>gi|115768313|ref|XP_783376.2|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MSQAASPSAQEGGDTKQSPAPKAGKLESLPK
EDL-------IKYVKKQAMQVQKMKAKCEDL-----------------------------
------------------------------------------------------------
---------------------AKKNAELQSEKKSSPTSAAS-------------------
----------------------------------------------DGKTSKMEEEL---
----------------KELREENEGVQAAYNAVQQQLAQAAEVQETLQ-----EALNAAS
D-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QRSEAEKQQQAAVAQLE
KANSKMKGLEEQIQCMEMK--------EETMRTTFQCLQEDQQAITNENKSLKEQITILT
EA----RDQTIESLKALKQS--------MSSESSKDDETKRRLDEVISEKNELAQKISCL
QEDQVTMLQEMDSLKSELKSIMEEEKQVMM------------KAGVELQEQVENLQNQLA
DAEE---GYKTRLETLMQTSEEASGCAQQL-----------------------------R
EELKTMNEDLARLLQEKE------------------------DLIITK----DEANARAN
ALEEKAHEWEREKEREQTKMEEYEEDMSRLK-------VQVEELNTLKDQLTK-------
----------LGAEKDSLKTEGERLSEDNSR----LTASMRETAEERTHLSEELESLKSG
QTDLN----QVLQKQLDDTTKEKN-SLKKNLQELELSYGCLQKEAT--------------
----AKEAELEEIKRSVGEKEQQL--------EKLQEDKLKKEEEMTKIEGSL---QQSL
DSAKEDAERMKEELKSVGEGVSSEENKK-----------------VEDLTNAKGELEKII
KEMKEDVVRKDEEMKDLKEKLEEVEGALESSR-----EEKRKKAQLVEDLEKELTAL---
-------------KHTMMKGDNEKIEEMCRKE---EELQLALGTAKEDAQKKEEEMKELK
EEMDVVKEQLMLIRMAHLES----MQQSSEYQQQVETLQKTQSSTS--------------
---KGDDIRASKLESKKAELEQ-----EKGEIEKKVTA-------------------LQK
EVDQGKKIIEELQEQKEQLQACITKLETE---MSSTMKELQDQMTLHEQEKETYQASLQE
LLDQMTLHEQEKETYQARLQELQDQMTLHEQEKETYQASLKELQDQMTLHEQEKETYQAS
LKELEQGAVQERRRLEEKILELEGSKEKYASNFEKLKKASTAKVQELQEQIKELRSSREQ
GDNNKETQLVQLQDKISSLSDTVTQLQDANDSLQSRLDELLSEKNALYADLETAMHQNEV
MGQKESDITHQVNDLEVTRQKLIGNLS--------YAKNVLEPHQLCRPMRESLEKLLV-
-------------------LLLCRCPRTRGGDLRDGRPVFYH------------------
------------GLETILVCK-VIHVRCMMDGAMASFPTRSNDAVVDLHKTLISVTGLPA
DQHLLLLAHGERLTDGTTILHSLFKNHAFQNGDRIVYLYP-----KSFPVKANFYIPPKT
PMVEALMTGKHLQVSENGF------KVMWKQS-----------------IHYCHNLIREA
LARQTGFIAYLNYNLKRKASLNQCAEEMKRCL-------HRLQAKAEFFLESMSTDTQQ-
-YARQVATGF--------------------------------------------------
-----------------
>gi|62740095|gb|AAH94096.1|	Xenopus laevis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EPGAQSQLSTMWKWYSGDESTLQGGAPDNEGSPAGTMSVADLTEQLAQT
EQL-------VVQLKELIREKDNELRKKDQQLKEKRESAESKISKAKLQNKAKIVSLTSQ
LE---------ELKKQQASSRPHEKKSENKKASGDGDYENSSANRGKILLLKRRVEELES
QLAHKNEELQKKEA-------DLEQQRLRGSQMDAMLS----------------------
---------------------------------------EKEQKLAAKEAYIIDLQMAAG
SNTSKNVPSSQDNTQETNKDKANQELQVLIQNLTRKVGESDEKCSLLQ-----EQAESLK
T----------------------------LLNKEKDHF----------------------
-------------KAREAMYTENIRVFQNLVQEKEK------------------------
--------------------------------------ELKEQSQKHEQDIFKLLAKSDA
NADLHQLLKALKQKLHEEEEVLL------------GKNQVIDVLQKELDNKEQQNMEITE
KCKR----LQSEKENLQ-----------SKLEAEKHVMRAQLRDMMDKHETELRGLHDKH
VAQIQEIQEKHELEIQEKCLTVQQLQHQLQNLGNNVGETAQPTNITEMAVVKLQDEVKLK
TEESQGKNQDLRGLSNRIVELEEEKHELETKLKTLTELQAINEQLLAKLVLYEEQQRKLQ
ADLE---QVAKRADSQTSESGSVDELHNQL--------------------LEWNEMSPEM
EEAPENSSEEKSVLALRM----AQIEEE-REAMDSGQQELEEELSAAR-----GLGKMRP
ARRKGSKAATKMQEEDDYSRKGFDDQNVTLDSIDSAEGENMGGLRTVVEELELERNQ---
----------LQEQIMSLEDRCQELEDRLQ-----LQLRIESLQGENERLQAQLGQLRQQ
QNRET-EKQHSFTSTLSEQLKGFT-DRNAFLENVIAEKEQIILEAAGKLEE-----LARL
K---KILKEKEDLNKAIAEKLDQS----ELQLEETSKKLAVLETESQALKLSNNELTEKA
ATLKEKLLKQDAALEKMQLDLEQTNEELDRLNTSHLEERSQLIYDLQRCEREMDVLREVL
QEKDKELASLSSSLTEYNEQVVILKEQIDLKN-----EQMREMSDALVKAERESQLL-RE
AQT-SDTREMSDKISSLTDQLSEMDMELNKAKYLSETKAKEAEELIRQINENGITIKNLR
SEIQAQSATHNNHAIECSTQI---TSLKQQINASVAKLDETETKYRKEIESLKLQLESDV
SEREKIAGLLAEKSSQERSFEN-----ELKVAKEQYNN-----LVSGISKKDEEIEKLLT
EVAEQKKFCDHLRKELQIKEKDASSLQEK---LLADIKDREEKLRGFQESTQALQAQLSE
KLDNINKSDATKNELVEQNKILKTALSEKDKNLEVHLTATEECRKSILELEQHNQQLLNE
KEHLAKELSEQKQFYDDLKKELNIKEENSLCLQQKL----EMDINNRDEKL---------
--TVLEERVLELQKQLDEELENIHNLNTAKDELDKRNKILEVALAEREKNLSVHLNKTEE
CRKHILDLEQQKQQLYSEKEHLVEELAKQKQCCDHLTAELQATEQKASTLQQKHEAHLKD
RDELLRVLQESTQKLQKQLEEKVEHINTLDAAKNGLCEQNKKLESSLAEKNENLGVYQNS
AEELRRNIVDLEQQKQQLHSE-KEHIRQELSARESA-LLSLNQVLHDLQGKMSEME-LLL
MEEKKWVSQLTLDKEELQLKISHMSEQSLERDTVISKQLE-DKALESFSLKDQLSEEKQN
AKNLLNQIHVQENQLKESQKRVQQSVEELELMKVEYNTIFESLKQNEERNVELQKHVEEL
TTALGRENQALKAELEQWKA-SFAALQNEENILREEHKRVSLQITELSAELLKLNVDQD-
-RLQQEAVQKTEENASLLKSLDSINVVADTLKKKK-------------------------
-----------------
>gi|73955878|ref|XP_863234.1|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MSSDTEMEVFGIAA
PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGRIKSSQDGKVTVETEDNRTLVVKP
EDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPV
YN---------PEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGK
TVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRF
GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELL-LI
TTNPYDYPFISQGEILVASIDDAEELLATDSAI-DILGFTPEEKSGLY-----KLTGAVM
HYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV
DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEE
CMFPKATDTSFKNKLYDQHLGKSSNFQKPKVVK--GRAEAHFSLIHYAGTVDYSVSGWLE
KNKDP---LNETVVGLY-QKSSNRL--LAHLYATFATADA---DSGKKKVAKKKGSSFQT
VSALF-RENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRIC
RKGFPN--RILYGDFKQRYRVLNASAIPEG------QFIDSKKACEKLLASIDIDHTQYK
FGHT---KVFFKAGLLGTLEEMRDDRLAKL------ITRTQAVCRGFLMRVEFQKMVQRR
ESIFCIQYNIRAFMNVKH-WPWMKLFFK-IKPLLKSAETE-KEMATMK----EEFQKTKD
ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ----AESENLLDAEERCDQLIKAKFQ---
----------LEAKIKEVTERAEDEEEINAE----LTAKKRKLEDECSELKKDIDDLELT
LAKVE-KEKHATENKVKNLTEELA-GLDETIAKLTREKKALQEAHQQALDD-----LQAE
E---DKVNSLTKIKSKLEQQVDDL----ESSLEQEKKLRVDLERNKRKLEGDLKLAQESI
LDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLGLQFQKK----IKELQARIEELEEEI
EAERATRAKTEKQRSDYARELEELSERLEEAG-----GVTSTQIELNKKREAEFQKM-RR
DLE-EATLQHEAMLATLRKKHADSVAELGEQI---DNLQRVKQKLEKEKSEFKLEIDDLS
SNVESVSKSKANLEKICRTL----EDQLSEARGKNEEIQRSMSELATQKSRLQTEAGELS
RQLEEKESIVSQLSRSKQAFTQ-----QIEELKRQLEE------------ESKAKNALAH
ALQSSRHDCDLLREQYEEEQEGKAELQRA---LSKANSEVAQWRTKYETDAIQRTEE---
LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKK
QRNFDKAAL---------------------------------------------------
--------------------------------------------------------EHEE
--AKILRIQLELTQVKSEIDRKIAEKDEE------IEQLKRNYQRTVETMQSALDAEVRS
RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL----RG
QEDLKEQLAMVERRANLLQAE-VEELRASLEQTER--ARKLAE--QELLDANERVQ-LLH
TQNTSLIHTKRKLEADLTQLQSEVEDAS-RDARNAEEKAK-KAITDAAMMAEELKKEQDT
SAHLERMKKNMEQTVKDLQ------HRLDEAEQLALKGGKKQIQKLETRIRELEFELEGE
QKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE--
-QANAHLTKFRKAQHELEEAEERADIAESQVNKLR------------------------A
KTRDFTSSRMVVHESEE
>gi|109084629|ref|XP_001092252.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MSSWLGGLGSGLGQSL
GHVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCT
D---------LEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSA
THSVPSGAGGVPATTASSSFAYGISHHPSTFHDDDMDFGDIISSQQEINRLSSEVSRLES
EVGHWRHIAQISKAQGTHNSEQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQN-----
--------------AHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVVETDISKI
YEMQKTIQVLQTEKVESTKKMEELEDKIKDIN--KKLSSAENDRDTLR-----REQEQLN
V-----------------------EKRQIMEECENLKLECSKLQPSA-------------
-------------VKQSDTVTEKERILAQSASVEAVFRLQQALSDAENEIMRLSSLNQD-
----NSLAEDNLKLKMHIEVLEKEKS------------LLSQEKEELQMSLLKLNNEYEV
IKSTATRDISLDSELHDLRLNLEAKEQELNQSI--SEKETLIAEIEELDRQNQEATKHMI
LIKDQLSKQQNEVDNII--SKLKQD--LNDEKNRVHQLEDDKMDITKELDVQKEKLLQSE
VA----LNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLE-LEERIRQNEEELSRM
RNELTQSLNQEDSDNNFKDTLLKEREAEVR------NLKQNLSELEQLNENLKKVAFDVK
MENE---KLVLACEDVRHQLEESLAGNKQLSLEKNTIVETLKMEKGEIEAELCRAKKRLL
EEANKYEKTIEELSNAGN-LNTSPLQLE-HEHLIKLNQKKDMEIAELK----KNIEQMDT
DHKETKDILSSSLEEQRQLAQLIKEKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT
IEEKDRSLGSMKEENNHLQEELERLREQQSRT---APVTDPKTLDSVAELASEVSQLNMI
KDHLE-EEIKHHQKIIEDQNQSKM-QLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKD
EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKXXXXXX--XXXX
XXXXXXIQALHARISST--SYTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEY
HKMMDIIAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQK
CQTLLAVLQTSSTGNEAGGVNSNQFEELLQER---DKLKQQVKKMEEWKQQVMTTVQNMQ
HESAQLQEELHQLQAQVLVD----SDNNSKLQVDYTGLIQSYEQNETKLKNFGQEL----
---AQVQHSIGQLCNTKDLLLG-----KLDIISPQLSSASLLTPQSAESLRASKSDVLSQ
SSELLQQEVEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQ---
LKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERVLILEMD
IGKLKGENEKIVETSKGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEK
E-QGKAGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFR
SNQELERLRNHLLESEDSYTREALAAEDR------EAKLRRKVTVLEEKLVSSSNAMEKA
SHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ----QE
EKAMYSAEL---EKQKQLIAE-WKKKAENLEGKVISLQERLDE-ANAALDSASRLT-EQL
DVKEEQIEELKKQNELRQEMLDDVQKKLMNLANSSEGKVD-KVLMRNLFIG-HFHTPKNQ
RHEVLRLMGSILGVRREEM------EQLFHDDQGGVTRWMTGWLGGGSKSVP---NTPLR
PNQQSVLNSSFSELFVKFLET-----ESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPE-
-SFKDTAESRSGRRTDVNPFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLP
ALPDSSAGVVLKDLLKQ
>gi|114145445|ref|NP_001041458.	Ciona intestinalis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MFNRIRKNLGNKDKDSTPTSPKNDVQQ
KPP-------VSEQSGFIC------PMCMVGLPTPEALQIHFDYEHSVPNSDSSNEKSND
K----------PKKTENKNFAPSATAPPVDASLATPSVTP---------------QNQLS
NVNGFANVEHVNNVSASQNAGLPNVTELEAEIKDLQASLTDE------------------
----------------------------KWYTTELKKEYDSLKEEHSNTCTDLENTK---
----QQMKIALATNEELARQKEELNQKAAKMA--EAVADLQAKKDEFE-----REKEAAC
Q-------------RSENQSVELEKAATWVRDLESQ------------------------
-------------LPSSNAHDDTTKLQR--------------------------------
--------------------------------------PGADDVMVLKKELVSVQTLMD-
-----------------------------------QMTRESEDKSHKVEEERQHLQQLLD
EARQQALLTQEEFDKYKAENE------RLKGENLEKEVEKDESKKLFAVETEKLRLLHAD
MDEIR-KEELNNVSAALEKE-----SSYSLLLEKEVNKLKEEKSEMKKQLQKLNEDVQSA
LEKSISSDKLMEETRTESDLLKMEKWEVEN------QLKSAEETQKSLKEKSETELTEMN
ARYE---SLICECDDLKSQINKSHEQCEDW---------------------------RIK
NETLALEFNQFKLVNKQLELESSGAKQQ-IE----------IQLSQIN----GKLEAVEA
ENKQLNDDKRKMSEDLQVMRASHQDERKLIE-------AKLLDSEKLVLQLKLQTTR---
----------FEEESSQRSRVIETSEQKLTF----VQSACDELKEKIHGLETELALGNHE
IASLK-DQLTSSASKLENETQRRE-DAIGEVTKLRDERNNLITKI---------------
----EVGDGEAAAHSQLQEENNKLRKQKEEAEEKVREVESEKEESLRTLSSKINDSQSII
VTLQNKVLELDDDLTKQRTLKEEAEEENLKI--------------ESELKEKTDTLLNVQ
ATSISHQAEASNEINNLRRNLEE--------------EINEKKSNSEKLKSTE-------
----LQLSNVQSQISEMREKHRKESSQLK------EELHLSSAATQEARVEVELTIDSVG
GEIQTKVKELGELKAINEQL----QLNIDKSAENIENLNQEHSATMCELNNVSMEL----
---EEAKKKLSQLETSECKTKE-----SLEELEGKINM------------LGEENKKMEE
QNMDLEKLLEATRESKSVLQQTIMTSQSRIEQLQNEKENVKEMLNQVKVEHGSEHER---
LLEQIEGHKTTVTKMEEEISLLNKQISDHKSQFEEKVLDNQSKDAEIEKLTSKLENMSAE
LTASEAVLQNTFVELEATKVESETLVTRSKEL--------TDSKSEIEEKL---------
--ETSRSQVVELNETLEKKD---VKLDEMKVSVDLLEKKYQSMKEEKEVEVDELKHKHQE
LSDMVVSLEEELENLKKKFSQVNESLAEE------EKENKRIQEEEEKKRRERLNEQLST
LEEAQSLLISSKVALQSELKSLKETSLSEKESLERAAEMD--------------------
------------KTVIQLKEDNISKLKVQLEEK----SRLLETNEADRVVNESRLQ-LEI
GALSENLSNARSEWRVTSQSLDVVRAEC-DDLRGQVVILQTNAHSNADERRALLERCLNA
EQQVEQLQVNINQLVKKLD----DAHSAMHEL---------------------------G
RENQALQVKHTTTISKKWTDDRSTA-ECRACNRAFSITVRKHHCRHCGEIFCGECS----
-SRTATVAASKNPVRVCERCYDDLLVAG--------------------------------
-----------------
>gi|149724319|ref|XP_001504905.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MSSDSEMEVFGIAA
PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEDYAKAKIKSTQDGKVTVETEDNRTLVVKP
EDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPV
YN---------PEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGK
TVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRF
GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELL-LI
TTNPYDYPFISQGEILVASIDDAEELLATDSAI-DILGFTPEEKSGLY-----KLTGAVM
HYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV
DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEE
CMFPKATDTSFKNKLYDQHLGKSSNFQKPKVVK--GRAEAHFSLIHYAGTVDYSVSGWLE
KNKDP---LNETVVGLY-QKSSNRL--LAHLYATFATADA---DSGKKKVAKKKGSSFQT
VSALF-RENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRIC
RKGFPN--RILYGDFKQRYRVLNASAIPEG------QFIDSKKACEKLLASIDIDHTQYK
FGHT---KVFFKAGLLGTLEEMRDDRLAKL------ITRTQAVCRGFLMRVEFQKMVQRR
ESIFCIQYNIRSFMNVKH-WPWMKLFFK-IKPLLKSAETE-KEMATMK----EEFQKTKD
ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ----AESENLLDAEERCDQLIKAKFQ---
----------LEAKIKEVTERAEDEEEINAE----LTAKKRKLEDECSELKKDIDDLELT
LAKVE-KEKHATENKVKNLTEELA-GLDETIAKLTREKKALQEAHQQTLDD-----LQAE
E---DKVNSLSKIKSKLEQQVDDL----ESSLEQEKKLRVELERNKRKLEGDLKLAQESI
LDLENDKQQLDERLKKKDFEHSQLQSKVEDEQTLGLQFQKK----IKELQARIEELEEEI
EAERATRAKTEKQRSDYARELEELSERLEEAG-----GVTSTQIELNKKREAEFLKL-RR
DLE-EATLQHEATVAALRKKHADSTAELGEQI---DNLQRVKQKLEKEKSEFKLEIDDLS
SNVESVSKSKANLEKICRTL----EDQLSEARGKNEEIQRSMSELTTQKSRLQTEAGELS
RQLEEKESIVSQLSRSKQAFTQ-----QIEELKRQLEE------------ESKAKSALAH
ALQSSRHDCDLLREQYEEEQEGKAELQRA---LSKANSEVAQWRTKYETDAIQRTEE---
LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKK
QRNFDKVLAEWKTKCEESQAELESSLKESRSLSTEL----FKLKNAYEEALDQLETVKRE
N-KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL-----EHEE
--AKILRIQLELTQVKSEIDRKMVEKDEE------IEQLKRNYQRTVETMQSALDAEVRS
RNEAIRIKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL----RG
QEDLKEQLAIVERRANLLQAE-VEELRASLEQTER--ARKLAE--QELLDSNERVQ-LLH
TQNTSLIHTKKKLETDVTQLQSEVEDAS-RDARNAEEKAK-KAITDAAMMAEELKKEQDT
SAHLERMKKNLEQTVKDLQ------QRLDEAEQLALKGGKKQIQKLETRIRELEFELEGE
QKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE--
-QANAHLTKFRKAQHELEEAEERADIAESQVNKLR------------------------A
KTRDFTSSRMVVHESEE
>gi|118084342|ref|XP_425585.2|	Gallus gallus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MEVQDGGQEMVASPATPGSGKSKLDTLPK
EDL-------IKFAKKQMMLIQKVKSRCTELEREIEELRSKPATGGADDIIQALTERLDV
VLLEKAESQQQCVALKKENLQRKQEAEAAVARTEELQKQLEQSNTDSL------------
----EEVKALKNELINAQSKYNEDLTKLKTELEEKEKKQMELVEQIKCCSDNQEE-----
--VKRLQDYVQKIKSTYEDQILCLNKQLETVNDDKNKEIAILQETIKSNSQCYHNEI--S
SLSAELKQLKIAHQEEVSELMNHIEISSKENE--EKQNQINQLQHSLAEADLIKEKNVKD
EAYGHTEQHERDFEQLKQVLNKNIEDKVNVLDMQEEPCVETKMEEKIRHLECSLGDLQSQ
HSI----------LKDELTYMSNVKLKLEEEIHRIKDEYFHEREDLDFKINELQLIKEDY
CCVIEKLKSELQTARHHYETTAEEHKL-----------ETQNLREQHEREISELNKTLLS
SSEKEKMALVLEMQELKDQLEKLTLEKEDAVLSYDSLRETLETIQTELGESAGKISQQFE
SMKQQ---QASDVSELQ-----------QKLRAAFNEKDG-LLETVNRLQAETQKLSSYQ
LE----IEELKHKIVSLQEENDTITSC-VHQKEASIKELEEKTIALANQNKDILNEVKCS
GEEREALQERCKQEQGKVQELQQEVDVVNQ------YNSDLKKKLEELTERLNDALTGKN
ENTK---MLEQLENQIDTLVRERENLSSEV-------------------SALREENKKIV
QEKEELSKELEKITYEKDGWLVLKEQFENLEKKLQMVTAEKDHISSLL----ESEQVHKS
LVRTQLYRILEQVGYSISDSNEECDFLNLLQ----IANEHLIKMKEKQCFALQ-------
----------NEEKVLHLQREIERLEEENATQYTEHRSLIQDFGREKDHLKEELEEVLSE
KEALQ-HDIQELRSAGEKATIENQ-DLLAKIEEMSEKLAFYESQIQEQQ-----------
----RGSKAQEELNFVLEQKETEL--------RNVKDELSSLKTVMESLTGK--------
NDEQSSVAELQEKIERLEKESAEKGEKLNKMKAVAVRAKKE----LDTSRKEMQALREEL
EVVRSEKDQLSASMKDVIQGAESYKNLLMEY------DKQGEELDSEKGRANSLERQ-ID
DLT-RQLQVSSQQVSSLHSANED----LLARV---ETLQCNSKLLEAQILELQKVKAKAE
KELEAEKLLKEQKIKEHSGT----VRELEELQMQLQKEKKYLQKIMQELELAKKDA----
-----QKSTLMDMEI--ADYEK-----LVKELNQKITD------------KDSRIEDLEQ
ETGIQKQKQETLQEEIKSLQSTMQEDEER-------NAKIKQLLVKTKKELADSKRAEND
HLMLQASLKGELEASQQQVEAFKIQVAALTSEKHKVQ---EHLRTSSEQHQRTLNAYQQK
IATLREECRAAQAEQASVTSEFESYKVRVHNV--------LKQQKNKTASQTETEGAKQE
R-EQLETVIEQLKAKLQETQ---HNLQINAAEFQALQSEHDTLLERHNKML-------QE
TVAKEAELREKFCTIQSENMVMKTEHAQA------LSQLTAQNEALRNNFRDQVRNLQEE
HRKTVETLQQQLSRVEAQLFQLKSEPSTRGPAVSN-----------------------PV
PKNLRE------RRNTDLP---VLDVH----------AIAREE--GEGMETTDTES----
------VSSASTYIPSLEQLLNSPETKP-------ETSQW-QTELTKDELIEKLSTTTKS
ADHLNELLRESEATNAILM----EQIKLLKSE---------------IRRL----ERNQE
REKSVANLEYLKNVLLQFIFLKSG--SERERLKPVIDTMLQLSPEEKGKLIAIAPGEE--
-ESSSRPSGWASYLHSWSGLR---------------------------------------
-----------------
>gi|78214226|gb|ABB36435.1|	Drosophila melanogaster
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MEAASPRETQKNP-NPIEALSK
DEI-------ISKYKGLLNIAKKAKQAKDEL-----------------------------
------------------------------------------------------------
---------------------TEENHRLKDALKRAAEK----------------------
----------------------------------------------QSSLPAMQEMV---
-------QDFTDKNLILTEEVNNLKRKTKEDA--DRLTQFEIENESLK-----RQLGRLS
D-----------------------------------------------------------
--------------EYDALLANVDRMEKAMQ-----------------------------
--------------------------------------QVNALGNEQRKNLELL------
--------------------------------------EVDIAKIKEAEAENASLRQQVA
TMEEESSVLQQKYQNIK-------------------ELNSEQRKKFNSLKDR--------
------FIDVHRKLKNLKEC-----KCVLLETQHEYAASVSKWQVEIIKASQLLC-----
--------AKMASLQAENEKLKLNNGKSDN----------------------NPQTIDTG
IDRK---RLLQRVQEMDRLAKIVKQKQKNQ------------------------------
----RSNLNVEYLL---------------------------KKITALE----ELAVIIKQ
QHRIDKEQLISVTKEQENTKNHARNLNVSL------------------------------
----------FQTKLDQMQNLVKVIAKERDN----QQRKLQELEAICIELRQHNEDLLTR
YHLKE-QEHGELLTEMRELNEALK-GRGDAISRLQEQHEAEVKRQ---------------
----------------------------------------------RDLEAQLSNSQQAA
QEKLQKIKQLQSRVEELEQANADAQSDVLS------------------------------
------------------------------------------------------------
----TSTISRAEELSRLRELDEG----YEEKY---HKLRAIAAKLKKKLQEQTQQLNEME
QSGAL-------------------KEELEAIKLAQAQLQQDLNAARAENQKLKSKE----
---KVKHSSVLNLEI--EAAEK-----SLSEVSAKLTA------------KSSELEAVKE
SLASKENTIVQLRKEIAILEEAKNGEAAH---SLELKEQIDRMQVQVKDAVHSKQQA---
-LTQNKDLEHGVEQAKLEAEQLRLQLSESAQQYESKLNTATQ---QLLSQTQELEMHLAE
QKRLETALRNAERALEDLRVEYTEYKLKAQSV--------LRKNQNKG------------
--SNREQELEEELVALRESE---RNLRASNDGRAARLAQLDSQIEELRQ-------DNTD
LQKRSKELVSLVDELRQQNDLLSLENQRQ----------LQFQHDLMQQHRQQVDELDAG
HQLQLTQVQEQLEEAQKMQANVSQHTTASAASVDTSPE--------------------QA
KIDYL-------LMDHETGLD-GHAGDVSLAQLAA--QRKISTASRRSHDFMPLDE-LLN
TSMNQITSDTVTTISNFGRSVSQQEDEEAEMAARGDFSVQ---SAQLQATKERLSIQESR
VKHLTALLAENEQDLAKLT----QMNDMLKEE---------------LRRQ----ERSEE
REQHMHNSEYLKNVFLKFLTLNNV--DERQRLVPVLNTILRLSRNEMEMLNCVAKGQKV-
-SADGSSRSWTGFLTAWSGGGSPNNNN---------------------------------
-----------------
>gi|126337351|ref|XP_001372662.	Monodelphis domestica
MFSELVKLMCFQNQQRVPRPTRYGKGWDGAGSRCSVTLDPRINSTSSEASIAAAAGNGSE
AALAAALALVATGRGGEKRWCLRRRRLSPFPCLPKSSRLRRPPQLTRHPSPPPSTPVGCL
KPPLIPPPPPFGPLPFPPEFGGSSVMTISAFLIYPPICLKHPTPHPTLPTPSSSLQPQAL
PVVLKRNAKREFADEAYFKELRLGNSKVLVLSFLQDPGQDVVASPATPGIGKSKLETLPK
EDL-------IKFAKKQMMIIQKAKSRCTELEKEIEELRSKPLAGGTDDVIQALTERLDT
ILLEKAEYEQHCLALKKENVKMKQETEHSITKMEDLQNELEHSRRSYL------------
----KEIESLKTDLVEVQSKYSEDKAGLEKELQEAMQKQIGLAEKLKINNNESQDD----
--VKKLQEEIQRIRPAYEGQILYLKKQLEAIADGKNQEINVLQNIIKANSQYYQGEI--S
SLLEELLQLKTAHKEEMATLMYQLEVCGKDSEE-ERNKSIQLKQSKVNEK---NIQEQVE
H------------ENLKEALNPIKENQVHDKKIQEDTAVKQIVNEKVKHLEDSLKEMESQ
HSM----------LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDFEFKVNELLLAKEDH
CCITEKLKSELEASRNQVSNTIKQHDM-----------EVERLKEAYQKEISELKQTFLS
DSKKENLAIMIEIQDLREQYENLQQEKQEAVLNYESLRETMEMLQRDLGESAGKISQEFE
SMKQQ---QASDVFELQ-----------QKLRAAFNEKDK-LLETLNDLKEREEVISKQD
E-----TEKQENVVKDLQEKNEEILIS-LNEKDLMVQELQAKICTLNDEKDHFLSKIQNA
QEELDNLHKKCERKEEEIIKLKEKEDQITQ------YNNELEQKVNASTVAWKEALKEKE
HNSQIVKKLEVQVKVLSEEQEMLLSQMKNL----------------------QKENEKLS
TERDQMNKDLDTFIAEKKEFSFKEKTTE-LGNKLQLAIKEKDNLEELF----VKEQTQNS
IVRCQLYNFLKEMGATGSEINEEQDVMIILQ----AVRDSLERMKEEKLSLDFQ------
----------KNEMVLQLQKENEYIKEENLANCKELRSLLEDYERERISLKEELDGCLSE
KVALQ-HDLQEMNNVKEKTQLENQ-NLLAQIKEVSQKLLCSKNEIQDQGE----------
----SSVEEQGNIRLLLEQREAEL-----------HDVKAELTTLKDSLEN-----STSV
KSDQHSVMELEDKIVNLEKESKEKEEKLSKIKLVALKARKE----LDSSRKEAQSLREEL
ELVQSERDHLSTSMKDLIRGAEGYKNLFLEY------DKQAEQLDMEKERANNFEHH-IE
DLK-RQLNTSTSQCDKLSSDNET----LLAHI---ETLQSNVKMLEAQILEVQRVKVTVD
KELETEKLQKEQKIKEHTNT----LKELEELQVQLQNEKKYLQKTMQELEMVKKDA----
-----QQTTLMDMEI--ANYER-----LVKELNQTITD------------QNSRIEDLEQ
EVKIYKQKQETLQEEMSSLQSSLTQAEDK-------NTKIKQLLVKTKKELKDSKQAEAN
QLKLHSSLKGELEANQQQVEVYKIQLAEVTSEKHKIQ---EQLRTSVEQHQRTLSSCHQK
ITILQEECNTAKAEQATIASEFESYKVRVHNV--------LKQQKNKSLSQSETEGAKQE
R-QHLEM-IDQLKMKLQDTQ---NNLQTSASELQVLQSEHDTLLERHNKML-------QE
TVAKEAELREKFCTIQSENMVLKSEYAQT------VSQLTSQNETLRSSFRDQMRHLQED
HRKTMETLQQQLSKVEAQFFQLKSDPAVRSSNSSH-----------------------QP
LKNLRE------RRNTDLP---LLEMH----------TVAREE--GEGMETTDTES----
------VSSTSIHTPSLEQLLNSPEAKF-------EPPLW-HEELTKEELVQKLNSTTKS
ADHLNGLLRETEATNAILM----EQIKLLKSE---------------VRRL----ERNQE
REKSVANLEYLKNVLLQFIFLKAG--SERERLLPVIDTMLQLSPEEKGKLIAIAQGEE--
-ESTSRPSGWASYLHSWSGLR---------------------------------------
-----------------
>gi|156547037|ref|XP_001601205.	Nasonia vitripennis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MFKKFKDKLAEEMKQSPAR-LQASMQQLAQAVVSPSLSNTSIQDLSS
KDN-------FSLTEETDETPKNSPAKHGFQTVDLTSPSVNSNTSRRSSVSSNVSDASFL
FP-----------VYEGSSSMYHLQSDMDQSASEIDDNISPQLDR---------------
--------VSKEQLYSAYRKARTKYDKYRGRFSDLVTH----------------------
------------------------------------------YREIERAKTKLESLL---
-VETQDKALRRISDLKEQCQLEQQAKAHLEEALRNDIEEKDHVINSLR-----TKIKLIQ
------------------------EKSPNIEGLETVEISEN-------------------
-------------HKEGDKVDILVDLSNNSEPDQPK------------------------
--------------------------------------KYKDMLKRSKDKMLEMTNEKN-
-----------------------------------TLERDYDILQKSSKEKLESVESELE
NSKEGFKNLREELDVLK----------KREEESVISLAEN--------------------
------KLSIHRELEGKEEQIKQL-RSELKQTLEHEKALKESIETQKLE----LEKVKLV
ANQNAE---------ANQEHLRGKSEALKK------VQSEMQQKLIDLEETMGAKYHEEA
NKNK---ELLSKIEELEKQSKETQHGSEAL---------------------------EKL
TKKLQDKENQVSELAIKK-EEYEKLLEE-YKTQ---NTNLNKEFTEIR----NSLEKIQT
ETETSSNALKDKYEKEINELKKTLEEKTDIS------EKSNLKIQEYTEASKTS------
----------DEEKMLRLQDEFESKNTEILG----LNSELKSYRTTITDLKKEINILANH
RQNLV-KNLKSCKKAVKGLKQDCA-SLKNDVHSRISEGKCAIS-----------------
----DAVEKTVNVFPMMDEKINNL----QSQIVELTEKTKTLEEFNRNCSDS----NVQL
EKILSEKMALEKELQAKQHEVETIQAKLID---------------FGELKENNGKLQSDI
ENLNFKISEYEKLCTEHSMEIQEAKL-----------EKDNLLKDITLKKQHNESLI---
----QEFSQKLSDKEVITQEFHEERNKLIHEI---QVLEFELASIKEELGKKNTELQYLQ
TKTTEEGEQTDKITNECENY----KKLLEENNQTLSQLNEELKNSKDERDKIRIEL----
---QESKDSLQKAMDTKNGFLQKLKLDELKSSKGELDS------------LKNEKVIMAE
ELKEIKSLHDLLHNENKSLKDNQNDLLRLNEVLNQSQSELTEKLRNLEKKNDDIAKENNA
FLTEIETFKYQLKNAHSEIENLKSQLAELEDMRKK-NNELSILLNEANNHQQNSAQLFTE
VERLTDTNRSLNSELQNLNNKILALEKQHEAS--------VNLEHELQVCRDRIVELE--
--NNLSSKIQELNSFSSNSENECHNLRIELEEKNGVLNEMELKNTKLLEEIDQLSSSKLD
SEEKANQEINKLREASIEFEKNLSDKEEN------LTKNIQDAISEKRKIESQLDETLVT
FQAKETQMQVLNEELRNQAAKLREQLKINEEEQSLRLKQIVKEFQAQLH---------DK
EKELQAALEKRFDRQQNYESDIIQEYREQLKDFQVELTKKSEEIERLILNNENTKK-EAQ
EEFEKLLDNINQIKLEHKEEIQELERRWKHIVNQKTSQLETKHEHEIAELTNEWKNERKN
DENTELLDKELESTTRVAMAAVQSNTGSFHTLQQTLLSQKRELAELRKLV-----KLRQE
SVEDSTEIEYLRNILYKYMMG-----KETMVLAKVIAAVVKFDQDQTSKILKKEEDKL--
-SLLGSLGLT--------------------------------------------------
-----------------
>gi|47214667|emb|CAG00903.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MAEDAVKVCVRVRPL--IAR
EQI-------STESTESVQLFWKADSNSIHLTDDGNSPSRSFSFDRVFTAEETTSQLYQD
FA--KPLVVSSVEGYNGTIFAYGQTSSGKTFTMMGGGHIPGVIP----------------
--------LAVEDVFQTIKNCPKKEFLLRVSYMEIYNE----------------------
------------------------------------TVTDLLVDSWKRKPLEIRETI---
---NKNIFVADLTEEMVTTPAQALAWISKGEKNRHYGKTKMNQRSSRS-----HTIFRMI
L---------ESRERSDPASGENADGAIIVSHLNLVDLAGS-------------------
-------------ERASQTGAEGARLKEGCNINRSLFTLGQ-------------------
--------------------------------------VIKKLTDENQKGFTNYR-----
----------------------------------------DSKLTRILQNSLGGNAKTVI
ICTITPATLDETLSTLQFASTAKNM--KNDPHVTEVSDDGALLKRYRNEIVDLKRRLQES
HEDLEKTEPSEQRAEELETQLQSDTRDQIHSSEHRVAELEAQLKHEATAKAEFLE-LRVT
--------DLERQLNEQNHLQDGADTQMTK------EFAETVQLREALASQKDLVATERD
YLKQ---ELGMFLEQLGQL-EKENALLSKELQEKKEVEEFESLEEEIRKEHELEQTEQQK
SSLEEKRNEMQQLLKDLE-ERLADSETS-RHTEEEISKELQQQLDELS----QELQRERS
EKELNAQRASETEGLISSLTAEREAFRTQLQ----EKVEMVENWKTYNGNQAAE------
----------TQALLQSLQEDLQHHREKNADLMKLSEQKDSETENLLRDLQRVRDEMAEA
QRSVETEELQSLVASLTAERDQLKMDLQENVEMMIENQGELRSALQRNQEQKELIKQLEK
EQTSAQDGSPPDNHEQLLTQIKVL----SEELESVKAERNRLRESDALALGDKHELQRRL
ISLTEEKEELGGRFSTLDREKEELQEIINVLRQEKQQLQAE----LEDQMELIEQLQTSL
QAASDERIRLEEDLQHNREMTIEALEHL---------GCLKEELQEQKLQMSEHMKLWEQ
QESELHQQTFCQQTTRLTEQLERAQAERDALV---TEKDSSHHAYTKEKEELHTSLVTLN
KELEELQEVVELLRQEKQQLRTELEDRMETMQSEFQQ-QLSSQSLSLQEERDHQLL----
-------VELQQLEENLQKSKQ-----ELNQLKSDLQE------------NVDLMIENQE
ELRVSQEKVRLLEEEIGDLRHQKSELEERHAEKEKLENRLVSLTEEEKIQNRLVSPC---
--EEKEALQSSLSSLNGEKEELQSQLVSLCEEKKALQNRVTYLSGDREKLRNHLMFVGEQ
KKKLKKQLSSLSEEKEELQKDLETLRQEKQQ---------LSAPRELPNSRG--------
--GQREAELQQAL-QAEERSRRCSLLQEEVQGAAVSTQQLLLKLQQAEDRVDLLSVEKQQ
LEEDQLQAHSRLSSHK-EATHLLQTELQD------SRAQVQDQENTIQTLQTRLEEAQKN
ASSA-EELEHLRSKLLRAEVELSSATEQHQKEVQSLTVLLK-----------------DK
EESL--------RKSKELLRK-SQQGQESVRQGQELYERLINP------KGYKITS-SIA
MEKARLEEEVQQLQQKITELESLVSSQAADISKWKSRAIKLKAKTNPEMDKPGSPCTPTK
RGHCTTSEPSHLLSPPKRF------------------------------------PLTPQ
KVLGSPKRSLLESPKSRFFDV-----GETSEHLSATCPRQFFDNSQLG------------
-TTQGESPSFLPSSGSDAPAF---------------------------------------
-----------------
>gi|118777920|ref|XP_308355.2|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MKTDFRGV-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------ADFAVVHYAGKVDYSATKWLM
KNMDP---LNENVVSLL-QASQDPFVVQIWKDAEIVGMAQ-QALTDTQFGARTRKGMFRT
VSHLY-KEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRIC
RQGFPN--RIPFQEFRQRYELLTPNVIPKG-------FMDGKRACEQMIKSLELDSNLYR
IGQS---KIFFRAGVLAHLEEERDYKITDL------IVNFQAFCRGFLARRNYQKRLQQL
NAIRIIQRNCAAYLKLRN-WQWWRLYTK-VKPLLEVTKQE-EKLVQKE----DELRQIRD
KLENLSKNSQEYEKKYQQAMEEKTHLAEQLQ----AEIELCAEAEEGRARLVARKQE---
----------LEELMQDLESRIEEEEERVNA----LTSEKKKLQINIQDLEEQLEEEEAA
RQKLQ-LEKVQLDAKLKKMEEDVA-LIEDQNHKLVKEKKLLEERANDLSQT-----LAEE
E---EKAKHLAKLKVKHESTIAEL----EERLLKDHQQRQEADRSKRKIETEVADLKEQI
NERRMQIEEMQQQLVKREEELAQTLVRIDEESAAKAAAQKT----QRELESQLAEIQEDL
EAEKLARSKAEKQKRDLNEELEALKNELLDSL-----DTTAAQQELRSKREQEVATL-KK
TLE-DESANHESTLMDMRHKHAQEISSINEQL---ENLKKMKGGLEKSKQQLEAENADLA
TELRNVNQSRQENDRRRKQA----ETQIAELQVKLADVDRVRVELQDKVTKLQQESENIT
QQLDEAELKASAAIKSAGNLES-----QLTEAQQLLEE------------ETRQKLALSS
KLRQIESEKEALQEQLEEDEEAKTNYEKK---LAELNFTIQEMKKRSEEDSD-IAKE---
LEESKKKMNKDIETLQRQIQELQAANDRLDKSKKKIQSELEDATIELDTQRTKVLELEKK
QKNFDKVLAEEKAISEQVAQERDAAEREAREKETKV----LSLTRELDEAFEKIDELETK
R-KGLQNELDELANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDL-----QLTE
--DAKLRLEVNMQALRAQFERDIQAKEEQ------SEEKRRGLVKALRDLEAELDEERKQ
RAAAVAAKKKLEGDLKDMEATLEMNNKVKEDALKQAKKLQAQIKDAIRDAEEAK----AA
KEELAAISKESERKVKTLEAD-LMQLTEDLSSSER--ARRAAE--GERDELLEEIN-SNS
SKGSLMIDEKRRLEARIAALEEELEEEQ-SNLELMVDRNR-KAQLTIEQLTTELATEKSN
SQNNETLKCGLERLNKELK------AKLSEQETALRTKLKAATAASEAKNLNLEKQLENE
TKERLAVQKANRKLEKRIKELTMNIEDERRHADQYKEQIEKANNRMKTLKRNLDEAEE--
-EIQKEKTLKRKAQRECEDMLESHEALSREVNALK------------------------S
KLR--------------
>gi|91094861|ref|XP_972405.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MESNTPSESGKKIVLENLSK
EEL-------VKRCERLLILAQKAKQAKDAL-----------------------------
------------------------------------------------------------
---------------------QEENNELKNRLKSESGDATT-------------------
-------------------------------------------AIIENLTQQKLQFV---
-------TTIEDLKSQNAALVNKVQNCTQDARLCEEKDRLESENISYK-----RQIKRLT
D-----------------------ENEQLITHLESLEKQLEECKNLG-------------
-------------LEQQNQLLMLEEANQKLRSDDTSDKSA--------------------
--------------------------------------ELQTMLSISLEEVKKLQAENN-
-----------------------------------TMREKIDVLKTNLGEKDKNILTIGQ
ELQEKLK-LVEDLEKIK-NESRENVELVEKLKGRLKFYHSKVVKLAGNVKVLKEN-----
------KNEVLRLLKTYSHQVEEW-KEQLGVASKKLCQEISDIKVQNSEYHKEIEGLKES
NAKYLKQLEAHKTDDEKSKELGEFERISKE----HKKLIEENQRLLQLQLDYQQTVETLT
VEKE---SLL---ENLSQLEERHQEEIKVF---------------------------DDQ
SKKDTIEIKNRIEENEKICIEYRKVISK-LEEDLDLNLRELNDAKQKN----YSLQEALE
HSKETERQIADKTSEEILKLVQENAQLVEMN-------RKLQTTRDNCKQVECQT-----
----------EDSTNSELEEVVSGLKRENSE----LLAEMNEMNQALKERGETISKLQSH
CEEVM-KKLQLYETQANKNVDNIS-QKEEIIKKLEDEIERLKATSDLNSNT---------
SEISDLKNEIENLKERLNSNLDSS-YADSECMSTSTISRTEESNRMKDLEGSW---EERY
GKLRNLAVKLKGKVRDLSNELVKEQNEKNDIQQKCASNVKT----IATLQAQCDKLQDEL
DENKKQIKEYSARL----------------------------------------------
----DSTLAEVSKDKQKLSENEEIITILKKEL---EELNQEKVTTEAWKKQISGKVSTFR
KELEANKVLKKEYEAKIAKL----TSDLEAKEQALKAESEYHQQTKNSLEHSNIER----
-----KKNSVLNLEM--QDYER-----SVKELSQKLEK------------KQEEINKLKS
QLESQKSTTNAVREQNKLLEERAEEMKSE---VGATQAEIIACKKQISDLESVMSSK---
-ENKIHDLTQILETVRSENEELSTELSKVIAEHQKVNTS---LKSEKENLKGQILGLQQT
LRDVQDALKLKEDELKIVQNDYENYKVRAQSV--------LRQNQSRDVGLE--------
---------EKLSEEVSALGVKCEALTAELNKCKTVVDDLKKENEALVHEKSEVLTKYED
VLSEVEDLKSLYDQLTNKHQQTMIEHSET------VRSLKVHAETLAQCYRQQLSEQEVR
HNREIIELQSKIEKAPSPELQLPPLPMHREEGEG--------------------------
-------------------------------------SESTENTSKNAMHPVPLER-LLG
SDNDQ----------------------------------------EIVFLKKQLSEEESK
VVHLTALLADTEQDLAKHA----QMNKLLKEE---------------IRRQ----QRSVE
REKHAENLEYLKNVVFKFVTLHSG--DERSRLVPVLNTILKLSPEETQKLNLVARGDP--
-----GIRGWTNYLPLWPSPSKP-------------------------------------
-----------------
>gi|151941941|gb|EDN60297.1|	Saccharomyces cerevisiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MDIIQGLIQQPKIQSVDETIPTLCDRVENSTLISD
RRSAVLGLKAFSRQYRESVIASGLKPLLNTLKRDYMDEDSVKAILETILILFIRGDGHDD
LT-----RGWISQQSRLQNGKYPSPLVMKQEKEQVDQFSLWIADALTQSEDLIHLLVEFW
EIDNFHIRLYTIQL--LEAVMATRPLKARSALISLPTSISTMVSLLDD------------
------------------------------MHEPIRDEAILLLMAVVNDSPHVQKLVAFE
NIFERLFSIIEEEGGLRGSLVVNDCLSLI-----NNILKYNTSNQTLF-----LEIGNLP
K-------------LAHLLSEPISQDEAFFWNDQR-------------------------
-------------IVNINTALDIVSLTVEPGNTVTTKHQNALLDSSVLMVVLRLAFFHNI
PKKVRPVALLTAANMIRSNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIKLIPVVSILIN
WMLYANSVHTFDTRVACSRLLKAYFMDNFDLQRDFLLKQVQLCNNSTNNVGDNAKENGGS
NKSDKERDSDKDTDGKDGTEYEGSF--KANLFEVLLNYDA-------ELNLNPFKLFFTT
DIFMFFFQQDHKYSEELREITRNVTTGNDLEDEEPLKAIQTISELLTTSLTAA--DIRIP
ISYLTFLIYWLFGDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVAYEFS
SKES---PFPRKEYFEFITKSLGKDNYASR------IKQFK-------KDSYFSKVDMNE
DSILTPELDETGLPKVYFSTYFIQLFNE-NIYRIRTALSHDPDEEPINKISFEEVEKLQR
QCTKLKGEITSLQTETESTHENLTEKLTALTNEHKELDEKYQILNSSHSSLKENFSI---
----------LETELKNVRDSLDEMTQLRDV----LETKDKENQTALLEYKSTIHKQEDS
IKTLE-KELETILSQKKKAEDGIN-KMGKDLFALSREMQAVEENCKNLQKE-------KD
KSNVNHQKETKSLKEDIAAKITEI-KAINENLEKMKIQCNNLSKEKEHISKELVEYKSRF
QSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEK
ENFQIERGSIEKNIEQLKKTISDLEQTKE--------EIISKSDSSKDEYESQISLL-KE
KLE-TATTANDENVNKISELTKT-REELEAEL---AAYKNLKNELETKLETSEKALKEVK
ENEEHLKEEKIQLEKEATET----KQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKE
RQYNEEISQLNDEITSTQQENE-----SIKKKNDELEG-----------EVKAMKSTSEE
QSNLKKSEIDALNLQIKELKKKNETNEAS---LLESIKSIESETVKIKELQDECNFK---
-EKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKTTELKIQLEKITNLSKAKEKS
ESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAF----EKERKLLNEGSSTITQEYSE
KINTLEDELIRLQN---ENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILS
YKDKITRNDEKLLSIERDNKRDLE----S------LKEQLRAAQESKAKVEEGLKKLEEE
SSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHE
KSDLI-------SRINESEKD-IEELKSKLRIEAKS-SSELETVKQELNNAQEKIR-VNA
EENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQ-KSEEES
RAEVRKFQVEKSQLDEKAM--------LLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQE
IEKLAKELDNLKAENSKLKEAN----EDRSEIDDLMLLVTDLDEKNAKYRSKLKDLGVE-
-ISSDEEDDEEEEDDEEDDEEDEEEGQVA-------------------------------
-----------------
>gi|125777061|ref|XP_001359482.	Drosophila pseudoobscura
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MDTASPRDTNQKNANPIEALSK
DEI-------ISKYKGLLNIAKKAKLAKDEL-----------------------------
------------------------------------------------------------
---------------------TEENRQLKEALKRAAEK----------------------
----------------------------------------------QNTLPAMQEMV---
-------QDFTDKNLILTEQVNSLKLKTKDDA--DRLGQLEIENESLR-----RQLGRLS
D-----------------------------------------------------------
--------------ENDDLLGDVDRMEKAMQ-----------------------------
--------------------------------------QVNALGNEQRKNLELL------
--------------------------------------EVDIVKIKEVEAENDTLRQELL
AADKKSELRASELQELQ------------EKYQHVKDLNSEQRKKFNSLKDR--------
------FIDVHRKLKKLKEC-----RCVLLETQHEYAASVSKWQEEIISASQLLC-----
--------DKMTSLHEENEMLKKESELVAK----------------------ETRNSDSG
IDRE---RLLLRINDLERLTKIVKQQKNGL------------------------------
--------DVESLL---------------------------KKLIAAE----QLAATVRE
QHKAEVDRLSILLSDQQKKDKESSNLNISV------------------------------
----------FGTKLDQLQSIVKSLQVERDT----QQIKVEDLEGACIALSQHNEDLFTR
LRLKE-KEHTGLLGEMRELNEALK-GRGDVISRLQEQHDVEVKKY---------------
----------------------------------------------RELEVNLSECQQSL
WEKSQKIEQLQTKVEELEQANADAQSDVLS------------------------------
------------------------------------------------------------
----TSTISRAEELSRLRELDEG----YEEKY---HKLRALAAKLKKKLQEQAQQIKEMD
QDTAM-------------------KEELEALKLAQAQLQQDLNSARAENQRLKSKE----
---KTKNTSVLNLEI--EAAEK-----SLADVSAKLTA------------KSNELETVKE
ALEGKESTIAQLRKEIAILEQAKNGEASH---SQQLKEQIDRMQVQVKDAVHGKQQA---
-LTQNKELEHSVEQAKLEAEQMRLQLADSAQQYESRLSKANQL---LESRTEQLEAHLEQ
HKQLETNLKNAERAQEDLRVEYTEYKLKAQAV--------LRKNQNKG------------
--SNKEQELEDELSVLRESE---KSLRASNDGMSARLAQLESQLEALQQ-------DNAD
LQKRSRELLILVDDLRQQNDTVTLENQRQ----------VQFQHDLMQQHRQQMDQMDVG
YQAQLKQLEQQLENSQQSHKKVSSHNNAAAAAAESSLE--------------------QA
KIDL--------LMDHDITID-GPSGETSLAQLAA--QRKISTASRRSHDFMPLDE-LLN
TSMNQISSDTVTTISHFGRSVSMQEDDEAELAAGGDFSAQ---VAQLQATKERLGIQESR
VKHLTSLLAENEQDLAKLT----QMNDMLKEE---------------LRRQ----ERSEE
REQHMHNSEYLKNVFLKFLTLNNA--DERQRLVPVLNTILRLSRNEMEMLNCVAKGQKG-
-DYPLNIYARFVVNRLLRLYFSVQ------------------------------------
-----------------
>gi|157112674|ref|XP_001651842.	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------VASGGSGTAKKGPASPFDNLSR
EDL-------VKKCRGLLGIAQKAKQAKDEC-----------------------------
------------------------------------------------------------
---------------------LEENRMLKEQLSQAETQKAAD------------------
----------------------------------------------KDCLKAMQEMV---
------------------GSLTEQKLSAA-----MRVDELEKAVAGLR-----REIDGAA
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------LLRDQLDKLS-----
-----------------------------------VENEAFQRQIKRLTDENEELLTDLS
SMEAKMKELGEEKDKVNTS--------KIALEQELLKAKNETALSGKEEKLIRKLKLYKN
K-----VQEISAKVLLLKSD-----RKILMKTVKDYSEQVPKWQRELLKASDVLF-----
--------TRIQTLERENAALKKANAESAN-------QKDVQERENELENKLQEMITEKV
ALET---SIVDKQKRLEVSNRDLQDRLQEA------------------------------
-------------------------------------ESTTKQLAEMI----EQLKADSA
QVAAKFVDFKEQNKKEFADDKNREE-----------------------------------
----------LQSSLSKAEHALSSKENELQQ----VQAQDEALKAEIKNLQKHLQTVQSK
LELVK-LENSDLLSELKEINEILK-ERGGVISLQL-------------------------
----SKISELESQKAALQQNSPDI-----------------------------DELKQRT
QDLERQLAEKEAELRDRDRSF-DAQSDVMS------------------------------
------------------------------------------------------------
----TSTISRAEESARMRDVDDS----FEEKY---NKLRSLAVKLKKKVAEQTLQLQKFE
KEQGQNQKLKATLKAKEKQL----NDELEAQK-----------ELKAEVEKCRLAA----
-----KKANVLNLEM--EAYEK-----SLAELNKKLEM------------KKVHEKELEG
TIEVQEGTIKSLKSQLTLLEQSMNAERSH---SLELKKNVDMQQEKLRISEHQRGE----
INVELAQLKVEYERIKLEMESNRVELSEAVTEKEKTNN---LMESEKSKLLKQIYALECD
AEELKSKLKEKSQEVEDVRTEFASYKIRAQSV--------LRQNQNKEGGKE--------
--RELQEEVQTLQKSLELSQLKMQTCSQQISELSKSCDELREDKTRLQN-------RCKE
LHDLLEESRLQNESLMEESRRSNLNHQEA------LKTQRLQNETLISCYKKQIEDLQEQ
HSKEPPFIISRTLPATPATTTIPSQPPA--------------------------------
------------PKINLLLME-REDGEGSESTSSHPQNLPSATRRKSSNSSQPPQQ-QRT
RSNRDLIPLDELLNSSFDDGSTVFEADS-----VADHSASGSPTVELQHTKDKLTKQESR
VRHLTALLAEAEQDLAKLT----QLNELLKEE---------------VRRH----ERAIE
REKHVHNSEYLKNVIFKFLTLNSG--DEKSHLVPVLNTILRLSPEETQKLNNVARGTD--
----GGGRGWTGILWN--------------------------------------------
-----------------
>gi|153792649|ref|NP_001093105.	Mus musculus
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MSSDTEMEVFGIAA
PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYVKGKIKSSQDGKVTVETEDSRTLVVKP
EDVYAMNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPV
YN---------PEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGK
TVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRF
GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELL-LI
TTNPYDYPFISQGEILVASIDDAEELLATDSAI-DILGFTPEEKSGLY-----KLTGAVM
HYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV
DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEE
CMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVK--GKAEAHFSLVHYAGTVDYSVSGWLE
KNKDP---LNETVVGLY-QKSSNRL--LAHLYATFATTDA---DGGKKKVAKKKGSSFQT
VSALF-RENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRIC
RKGFPN--RILYGDFKQRYRVLNASAIPEG------QFIDSKKACEKLLASIDIDHTQYK
FGHT---KVFFKAGLLGTLEEMRDERLAKL------ITRTQAVCRGFLMRVEFQKMMQRR
ESIFCIQYNIRAFMNVKH-WPWMKLFFK-IKPLLKSAETE-KEMATMK----EEFQKTKD
ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ----AESENLLDAEERCDQLIKAKFQ---
----------LEAKIKEVTERAEDEEEINAE----LTAKKRKLEDECSELKKDIDDLELT
LAKVE-KEKHATENKVKNLTEELA-GLDETIAKLTREKKALQEAHQQTLDD-----LQAE
E---DKVNSLSKLKSKLEQQVDDL----ESSLEQEKKLRVDLERNKRKLEGDLKLAQESI
LDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKK----IKELQARIEELEEEI
EAERATRAKTEKQRSDYARELEELSERLEEAG-----GVTSTQIELNKKREAEFLKL-RR
DLE-EATLQHEATVATLRKKHADSAAELAEQI---DNLQRVKQKLEKEKSEFKLEIDDLS
SSVESVSKSKANLEKICRTL----EDQLSEARGKNEEMQRSLSELTTQKSRLQTEAGELS
RQLEEKESIVSQLSRSKQAFTQ-----QIEELKRQLEE------------ENKAKNALAH
ALQSSRHDCDLLREQYEEEQEGKAELQRA---LSKANSEVAQWRTKYETDAIQRTEE---
LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKK
QRNFDKVLAEWKTKCEESQAELEAALKESRSLSTEL----FKLKNAYEEALDQLETVKRE
N-KNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAAL-----EHEE
--AKILRIQLELTQVKSEIDRKIAEKDEE------IEQLKRNYQRTVETMQGALDAEVRS
RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDAL----RG
QEDLKEQLAIVERRANLLQAE-VEELRATLEQTER--ARKLAE--QELLDSNERVQ-LLH
TQNTSLIHTKKKLETDLTQLQSEVEDAC-RDARNAEEKAK-KAITDAAMMAEELKKEQDT
SAHLERMKKNLEQTVKDLQ------HRLDEAEQLALKGGKKQIQKLETRIRELEFELEGE
QKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE--
-QANAHLTKFRKAQHELEEAEERADIAESQVNKLR------------------------A
KTRDFTSSRMVVHESEE
>gi|66472252|ref|NP_001018343.1	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MGDAVMAEFGSAA
PFLRKSDKERLEAQTRIFDMKKECFVPDPEVEYVKASITSRDGDKVTVDTEYGKTLTFKE
CDVHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPV
YD---------SSVVKAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGK
TVNTKRVIQYFASIAAVSGK-KDAASEKKGTLEDQIIQANPALEAFGNAKTIRNDNSSRF
GKFIRIHFGVSGKLASADIETYLLEKSRVTYQLKAERDYHIFYQILSQKKPELLEML-LI
TNNPYDYSYISQGETQVASIDDAEELIATDDAF-DVLGFTQDEKSGIY-----KLTGAIM
HFGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNV
QQVYYSIGALAKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEIFDFNTFEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQACIELIEKPMGIMSILEEE
CMFPKASDQTFKAKLYDNHLGKNPTFQKPRIVK--GRPEAHFALVHYAGTVDYNISNWLV
KNKDP---LNETVVGLF-QKSTVKL--LSFLFAGYSGADSAQDSKGGKGGGKKKGSSFQT
VSALH-RENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRIC
RKGFPN--RILYGDFKQRYRILNPSANPEG------QFIDNKKAAEKLLGSLDIDHNQYK
LGHT---KVFFKAGLLGTLEEMRDDRLALI------ITGIQARARGILSRLEFQKIVERR
DSLLVIQWNVRAFMGVKN-WPWMKLYFK-IKPLLKTAETE-KEMANMK----EEFTKLKE
AYAKSEARKKELEEKMVSLLQEKNDLQLAVQ----SEQDNLVDAEERCEGLIKSKIQ---
----------LEAKAKELTERLEDEEEMNAE----LVAKKRKLEDECSELKKDIDDLELT
LAKVE-KEKHATENKVKNLTEEMA-ALDEIIAKLTKEKKALQEAHQQTLDD-----LQSE
E---DKVNTLTKAKAKLEQQVDDL----EGSLEQEKKLRMDLERAKRKLEGDLKLTQESI
MDLENDKQQMEEKLKKKDFEISQLNSKIEDEQALGAQLQKK----LKELQARIEELEEEL
EAERAARAKVEKQRADLSRELEEISERLEEAG-----GATAAQIEMNKKREAEFQKL-RR
DLE-EATLQHEATAATLRKKHADSVADLGEQI---DNLQRVKQKLEKEKSELKLELDDVV
SNMEQIVKSKSNLEKMCRTL----EDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELS
RQLEEKDSLVSQLTRGKQSYTQ-----QIEDLKRQLEE------------EVKAKNALAH
AVQSARHDSDLLREQFEEEQEAKAELQRS---LSKTNSEVAQWRTKYETDAIQRTEE---
LEDAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK
QRNFDKVLAEWKQKYEESQTELESAQKESRSLSTEL----FKLKNSYEEVLDQLETMKRE
N-KNLQEEISDLTEQLGETGKSIHELEKIRKQLEQEKAEIQTALEEAEGSL-----EHEE
--GKILRAQLEFNQVKADIERKLSEKDEE------MEQAKRNQQRVVDTLQSSLESETRS
RNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHVKDSQMQLDDAL----RG
NDDLKENIAIVERRNNLLQAE-LDELRSLVEQTER--GRKLAE--QELMDVSERVQ-LLH
AQNTSLLNQKKKLEGDNTQLQTEVEEAV-QECRNAEEKAK-KAITDAAMMAEELKKEQDT
SAHLERMKKNMEQTIKDLQ------HRLDEAEQIAMKGGKKQVQKLEARVRELENEVELE
QRKASESVKGVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRAAEEAEE--
-QANSNLGKFRKLQHELDEAEERADIAESQVNKMR------------------------A
KSRDSGPKKGHDEG---
>gi|109509513|ref|XP_228197.4|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MEDSAQDAVTAAPSGTPKSKLETLPR
EDL-------IKFAKKQMMLLQKAKARCTELDKEVEELKSKPVDGGTDDMIKVLTERLDA
LLLEKAETEQQCLCLKKENIKMKQEVEDSVTKLEETQKEFEQSHRNYV------------
----REMESVKNELIAVHSEHSKEKAALQRDLEGAVHRQAELLEQLKSQSDSEDN-----
--VKKLQEEIQNITAAFEEQTSCLQKQLEATSDEKQQEIIHLQKVIEDNAQHYQKDI--N
TFQEEIVQLRATHKEEVNELMSQMETLAKEHE--AAVNKLKENRVTLC-----ETSETIP
E-----NYQCESESLNEDTSDASQENQKCSVALQEDPFAEHTVYDKVRQLEDSLKELESQ
HSI----------LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ
SYVVEKLKYEREDLNRQLCCTVEQHNK-----------EIQRLQEHHQKEISELSETFMS
GSEKEKLALMFEIQGLKEQCENLQHEKQEVVLNYESLREMMEILQTELGESAGKISQEFE
TMKQQ---QASDVHELQ-----------QKLRTAFNEKDA-LLETINRLQGENEKLLSQE
L-----VSELESTMKNLKADNSMYLAS-LGQKDTLLQELEAKISSLAEEKDDFISKIKTS
REEIDDLHQKWEREQKLSVELREAAEQAAQ------HNSELRQRVSELTGKLDEILREKS
QNDQ---NIMVQMKTMTEDQEALSSKIKSL----------------------YEENNRLH
SEKVQLSRDLEALQSQQD-FAYKEHVAE-FEKKLQLMVEERDDLNKLL----ENEQLQKS
FVKTQLYEFLKQMRPSILEDNEEEDVVTVLK----AVGESLVTVKEEKHNLVFE------
----------YDARVLELERRIKCLQEESVVQCEELRALVRDSEQEKILLRKELDEVTST
KEALQ-CDILEMKNTNEKTSLENQ-TLSTRVEELSRSLHSKNEVHNEK------------
----DLVIEHENLRLSLEQRESEL-----------QDVRAELMLLKDSLEKS----PSVK
NDQLSLVKELEEKIESLEKESKDKDEKISKIKLVAVRAKKE----LDSNRKEAQTLRDEL
ESVQSEKDRLSASMKEFIQGAESYKNLLLEY------DKQSEQLDVEKERANNFEHH-IE
DLT-KQLRDSTCQYEKLTSDNED----LLARI---ETLQANARLLEAQILEVQRAKGVVE
KELEAEKLQKEQKIKEHVST----TNELEELQLQFQKEKKQLQKTMQELELVKKDA----
-----QQTTLMNMEI--ADYER-----LMKELNQKLTN------------KNSKIEDLEQ
EMKIQKQKQETLQEEMTSLQSSVQHYEEK-------NAQIKQLLVKTKKELADAKQAETD
HLLLQASLKGELEASQQQVEVYKIQLAEMTSEKHKIH---EHLKTSAEQHQRTLSAYQQR
VVALQEESRTAKAEQAAVTSEFENYKVRVHNV--------LKQQKNKSVSQAETEGAKQE
R-EHLEMLIDQLKIKLQDSQ---NSLQISVSEFQTLQSEHDTLLERHNRML-------QE
TVTKEAELREKLCSAQSENTMLKSEHAQT------MCQLTSQNEALRNSFRDQVRHLQDE
HRKTVETLQHQLSKVETQLFQLKSEPPTKSPASSH-----------------------QP
SKSLRE------RRTTDLP---LLDMH----------TVTREE--GEGMETTDSES-VSS
A------------GTHIQSLEQLLSSPDSKLERLTEASLW-HTEFTKEELAEKLSSTTKS
ADHLNGLLRETEATNAILM----EQIKLLKSE---------------IRRL----ERNQE
REKSVANLEYLKNVLLRFIFLKPG--SERERLLPVIDTMLQLSPEEKGKLATVAQGEE--
-ESASRSSGWASYLHSWSGLR---------------------------------------
-----------------
>gi|156120319|ref|NP_001095305.	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MSSDTEMEVFGIAA
PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGRIKSTQDGKVTVETEDNRTLVVKP
EDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPV
YN---------PEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGK
TVNTKRVIQYFATIAATGDLAKKKDSKMRGTLEDQIISANPLLEAFGNAKTVRNDNSSRF
GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELL-LI
TTNPYDYPFISQGEILVASIDDAEELLATDSAI-DILGFTPEEKSGLY-----KLTGAVM
HYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV
DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEE
CMFPKATDTSFKNKLYDQHLGKSANFQKPKVVK--GRAEAHFSLIHYAGTVDYSVSGWLE
KNKDP---LNETVVGLY-QKSSNRL--LAHLYATFTTADA---DSGKKKVAKKKGSSFQT
VSALF-RENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRIC
RKGFPN--RILYGDFKQRYRVLNASAIPEG------QFIDSKKACEKLLASIDIDHTQYK
FGHT---KVFFKAGLLGTLEEMRDDRLAKL------ITRTQAVCRGFLMRVEFQKMVQRR
ESIFCIQYNIRAFMNVKH-WPWMKLFFK-IKPLLKSAETE-KEMATMK----EEFQKTKD
ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ----AESENLLDAEERCDQLIKAKFQ---
----------LEAKIKEVTERAEDEEEMNAE----LTAKKRKLEDECSELKKDIDDLELT
LAKVE-KEKHATENKVKNLTEELA-GLDETIAKLTREKKALQEAHQQTLDD-----LQAE
E---DKVNSLSKIKSKLEQQVDDL----ESSLEQEKKLRVDLERNKRKLEGDLKLAQESI
LDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKK----IKELQARIEELEEEI
EAERATRAKTEKQRSDYARELEELSERLEEAG-----GVTSTQIELNKKREAEFLKL-RR
DLE-EATLQHEAMVAALRKKHADSVAELGEQI---DNLQRVKQKLEKEKSEFKLELDDLG
SNVESVSKSKANLEKICRTL----EDQLSEARGKNEEIQRSLSELSTQKSRLQTEAGELS
RQLEEKESTVSQLSRSKQAFTQ-----QIEELKRQLEE------------ESKAKSALAH
ALQSARHDCDLLREQYEEEQEAKAELQRA---LSKANSEVAQWRTKYETDAIQRTEE---
LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQAEVEDLMVDVDRANSLAAALDKK
QRNFDKVLAEWKTKGEESQAELEASLKESRSLSTEL----FKLKNAYEEALDQLETVKRE
N-KNLEQEIADLTEQIAESGKTIHELEKSRKQIELEKADIQLALEEAEAAL-----EHEE
--AKILRIQLELTQVKSEIDRKMAEKDEE------IEQLKRNYQRTVETMQSALDAEVRS
RNEAIRIKKKMEGDLNEIEIQLSHANRQAAETVRHLRSVQGQLKDTQLHLDDAL----RG
QEDLKEQLAIVERRANLLQAE-VEELRATLEQTER--SRKIAE--QELLDASERVQ-LLH
TQNTSLIHTKKKLETDLAQLQSEVEDAS-RDARNAEEKAK-KAITDAAMMAEELKKEQDT
SAHLERMKKNLEQTVKDLQ------HRLDEAEQLALKGGKKQIQKLETRIRELESELEGE
QKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQMKVKSYKRQAEEADE--
-QANAHLTKFRKAQHELEEAEERADIAESQVNKLR------------------------A
KTRDFTSSRMVVHESEE
>gi|98986453|ref|NP_002461.2|	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MSSDTEMEVFGIAA
PFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKP
EDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPV
YN---------PEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGK
TVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRF
GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELL-LI
TTNPYDYPFISQGEILVASIDDAEELLATDSAI-DILGFTPEEKSGLY-----KLTGAVM
HYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV
DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLC
INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEE
CMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVK--GRAEAHFSLIHYAGTVDYSVSGWLE
KNKDP---LNETVVGLY-QKSSNRL--LAHLYATFATADA---DSGKKKVAKKKGSSFQT
VSALF-RENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRIC
RKGFPN--RILYGDFKQRYRVLNASAIPEG------QFIDSKKACEKLLASIDIDHTQYK
FGHT---KVFFKAGLLGTLEEMRDDRLAKL------ITRTQAVCRGFLMRVEFQKMVQRR
ESIFCIQYNIRSFMNVKH-WPWMKLFFK-IKPLLKSAETE-KEMATMK----EEFQKTKD
ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ----AESENLLDAEERCDQLIKAKFQ---
----------LEAKIKEVTERAEDEEEINAE----LTAKKRKLEDECSELKKDIDDLELT
LAKVE-KEKHATENKVKNLTEELS-GLDETIAKLTREKKALQEAHQQALDD-----LQAE
E---DKVNSLNKTKSKLEQQVEDL----ESSLEQEKKLRVDLERNKRKLEGDLKLAQESI
LDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKK----IKELQARIEELEEEI
EAERATRAKTEKQRSDYARELEELSERLEEAG-----GVTSTQIELNKKREAEFLKL-RR
DLE-EATLQHEAMVAALRKKHADSVAELGEQI---DNLQRVKQKLEKEKSEFKLEIDDLS
SSMESVSKSKANLEKICRTL----EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELS
RQLEEKESIVSQLSRSKQAFTQ-----QTEELKRQLEE------------ENKAKNALAH
ALQSSRHDCDLLREQYEEEQEGKAELQRA---LSKANSEVAQWRTKYETDAIQRTEE---
LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKK
QRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL----FKLKNAYEEALDQLETVKRE
N-KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL-----EHEE
--AKILRIQLELTQVKSEIDRKIAEKDEE------IEQLKRNYQRTVETMQSALDAEVRS
RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL----RG
QEDLKEQLAIVERRANLLQAE-VEELRATLEQTER--ARKLAE--QELLDSNERVQ-LLH
TQNTSLIHTKKKLETDLMQLQSEVEDAS-RDARNAEEKAK-KAITDAAMMAEELKKEQDT
SAHLERMKKNLEQTVKDLQ------HRLDEAEQLALKGGKKQIQKLETRIRELEFELEGE
QKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE--
-QANAHLTKFRKAQHELEEAEERADIAESQVNKLR------------------------A
KTRDFTSSRMVVHESEE
