALKEINLDSE-EGTPSTA
IREISLMKELDHEN-IVTLYDVIHTE-NKLTLVFEYMDKDLKKYMEVH---GNHGALDLK
VVKSFMFQLLK----------GIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAF
GIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSA---GCIFAEMC-TGKPLFPGTAN
EDQLIKIFRLMGTPNERTWPNITQFSNYKN--NWQIFVP-QDLRLLVPN-----LDSMG-
---MNLLQSMLQMRPEARITARQALQHPWFHEITLPTPAVQHHLSDPYQQQQQQQQQQQQ
QQQQQQQQHAQQSLNPHQPIIDQQY---
>gi|2564703|gb|AAC06329.1|	Pneumocystis carinii
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
QYQRLEKIG-------------EGTYGVVYKAKD-LESGTIVALKKIRLEAEDEGVPSTA
IREISLLKEMHNDN-VVRLLNIIHQE-SRLYLVFEFLDLDLKKYMNSI---PKDMMLGAE
MIKKFMSQLVS----------GVKYCHSHRILHRDLKPQNLLIDREGNLKLADFGLARAF
GVPLRGYTHEVVTLWYRAPEVLLGGRQYATALDIWSI---GCIFAEMA-TKKPLFPGDSE
IDEIFRIFRILGTPDENSWPGITSYPDFKA--TFPKWSP-KNLGELITE-----LDSDG-
---IDLLQKCLRYYPAERISAKKALDHPYFDDFININRSNVVL-----------------
----------------------------
>gi|6325226|ref|NP_015294.1|	Saccharomyces cerevisiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MSSSS
QFKQLEKLG-------------NGTYATVYKGLN-KTTGVYVALKEVKLDSE-EGTPSTA
IREISLMKELKHEN-IVRLYDVIHTE-NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN
LVKYFQWQLLQ----------GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF
GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSC---GCILAEMI-TGKPLFPGTND
EEQLKLIFDIMGTPNESLWPSVTKLPKYNP--NIQQRPP-RDLRQVLQPHTKEPLDGNL-
---MDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS----------------------
----------------------------
>gi|115432970|ref|XP_001216622.	Aspergillus terreus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MDSRNLKTSHPPPSTYHDIVSS
LVSPKSFLFHSQRPKPSSSRPSTSRRSPSSTASR-----------------TMDKAQQPS
SFQQLEKLG-------------EGTYATVFKGRN-RQTGELVALKEIHLDSE-EGTPSTA
IREISLMKELKHES-IVSLYDVIHTE-NKLMLVFEYMDKDLKKYMDTR---GDRGQLDQA
TIKSFMHQLLK----------GIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAF
GIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSA---GCIMAELY-TGRPLFPGTTN
EDQLQKIFRLMGTPSERSWPGISQLPEYKP--NFHVYAT-TDLGLILPQ-----IDPLG-
---LDLLNRMLQLRPEMRISAHDALQHPWFHDLPQLQAQLQQQ---QQHQQQQQMAGA--
--------------YGGMVPPQQAY---
>gi|125808284|ref|XP_001360694.	Drosophila pseudoobscura
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MQ
KYDKMEKIG-------------EGTYGTVFKGRN-RDTMEIVALKRVRLDEDDEGVPSSA
LREICLLKELKHKN-IVRLIDVLHSD-KKLTLVFEHCDQDLKKYFDSL---NGE--IDMA
VCRSFMLQLLR----------GLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAF
GIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSA---GCILAELADAGRPLFPGSDV
LDQLMKIFRVLGTPNEDSWPGVSHLSDYVA---LPSFPAITSWSQLVPR-----LNSKG-
---RDLLQKLLVCRPNQRISAEAAMQHPYFTDSTSSGH----------------------
----------------------------
>gi|45187931|ref|NP_984154.1|	Ashbya gossypii
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MSDLT
NYKRLEKVG-------------EGTYGVVYKAVDLRHGQRIVALKKIRLESEDEGVPSTA
IREISLLKELKDDN-IVRLYDIVHSDAHKLYLVFEFLELDLKRYMESV---PKDQPLGDK
IIKKFMMQLCK----------GIAYCHAHRIIHRDLKPQNLLINRNGNLKLGDFGLARAF
GVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDVWSI---GCIFAEMC-NRKPLFSGDSE
IDQIFKIFRLLGTPNESVWPDIVYLPDFKP--TFPKWQR-RDLAQVVPS-----LNEHG-
---LDLLDKLVTYDPIHRISAKRAVTHPYFKDE---------------------------
----------------------------
