>gi|47226674|emb|CAG07833.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MLRSNDPDRFQVMFRYFE
DKAIQKD-KSGMMQCIICVGDK---------------VFAVFLQMMAEKPR---TKEHEE
ELERHAQFLLV-------------------------NFNHTHKRIRR---VADKYLSGLA
DTFPHLLWS--GRVLKTMLDILQTLSLSLSADIH-KD---QPYYDIPDTPYRITVPDTYE
ARENIVKDFAAR-------CGEILKEAMKWAPSVTKSHLQEYLNKHQNWVSGL-------
-------SQHTGLAMATESILHFA-------GYNRQSTTLGATQLTERPACVKKDYSNFM
AS--LNLRNR-YTGEVA-------------------G-MIQFSEATQT---RSDLSKLLI
YQMTSVLEKKDP--EAFTQAMFKMAALLITTKNCDPLLLHHLCWSPLKMFTEHSMETAIA
CWEWLLAAHNGVEVPFMRE-------------MAGAWQMTVELKMGLFSETKVEAGPLAV
SEESQPTPCAPEVIPHFLWIEFLVQRFEIAKYSSADQVEIFTAILQRSLSLSVGGPKSSL
NRHVAAIGPRFRLLTLGLTLLHADVVTNATIKNVLREKIYSTGFDYFSTTPKFPTQTDKR
LREDISIMIKFYASLQSDKRYLTAHQLVPPDPQEMSVNSLSVVAVTESRSSLDAAVGQRQ
PVTQGWINTYPLSSGMSTISKKSGLSKKSNRGSQLHKYYMKRRTLLLALLVFSSVRSLFK
PPTKIQPLFQFQFCRFLFTLCLQANEIERLTIWYNPLSTQELAIAMEQSVETSIANWRSK
YISLTEKQWKDNVNLAWSIAPYLALQLPARFKNTEAIVSEVTRLVRMDPSAVCDVPEAVK
FLVTWHTIDADSPELSYILCWAPADPPTGLSYFSSLYPPHPLTAQYGVKVLRSFPPDAIL
FYIPQIVQALRYDKMGYVREYILWAAQKSQLLAHQFIWNMKTNIFLDEEGSQKDPDIGEL
LEQMVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPFPKGEERKRACLETLSQIQVQ
PGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKE------GLQCR
ADSEDEVKSEE-EAKRICWQAAIFKVGDDCRQDMLALQIISLFKNIFQLVGL-DLYVFPY
RVVATAPGCGVIECIPDCKSRDQLGRQTDF---------------GMYDYFRNQYG--DE
STLAFQKARYNFIRSMAAYSLVLFLLQIKDRHNGNIMLDSQGHLIHIDFGFMFESSPGGN
LGWE-PDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLD---
-------------------TGLPCFR-GQ--TIKLLKQRFNPGLSEKDAASFIIK-VIQN
CFLSNRSRTYDMIQYYQNQIPY
>gi|119623341|gb|EAX02936.1|	Homo sapiens
-------------MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRP
ASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGL
-PKVYWVEESTARKGRGALPVAESFSFCLVTLLSD---------VAYRDPSLRDEILEVL
LQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGR------------------YSN
MEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSN----------LLTVCQEG
TLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFST------
------------------ISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVL
KS-LDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVL
EQFNTSQGELQKI-LHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLS
EKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYK
YHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTV
DPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQ
K------FCQPPSPLDVLII----------------------------------------
---------------------------------------DQLGCLVITGNQYIYQEVWNL
FQQISVKASS-------------VVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHL
VDE----------LLMNLLELFVQLGLEGKRASE--RASEKGPALKASSSAGNLGVLIPV
IAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATK----
-------SPLLTFPSKEP--------LRSVLQYNSAMKNDTVTPAELSELRSTIINLLDP
PPEVS-------ALINKLDFAMSTYLLSVYR------LEYMRVLRSTDPDRFQVMFCYFE
DKAIQKD-KSGMMQCVIAVADK---------------VFDAFLNMMADKAK---TKENEE
ELERHAQFLLV-------------------------NFNHIHKRIRR---VADKYLSGLV
DKFPHLLWS--GTVLKTMLDILQTLSLSLSADIH-KD---QPYYDIPDAPYRITVPDTYE
ARESIVKDFAAR-------CGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGL-------
-------SQHTGLAMATESILHFA-------GYNKQNTTLGATQLSERPACVKKDYSNFM
AS--LNLRNR-YAGEVY-------------------G-MIRFSGTTGQ---MSDLNKMMV
QDLHSALDRSHP--QHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMET---
--------------------------------ALACWE----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------WLLAG------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------KDGVEVP-----------------------------
------------------------------------------------------------
-----------FMREMAG--------------------------------------AGT-
------------------------------------------------------------
------------------------------------------------------------
----------------------
>gi|84778262|dbj|BAE73184.1|	Pichia pastoris
------------------------------------------------------------
------------------------------------------------------------
---------MDQSGNALLLRFINSQHFNLYYCISY---------LQRYSDN---------
IGVHHYLCEKVKT----YPIEELKFFIPQFLQLIITVET---------------------
-----------------------------------DSMALEE----------MIKDL---
----------------------CTRDVHFSLITFWHLQSSLQELSTQPNST---------
---------------------------------------GFQVCKRILNDVQFQLFSLSP
PN-ATVSSRVGSSGIV--------------------------------------------
-----------------------------------------------------------Y
KNSQHAMKQF-------------------RENVSPSAVLISSVLSSAAFPQLGKSAE---
------------------------------------------------------------
--------------------------HLVRTQGKLSRSFVFQIAKGLQQQMNENLTMKNT
R------L----------------------------------------------------
-------------------------------------------------NAELSSHTVVN
AAELDASQAE-------------KPYRRAKSLSLTSLQGKRQGQQ----------DQHPK
HNE----------HSENLDFSIIDKYAETNLPHL--NRAISNPNMKRFKNKRLSQALDVK
QSVMSD-LYPMSPEKGYDNLTLKN----------------LQRLRSESQLNNDSIT----
-------ASMPELHPTHT----------------------------NSTAVSEVESLYDS
GNERS------PTISLNGSYKRQPIKLSVPQK-----IKVLKNNYFKCETQFVIALQNIS
IKLSNVP-KETRLACLRAELTL---------------MNKD-LPCEIDVPLLLP--NAKS
GKLHK----IV-------------------------NIPANEAAVLN---SAERV-----
---PYLLLI--EYVS-NEVDFSPESKENKQLLERLND----NSSDVNGDSKRYVFDLAGI
MRAS---------------DSRRTNDYGKSMSTLQNGEMPLEADL---------------
-------ADLSIVNLSNRKESEFL-------KREQFVQAASEVPILEGDSPLRQDV----
----LNFQSH-YETDSL-------------------TDKSDFAT-------QMRIAAVML
SQLDSSTSHLPM--DQAGAIKARIVSSMQSLQH------EFGVKDLQDI---NTEA----
-------GERKFSNDLKVAGVKSNLKNKNDYYLGEDWN----------------------
------------------------------------------------------------
-------------------------------------------------------SKKER
IRKQSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLEH-----------------WNLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKTGDDLTQEAFACQLIQSMATVWHNHGV-NIWVKRM
RILVTSNSTGLVETITDAVSIHSIKKSLTEYLIENNE-DHRGAIATLLDHFRMTFG--DP
NSARYRKAQNNFAISLAAYSVICYILQIKDRHNGNIMLDNEGHIIHIDFGFLLSNSPGS-
VGFEAAPFKLTLEYVDVLGG-LDGEYFQVFKQSTKEAFKSLRRNAESLITMVELMQRD--
-------------------STLPCFKAGENTSVQ-LRQRLQLHLSEEDSDYFVENFLIGK
SIGSIYTKLYDQFQLLTQGIYS
>gi|157121275|ref|XP_001659896.	Aedes aegypti
------------------------------------------------------------
---------------------------------MTQHHRNRSLDSALQRIPEVEVSSPSA
-ESENTLCTNSILGTTMCTKIMQSSSTNPPNTPAL---------TRGND-----------
NGAEDGNTGGCSTSNSSRSSSTSSNGGTGMMDVGGAGSA---------------------
----LVSSGSTRSGKVTDGDAHGGKENDSKKREDLTSLGSDD----------SGIIC---
----------------------GSEPDHTSLTRIRRSRESLDSGEIDP------------
---------------------------------------SEEECIEILETTSMDEEYRML
QS-DLCFYPLTLSSNGGGGADGQSTSSSTIGGSGSGGTRDSRSAKSFESGGSQSSTADPV
PVSEKMRYREQNI-NRAAIMLETICVPIDYEDGPGEE----------------------N
EGPVADAT---------------------GEAITPVVESKEAVPANPVPSTTSQKSD---
---------------QKNEIIFRNFFGATKNAIFRTAQSIIDNHEKKNAKNKEKDE----
--------------------------EKVKSPTEISKKREFGVLRSRMRKSEASNSSSSA
A------AINSSSTVPTITNNNNTLSPEPLQSPEAEIKSLSKSSSTSSLKVPGVAVATCI
NPKEIIEPQLKTER-------------------------GQSGLLRFFESPVFNIHFAVH
YLFYSKEPGV-------------LSFIGNKIFSFPDIEVDLYIPQLIVMYMQIE-ELSEV
LDP----------YLVYRCRRSVDFSLKCVWLLE---AYNFNMGMLSNNGNSIRKH----
-LCLLKELYPKRERKQHLKAMESLPP----------------------TVDTVKKTHH--
-------RSQSDATGLMG---------------------SLSLNPRLYPSLAKPLCLGDL
SSGRA-------FDNGCLCFESVRGTVNDLLGQQT--ICSCGAPKLTPEREFMKSLIDIG
RMLTSLQTKIEKTSRLRILLNL---------------INKN-LPARVWLPL-------HS
ETPHH----VV-------------------------RITEEKTAVLN---SKDKT-----
---PYIIYV--EVVEVNDIYTSPVIPKMMPTLRHTKSEERLDSGAQPNASSETNIPAATG
TGAA---------------TGNQVQSAVKLRVSKMSEC----------------------
-------SNGGELASPNAHI-----------GGYSSSGNLGVYDFGFTED----------
----DVWSQE--DDEIT-------------------AQYLNLHKSLSE---RDSLSQFSM
DSYDSR-EQSTPAVFNIGEVRNRHCANLSSEST------RPFSNDPEDP---SAAV----
--------------------------------LKEPWH----------------------
------------------------------------------------------------
-------------------------------------------------------EKERQ
IRESSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLQN-----------------WKLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------AIVKCGDDLRQELMATQLLEMFQLIWKEENV-DLWVRPY
KIVCLSNDSGLIEPILNTVSLHQIKKNSSK---------------SLSDYFADEYGGDSE
DSDRFRTAQRNFMQSCAAYCLISYLLQVKDRHNGNILLHSDGHLIHIDFGFILSISPKN-
LGFEQSPFKLTPEFVDVMGG-PSSELWLEFKYLLLEGLKAARKHMDRIINIVEIMRSS--
-------------------SQLPCFKNGCSGTVRNLRNRFHINLTEQELERKVEQ-LIQD
SLNSFTTKLYDSYQYFTNGIL-
>gi|148706816|gb|EDL38763.1|	Mus musculus
------------------------------------------------------------
------------------------------------------------------------
------------------GGGVGSPTPTACTPSAR---------V---------------
-----------------PRSLEARSLAVAMGDMVVEPAT---------------------
-------------------------------------LKPTS----------EPTPS---
----------------------PSGNNGGSLLSVI--TEGVGELSVIDPEV---------
---------------------------------------AQKACQEVLEKVKLLHGGVAI
SS----------------------------------------------------------
-----------------------------------------------------------K
GTPLELVN---------------------GDGVDNEI-------RCLDDPPAQIREE---
------------------------------------------------------------
-----------------------------------EDEMGAGVASGTAKGARRRRQNNSA
------------------------------------------------------------
---------------------------------------KQSWLLRLFESKLFDISMAIS
YLYNSKEPGV-------------QAYIGNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDA
IKP----------YIVHRCRQSINFSLQCALLLG---AYSSDMHISTQRHSRGTKLRK--
-LILSDELKPAHRKRELPTLSPAP----------------------DTGLSPSKRTHQ--
-------RSKSDATASIS-----------------------------------------L
SSNLK-------RTASNPKVENEDE-----------------PVRLAPEREFIKSLMAIG
KRLATLPTKEQKTQRLISELSL---------------LNHK-LPARVWLPT--------A
GFDHH----VV-------------------------RVPHTQAVVLN---SKDKA-----
---PYLIYV--EVLECENFDTTSVPAR-------------IPENRIRSTRSVENLPE---
-------------------CGI--------------------------------------
-------------------------------THEQRAGSFSTVPNYDNDD----------
----EAWSVD-DIGELQ-------------------VELPEVHTNSCD-----NISQFSV
DSITSQ-ESKEPVFIAAGDIRRRLSEQLAHTPT-------AFKRDPEDP---SAVA----
--------------------------------LKEPWQ----------------------
------------------------------------------------------------
-------------------------------------------------------EKVRR
IREGSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLPN-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELLAFQVLKQLQSIWEQERV-PLWIKPY
KILVISADSGMIEPVVNAVSIHQVKKQSQL---------------SLLDYFLQEHG--SY
TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRN-
LGFETSAFKLTTEFVDVMGG-LNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQG--
-------------------SQLPCFHGSS--TIRNLKERFHMSMTEEQLQLLVEQ-MVDG
SMRSITTKLYDGFQYLTNGIM-
>gi|24654710|ref|NP_728519.1|	Drosophila melanogaster
------------------------------------------------------------
----------------MGILLPPVSQVTNNHINHTQHHRNRSLDSALQRIPEVEVSSPNA
-ESENTFCSPSILGATMCSK-IATTAATVTSALSP---------PGTPTPALMSTACTPT
IGAVKGNVQHPVP----KHEQSISLAAACRSSAVVESCPTLRMRPKSSESV------AAN
GQEMIGVIVSSTGNGSSSSNNSCSSAGSTKKREDLTSLGSDD----------SGIIC---
----------------------GSESDQISLNRICHSHESLDSGEMDADAD---------
---------------------------------------AEEECVDLMDTTSIDEEYNIM
QPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKNLPSQNQIESEDSVDAGVDAR
TRYRVMNMSQAAINVELGTASNEIDPDVNYRES--------------------------H
QDPIADAPSLSTPSVAS------------TASATPSVTPTPIATPTPTESTKNDQVL---
---------------------FKNFFGATKNAIFRTAQSIIENHEKKNAAKQKEQPD---
-------HSGTVSLVGSPNGGSSVPQDLVKSPTDISKKKEFFSLLTSSSSIKAAAAAAAN
S------AASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLNLRLPGDSEGSEGAL
TKCSSINSIHKLKLPVPGVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAVH
YLFYSKEPGV-------------LSFIGNKIFSFPDQEVDLYIPQLVVMYIQMD-ELAEV
LDP----------YLTIRCRKSVDFSLKCLWLLE---AYNYQVDSLGNSHNSSRKSK---
-LALMKEIFSKREHKQTQNDLKSA------------GTGGLHVGEPRSVVALAKKTHH--
-------RSQSDATVLLA-----DFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDL
TSGHA-------FDNGCTCFETVRGQVNGLLGQRT--LCSCGAPKTSPQKEFMKALMNVG
KNLTSWPSKAEKTSALRMSLNL---------------INKN-LPARVWLPL-------YS
DIPHH----VV-------------------------RITEEKTAVLN---SKDKT-----
---PYIIYV--EVVEIPDIYTSPLIPKMMPSLRHTKSEEHLDGSCLNSHQHLS-------
-------------------CSRTSSCSSSQQGTSCRRKK---------------------
-------------------------------GADVDGGCGDAGPHNSCSNVHSLGGLQFQ
ED--DVWSQE--EDEIT-------------------AQYLNMRKVSE----RDTISQISL
DSCDSR-DQGPPVVFNIGDVRLRHCSNLSCENT------KSFSNDPEDP---SAAA----
--------------------------------LKEPWH----------------------
------------------------------------------------------------
-------------------------------------------------------EKEKL
IRESSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLSN-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------AIVKCGDDLRQELMATQLLQMFKIIWQEEQV-DLWVRPY
KIVCLSNDSGLIEPILNTVSLHQIKKNSNK---------------SLKEYFIDEYG--SP
SGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKN-
LGFEQSPFKLTPEFVEVMGG-TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSN--
-------------------AHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQ-LVQD
SLKSLSTKLYDGYQYYTNGIL-
>gi|73981580|ref|XP_540314.2|	Canis familiaris
---------------------------------------------------------MVG
ARTRQQAGRSPLEARNPGPHPREERRLCGRVEPVQAARRPPQAAPRAAPKPGPGSAAAAA
-VREAQAANGTRERPRLLRRRCRQPDPDRPHPSAG---------VSERGPS---------
-PSTFGACSREKQF---RESLEARSLAVAMGDMVVEPAP---------------------
-------------------------------------LKPTS----------EPTTG---
----------------------LPGNNGGSLLGVI--TEGVGELSVIDREV---------
---------------------------------------AQKACQEVLEQVKLLHGGVAI
SS----------------------------------------------------------
-----------------------------------------------------------T
DTSLELVN---------------------GDVPDSAI-------RCLDDPPTQIREE---
------------------------------------------------------------
-----------------------------------EDEMGATVASGTAKGARRRRQNNSA
------------------------------------------------------------
---------------------------------------KQSWLLRLFESKLFDISMAIS
YLYNSKEPGV-------------QAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDA
IKP----------YIVHRCRQSINFSLQCALLLG---AYSSDMHISTQRHSRGTKLRK--
-LILSDELKPAHRKRELPSLSPAP----------------------DMGLSPSKRTHQ--
-------RSKSDATASIS-----------------------------------------L
SSNLK-------RTASNPKVENEDEELSSSTESID--NSFSSPVRLAPEREFIKSLMAIG
KRLATLPTKEQKTQRLISELSL---------------LNHK-LPARVWLPT--------A
GFDHH----VV-------------------------RVPHTQAVVLN---SKDKA-----
---PYLIYV--EVLECENFDTTNVPAR-------------IPENRIRSTRSVENLPE---
-------------------CGI--------------------------------------
-------------------------------THEQRAGSFSTVPNYDNDD----------
----EAWSVD-DIGELQ-------------------VELPEVHTNSCD-----NISQFSV
DSITSQ-ESKEPVFIAAGDIRRRLSEQLAHTPT-------AFRRDPEDP---SAVA----
--------------------------------LKEPWQ----------------------
------------------------------------------------------------
-------------------------------------------------------EKVRR
IREGSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLPN-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELLAFQVLKQLQSIWEQERV-PLWIKPY
KILVISADSGMIEPVVNAVSIHQVKKQSQL---------------SLLDYFLQEHG--SY
TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRN-
LGFETSAFKLTTEFVDVMGG-LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQG--
-------------------SQLPCFHGSS--TIRNLKERFHMSMTEEQLQLLVEQ-MVDG
SMRSITTKLYDGFQYLTNGIM-
>gi|50422459|ref|XP_459796.1|	Debaryomyces hansenii
------------------------------------------------------------
------------------------------------------------------------
----------MDQAYESLLESTESPTFDIFQCLYQ---------LKINIDN---------
IGVHHYLVKKLYN----FSYLEVEFHIPQLIQLLVSFET---------------------
-----------------------------------DSMALNE----------FMLDY---
----------------------SRKYPHFCLITFWNLQAYVFELKNDPESY---------
---------------------------------------SFHIVRSFINELQNVMFNQEA
L-----------------------------------------------------------
-----------------------------------------------------------Y
DSPVAQKKHGEF-----------------RENLQPSIAMCGAVLASIAVPQINVYAK---
------------------------------------------------------------
--------------------------PIIASQGKQQKSLLFKLA-NFHKSLTKNLTLKNR
G------RATSH------------------------------------------------
---------------------------------------SEHANIDQGHRSLSNPGTTKT
HEESAKESAD-------------STSKALRKLQNSATMSSL--------------DTWED
RHY----------NSDYSLERDMKINTR---------IISKKSYIRRAKELEQLGLGSES
LIDVNADIYTRPPLKDNKIAF---------------------------------------
-------HSMPDLRSNNR-------------------------EGSLDEMPITPVISGSS
STSLA------SLDLQEHKYANNHRILPMHQDQK---IKYLQVNYFKKETEFMMGLQNIS
TRLSQVP-KEARLTSLRAELSI---------------INNTIFPSEIDIPQLLPISSNQN
KKFHR----II-------------------------KLNVNEACVLN---SAERV-----
---PFLLLI--EYLS-EEMDFDPLNEHNKSIILS-KS----TNDFVYASGRRNKTPTTDF
TRSSN--------------DSTRQTDSTEPNTGFDEADL---------------------
-------GDMSVVALSNEKSFITN-------HLNSRQANDMNTHRVDISLPAPQK-----
----ANMERR-QTPDLTSPSS--------------PGTPTFDTRDLST---QMRIAAVML
QQLEKS-GQTNT--EQTAAIRARIIDSMKALQD------KFENIDYKQI---QAMQSVHV
GRNSSDAGERKLENDFK---------------LSEDWA----------------------
------------------------------------------------------------
-------------------------------------------------------TKKNR
IRQASA------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLKN-----------------WDLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKNGDDLPQEAFACQLISMISNIWKANNV-GVWTKNM
KIIVTSANTGLVETINNAMSIHSIKKTLTDLTLKSGE-NPKGKVASLKDYFNKVYG--DE
DSYKYKKAQSNFARSLAAYSVICYVLQIKDRHNGNIMLDNEGHIIHIDFGFLLSNSPGS-
VGFEAAPFKLIFEYVEVLGG-LEGAQYLKFKELCKECFKALRKNCDHLINIVDLMQKD--
-------------------SSLPCFKNGAQTSVL-LKQRLQLDLSDEECDAFVETGLIGK
SIGSVYTRLYDQFQLLTQGIYS
>gi|7547268|gb|AAB36289.2|	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------PVQILQQKF------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------CQPPSPLDVLII---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------DQLGCLVITGNQYIYQEVWNL
FQQISVKASS-------------VVYSATKDYKDHGYRHCSLAVINALANIAGNIQDEHL
VDE----------LLMNLLELFVQLGLEGKRASE--RASEKGPALKASSSAGNLGVLIPV
IAVLTRRLPPIKEPKPRLQKLLRDFGLYSVLMGFAVEGSGLWPEEWYEGVCDIATK----
-------SPLLTFPSKEP--------LRSVLQYNSAMKNDTVTPAELSELRSTIVNLLDP
APEVS-------ALIGKLDFAMSTYLLSVYR------LEYMRVLRSSDPARFQVMFCYFE
DKAIQKD-KSGMMQCVIAVADK---------------VFDAFLNMMAEKAK---TKENEE
ELERHAQFLLV-------------------------SFNHVHKRIRR---VADKYLSGLV
DKFPHLLWS--GTVLETMLDILQTLSLSLSADIH-KD---QPYYDIPDVPYRITVPDTYE
ARESIVKDFAAR-------CGMILQEAMKWAPTVTKSHLQEYLSKHQNWVSGL-------
-------SQHTGLAMATESVLHYA-------GYNKQSTSLGATQLTERRACVKKDYSNFM
AS--LNLRNR-YAGEVY-------------------G-MIRFSDATGH---TSDLNKMMV
QELKAALGAGDA--QQYTQAMFKLTAMLISSRDCDPQLLHHLCWGPLQMFNEHGMETALA
CWEWLLAGKNGVEVPFMRE-------------MAGAWQMTVEQKFGLFSAEMKEADPLAA
SEASQPKPCAPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFCSLLQRSLSLSIGGTAGSM
NRHVAAIGPRFKLLTLGLSLLHADVLPNATIRNVLREKIYSTAFDYFSCPPRFPTQGEKR
LREDISVMIKFWTAMFSDKKYLTASQLVPPDNQD-------------TRSNLDIAVGSRQ
QATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLL----------
-----------------------ATEIERLITWYNPLSAPEL--ELDQAGESSVANWRSK
YISLSEKQWKDNVNLAWSISPHLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIK
FLVTWHTIDADAPELSHVLCWAPADPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAIL
FYIPQIVQALRYDKMGYVREYILWAASQSQLLAHQFIWNMKTNIYVDEEGHQKDPDIGDL
LEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQ
PGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKE------GLRCR
SDPEEEGSMQEADGQKISWQAAIFKVGGDCRQDMLALQIIDLFKNIFQLVGL-DLFVFPY
RVVATAPGCGVIECIPDCTSRDQLGRQTDF---------------GMYDYFTRQYG--DE
STLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHLIHIDFGFMFESSPGGN
LGWE-PDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLD---
-------------------TGLPCFR-GQ--TIKLLKHRFSPNMTEREAANFILK-VIQS
CFLSNRSRTYDMIQYYQNDIPY
>gi|19074845|ref|NP_586351.1|	Encephalitozoon cuniculi
------------------------------------------------------------
-----------------------------------------MPGLLLDDMVQIPYTPTNI
-SNMRIEVMIKGNSKEICIPLIKETTLEDIRELSE---------VEVYDIS---------
SGLNAYAILKNSTVCLEYSSKLYEMYIAIFLKMLDDTAT---------------------
-----------------------------SKEIMSDMGGMEP----------YSLLE---
----------------------VGLINAFIEALIW--RVEQGEVVGRYEAF---------
---------------------------------------VEDLCRKMSSNLLCEIVSWKQ
EE-DIMNTKFDYLLLSLRLIVMMVEYKTK-------------------------------
-----------------------------------------------------------E
EGEIEKKSTFAFAKEYFYKAFALLGETKDLEDDMAFVFRASLTIDALVTRQVAGRIS---
------------------------------------------------------------
-----------------------EVFPIVEDLPISKKNMFGIYIQMAEVCMSEDGALNDL
L------YSV--------------------------------------------------
---------------------------------------FTTSCLVSLDTGYGNEFVEVL
IAMVEQDGGSGGKRIGNVMETFRMIFHSLQDSESRGRERLIWNFLSFLSRIRMGRDMGDL
NSI----------FLKFIVKYPETIELYSNFILI--NKIDFPLHTLHGISSFGFMKRF--
YSVLFNKVRKERHDKAHVDKLISEFLKF-FLATKNKELIGILPLVPYIPSKREVLYVLYE
IYSFLFEKEVIEHVGLFLLKTPALVGISSSIYYNVRYLRHLATRLSLVDVEPRMVVFLGI
VYYCESKKLYNFNYTGILEYIQDEDGIRMSRDGLVGVIELIHSGYISRSHEFTLSYVNSL
LTIALKP-KTIETTLVIIEIILRRILEKEEKIIFMKGIHQRFQELFVLLSSKRFLSDEVS
DSYRRLYRSIVERIKCAPNFYNYVVLCLADISFFDGEFPRGHFKSFNDLYNHTLSRMGVV
EGFPDIFMVDHGWSCSENTDKAVSGPFLHRVCGSGKEEETKPRETKSHNMYDIIRTGTND
SVMSLESSTGSISLHSS--APMPSISRKAWLEMLDEGIR----KREKSVSWLIDVIYTRR
SQSSTIRTVLDLLKLRLRNKFEYEDLYILLKAYNILSIRENDSEEFLKHALHRGLDFKTD
PAICYKLSME-TNGFYR-------------------FFFRALHLAVSNLPCNEDLSFPER
TQLVSRFDTADLV-HIQNTFKQKMVQKLLERSRSPSYRTYFFNVDSLGVIDSLTII----
---------RRLDDPSL---------------VSRAFE----------------------
------------------------------------------------------------
-------------------------------------------------------RLRES
KNEMLF------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-YVPQLVQMLRYKKVFEMAFSTLKELAKDEYVAHQLIWNLKANLYVDGRAAVNNYHGTFV
RCIEEIMKEMPDGSRDIFLKEEEFISSLTKISSELTPHLRSSKDEKRRRINEYLSRIKLH
PGIYIPFYPDLKIIEIVNGSARALQSHSKVPFMASFRVQD--------------------
------------PGGQISIKQLIFKSGDDCRQDMLALQIISMFESIFKQANL-DIFLYPY
KVMATSSGTGIIEVIPNSKSRDQIGKENIN---------------NLLEYFEYKFG--FK
ESEGYLTAICNFASSLAGYSLVGYFLNIKDRHNGNIMIDDQGRMIHIDFGYMLEMSPGN-
LNIE-APLKLTKEIEELLGG-TSGKGFEIYQELMVKGFLALRRRSKDLVMMVDSFVD---
-------------------SELPCYR---RNAVENFILRFRFELSDKNARRFVLS-LIAE
SSQKFRTWMYDQYQKITNNIAF
>gi|45199185|ref|NP_986214.1|	Ashbya gossypii
------------------------------------------------------------
------------------------------------------------MSKEVSSTEVGS
-SQDELQASVVPGSNELLLKFINSAHFTLYHNIEY---------LTRYAGN---------
VGIHFHICQKLLS----FPHNELQFYIPQLVQVLLTVET---------------------
-----------------------------------ESMALED----------LLMKL---
----------------------SGENPHFALLTYWQLHALLSDLATDPASY---------
---------------------------------------GFQVARRMINKLQVVLCSTSS
IP----------------------------------------------------------
-----------------------------------------------------------Q
ETKV-------------------------HENLSPSLVLASMVMSSIAFPQLAVSAK---
------------------------------------------------------------
--------------------------PLVESQGKRQRSHVFKLAKNAIGNLGKNISLKNT
V-----------------------------------------------------------
-------------------------------------------TGRRPGSNKKTTGSAVD
LVDVKTKED--------------TQFKKQKEKDIPSLNFDM---------------VDNV
GDH----------LLEDKLSSSIVLPKRRQKNTD--QSYMHRIYKPKDNDGAKL------
-EEYTNSMPNLHLNSRSSTSL---------------------------------------
-------HSYKDQQSLEQ--------------------------HGSGSITQSPSNDLKK
SHKRK------TSRHGANIYNLEPSSLSATHK-----IKILKANYFRCEMQFVIALETIS
RKLAQVP-TEARLTSLRAELSI---------------MNRD-LPAEVDIPTLLP--PNKK
GKLHR----IV-------------------------NIAANEAQVLN---SAEKV-----
---PFLLYI--EYLR-DDMDFDPATEKNDSLLKV-KP---DDGSFIFDLSNLDNNDNQDI
MCDSNLS------------CGAISEPGTPTIRKEIDL-----------------------
-------GDLSMVKITDQSDMDTN-------RREMLLNTAETVPKISSNSVSRNSELSFI
SNL-DEMTQR-FMGVEG-------------------GEPPNFSDDLAT---QMRISAMML
AQLDKSPQQLS---DTTNQIRAKIIASMQEAQD------RFGYYDLESV---HGMA----
-------GERKFENDLKTGGIYPTDRKNTTY-LGEDWN----------------------
------------------------------------------------------------
-------------------------------------------------------TKKEK
IRSASQ------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GQHEN-----------------WDLFS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKSGDDLRQEAFACQLIQAMANIWNKEKV-DVWVKKM
KILITSANTGLVETITNAISVHSIKKSLTKQMIEEGELNEKGTIATLCDHFSRSFG--EP
NSFRYKRAQDNFASSLAAYSLICYILQIKDRHNGNIMIDNEGHLVHIDFGFMLSNSPGS-
VGFEAAPFKLTQEYVDVLGG-IEGEPYKKFIRVVKEAFRALRKHADMFVSMCEVMQKD--
-------------------NMQPCFNAGEQTSIQ-LRQRFHTELAEDECDDFVENVLVAK
SLGSIYTRLYDQFQLMTQGICT
>gi|149237689|ref|XP_001524721.	Lodderomyces elongisporus
------------------------------------------------------------
------------------------------------------------------------
-----------MDGINNVREKINSPDLSLLQCIDL---------LRIHCSN---------
IGLLHALVNRLYS----YPYEEVEFFIPQFVQLLVMFET---------------------
-----------------------------------DSVALEE----------FLLDH---
----------------------CASYPHFSLTVFWVLQAFLFELRNEPTSY---------
---------------------------------------AFQIVRNLINKLQDILFN---
------------------------------------------------------------
-----------------------------------------------------------Y
DIPSVKEPKF-------------------RENPLPALVLCGAVASSFATPSLNNYIS---
------------------------------------------------------------
--------------------------KMIKSQGKQQRSLVFKLA-NFQKTLTKNLTMKNQ
A-----------------------------------------------------------
-----------------------------------------TSTLEAIGDNLSKEDLQEA
IQISSSSSSP-------------VLSGKEILANSRRLANQYLLDDSEETGVGTDEEDTRS
NRPRSSTLNHAFSIAEDQIKINTAIKLKKRRSLK-------AMHLHSSIPGAGLGGVGAS
GISGISGTSGTSGAAAALNS--------------------------QSGLDRPSQVQT--
-------QSLPDLTRSMS--------------------------RPELPVTESEYLVNQV
RYSAD-------SYLAKGWPRRAAIANKSYQEL----LKILRVNYSKKQTEFMMSLQDIS
MRLSLVP-KAARVSALRAELSI---------------LNDTILPSEIDIPQLLPHTSNRN
KKFHK----IL-------------------------RLNINEACVLN---SAERV-----
---PYLLLI--EYLS-DEFDFNPFTEYNQKLIT--EKLQSRESKNSPDISANTTIDNGNN
INNIN--------------SNNTINNSNNFDQESITSD----------------------
-------AQSSFIAGVGGDDGKFL---------PLDETDLGELSIIDSHVISGNRSRSQS
GNFSPGGSNSIASGSLPAAPQ--------------SLNAADTTLYLAD---QMRIASLML
QQLENS-GQANS--QQFLSIKTRIIDSMISLQD------RFESIDYEKM---KELR----
-TDEQGAGQRKLENDFK---------------IGEDWE----------------------
------------------------------------------------------------
-------------------------------------------------------AKKRR
IRKASA------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLKN-----------------WELCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKNGDDLPQEAFACQLIILISNIWKKYGI-HFWTKKM
KILITSANAGLVETITNSMSIHSIKKSLTELSIASGE-NSKGRIFTLRDYFEKLFG--PP
SSRAYRRAQGNFATSLASYSVICYVLQIKDRHNGNIMIDHEGHIIHIDFGFLLGNSPGSN
IGFEAAPFKLTTEYIDLLGG-MESEHYQTFVSVFKDCFRVLRKEWTQIVSIVELMQKD--
-------------------SNLPCFNNGDNTSVL-LKQRLQLQLSDDDLDAFAETYLINK
SLNSLYTRWYDQFQLITQGIFA
>gi|116175243|ref|NP_001030149.	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
-----MGDTELELSPTHLEELQKSPSTSTTSSLSL---------PSSPSSG---------
-------------------PHPLTSSSPSTSEGL--------------------------
------------------------------------------------------------
----------------------PTSSPPLDVI-----SEGLGELSLVIDTEV--------
---------------------------------------AKKACQEVLQKVKFLK-----
------------------------------------------------------------
-----------------------------------------------------------G
DGEVSSAS---------------------SEPILANGTAHPEANDGGQPPKISEEEV---
------------------------------------------------------------
---------------------------------------------EPIKSVRRRQKNNSS
------------------------------------------------------------
---------------------------------------KQSWLLRLFESKLFDISMAIS
YLYNSKEPGV-------------QAYIGNRLFSFRNEDVDFYLPQLLNMYIHMDEDVGDA
IKP----------YVVYRCRQSINFSLQCAWLLG---AYSSDMHISTQRHSRGTKLRK--
-LILSDELKPSSQRIRREVPQPPPPYPPPLHHG---------PGMSEHSLSPSKRTHQ--
-------RSKSDATVSIS-----------------------------------------L
SSNLK-------RTASNPKVETSQDE----------------PVRLTPQREFIKSLMGIG
KRLATLPTKEQKTQGLISELSL---------------LNHK-LPARVWLPT--------A
AFDHH----VV-------------------------RVPHTQAVVLN---SKDKA-----
---PYLIYV--EVLECENFETSSVPVR-------------IPETQIRSTRSVENLPD---
-------------------CGI--------------------------------------
-------------------------------TPDQRASSFSTVPNYDNDD----------
----EAWSVD-DIGELQ-------------------VELPEIHTNSCD-----NISQFSV
DSITSQ-ESKEPIFIAAGDIRRRLSEQLAHTPT-------TFRKDPEDP---SAVA----
--------------------------------LKEPWQ----------------------
------------------------------------------------------------
-------------------------------------------------------EKVRR
IREGSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLPN-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELLAYQVLKQLQIIWEQERV-PLWIKPY
KILVISSDSGMIEPVVNAVSIHQVKKQSQL---------------LLLDYFRQEHG--NF
NTEEFLTAQRNFVQSCAGYCLICYLLQVKDRHNGNILLDSEGHIIHIDFGFILSSSPRN-
LGFETSAFKLTSEFVDVMGG-LDGDMFNYYKMLMLQGLIAARKHMEKVIQIVEIMQQG--
-------------------SQLPCFHGSS--TIRNLKERFHMNLTEEQLQVLVEQ-MVDG
SMRSITTKLYDGFQYLTNGIM-
>gi|50291259|ref|XP_448062.1|	Candida glabrata
------------------------------------------------------------
-----------------------------------------------------------M
-NIIENRPKNQNQASEEVIEAVNSPTFNVHRCIEL---------LCKNANN---------
IGIHFFLCQRLEN----FPHSELQFYIPQLVQILLTIET---------------------
-----------------------------------ESMALED----------LLLKL---
----------------------RTENPHFALLTFWQLQALLTDLSTDPESY---------
---------------------------------------GFQVARRVLNSLQANLFST--
------------------------------------------------------------
-----------------------------------------------------------D
VSEIEKKTKM-------------------HENVAPALVMSSMVFSCMALPQLAESIE---
------------------------------------------------------------
--------------------------PLVRSQGRRQKSYVFKLAKNLMKDFTRNMTLKNT
L-----------------------------------------------------------
-----------------------------------------HNKSHKKKTKHITQAAPVD
IINPTTTKED-------------VMFRKSKSTEI-NLDFDM---------------VDNV
GQK----------VFEERISTSIRMPKRKTRPTDGMQRTSTDTSIRTLGTSKPQRLRGFD
AVSSPEESPRVSQTNTGQNSDESD---------------EETDSESRIPMKTDRFI----
-------SSMPDLIGNKP-------------RNSGSSYTSLAKSSGGLSRSHSQSVKHDA
TRNYT--------NTDSRFKELDPSKIPTTVK-----IKMLKANYFRCETQFAIALETIS
RSLAQVP-TEARLSALRAELSL---------------LNRD-LPACVDIPTLLP--PNKK
GKLHK----LV-------------------------LITANEAQVLN---SAEKV-----
---PYLLLI--EYLR-DEFDFDPTTPENEEIIKK-GN---NHSNLIFDLNYITKNRKKFD
EDTIFS-------------STDAIPSKNSRHASSTPGEDTSKSNSSVNLLKEEDL-----
-------GDMSMIRVKNLSDAEAY-------RSSLVLKRASNVPVLPTDSHDRTPELNFS
ST--MQEFIN-QGNNLS-------------------DSFKSQTDDLAD---QMRVSAVML
AQLDQSPQQLS---ETTNQIRAQIIASMKEVQD------RFGYKDVENL---HGKA----
-------GERKLENDLITAGISSSY-------LGEDWA----------------------
------------------------------------------------------------
-------------------------------------------------------TKKER
IRKTSE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLEN-----------------WDLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKTGDDLRQEAFACQLIQAMAQIWTSERV-DVWVKRM
KILITSANTGLVETITNAMSVHSIKKALSKKMIEDGELDANGGIATLKDHYLRMFG--DP
EGFKFKRAQDNFASSLAAYSIICYLLQIKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGS-
VNFEAAPFKLTYEYVELLGG-LDGAPYKKFVQLTKDSFKALRKYADQIVSMCEIMQKD--
-------------------NMQPCFNAGQQTSIQ-LKQRFHLELTEEETDAFVDNFLIGR
SLGNIYTRLYDQFQLLTQGIYS
>gi|48097614|ref|XP_391922.1|	Apis mellifera
------------------------------------------------------------
----------------------------------------------MSEVVAVTPSGGST
-RQESVVHIKRHKLANCNVPLVHGRSNPPINSRNR---------LTTHQRNHSLDFRSMG
ILLPPVPQASATTLTHHHRNRSLDSALQRIPEVDVTPSP---------------------
-------ECETTPAPVTKVVVVPACKARSREREDLASLGSDD----------SGILCGSD
SGSSDA----------------TNAATRESSVDHLHSRESLDSSLSQPGDMDS-------
---------------------------------------VDTVDGEETSALDSVTVSVQV
SPVELVHLSEPSSKKGGDNSEPHKHENTIS------------------------------
-----------------------------------------------------------G
NHDSQETCSNNVCTVNEFESHEYTQDEQRCTDVGVTVGTRDFQNSMEVLPVNDKQSE---
------------------------------------------------------------
--------------------LAGAAMTLCCGTAVQSEINEAAVKKQTGIVCRRQETVQPK
P-----------------------------------------------------------
---------------------------------------SEGCLLRLFESQIFDMSMAIS
YLFNSKEPGV-------------QSYLGNKMFSFPDNDVDFYLPQLVVMYIQLH-DVTEV
LYP----------YLVHRCRQSADFSLKCAWLLD---AYSSDAHLPSKKKSHGTKLKN--
-LILSDELRPKGNENKKRVTGLQTPAPLSLIPM-------------QNITSPNKKTHQ--
-------RSQSDASGLFQ------------------------TLRRSHSGTINKVSLGDL
SSGRA-------FDNGCTCFYSCQGVVNDLRGQKT--DCFCNAPRLAPELEFIQALISIG
KLLGTIPTKESKTVQLIAELNT---------------LNLN-LPARVWLPL-------HS
SIPHH----IV-------------------------RVPPQYAAVLN---SKDKA-----
---PYIIYV--EVLEVEDIYTSPVPTK-------------IVGCSLRHTKSEENLTGGEQ
SNV----------------MGSSNISASE-------------------------------
-------TQQNMLPIRQTPIKNIS-------PYSVRNTEVAFNFPDDDPS----------
----DCWSQE--DDEIT-------------------QQYLQLRKPKD----RDTISQLSQ
ESSDSK----EPI-FVPGDIKRRLSEMAAAPSA-------TFNHDPEDP---SAAV----
--------------------------------LKEPWE----------------------
------------------------------------------------------------
-------------------------------------------------------LKQRR
IRSSSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLAS-----------------WRLLA------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELLASQLLSMLQKIWQDEHV-PLWVRPY
KILCLSNDSGLIEPILNTVSLHQVKKQCQL---------------TLYQYFEREFG--PS
MSEAFIIAQRNFIQSCAAYCLVCYLIQVKDRHNGNILLHSDGHLIHIDFGFILSTSPRN-
LGFETSPFKLTPEFVEVMGG-SQSKQFQEFKTLILQGLIAARKHMEKIVNLVEIMLSG--
-------------------SQLPCFRSGGAATVQGLKNRFHLTLTEDQLRRHVED-LVEA
SIHSWSTKLYDRYQYFANGTL-
>gi|91091704|ref|XP_972821.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
---MSEVQQQPMAAHVKRPKFVGCKDTTVPSVHGR---------PNNHLNN---------
-KIRLSNHQRNLS----LDFRSMGILLPPVAQITSSTSP---------------------
------------------------------------------------------------
-----------------------------HLTLHHRNRSLDSALQRIPEVDVT-------
---------------------------------------PSPECEPTVVVVVPPIVDPKT
------------------------------------------------------------
------------------------------------------------------------
-----------------------------TRDELASLGSDDSGILCGSDSGSSDTST---
------------------------------------------------------------
--------------------------------TTRESSVDETKAECCITPTTTLSQSNET
S-----------------------------------------------------------
---------------------------------------KGFGMLRLLESKVFDVSMAMH
YLFKSKEPGV-------------QSYIANKMFSFDDGEVDFYLPQLVCMYIQMH-DVAEV
IHP----------YLIHRCRKSIDFSLKCAWLLD---AYSSDASVPSKKKPLGIKLRN--
-LILSDELRPKDHKTPIMVSTTFS----------------------TLHSTTTKKSHQ--
-------RSQSDASALGT---------------------------RRPSTTDKRLCMGDL
TSGRA-------FDNGCTCFDSCRGVVNDLRGKKT--ECTCSAPRLAPELEFMKALISIG
KLLSSIPTKEAKTTRLVAELTT---------------LNLN-LPARVWLPL--------A
TTPHH----IV-------------------------RIPPQVGAVLN---SKDKA-----
---PYIIYV--EVVEVDDLHTSIVTPK-------------IWP-TLRHTKSEENLGDTTS
LSAFSM-------------CG---------------------------------------
-------------------------------GLCDDTD----------------------
----PDWSQE--DDEIS-------------------QQYTQLKR-IAD---RDTLSQMSQ
ESSDSR---EPPMWIAAGEIRRRLSDSIHEEKN------KQFTHDPQDP---SAAV----
--------------------------------LKEPWH----------------------
------------------------------------------------------------
-------------------------------------------------------DKERR
IRECSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLTS-----------------WTLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELMASQLLQMFQKIWEMEHV-PLWVHPY
RILCLSNDSGLIEPILNTVSLHQIKKHRQL---------------SLLEYFINEYG--PI
TCEEFLTAQKNFVQSCAAYCLFCYLIQVKDRHNGNILLKSDGHLIHIDFGFILSMSPKN-
LGFETSPFKLTAEFVEVMGG-DQSDMFEYFKILILQGLVAARKHMDMIVPLVEIMRSG--
-------------------SQLPCFKSG-AATVQNLKNRFHMSMTEEQLQLEVNR-MVEV
SIHSLSTKLYDGFQYFTNGIL-
>gi|151944281|gb|EDN62559.1|	Saccharomyces cerevisiae
------------------------------------------------------------
------------------------------------------------------MHKASS
-SKKSFDDTIELKKNEQLLKLINSSEFTLHNCVEL---------LCKHSEN---------
IGIHYYLCQKLAT----FPHSELQFYIPQLVQVLVTMET---------------------
-----------------------------------ESMALED----------LLLRL---
----------------------RAENPHFALLTFWQLQALLTDLSTDPASY---------
---------------------------------------GFQVARRVLNNLQTNLFNTSS
G-----------------------------------------------------------
-----------------------------------------------------------S
DKNVKI-----------------------HENVAPALVLSSMIMSAIAFPQLSEVTK---
------------------------------------------------------------
--------------------------PLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNT
L------LNK--------------------------------------------------
---------------------------------------KTSRSKRVSSNRSSTPTSPID
LIDPIKTKED-------------ASFRKSRHSEVK-LDFDI---------------VDDI
GNQ----------VFEERISSSIKLPKRKPKYLD--NSYVHRTYDGKNINRDGSISNTAK
ALDGNKGDYISSKGRNDENSEIGN----------NEDETGGETEEDADALNSDHFT----
-------SSMPDLHNIQP--------------RTSSASFASLEGTPKLNRTNSQPLSRQA
FKNSK-------KANSSLSQEIDLSQLSTTSK-----IKMLKANYFRCETQFAIALETIS
QRLARVP-TEARLSALRAELFL---------------LNRD-LPAEVDIPTLLP--PNKK
GKLHK----LV-------------------------TITANEAQVLN---SAEKV-----
---PYLLLI--EYLR-DEFDFDPTSETNERLLKKISG---NQGGLIFDLNYMNRKENNEN
RNESTLTSNNTRSSVYDSNSFNNGASRNEDLSSTSRSDSASTAHVRTEVNKEEDL-----
-------GDMSMVKVRNRTDDEAY-------RNALVIQSAANVPILPDDSQDRSPELNFG
SNLDEVLIEN---GINS-------------------KNIHSQTDALAD---QMRVSAVML
AQLDKSPQQLS---ESTKQIRAQIISSMKEVQD------KFGYHDLEAL---HGMA----
-------GERKLENDLMTGGIDTSY-------LGEDWA----------------------
------------------------------------------------------------
-------------------------------------------------------TKKER
IRKTSE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHFEN-----------------WDLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKTGDDLRQEAFAYQMIQAMANIWVKEKV-DVWVKRM
KILITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFG--NP
NGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGS-
VGFEAAPFKLTYEYIELLGG-VEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKD--
-------------------NMQPCFDAGEQTSVQ-LRQRFQLDLSEKEVDDFVENFLIGK
SLGSIYTRIYDQFQLITQGIYS
>gi|63101123|gb|AAY33180.1|	Candida parapsilosis
------------------------------------------------------------
------------------------------------------------------------
-----------MFKNEKLRKEVYSPSLSLLSCIRL---------LSENGKN---------
IGVHHALVQRLHS----FSYDEIEFFIPQFIQLLVSFET---------------------
-----------------------------------DSMALED----------FLLRY---
----------------------CENYHHFSLIVFWCLQAFLFELRNEPASY---------
---------------------------------------AFQTVRNFINKLQSILFN---
------------------------------------------------------------
-----------------------------------------------------------V
GNSVSRKREF-------------------RENLDPALVLSGALLSSFALPLAHDYVT---
------------------------------------------------------------
--------------------------PIIKSQAKQPKSFVFNVA-NFQKNLTKNLTLKNQ
------------------------------------------------------------
---------------------------------------------KISDDRKFDVPVEEK
QAYETGGKIIDS-----------SRFGRKVPSYFSSDDSETNTT-----------DDED-
----------------------TKLTFKH--------GYSKEAAFSNVGHTLKINTTIKR
KKSFGKDFSSLRNEMNRSA-----------------------------------------
-------QSLPDLTRSHS--------------------------RPDLLSTESEMALHSS
RYSTD-------AGTKRINSPSASSKTKSYSEL----VKILRVNYSKKETEFIMSLQDIS
MRLSSVP-KAARLSALRAELAI---------------INDTLLPSEIDIPQLLPVTSNKN
KKFHK----IL-------------------------KLSINEACVLN---SAERV-----
---PYLLLI--EYLS-DELDFNPFTEYNQK----------LINGKLQETESKRSYESNNN
DTESLVSD-----------VRSISARDGLNGIANIETDL---------------------
-------GELSILGSRRE-------------SREWVNSKLGSMSPRLSQDEPRSP-----
-----------LLGTSG-------------------TSNLPESSVLAD---QMRIASVML
QQLESS-GQANT--QQFLAIKNRIIDSMISLQD------QFESIDYETM---KELK----
-TDEQDAGQRKLENDFK---------------ISEDWA----------------------
------------------------------------------------------------
-------------------------------------------------------SKKQR
IRKASA------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLSN-----------------WDLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKNGDDLPQEAFACQLITMISNIWKKHGI-SFWTKRM
KILITSANAGLVETITNAMSIHSIKKSFTELSIASGS-NTRGRIFTLKDYFERLYG--NE
SSRKYRQAQENFARSLASYSIICYVLQIKDRHNGNIMLDHEGHIIHIDFGFLLGNSPGSN
IGFEAAPFKLTTEYVDILGG-TESEFYKLFVEVCQDCFKVLRKESDQIVSIVELMQKD--
-------------------SSLPCFNNGENTSVM-LESRLQLSLPDESINQFVETSLVGK
SLNSMYTRLYDQFQMVTQGIYN
>gi|126313830|ref|XP_001371442.	Monodelphis domestica
----------------------------------------------------------MK
QWSVDCTESRRIQSYPGAAGMGNSMSVVPRRRGRFESVAGPFKGGTVVGLAVFLLPARGS
-LKTPLLCRRPPKQPSASRVGFHPEEAGMRHALDT---------SADSIGYYGLRGVLST
GDARRKIPGREDS----DSETDTTRQNPAVPRAAPQPGPGAAAAAAAAAAA------VAA
AAVKEAEAADGVRERRLLLLRRRRRRPDTDPSPRPLRGGPWS----------LEVLCLAV
AMGDTAVEPAPLNSSSSEPTPSPPGNNGGALLSVI--TEGVGELAVIDPEV---------
---------------------------------------AQKACEEVLEKVKLLHGGTAS
SP----------------------------------------------------------
-----------------------------------------------------------E
ESTLELVN---------------------GDSVGSEL-------RCLDEPPSRIQEE---
------------------------------------------------------------
---------------------------------------DEAGTSGSAKGARRRRQNNSA
------------------------------------------------------------
---------------------------------------KQSWLLRLFESKLFDISMAIS
YLYNSKEPGV-------------QAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDA
IKP----------YIVHRCRQSINFSLQCALLLG---AYSSDMHISTQRHSRGTKLRK--
-LILSDELKPAHRKRELPSLSPAP----------------------DTGLSPSKRTHQ--
-------RSKSDATASIS-----------------------------------------L
SSNLK-------RTASNPKVENEEEELSSSTESVD--KSFSSPVRLAPEREFIKSLMAIG
KRLATLPTKEQKTQRLISELSL---------------LNHK-LPARVWLPT--------A
GFDHH----VV-------------------------RVPHTQAVVLN---SKDKA-----
---PYLIYV--EVLECENFDTTSVPTR-------------IPENRIRSTRSVENLPE---
-------------------CGI--------------------------------------
-------------------------------THEQRAGSFSTVPNYDNDD----------
----EAWSVD-DIGELQ-------------------VELPEVHANSCD-----NISQFSV
DSITSQ-ESKEPVFIAAGDIRRRLSEQLAHTPT-------AFKRDPEDP---SAVA----
--------------------------------LKEPWQ----------------------
------------------------------------------------------------
-------------------------------------------------------EKVRR
IREGSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLPN-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELLAFQVLKQLQSIWEQERV-PLWIKPY
KILVISADSGMIEPVVNAVSIHQVKKQSQL---------------SLLDYFLQEHG--SY
TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDADGHIIHIDFGFILSSSPRN-
LGFETSAFKLTTEFVDVMGG-LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQG--
-------------------SQLPCFHGSS--TIRNLKERFHMSMTEEQLQLLVEQ-MVDG
SMRSITTKLYDGFQYLTNGIM-
>gi|3688225|emb|CAA09718.1|	Candida albicans
------------------------------------------------------------
------------------------------------------------------------
-----MSADITETPNKQLLEQIRSPSFSLFNCIYE---------LKNHTDS---------
IGIQHELVKKLYS----FPYEDLQFFIPQFVQLLVTYDS---------------------
-----------------------------------ESMALEE----------FIITY---
----------------------SSGYPHFSLIVFWNLQAYIFELKNEPESR---------
---------------------------------------SFQAVRNLITKIQNIMFN---
------------------------------------------------------------
-----------------------------------------------------------A
DQQTVKAPEF-------------------RENFLPALVLCGAVASSVLLPSFKSYCL---
------------------------------------------------------------
--------------------------PMIKAQGKQQKSLVFKLV-NFQKSLTKNLTLKNQ
R---MSA-----------------------------------------------------
---------------------------------------DIPKGSHSDDETATSSSIKPS
LSRSASVP---------------RRNTKKTSLSFSSDESEAY-------------TTDDD
DNK----------TSIELEKDFYKIDLDGL-------SKEKSANFLEPEEN---------
-LNVNTAIKSKKRLSTLTSKVMTQPW---------------------NGIDGYNVNS---
-------QSLPDLSKAEG-----------------------RDLIPFISSTESETSLLYH
NNSIS--------NDLQKNIPRQQKFSPGFDNVYL--TKLLQVNYAKNETQFIMALQNIS
IRLSQVP-KEARLSALRAELSI---------------INDTLLPSEIDIPQLLPITSNRN
KKYHK----IL-------------------------KLNVNEASVLN---SAERV-----
---PFLLFI--EYLS-DEIDFNPTTEYNQRIIAR-KKMNGATSMTVKKINSFSEVADGNF
EKENKIKSSTPETV-----SNIIYNENTEE------------------------------
-------ADLSEMPLDRKTTV----------SSDSFSPEMLVTPAITEQSKLSNF-----
----PSLNTK----EVS-------------------------TKVLAD---QMRIAAVML
QQLDSS-GKANS--EQSFLIKNRIVESMIALQD------QFDSFDFEKL---SQLQ----
-SDEPSAGERKLENDFK---------------LGEDWN----------------------
------------------------------------------------------------
-------------------------------------------------------TKKQR
IKKSSA------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLKN-----------------WDLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKNGDDLPQEAFACQLISMISNIWKKNNI-PVWTKRM
KILITSANTGLVETITNAMSIHSIKKSFTEHSIKSGE-NSKGKIFTLLDYFHSVFG--SP
NSTSFRTAQQNFAKSLAAYSIICYVLQIKDRHNGNIMVDGDGHIIHIDFGFLLSNSPGS-
VGFEAAPFKLTVEYVELLGG-VDSEIYSQFVYLCKQCFKSLRDNSEEIIEIVELMQKD--
-------------------STLPCFNNGENTSVL-LKQRLQLQLNDEDTDQFVENFLIGK
SLGSMYTRLYDQFQMITQGIYS
>gi|157020044|gb|EAA04661.4|	Anopheles gambiae
------------------------------------------------------------
----------------MGILLPPVSQVTNNRINMTQHHRNRSLDSALQRIPEVEVSSPSA
ESENTLHCTNGILTGTMCSKIIQSSSTNPTNTPSNSGRGISSMSLTAGSGKSGSNGSEAD
ADTVVTTAAASATNSTTHHHQPSRQQMSRKVDLLEQGAT---------------------
----LRTLKGSHSNDAETIVNSIVKDSDSKKREDLTSLGSDD----------SGIIC---
----------------------GSEPDHTSLTRIRRSRESLDSGEIDP------------
---------------------------------------SEEECIEILETTSMEEEYRML
QSDLCFYPTAMDRTAKEDGSDSDSRPLDNCIEQPPAHQSTLTSANNGGPLSDKVRYRQQN
MTRAAIMLEKLFVPINYEDGENAAAVDGDGGSSLGNEEDEMLSHPDAATPIV-------S
EGKSLTTPTNAVTPTGPSFSQQQQSAASTNVPSTAAVSPSDTSKPATSDPPKADQKN---
------------------EVMFRNFFGATKNAIFRTAQSIIDNHEKKHAKQREKQAATTS
ATTPDDAGAAPAVGGAASGATTASSTSTVKSPTELLRKREFGSMFARSSNSSKHHHHNQQ
QPASSSSAVTPTATTTTASVSMEFDTTSSSTESGSSQLNIPKASLSKSSSTASLKVVPGV
AVAAVPSTSSTAASSSSSCVAPFSSSGPRDESQIRTERTGQSGLLRFFESPVFNIHFAVH
YLFYSKEPGV-------------LSFIGNKIFSFPHIEVDLYIPQLIVMYMQIE-ELSEV
LDP----------YLVYRCRQSVDFSLKCVWLLE---AYNFNTEMLSGAGNSIRKH----
-LSLLRELYPKRERVKLAAAAANNAPIITTTGSELLATGNDPTLQAHPALSAVRKTHH--
-------RSQSDATGMMG------LLAQHHHHHHHAHHAAPLPGGVPGPSSRTPVCLGDL
STGRA-------FDNGCVCFESVRGTVNDLLGQQT--VCSCGAPKLAPEKEFMKALIDIG
KMLTCLQTKIEKTSRLRILLNL---------------INKN-LPARVWLPL-------HS
ETPHH----VV-------------------------RITEEKTAVLN---SKDKT-----
---PYIIYV--EVVEVQDIYTSPVIPKMMPTLRHTKS-----EERLDSSISASALNGDEA
GSNPSKTEQTTTTTSSSAACQQTGDETAAPLPAAAAASLAASR-----------------
-------SRHSKLSECSVDN-----------GGNGGNGGGSMMELGLTED----------
----DVWSQE--DDEIT-------------------AQYLSLTKMSSD---RDAISQFSV
DSYDSR-DHHTPALFNIGEVKKRHCANLNSENA------KPFSNDPSDP---SAAA----
--------------------------------LKEPWH----------------------
------------------------------------------------------------
-------------------------------------------------------EKEKQ
IRNSSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLQS-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------AIVKCGDDLRQELMATQLLQMFKLIWEEEKV-GLWVQPY
RIVCLSNDSGLIETIVNTVSLHQIKKNSNK---------------SLKDYFIDEFG--DV
ETVAFRRAQRNFMHSCAAYCLISYLLQVKDRHNGNILLHSDGHLIHIDFGFILSISPKN-
LGFEQSPFKLTPEFVDVMGG-PESELYCEFKYLLLDGLKAARKHMDRIINIVEIMRSS--
-------------------SQLPCFKNGCSGTVRNLRNRFHMNLTEQELERKVEQ-LIQD
SLNSLSTKLYDGYQYITNGIL-
>gi|149019737|gb|EDL77885.1|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MEPILQILQQKF-----
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------CQPPSPLDVLII---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------DQLGCLVITGNQYIYQEVWNL
FQQISVKASS-------------VVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHL
VDE----------LLMNLLELFVQLGLEGKRASE--RASEKGPALKASSSAGNLGVLIPV
IAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATK----
-------SPLLTFPSKEP--------LRSVLQYNSAMKNDTVTPAELNELRSTIINLLDP
PPEVS-------ALINKLDFAMSTYLLSVYR------LEYMRVLRSTDPDRFQVMFCYFE
DKAIQKD-KSGMMQCVIAVADK---------------VFDAFLNMMAEKAK---TKENEE
ELERHAQFLLV-------------------------NFNHIHKRIRR---VADKYLSGLV
DKFPHLLWS--GTVLKTMLDILQTLSLSLSADIH-KD---QPYYDIPDAPYRITVPDTYE
ARESIVKDFAAR-------CGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGL-------
-------SQHTGLAMATESILHFA-------GYNKQNTTLGVTQLTERPACVKKDYSNFM
AS--LNLRNR-YAGEVH-------------------G-MIRFSGATGQ---MSDLNKMMV
QDLITALDHSHP--QHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALA
CWEWLLAGKNGVEVPFMRE-------------MAGAWHMTVEQKFGLFSAETKEADPLAA
SEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLHIGGARGSM
NRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKR
LREDISIMIKFWTAMFSDKKYLTASQLVPPDNQD-------------TRSNLDITVGSRQ
QATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLL----------
-----------------------ATEIERLITWYNPLSAPEL--ELDQAGENSVANWRSK
YISLSEKQWKDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIK
FLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAIL
FYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDL
LEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQ
PGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKE------GLQCR
SDTEDECRRQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGL-DLFVFPY
RVVATAPGCGVIECIPDCTSRDQLGRQTDF---------------GMYDYFTRQYG--DE
STLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGN
LGWE-PDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLD---
-------------------TGLPCFR-GQ--TIKLLKHRFSPNMTEREAANFIMK-IIQN
CFLSNRQPDLRHDPVLPE----
>gi|50304695|ref|XP_452303.1|	Kluyveromyces lactis
------------------------------------------------------------
------------------------------------------------------------
------MESTDDRNPDILLKYINSSNFTLYNNIEY---------LTRYADN---------
IGIHFYLCEKLLS----FPHKELQFYIPQLVQILLTMET---------------------
-----------------------------------ESLALEE----------ILLRL---
----------------------SSENPHFALITFWQLQALLGDLAHDPTSY---------
---------------------------------------SFQVARRVLNHLQFILFNTTR
KN----------------------------------------------------------
-----------------------------------------------------------D
NEKI-------------------------NENIAPALILCSMVTTGFAFPGLLEHTK---
------------------------------------------------------------
--------------------------PLIKSQGRRQKSYVFKLAKHAMKNLTKNLTLKNT
L-----------------------------------------------------------
---------------------------------------ANSSSGRKVSSDSVTNIANVD
LVDTVTTKED-------------VTYKKKRQDSISDLSFDM---------------VDDI
GEK----------LFEDHISNSIKLPKRRDT------SYIHAVYKNPPITE---------
-EEYTNSMPDLRARSSSS------------------------------------------
-------ASMPDLSAKKS-----------------------------------MDAIRET
TTNPS-------SYNESKRQMIDVTHLSTTKK-----IKLLKVNYFHCCTQFAIALESIS
QRLAQVP-PEARLSALRAELSI---------------LNRD-LPAEVDIPELLP--VNKK
GKLHK----LI-------------------------KISANEAQVLN---SAEKV-----
---PYLLFI--EFLK-DDFDFDPTSEQNIKLLEN-NP---RSSY-IFDLSYVKQNNAPFK
ANMPLETS-----------SGSANQEMDL-------------------------------
-------ADVSMVKLTNQSEAENY-------RHELMMKNAKTVPVIPPDSHTRGSELDFV
AD--LQEATE-RLTDIK-------------------L-HRDSSDDLAT---QMRVSAMML
AQLDQSPQQLS---DSANQIRAKIIASMQEMQD------KFGYRDLEAI---HGMA----
-------GERKLENDFKTGGLTTSNDKTSTSYLGEDWN----------------------
------------------------------------------------------------
-------------------------------------------------------AKKEK
IRKSSE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-F-------------GHLPN-----------------WDLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VISKSGDDLRQEAFACQLIQAMAAIWSKENV-GVWVKKM
NILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYG--DP
NGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGS-
VGFEAAPFKLTYEYVEVMGG-SESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKD--
-------------------SLQPCFQAGDQTSVQ-LRQRFHLELSDEECDEFVENVLISK
SLGSRYTRLYDHFQLLTQGIYS
>gi|149751251|ref|XP_001492276.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MRFLEARSLAVAMGDTVVEPAL---------------------
-------------------------------------LKPTS----------EPTPG---
----------------------PPGNNGGSLLSVI--TEGVGELSVIDPEV---------
---------------------------------------AQKACQEVLEKVKLLRGGVAI
SS----------------------------------------------------------
-----------------------------------------------------------R
GTPLELVN---------------------GDGVDSEI-------RCLDDPPAQIREE---
------------------------------------------------------------
-----------------------------------EDEMGASVAAGTTKGARRRRQNNSA
------------------------------------------------------------
---------------------------------------KQSWLLRLFESKLFDISMAIS
YLYNSKEPGV-------------QAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDA
IKP----------YIVHRCRQSINFSLQCALLLG---AYSSDMHISTQRHSRGTKLRK--
-LILSDELKPAHRKRELPSLSPAP----------------------DTGLSPSKRTHQ--
-------RSKSDATASIS-----------------------------------------L
SSNLK-------RTASNPKVENEDEELSSSTESID--NSFSSPVRLAPEREFIKSLMAIG
KRLATLPTKEQKTQRLISELSL---------------LNHK-LPARVWLPT--------A
GFDHH----VV-------------------------RVPHTQAVVLN---SKDKA-----
---PYLIYV--EVLECENFDTTNVPAR-------------IPENRIRSTRSVENLPE---
-------------------CGI--------------------------------------
-------------------------------THEQRAGSFSTVPNYDNDD----------
----EAWSVD-DIGELQ-------------------VELPEVHTNSCD-----NISQFSV
DSITSQ-ESKEPVFIAAGDIRRRLSEQLAHTPT-------AFKRDPEDP---SAVA----
--------------------------------LKEPWQ----------------------
------------------------------------------------------------
-------------------------------------------------------EKVRR
IREGSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLPN-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELLAFQVLKQLQSIWEQERV-PLWIKPY
KILVISADSGMIEPVVNAVSIHQVKKQSQL---------------SLLDYFLQEHG--SY
TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRN-
LGFETSAFKLTTEFVDVMGG-LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQG--
-------------------SQLPCFHGSS--TIRNLKERFHMSMTEEQLQLLVEQ-MVDG
SMRSITTKLYDGFQYLTNGIM-
>gi|115959861|ref|XP_001196142.	Strongylocentrotus purpuratus
------------------------------------------------------------
--VQQLLQMCPQIPAVGGGLCRIDQRRQDAMVALGVFLLESDLKFKDKLVPYFISLVRSI
-PNAQWIEETGYRVID-VLPMSERFAFTITTLLSD---------IATKDSHYRDQILSTL
VEVLQALCRICQQPSEHPQVAICKHVMPAFLGMSRAIGR---------------------
---------SSQDPSCSLLSRMYPSSKHTASQTPPPSSGLDQTSPMYSSFRLIVSDVMEQ
KLRQSEGSRQDALPLADDSREERATEGPSHLLTVVGSSFGISTETCESGSD---------
------------------------------GAQVGSLDLTTPQLQTILNVCQKMISGTLL
QSLDGMAQQYALQPGSKKNLPYKSYSEVINVVLVSLLRHLLQQHKGLPMGFQTEVHAFVR
ELFLSGQTELQDLSVESATRGPCRFNSRELALRANATCVDLLVWAANDETGADSLISRLT
EKLHSSAGSKQLIADMPLLLCSLQGLGTLAEKFPTVAHATIGSLRDFLMGPSRIIVK---
---LHKHHEVESSKSSAGPTIRVMDSTLQRSVGEGSHPYERLRNAAMSNLCRSLRSGLVE
DPDCIQAFLASVSNALYIAEASDRDSTLISSNAILAMGHVAVLLSETTRTIESVQQIFQQ
R------FCTPPSSLDVLIV----------------------------------------
---------------------------------------DMLGCLVLAGNAAVTQEVMNM
FIQISVEAGS-------------SDYAPNSSQASQRFRHCSMAIINALANIAAFIDGENE
QQE----------LLVRLLELFVQLGLEGKRASE--R---APTAIKASSSAGSLGILIPV
LATLIKRLPPIQDPKPRLHKFFRDFWLYCVVMGFAVEDSGLWPKEWYEGVCHIAAK----
-------SPLLTSSPGEH--------LRSELQYNSALRNDSMTYNDLNELRQNILGLMEH
SPEVT-------VIVNKLNFAQCTYLLSVHR------LETLRVSNAVPTS-FAAVFSYLE
DKAIIKD-KAGMWQCLLASFDK---------------VFDMFLDIKAKMPR---TEEREK
ELVHHAQFLLV-------------------------KFNHVLKQIRK---VADKYLSRLV
DRFPQLLWN--GDVLWSMLDLLQLLSKAAAEESL-QE---VREFPVFKGMFMLTVMDTKE
SREGIVRDFAAR-------CGGIFQEAVKWAAYATRSHIQQYIIHLENSSDSL-------
-------SQRSNLELGTESAFQCA-------EFTKGTHRICG-RYRQGTDSLTSESANFV
SV--MSLRSR-FAGEVS-------------------GMKAIYTDAGPG---GLSLSHVLN
KQLDKACDAKKI--DAFTNSMFRVCALLISSEGVDRYLLYSLCRAPVRLFTTHAMEKAVA
CWEWLLAARSDMELQLMRE-------------MAGAWQMSMDNRLGLFSIDVEDPSPL--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------AAISGDDVPDPKHPN---ATPHHIWTQ----LLW----
------------------------------------------------------------
--------------------------------NGDVL-----------------------
--------------------------WSMLDLLQLLSKAAAEESLQEV------------
-------------------REFPVFKG-----------MFMLTVMDTKESRE--------
----------------------
>gi|150866662|ref|XP_001386330.	Pichia stipitis
------------------------------------------------------------
------------------------------------------------------------
---------MSLKENELLLEKIRSSDFTALDCIDN---------LRGYRES---------
IGIQHTLVQKLRS----YSYDELEFYIPQFVQLLVAFET---------------------
-----------------------------------DSMALEE----------FLLEY---
----------------------CSKYPHYSMVVFWNLQSCVFELRNDPESY---------
---------------------------------------SFQVVRNFINKLQNILF----
------------------------------------------------------------
-----------------------------------------------------------N
NEELMKKPEF-------------------RENFQPAIILCGVIASAIGAPRFNDYAS---
------------------------------------------------------------
--------------------------SLVRSQAKQQKSFVFKLA-NFQKTLTKNLTMKNK
R------LSSE-------------------------------------------------
---------------------------------------TATETMSDDEARKVGGKLSHG
HQRSASVP---------------RMQPKKNSLTISSDESEYYT------------SDEES
EFR----------SSTHIENEMSKLGMRS--------ENRHRSYIEVEEN----------
-LKINTVITPKRKNRARQLTLDSL-------------------STKYEGTDAYVS-----
-------HSLPDLSRVHE-----------------------ADSQPYLSPAESESSLNFP
HSSIE-------QGLKRNLSLHSTVQTPSYNQL----LKVLQINYAKKETEFIMALQNIS
LRLSSVP-KEARLSALRAELSI---------------INETLLPSEIDIPQLLPITSSKN
KRYHK----IL-------------------------KLSINEACVLN---SAERV-----
---PFLLLV--EYLS-DEFDFNPFTDANQKIIAN------RNNHEETSKSSHDLLNEMIE
GSQ----------------SGLKSPVSVRASTENTEDSLVYVEEEETDL-----------
-------GELPMLTVKSD-------------RSFVIQSDIERSPKTEQDKKL--------
----SSFPSN-TNADTT--------------------------KLLAD---QMRIASVML
QQLESS-GQASS--EQSSAIKSRIVESMISLQD------QFDTINYERL---NLLK----
-GDLPDAGERKLENDFK---------------LGEDWN----------------------
------------------------------------------------------------
-------------------------------------------------------TKKER
IRKSSV------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLDN-----------------WELCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKNGDDLPQEAFACQLISLITSIWKRQGVKDAWTKRM
KILITSANTGLVETINNAMSIHSIKKSMTEISINDGE-NTKGRIFTLQDYFENMFG--SP
TSQKYKRAQNNFARSLASYSIICYVLQIKDRHNGNIMLDNDGHIIHIDFGFLLSNSPGS-
VGFEAAPFKLTSEYVNLLGG-NESAPYLSFVDMCKKCFNALRKEHRQIVNLVELMQKD--
-------------------STLPCFKNGENTSVL-LEQRLQLQLSEEESEAFVENTLIGR
SYGSMYTRLYDQFQMITQGIYS
>gi|109016164|ref|XP_001106356.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MRFLEARSLAVAMGDTVVEPAP---------------------
-------------------------------------LKPTS----------EPTSG---
----------------------PPGNNGGSLLSVI--TEGVGELSVIDPEV---------
---------------------------------------AQKACQEVLEKVKLLRGGVAV
SS----------------------------------------------------------
-----------------------------------------------------------R
GTPLELVN---------------------GDGVDSEI-------RCLDDPPAQIREE---
------------------------------------------------------------
-----------------------------------EDEMGATVASGTAKGARRRRQNNSA
------------------------------------------------------------
---------------------------------------KQSWLLRLFESKLFDISMAIS
YLYNSKEPGV-------------QAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDA
IKP----------YIVHRCRQSINFSLQCALLLG---AYSSDMHISTQRHSRGTKLRK--
-LILSDELKPAHRKRELPSLSPAP----------------------DTGLSPSKRTHQ--
-------RSKSDATASIS-----------------------------------------L
SSNLK-------RTASNPKVENEDE-----------------PVRLAPEREFIKSLMAIG
KRLATLPTKEQKTQRLISELSL---------------LNHK-LPARVWLPT--------A
GFDHH----VV-------------------------RVPHTQAVVLN---SKDKA-----
---PYLIYV--EVLECENFDTTSVPAR-------------IPENRIRSTRSVENLPE---
-------------------CGI--------------------------------------
-------------------------------THEQRAGSFSTVPNYDNDD----------
----EAWSVD-DIGELQ-------------------VELPEVHTNSCD-----NISQFSV
DSITSQ-ESKEPVFIAAGDIRRRLSEQLAHTPT-------AFKRDPEDP---SAVA----
--------------------------------LKEPWQ----------------------
------------------------------------------------------------
-------------------------------------------------------EKVRR
IREGSP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLPS-----------------WRLLS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIVKCGDDLRQELLAFQVLKQLQSIWEQERV-PLWIKPY
KILVISADSGMIEPVVNAVSIHQVKKQSQL---------------SLLDYFLQEHG--SY
TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRN-
LGFETSAFKLTTEFVDVMGG-LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGCR
RCSGSSPSGPMMTVAQVICSQLPCFHGSS--TIRNLKERFHMSMTEEQLQLLVEQ-MVDG
SMRSITTKLYDGFQYLTNGIM-
>gi|51900535|gb|AAU13915.1|	Candida dubliniensis
------------------------------------------------------------
------------------------------------------------------------
-----MSENTPEAPSKQLLERIQSSSFSLFNCIYE---------LKNHNDS---------
IGIQHELVKKLYS----FPYEDLQFFIPQFVQLLVTYDS---------------------
-----------------------------------NSMALEE----------FIITS---
----------------------SCRYPHFSLIVFWNLQAYIFELKNEPESR---------
---------------------------------------SFQAARNLVTKIQNIMFN---
------------------------------------------------------------
-----------------------------------------------------------T
ELSVVKAPEF-------------------RENLFPALVLCGAVASSALLPSFKNYCL---
------------------------------------------------------------
--------------------------PMIKAQGKQQKSLVFKLA-NFQKSLTKNLTLKNQ
R---MSA-----------------------------------------------------
---------------------------------------DIPKESHSDDETVVSSSIKPS
LSRSASVP---------------RRSTKKASLSFSSDESEAY-------------TTDDD
DNK----------TSIELEKEFYKMDLNGSL------KGGSTKFLETEEN----------
-LHVNTAIKSKKRLSTLTSKVMASSW---------------------DSMDGYNVNS---
-------QSLPDLSKADS-----------------------RDLIPFLSSTESETSLLYN
NNAIA--------NDLQKXTLQQPKFMPGFDNDYL--TKILQVNYAKNETQFIMALQNIS
IRLSQVP-KEARLSALRAELSI---------------INDTLLPSEIDIPQLLPVTSNRN
KKYHK----IL-------------------------KLNVNEASVLN---SAERV-----
---PFLLFI--EYLS-DEIDFNPTTEYNQRIIAR-KNIVGATNTSVKKMNSFSEVPDGNF
SKENNLESHITETVTSAI-CNESTEE----------------------------------
-------ADLSEMPIARRTAV----------SSDSFSPEMLVTPTVTEQSKLSGF-----
----PSLNSK----EVS-------------------------TKVLAD---QMRIAAVML
QQLDSS-GKANS--EQSFLIKNRIVESMIALQD------QFDSFDFEKL---SQLQ----
-SDQPSAGERKLENDFK---------------LGEDWN----------------------
------------------------------------------------------------
-------------------------------------------------------TKKQR
IKKSSA------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-Y-------------GHLKN-----------------WDLCS------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VIAKNGDDLPQEAFACQLISMISNIWKKNQV-PVWTKRM
KILITSANTGLVETITNAMSIHSIKKSFTEHSIKSGE-NDKGKIFTLLDYFHSVFG--SE
NSVSFRTAQQNFAKSLAAYSIICYVLQIKDRHNGNIMVDRDGHIIHIDFGFLLSNSPGS-
VGFEAAPFKLTVEYVELLGG-VDSEIYSQFVHLCKQCFKSLRDNSEEIIEIVELMQRD--
-------------------STLPCFNNGENTSVL-LRQRLQLQLNDEDTDQFVENFLIGK
SLGSMYTRLYDQFQMITQGIYS
