>gi|109484054|ref|XP_236676.4|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MASFPETDFQ------ICLLCKEMC----GSPAPLSSSSSASSSSSQTSTSS-A
GGGGPGAAARRLHVLPC-------------------LHAFC-RPCL-----EAHRLPAPG
GAGPAEALK-----------------LRCPVCDQKVVLAEAA-GMDALPSSAFLLSNLLD
AVVATADEPPPKNGRAGG-GPG---GAGGH-SNHRHHAHHPAQRAAAPA------PQPPP
---------GPAASPGSLLLRRPHG------CSSCD----EGNA--ASSRCLDCQEHLCD
NCVRAHQRVRLTKDHYIER----GPPGPAAASAA---QQLGLGPPFAGAPFSILSVFP--
--------ERLGFCQHHDDEVLHLYCDTCSVPI-CRECTLGRHG------GHSFAYLQDA
LQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEE
RECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLAR---
DRMLAQVQELKTIRGLLQ---------PQE--------------------DD------RV
MFTPPD--QALYLA--LK-SFG-FVSSGAFAPLTKAAGDG--IKRALQG--KVASFTVMG
YDHNGEPR---------LSGGDLMSVVVL--GP--DGNL-FGAE----------------
VSDQQNGTYVVSYR------PQLEGEHLVSVTLYNQHIENSPFKVVV----------KSG
RSYV-------------GIGLPVLSF--------------------G------------S
EGDGEGKLCRPWGVSVD-K-EGYIIVADRSNNRIQVFKPC-GSFHHKFGTLGSRPGQFDR
PAGVACDASRRIVVADKDNHRIQIFT-FEGQFLLKFGEKGTKNGQFNYPWDVAVN-SEGK
ILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFD--------------------SPRGV
AFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGN------GQFLRPQGVAVDQEGR
IIV--ADS-RNHR--VQMFE-ANGSFLCKFGAQGSGFGQMDRPSGIAVTPEGLIVVV---
------------------------------------------------------------
------------------------------------------------------DFGNNR
ILIF------------------
>gi|91092518|ref|XP_969733.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MVSMNSTL
VETVSINYEDFNESFL------TCGTCLCMYDGNEHTP----------------------
------------KLLQC-------------------SHTVC-LHCL-----TKI-----A
ASQTRDTGS-----------------FRCPICRELITIPRG--GVSALPP-SFLVNQLLD
LMSRQR------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------R--
--------EVIPKCSVHINQEL-LFCETCDTVF-CTLCTEGSHNDTTNSCEHTIIPFSIA
I---KRMSEILLYKANECISKLTQAQEGVSSELRRLETAKENCLDQINATFQKVQAFLDN
RKQEMIEALNSTCAEKRRVLEEQHSLIECEKNKVEQECQGLQ------YQVEVRNIT---
QRIESLTEKLDAASNLGE---------PRE--------------------NA----FLSC
DFTQNNSLEIIQEQ--LN-ILGRVRTSTTFPSLCSATVEG----DIIAG--IESSITLNT
VDYHGNQR---------KTGGDPIEAELLPVTP--EQNINSVPLE---------------
VIDNEDGTYTITFR------APKSGRYGVRISIFERSIKDSPLFFDV-------------
----------------SEHNNPVMAY--------------------G------------C
HGSGKDEFIQPVAVVVDET-DQSVYVLDTGNSRIKVLNEN-LEFVKHI----TNEGLLGR
SCTGITLSSNGLIVVNWRNKSITEMS-KDGETIKTFT-----YNAFQEPIDVAVDKNYGH
ILVADNGMNCVFVFDADGKILFQVGKKGTFCQISS------------------------V
TVGPNSEILVADY---RIQVFSAKGDFMEVIRDEGKGK------GRY---GGVAIDSEGR
ILASRSEQKGKNY--VQVLSLTDTNINNHIDSHES---KLKRPSGVAVTAGNHVIVV---
------------------------------------------------------------
------------------------------------------------------DLGNNC
IKKYRYW---------------
>gi|118790686|ref|XP_318765.3|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------CGLCQKLL----REP----------------------
------------RVLDC-------------------LHTFC-RACL-----ERVAATVTH
GQDSAQEKV-----------------LVCPTCNHPTELPAGPGGIGQLPQ-HFVLARKIE
NIVSQHSSSPGSSRH-GS------------------------------------------
-------------------------------PTNCA----PSSI--AFAMCELCSEELCN
FCREAHRRQRDTASHSRPR--RTLPVPGEADS-------------------------V--
--------PRSIKCPMHPEHQLKLFCTTCHQVI-CGECSTLLHR------DHRCTTVSRA
GKVYGRFVRSAIEQTRPLEDYALQSVGRLNDLTVRINSRCEAVQQEVDAFVDEYVAALEE
HRRTLSEQIGNIRQAKMEMIMAQKLDLERRSQNSRAAIEFAEELMTEGSEVENLLFV---
SILLKRFEQCLKSTRALD---------STV--------------------TD------TV
QFLADEEAPNVRVQTGVP-LFGIVTTQKADPQQSGIEHSAGELATLKAH--KRVQLTLVV
RDYEGRRL---------GHGGITVQTDLRFRDD--DDHS-VPMT----------------
IADNRDGSYGLTFV------PSRPGVMHLMLFVDGKLLEECPVVLRI-------------
------------------------------------------------------------
----------------------------------HKLRPHYGVFH---------------
------------------------------------------------------------
--------CCTFC--------SSSGSKGGTC-----------------------------
-----------------------ACGSIMPGGYRGCGH------GHEGHPGQ--------
-----RHW-----------S-CCGSLQEFSDC----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------
>gi|109052675|ref|XP_001098706.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MASFPETDFQ------ICLLCKEMC----GSPAPLSSNSSASSSSSQTSTSSGG
GGGGPGAAARRLHVLPC-------------------LHAFC-RPCL-----EAHRLPAAS
GGAPGEPLK-----------------LRCPVCDQKVVLTEAA-GMDALPSSAFLLSNLLD
AVVATADEPPPKNGRA-G-APA---GASGH-SNHRHHAHHAHPRASASA--PPLPQAPPP
AAASRSAPGGPAASPSALLLRRPHG------CSSCD----EGNA--ASSRCLDCQEHLCD
NCVRAHQRVRLTKDHYIER----GPPGPGAAAAA---QQLGLGPPFPGPPFSILSVFP--
--------ERLGFCQHHDDEVLHLYCDTCSVPI-CRECTMGRHG------GHSFIYLQEA
LQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEE
RECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLAR---
DRMLAQVQELKTVRSLLQ---------PQE--------------------DD------RV
MFTPPD--QALYLA--IK-SFG-FVSSGAFAPLTKATGDG--LKRALQG--KVASFTVIG
YDHDGEPR---------LSGGDLMSAVVL--GP--DGNL-FGAE----------------
VSDQQNGTYVVSYR------PQLEGEHLVSVTLCNQHIENSPFKVVV----------KSG
RSYV-------------GIGLPGLSF--------------------G------------S
EGDSDGKLCRPWGVSVD-K-EGYIIVADRSNNRIQVFKPC-GAFHHKFGTLGSRPGQFDR
PAGVACDASRRIVVADKDNHRIQIFT-FEGQFLLKFGEKGTKNGQFNYPWDVAVN-SEGK
ILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFD--------------------SPRGV
AFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGN------GQFLRPQGVAVDQEGR
IIV--ADS-RNHR--VQMFE-SNGSFLCKFGAQGSGFGQMDRPSGVAITPDGMIVVV---
------------------------------------------------------------
------------------------------------------------------DFGNNR
ILVF------------------
>gi|114615086|ref|XP_527840.2|	Pan troglodytes
MGDWVIDYRPEPAALAGDRAPSSGPGWQRWFRVDGAAGTGSTAQACHLPAGVGALEGEDG
AGWGGRRGLRLCEASRCVPGWDGSCTTSTISFSFVSFPGTQQRRPPGPRPPHHPRGQDQL
WLVLTGLTQQVALTFLCLLDVHTEVEEEEEKEEGSSLAQEQVAQGLRRLEGTSWPFSMVS
HGSSPSLLEALSSDFL------ACKICLEQL----RAP----------------------
------------KTLPC-------------------LHTYC-QDCL-----AQL------
----ADGGR-----------------VRCPECRETVPVPPE--GVASFKT-NFFVNGLLD
LVKARACGDLRAGKPA--------------------------------------------
-------------------------------CALCPLVGGTSAGGPATARCLDCADDLCQ
ACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARE--------------------------
--------RQAAQCPQHPGEALRFLCQPCSQLL-CRECRLDPHL------DHPCLPLAEA
VRARXPXLEGLL------LPQLELH-----------------------------------
------------------------------------------------------------
---------------------------PGL--------------------LDKNCHLFRL
SFEEQQPQKDGGKD--RAGTQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPKEEKAQT
TREEGAQT---------LEED---RAQTP--HE--DGGPQPHRG----------------
GRPNKKKKFKGRLKSISREPSPALGRNLDGSGLLPRPIFYCSFPTRM-------------
------------------------------------------------------------
--PGDKRSPRITGLCPF-G-PREILVADEQNRALKRFSLN-GDYKGTVPVPEG-----CS
PCSVAALQSA---VAFSAGARLYLIN-PDGEVQWRRA-----LSLSQASHAVAALPSGDR
VAVSVAG--HVEVYNMEGSLATRFIPGGKASRGLR--------------------ALVFL
TTSPQGHFVGSDWQQNSVVICDGLGQVVGEYK--GPGL-------HGCQPGSVSVDKKGY
IFLTLREV---NK--VVILD-PKGSLLGDFLTAYH---GLEKPR-VTTMVDGRYLVV---
------------------------------------------------------------
------------------------------------------------------SLSNGT
IHVFRVRSPDS-----------
>gi|149640463|ref|XP_001514346.	Ornithorhynchus anatinus
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MASEG
SNIPSPVVRQIDKQFL------ICSICLERY----KNP----------------------
------------KVLPC-------------------LHTFC-ERCL-----QNY------
--IPAHSLT-----------------LSCPVCRQTSILPEK--GVSALQN-NFFITNLMD
VLQRTP------------------------------------------------------
-------------------------------GSNIE----ESSILETVTAVA--------
---------------------------------------------------------A--
--------GKPLSCPNHDGNVMEFYCQSCETAM-CRECTEGEHA------EHPTVQLKDV
VEQHKASLQVQLDAVNKRLPEIDTALHFISEIIHQLTNQKASIVDDIHSTFDELQKTLNV
RKSVLLMELEVNYGLKHKVLQTQLDTLLEGQESIKSCSNFTAQALNHGTETEVLLVK---
KQMSDKLNELADQDFPLQ---------PRE--------------------ND------QL
DFIVET--EGLKKS--IH-NLGTILTTNAVASETVATGEG--LRQTVIG--QPMSVTITT
KDKDGELC---------KSGNAYITAELS--TP--DGSV-SDGE----------------
ILDNKNGTYEFLYT------VQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGV
KRRVKSPGS--GHVKQKAVKRPASMYST--GKRKENPIEDDLIFRVG------------T
KGRNKGEFTNLQGVAAS-T-NGKILIADSNNQCVQIFSND-GQFKSRFGIRGRSPGQLQR
PTGVAVHPSGDIIIADYDNKWVSIFS-SDGKFKTKIG-----SGKLMGPKGVSVD-RNGH
IIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFA--------------------GPHFA
AVNSNNEIIVTDFHNHSVKVFNQEGEFMLKFGSNGEGN------GQFNAPTGVAVDSNGN
IIV--ADW-GNSR--IQVFD-GSGSFLSYINTSAD---PLYGPQGLALTSDGHVVVA---
------------------------------------------------------------
------------------------------------------------------DSGNHC
FKVYRYLQ--------------
>gi|148229109|ref|NP_001085492.	Xenopus laevis
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MASEG
SNIPSPVVRQIDKQFL------ICSICLDRY----KNP----------------------
------------KVLPC-------------------LHTFC-ERCL-----QNY------
--IPAHSLT-----------------LSCPVCRQTSILPEK--GVSALQN-NFFITNLMD
VLQRSP------------------------------------------------------
-------------------------------DNGIE----ESSILETVSAVA--------
---------------------------------------------------------A--
--------GKPLSCPNHDGNVMEFYCQSCETAM-CQDCTGGEHA------EHPTVPLKDV
VEQHKAALQTQLDAVKKRLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFDDLQKTLNV
RKSVLLMELEVNYGLKHKVLQTQLDTLIEGQDSIKSCTTFTAQAFNHGTETEVLLVK---
KQMSDKLNELAEQDFPLQ---------PHE--------------------ND------QL
DFIVET--EGLKKS--IH-NLGTILTTNAVASETVATGEG--LRQSVIG--QPMSVTITT
KDKDGELC---------KTGSACLSADLF--TP--DGSV-TDGE----------------
IVDNKNGTYEFSYT------IPAEGDFTLSLRLYDQHIKGSPFKLKVIKSADVSPTTEGV
KRRVKSPGS--SHVKQKAVKRPASMYST--GKRKENPIEDDLIFRVG------------T
KGRNKGEFTNLQGVAAS-T-NGKILIADSNNQCVQIFSND-GQFKSRFGIRGRSPGQLQR
PTGVAVHPSGDIIIADYDNKWVSIFS-ADGKFKTKIG-----SGKLMGPKGVSVD-RNGH
IIVVDNKACCVFIFQPNGKIVTRFGSRGNGDKQFAGTL----------------HGPHFA
AVNSNNEIIVTDFHNHSVKVFNQDGEFILKFGSNGEGN------GQFNAPTGVAVDSNGN
IIV--ADW-GNSR--IQVFD-GSGSFLSYINTSAD---PLYGPQGLSLTSDGHVVVA---
------------------------------------------------------------
------------------------------------------------------DSGNHC
FKVYRYLQ--------------
>gi|60459910|gb|AAX20126.1|	Lymnaea stagnalis
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MTSVR
MTSTATRFWDSNINLL------SCAICDQRY----KDP----------------------
------------KVLPC-------------------LHTFC-ELCL-----SNV------
--IPSESLS-----------------VTCPVCRQQSILPLD--GVSALQT-NGFVLNLLN
AITSPDV-----------------------------------------------------
-------------------------------CTSCG----VISSR-PTSKCLDCQKFLCD
TCSVQH-CNMDNTNNNIQDPSPKLDPDNKMNAHSENGEGQGLHHVVSLAEMASRKSPPLT
NGGIKDDGGGDIVCPNHAGSPLKYYCSLCDTAV-CETCTQVEHI------GHMTVVLSEA
VTEHKTTLTSLVARVRQMTPEVERAIEEVEVMQNQLHANTTDAESKIKELFDELVTILEE
RKQSAIEELAKVSAVKEYVLDEQKKALHKHLSCISSCCELTEDSLLHGNDMDVVMVK---
KEMAGKLNDLLTNGVTLQ---------PET--------------------NP-------L
ALFDEKDFEGLRET--IN-CLGSVCNNSAIPQQTTVGGEA--FSGCVAG--KASTVTVTT
RDRNGDLV---------KTGFAPITAFIS--TD--KSEDRLTPT----------------
ITDHQNGTYDLTFV------LQAPGIYYLTVTMFGQHTKGSPYKIRA---VDIGEANGDG
SARIPRTMA----VKQKGVKRPSSSRSQGSSNRRTNRIEDDLIIRIG------------V
KGRNKGEFSNPQGLCYH---EEKVLVADSNNQAVQVFVPS-GECRLKFGTPGRAPGKIQR
PTGVAVTQNGNYLVADYDNKWISVFS-PDGKYMSRIG-----AGRLQGPKGVAVD-REGR
IIVVDNKSSCILIFQSNGKLLHKFGTRGNRDDQFA--------------------GPHYA
AINENNDIIISDFHNHCVKVFDRDGAFKFCFGSNGEGN------GQFNAPTGVAVDDKGN
MLV--ADW-GNSR--IQVFD-STGSFLSYVNTASE---PLYGPQGLAVTTQGILVVA---
------------------------------------------------------------
------------------------------------------------------DSGNHC
IKYYKYLQ--------------
>gi|109014597|ref|XP_001113121.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MSENR
KPLLGIVSKLPNGTALGNSGKTHCPLCLGLF----KAP----------------------
------------RLLPC-------------------LHTVC-TTCLEQL--EPFSVVDIR
GGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVDLPMG--GVKALTI-DHLAVNDVM
-LESLRGEGQGLV-----------------------------------------------
-------------------------------CDLCN----DREV--E-KRCQTCKANLCH
FCCQAHRRQKKTTYHTMVD----LKDLKGYSR-------------------------I--
--------GKPILCPIHPAEELRLFCEFCDRPV-CRDCVVGEHR------EHPCDFTSNV
IHKHGDSVRELLKGTQPHVEALEEALAQINIMNSALQKRVEAVAADVQTFSEGYIKAIEE
HRDKLLKQLEDIRIQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITK---
GVVVERLRKLNKVQYSAR---------PGV--------------------ND------KI
RFCPQE-------------KAGQCHGYEIYD-----------LHRAREK--QTASFTLLC
KDAAGEIM---------GRGGDNIQVAVLPKDK--KDSP-VRPM----------------
VQDNKDGTYYISYT------PKEPGVYTVWVCVKEQHVQGSPFTVTV-------------
------------------------------------------------------------
--------------------------------RRKHRPHP-GVFH---------------
------------------------------------------------------------
--------CCTFC--------SSGGQKTARC-----------------------------
-----------------------ACGGTMPGGYLGCGH------GHKGHPGR--------
-----PHW-----------S-CCGKFNEKSECTWTG--GQSAPRSLLRT-----VAL---
------------------------------------------------------------
------------------------------------------------------------
----------------------
>gi|149756018|ref|XP_001492544.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVSQG
--SAPSLLEALNSDFL------ACKICLEQL----RAP----------------------
------------KTLPC-------------------LHTYC-QDCL-----AQL------
----AEDGH-----------------LRCPECRETVPVPPA--GVAAFKT-NFFVNGLLD
LVRARAGGDLRAGKPA--------------------------------------------
-------------------------------CALCPLMGGASAGGPATARCLDCADDLCQ
ACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARE--------------------------
--------RQAAQCPQHPGEALRFLCQPCSQLL-CRECRLDPHL------DHPCLPLAEA
VRARRPGLEELLAGVDNNLAELEASRMAEKEALARLREQAARVGTQVEEAAEAVLRALLA
QKQEVLGQLRAHVEAAEEAARERLGELEGREQVAREAAAFARRVLSLGREAEILSLEGAI
AQRLQQLQGCPWMPGPTRCLLPQLELHPGL--------------------LDKNCHLLRL
SFEEQQSQKDGGKD--GAGTKGCDKTQSWREDGTQTEKHGGIQPQSRDGAQTPKEDRAQT
PQEDGAQTPKAEIAKTPQEDGTQTPKEARAQTPQEEGGALTPRG----------------
GRSNKKKKFKGRLKSVSREPSPAPGPHLEGSGLLPRPIFSCSFPTRM-------------
------------------------------------------------------------
--PGDKRSPRITGLCPF-G-PREILVADEQNRALKRFSLN-GDYKGAVPVPEG-----CS
PCSVAALQGA---VAFSASARLYLIS-PDGKVQWRRA-----LSLSQASHAVAAMPSGDR
VAVSVSG--HVEVYNMEGSLATRFIPGGKANRGLR--------------------ALVFL
TTSPEGNFVGSDWQQNSVVVCDGLGQVVGEYR--GPGL-------HGCQPGSVSVDKKGY
IFLTLREV---NK--VVILD-PKGSLLGDFLTAYH---GLEKPR-VTTMVDGRYLVV---
------------------------------------------------------------
------------------------------------------------------SLSNGT
IHVFRVRSPDS-----------
>gi|126330157|ref|XP_001363305.	Monodelphis domestica
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAKR
EGSTSPVVRQIDKQFL------VCSICLDRY----HCP----------------------
------------KVLPC-------------------LHTFC-ERCL-----QSY------
--IPAQSLT-----------------LSCPVCRQTSILPEQ--GVSALQN-NFFISNLIE
VMQRTPD-----------------------------------------------------
-------------------------------GGRDP----TAPHPL----CAV-------
---------------------------------------------------------A--
--------GRPLSCPNHEGKTMEFYCESCETAM-CGECRAGEHG------EHRTVLLRDV
VEQHKAALQRQLDTVRSRLPQLTAAIALVGEISQQLLDRKAEALAQISGAFEELEHALQQ
RKGALVRDLEAICGAKQKVLQAQLETLRQGQEHIGSSCSFAEQALRLGSETEVLLVR---
KQMGERLAALASQAFPER---------PHE--------------------NG------QL
ELLLET--DGLRRS--IL-NLGALLTTSATAHETVATGEG--LRQALVG--QPASLTITT
KDKDGQLV---------RTGSAELRAELT--GP--DGAR-LEAH----------------
VLDHKNGTYELVYT------ARAEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDV
KRRVKSPGGPGGHVRQKAVRRPSSMYSTG-GKRKDNPIEDELVFRVG------------S
RGREKGEFTNLQGISAA-N-SGRIVVADSNNQCIQVFSNE-GQFKLRFGVRGRSPGQLQR
PTGVAVDTNGDIIVADYDNRWVSVFS-PEGKFKTKIG-----AGRLMGPKGVAVD-RNGH
IIVVDNKACCVFTFQPNGKLVGRFGGRGATDRHFA--------------------GPHFV
AVNNKNEIVVTDFHNHSVKVYSADGDFLFKFGSHGEGN------GQFNAPTGVAVDSNGN
IIV--ADW-GNSR--IQVFD-STGSFLSYINTTAE---PLYGPQGLALTSDGHVVVA---
------------------------------------------------------------
------------------------------------------------------DAGNHC
FKAYRYLQ--------------
>gi|119914284|ref|XP_610389.3|	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MASFPETDFQ------ICLLCKEMC----GSPAPLSSNSSASSSSSQTSTSSGG
GGGGPGAAARRLHVLPC-------------------LHWRA-GAAA-----GAGGHGSNH
RHHAHHAHP-----------------RAAPSAPPPPLPPAPPPPAPPRSAPGGPAGSPSA
LLLRRPHG----------------------------------------------------
-------------------------------CSSCD----EGNA--ASSRCLDCQEHLCD
NCVRAHQRVRLTKDHYIER----GPPGPAAAAAAAAAQQLGLGPPFPGAPFSLLSVFP--
--------ERLGFCQHHDDEVLHLYCDTCSVPI-CRECTVGRHG------GHSFVYLQEA
LQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEE
RECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLAR---
DRMLAQVQELKTVRSLLQ---------PQE--------------------DD------RV
MFTPPD--QALYLA--IK-SFG-FVSSGAFAPLTKATGDG--LKRALQG--KVASFTVIG
YDHDGEPR---------LSGGDLMSAVVL--GP--DGNL-FGAE----------------
VSDQQNGTYVVSYR------PQLEGEHLVSVTLCNQHIENSPFKVVV----------KSG
RSYV-------------GIGLPGLSF--------------------G------------S
EGDSDGKLCRPWGVSVD-K-EGYIVVADRSNNRIQVFKPC-GAFHHKFGTLGSRPGQFDR
PAGVACDASRRIVVADKDNHRIQIFT-FEGQFLLKFGEKGTKNGQFNYPWDVAVN-SEGK
ILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFD--------------------SPRGV
AFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGN------GQFLRPQGVAVDQEGR
IIV--ADS-RNHR--VQMFE-SNGSFLCKFGAQGSGFGQMDRPSGIAVTPDGMIVVV---
------------------------------------------------------------
------------------------------------------------------DFGNNR
ILIF------------------
>gi|54020865|ref|NP_001005680.1	Xenopus tropicalis
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MASEG
SNIPSPVVRQIDKQFL------ICSICLDRY----KNP----------------------
------------KVLPC-------------------LHTFC-ERCL-----QNY------
--IPAHSLT-----------------LSCPVCRQTSILPEK--GVSALQN-NFFITNLMD
VLQRSP------------------------------------------------------
-------------------------------DNGIE----ESSILETVSAVA--------
---------------------------------------------------------A--
--------GKPLSCPNHDGNVMEFYCQSCETAM-CQDCTGGEHA------EHPTVPLKDV
VEQHKAALQAQLDAVKKRLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFDDLQKTLNV
RKSVLLMELEVNYGLKHKVLQAQLDTLIEGQESIKSCTTFTAQALNHGTETEVLLVK---
KQMSDKLNELAEQDFPLQ---------PHE--------------------ND------QL
DFIVET--EGLKKS--IH-NLGTILTTNAVASETVATGEG--LRQSVIG--QPMSVTITT
KDKDGELC---------KTGSAYISAELF--TP--DGSV-TDGE----------------
VVDNKNGTYEFSYT------IPTEGDFTLSLRLYDQHIKGSPFKLKVVKSADVSPTTEGV
KRRVKSPGS--GHVKQKAVKRPASMYST--GKRKENPIEDDLIFRVGSRKDEDVRSLTGT
KGRNKGEFTNLQGVAAS-T-NGKILIADSNNQCVQIFSND-GQFKSRFGIRGRSPGQLQR
PTGVAVHPSGDIIIADYDNKWVSIFS-ADGKFKTKIG-----SGKLMGPKGVSVD-RNGH
IIVVDNKACCVFIFQPNGKIVTRFGSRGNGDKQFAGTL----------------DGPHFA
AVNSNNEIIVTDFHNHSVKVFNQDGEFILKFGSNGEGN------GQFNAPTGVAVDSNGN
IIV--ADW-GNSR--IQVFD-GSGSFLSYINTSAD---PLYGPQGLSLTSDGHVVVA---
------------------------------------------------------------
------------------------------------------------------DSGNHC
FKVYRYLQ--------------
>gi|84993742|ref|NP_001034200.1	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MASFPETDFQ------ICLLCKEMC----GSPAPLSSNSSASSSSSQTSTSSGG
GGGGPGAAARRLHVLPC-------------------LHAFC-RPCL-----EAHRLPAAG
GGAAGEPLK-----------------LRCPVCDQKVVLAEAA-GMDALPSSAFLLSNLLD
AVVATADEPPPKNGRA-G-APA---GAGGH-SNHRHHAHHAHPRASASA--PPLPQAPQP
PAPSRSAPGGPAASPSALLLRRPHG------CSSCD----EGNA--ASSRCLDCQEHLCD
NCVRAHQRVRLTKDHYIER----GPPGPGAAAAA---QQLGLGPPFPGPPFSILSVFP--
--------ERLGFCQHHDDEVLHLYCDTCSVPI-CRECTMGRHG------GHSFIYLQEA
LQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEE
RECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLAR---
DRMLAQVQELKTVRSLLQ---------PQE--------------------DD------RV
MFTPPD--QALYLA--IK-SFG-FVSSGAFAPLTKATGDG--LKRALQG--KVASFTVIG
YDHDGEPR---------LSGGDLMSAVVL--GP--DGNL-FGAE----------------
VSDQQNGTYVVSYR------PQLEGEHLVSVTLCNQHIENSPFKVVV----------KSG
RSYV-------------GIGLPGLSF--------------------G------------S
EGDSDGKLCRPWGVSVD-K-EGYIIVADRSNNRIQVFKPC-GAFHHKFGTLGSRPGQFDR
PAGVACDASRRIVVADKDNHRIQIFT-FEGQFLLKFGEKGTKNGQFNYPWDVAVN-SEGK
ILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFD--------------------SPRGV
AFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGN------GQFLRPQGVAVDQEGR
IIV--ADS-RNHR--VQMFE-SNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVV---
------------------------------------------------------------
------------------------------------------------------DFGNNR
ILVF------------------
>gi|123889648|sp|Q1PRL4|LIN41_C	Gallus gallus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MASFPEADFQ------VCPLCKEMC----GSPAPLSSNSSTSSSSSQTSGSSGG
GGSSCGGAARRLHVLPC-------------------LHAFC-RQCL-----EAQRHPAAG
-----DALK-----------------LRCPICDQKVVISEPS-GMDALPSSNFLLSNLLD
VVVVAAAADEQKNGRAAGSGPAAGSGAGGGGANNRHHGRPPPHRAAAAASSPAAGSAAPS
ASSSSSSGGG---GPAALLLRRPHSRQGEPRCSSCD----EGNA--ASSRCLDCQEHLCD
NCVRAHQRVRLTKDHFIER----FAAGPAAASAG-PAAPLALSPPYPASPYNILSVFP--
--------ERASYCQHHDDEVLHFYCDTCSVPI-CRECTMGRHV------GHSFIYLQDA
LQDSRTLTIQLLADAQQGRQAIQLSIEQAQAVAEQVEMKAKVVQSEVKAVTTRHKKALEE
RECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLDNTISAVQQVLEEGRTIDILLAR---
DRMLAQVQELKNVRGLLQ---------PQE--------------------DD------RI
MFTPPD--QALYMA--IK-SMG-FVSSGAFAPLTKATGEG--LKRALQG--KVASFTVIG
YDHDGEPR---------LSGGDMISAVVM--GP--DGNL-FGAD----------------
VSDQQNGTYLVSYR------PQLEGEHLVSVMMCNQHIENSPFKVVV----------KSG
RSYI-------------GIGLPGLSF--------------------G------------S
EGDSDGKLCRPWGVSVD-K-EGYIIVADRSNNRIQVFKPC-GTFHHKFGTLGSRPGQFDR
PAGVACDVSRRIVVADKDNHRIQIFT-FEGQFILKFGEKGTKNGQFNYPWDVAVN-AEGK
ILVSDTRNHRVQLFGPDGVFLNKYGFEGALWKHFD--------------------SPRGV
TFNHEGHLVVTDFNNHRLLVIHADCQSARFLGSEGSGN------GQFLRPQGVAVDQEGR
IIV--ADS-RNHR--VQIFE-SNGSFLCKFGAQGSGFGQMDRPSGIAVTPDGMIVVV---
------------------------------------------------------------
------------------------------------------------------DFGNNR
ILVF------------------
>gi|157115807|ref|XP_001658291.	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MITNDESN----RENEKFLAGATSTHESS--------
------------RAINCAANHDGFSGESRFDQIRASFQNFKEKNCLKSPSKERTKSNLKL
AAKIDQEKD-----------------LICPSCGLATVLPLG--GVNRLPP-HFVMERKIE
DMVSACGNPPPNL----F------------------------------------------
-------------------------------CELCT----NEVT--ATSSCSTCSLKLCS
FCKEAHQRQRNTAQHKVRSLGELLKKSRHNDP-------------------------E--
--------ARSIKCPMHPEHQLKLFCTTCHQVI-CNECTAFIHR------DHKYTSASKA
GKVYSKFVKNAIEQTKPLEDYAMQSIGRLNDMSIRINSKCEAVQRDVEAYIDEYVAALED
HRKALLKQIGEVREAKMAMIMAQKVDLEQRSQNARTAIDFAEEIINEGNEIENLIFV---
SILLKRFEQCLRSNRALD---------FKV--------------------TD------TL
EFLPDEMTPCFRVQNLVP-LYGIITTQKADPRKCSLVNCA-ELASLKVH--RKVELSLVT
KDYEGRPM---------NHGGITVQTDLRHQED--DSRP-ISLN----------------
VADNRNGTYGLSFV------PERAGVMSLMVSVDGKIIEGCPYVLRI-------------
------------------------------------------------------------
----------------------------------HNLRPHNGVYH---------------
------------------------------------------------------------
--------CCSFC--------SSNGSKYSTC-----------------------------
-----------------------ACGSIMPGGYKGCGH------GHEGHPGH--------
-----RHW-----------S-CCASLLEHSDCTTK---KVK-------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------
>gi|73988279|ref|XP_862689.1|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAKR
EDSPGPEVQPMDKQFL------VCSICLDRY----RCP----------------------
------------KVLPC-------------------LHTFC-ERCL-----QNY------
--IPAQSLT-----------------LSCPVCRQTSILPEQ--GVSALQN-NFFISSLME
AMQQAPDG----------------------------------------------------
-------------------------------AHDPE----DPHPLSAVA-----------
------------------------------------------------------------
--------GRPLSCPNHEGKTMEFYCEACETAM-CGECRAGEHR------EHGTVLLRDV
VEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAVFEDLEQALQQ
RKQALVSDLEAICGAKQKVLQTQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVR---
KHMRERLAALAAQAFPER---------PHE--------------------NA------QL
ELVLEV--DGLRRS--VL-NLGALLTTSATAHETVATGEG--LRQALVG--QPASLTVTT
KDKDGRLV---------RTGSAELRAEIT--GP--DGAR-LPVP----------------
VVDHKNGTYELVYT------ARAEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDV
KRRVKSPGGPGSHVRQKAVRRPSSMYSTG-GKRKDNPIEDELVFRVG------------S
RGREKGEFTNLQGVSAA-S-SGRIVVADSNNQCIQVFSNE-GQFKFRFGVRGRSPGQLQR
PTGVAVDTNGDIIVADYDNRWVSIFS-PEGKFKTKIG-----AGRLMGPKGVAVD-RNGH
IIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFADTLLHPSVPAHCPRDHFVFSGPHFV
AVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGN------GQFNAPTGVAVDSNGN
IIV--ADW-GNSR--IQVFD-SSGSFLSYINTSAE---PLYGPQGLALTSDGHVVVA---
------------------------------------------------------------
------------------------------------------------------DAGNHC
FKAYRYLQ--------------
>gi|47227079|emb|CAG00441.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAKHE
AGRTSPVVRQIDKQFL------VCSICLDHY----RTP----------------------
------------KVLPC-------------------LHTFC-ESCL-----QNY------
--IPPESLT-----------------LSCPVCRQTSILPEK--GVCALQN-NFFITNLME
VLQRDSE-----------------------------------------------------
-------------------------------CPRPE----ACSVLESVSAAA--------
---------------------------------------------------------A--
--------GKPLCCPNHEGKVMEFYCESCETAM-CLDCTEGEHR------EHVTVPLRDV
VEQHKAVLKTQLDAIRGRLPQLTAAIELVGEISRQLNERKSEAVAEITGTFEELERALHQ
RKTALITDLENICTTKQKAVPRHTSFLSIHLNAGPAGSALSAPP-GEGAHPKQLQLHGAS
AQPRQRHGGAAGSEADER---------AGDGAGQTRLPREATSERTFGLSDD----IERL
SLSSQVETDGLRRS--IQ-NLGVLVTTAAVAHTSVATGEG--LRHAATG--QHHTITVTT
KDKDGELV---------RTGNAVLKAEIT--LT--DGSRGAETE----------------
VSDNKNGTYEVGYT------LHSEGEYSFSLMLYGQPVRGSPFRLRAVKPSDVPQSPDDV
KRRVKSPSGTGGHIRQKAVRRPSSMYST--TKKKENPIEDELIYRVG------------S
RGREKGEFTNLQGISAS-S-NGRVVVADSNNQCIQIFSND-GQFKMRFGIRGRSPGQLQR
PTGVTVDMNGDIVVADYDNRWVSIFS-AEGKFKNKIG-----AGRLMGPKGVAVD-KNGH
IITVDNKACCVFIFQSNGKLVTKFGGRGTADRQFA--------------------GPHFV
AVNNKNEIIVTDFHNHSVKVYNADGEFLFKFGSHGEGN------GQFNAPTGVAVDANGN
IIV--ADW-GNSR--IQVFD-STGSFLSYINTSAD---PLYGPQGLALTSDGHVAVA---
------------------------------------------------------------
------------------------------------------------------DSGNHC
FKVYRYLQ--------------
>gi|109948300|ref|NP_001035968.	Mus musculus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MASFPETDFQ------ICLLCKEMC----GSPAPLSSNSSASSSSSQTSTSS-A
GGGGPGAAARRLHVLPC-------------------LHAFC-RPCL-----EAHRLPAPG
GAGPAEALK-----------------LRCPVCDQKVVLAEAA-GMDALPSSAFLLSNLLD
AVVATAEEPPPKNGRAGG-GPG---GAGGH-SNHRHHAHHPAQRAAAPA------PQPPP
---------GPAASPGSLLMRRPHG------CSSCD----EGNA--ASSRCLDCQEHLCD
NCVRAHQRVRLTKDHYIER----GPPGPAAASAA---QQLGLGPPFAGAPFSILSVFP--
--------ERLGFCQHHDDEVLHLYCDTCSVPI-CRECTLGRHG------GHSFAYLQDA
LQDSRALTIQLLADAQQGRQALQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALED
RECELLWKVEKIRQVKAKSLFLQVEKLRQSLSKLESTISAVQQVLEEGRALDILLAR---
DRMLAQVQELKTIRGLLQ---------PQE--------------------DD------RI
MFTPPD--QALYLA--LK-SIG-FVSSGAFAPLTKATGDG--IKRALQG--KVASFTVMG
YDHDGEPR---------HSGGDLMSVVVL--GP--DGNL-FGAE----------------
VSDQQNGTYIVSYR------PQLEGEHLVSVTLYNQHIENSPFKVVV----------KSG
RSYV-------------GIGLPGLSF--------------------G------------S
EGDGEGKLCRPWGVSVD-K-EGFIIVADRSNNRIQVFKPC-GSFHHKFGTLGSRPGQFDR
PAGVACDASRRIIVADKDNHRIQIFT-FEGQFLLKFGEKGTKNGQFNYPWDVAVN-SEGK
ILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFD--------------------SPRGV
AFNNEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGSGN------GQFLRPQGVAVDQEGR
IIV--ADS-RNHR--VQMFE-ANGSFLCKFGAQGSGFGQMDRPSGIAVTPDGLIVVV---
------------------------------------------------------------
------------------------------------------------------DFGNNR
ILIF------------------
>gi|72152617|ref|XP_795170.1|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAEEI
------------KRLL------ECPMCLELFTSSSRKP----------------------
------------KLLPC-------------------QHTLC-LECM-----DML------
----NQGNR-----------------IQCPQCRQQHTCPGD--GPAQLPN-NFTMLALLD
VQQKSSPSPTPMSM----------------------------------------------
-------------------------------KESSP----PVPARPETDRPPAINEGVRN
SIALLARKLQEKSVE------------------------------------------L--
--------GRIDIKEKQTEDLLLSVKNQVDSAFEARTRDLHTRR------DQLIKQLASA
RQEELAFIQGQRASAYQYLHKLQTDFSKMRHALTASVEPREADLINLLSLCRGYLSQIEQ
YALNIDQRICNVAFTDPNQQQLSISIQAYGCLEISTDKAKSVQAVRPTMIPGTAVSQSSP
SNPFNSSMSLPATTSSAS---------SSS--------------------IP-----TPL
SQSSSAASLGDGRS--PS-PFASASSSPTITPVTPDVIPG-QDDRSIVARQQPRSSRRLS
----EPIG---------QSGQPALSAGVP--VP--SQSARLSRHLSMDTVGVALPAATSA
SLPNPAGGDQPPPV------PRRPGIARMSSINEQQPSVDRPRSILLRQHTVPSAVSQTR
GDAPPLPPRTSVQVPSPSVQPSVVEGASFQSSSNSNNPSQPWVTFTSNGAQSSSQVQKKR
GVVIPQVFEKPVGVHVLEKLNNCFAVVDELQHCVMIINEE-GRLLRQMGSKGGGAGQMQF
PKGICSNSAGHIIITDCYNHKVQVWDLSTGRCLKQFGSRGQSNNCFDSPTGVVCD-KQDN
IYVCDYNNGCVKVFNPAGMFIRLIGKKGERDGQFR--------------------NPAFI
AFTQGGELLITDAFKHCVQVFSSQGTYLYRFGNWGTSP------GDLNCPSGITVDAQGY
IYV--ANR-GNHR--VEVFN-PSGSYALNLGRHGSEEGQLDEPLGVSITKDGRLLVS---
------------------------------------------------------------
------------------------------------------------------DSGNKR
LQLLWP----------------
>gi|93002986|tpd|FAA00076.1|	Ciona intestinalis
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MSPIRTRASSTPDYNIFKENIRFAGHM
MASSIDLLTKINDEFL------TCQICFETY----TRP----------------------
------------KSLNC-------------------QHTFC-LKCL-----EEY------
--TPPNSVR-----------------VICPTCRSEQPLTAD--GINGLKD-NFFISSMSD
MLKTVKEIRSEDKDGTSLM-----------------------------------------
-------------------------------CDTCD----HDNRKVAIARCLDCTDFLCN
ECSTWHIRTKLTRRHKIVS----LSE-------------------FESGIHNQELK-S--
--------RAKIYCMIHDGEAAKIYCQSCQCPI-CHECVESGHS------RHRRCSLKEE
VLNQSHQIENLLKTAKEKTDVLRTLQRTLKDIKQTKKLDRDKAESEIERICEIFINTIHR
RKQELTDELHNMHATEVKRINADEDSVEMQLSSLVSCTEFSRKVLEYGTPKEVLGLN---
NQMTQILHQLLETHPAATYHN------TNQ--------------------TD------NI
QFDTNA--DASVRV--IRDNLGRLIIQKATFDEVV---------NKVLK--QLDSFCVA-
-DNHSMVR---------RNGKTLIQ-----------------------------------
RAESTETKLVVQLG----------------------------------------------
-----------------------------------------------------------K
QGIADGEFESTPNLAIN-S-VNEVITADYDGAKIQIFDPQ-GNFKDSFVTEVNK--RMCK
PAGIAILDNDDIVVCCEDQ--VHIWT-HEGKSVLGFG-----KGQFGNCSSIAVN-SENR
IVVADVGKHCISVFTDTGKMLLQFGAQGKGESKLV--------------------EPRYV
ACDSQNNIIVSDGGDCSVKKFSSQGEFLLSFGAEGPER------GQFQGPRGLCTDEHDN
ILV--ADC-WNHR--VDIFT-PDGCFMRHIATGAD---SLHFPWCISLTTNGKLIISPTT
LIPDFDQLAGQFDLPNLLSNKVSWWLTSPNAQDPEHAVNGLTNGNIHNTIATSSITRKPS
KTLASKKSSSSDSDLTAMTPLSPIAPPSTPSLTGQQALDAVLNGTNGGSNGSLSSTGSGK
IHYQGKVTSLNDHVPVTMVNGT
