>gi|126135008|ref|XP_001384028.	Pichia stipitis
-----------------------------------------------------------M
FRASIYKHSAHRALSARSFSVSAA--------------------------ALAKIKVKNP
IVELDGDEMTRIIWQRIKDK--------------------------LIN-P-YLDIDLKY
YDLGIESRDATDDKITIDAANAIKEYGVGVKCATITPDEQRV------------------
---------EEFGLKKMWLSPNGTIRNILGGTVFRESIIIPRVPRLIPGWKEPIVIGRHA
HGDQYKATDLVISEPGKVELVFTPANGGAPETRTVYDYK-SPGVALAMYNTDESIRGFAH
SSFKMALTKKLPLYMSTKNTILKKYDGRFKDIFQEIYEAEYASQFKAAGLWYEHRLIDDM
VAQMIKSKGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKAFESEAAHGTVTR
HYRQHQQ-GKETSTNSIAS-------------IFAWSR-----GIAQRGRLDNTPE---V
VDFANTLEKATLDTVQEDGIMTKDLALA----CGKTDRAS-YVTTTEFLDAVADKLKAQV
KV--------
>gi|91083633|ref|XP_970446.1|	Tribolium castaneum
------------------------------------------------------------
------MAGTLTKFSKSLNAVATK--NGLLQGRNY---------------GTQRVVAKNP
VVEMDGDEMTRIIWEKIKER--------------------------LIF-P-YVKLESLY
FDLGLPHRDQTNDQVTIDAANAILKHNVGIKCATITPDEQRV------------------
---------QEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPKLVPGWTKPIVIGRHA
HGDQYKAKDFVVTKPGTVELVYTSDDG-KVEKYELFKYK-GGGVALGMYNTDESIRAFAH
SSFQVALNKGWPLYLSTKNTILKKYDGRFKDIFQEIYEKEYKSQYEAKKIWYEHRLIDDM
VAQGLKSSGGFVWACKNYDGDVQSDIVAQGYGSLGMMTSVLMCPDGKTIESEAAHGTVTR
HYREHQK-GNPTSTNPIAS-------------IFAWTR-----GLEHRAKLDGTPD---L
AKFAQTLEKACVDCV-ESGKMTKDLAASIHG-LPNVKPGM-YLNTQDFLEAIAEELERQM
K---------
>gi|110764717|ref|XP_623673.2|	Apis mellifera
------------------------------------------------------------
---------------------------------------------------MTKIQVG-P
VVDVLGDEMTRVIWDSIKEK--------------------------LIL-P-YLDIKLHT
YDLSIENRDATNDNVTVECAEAIKKYNVGIKCATITPDEKRV------------------
---------KEFNLKKMWKSPNGTIRNILGGTVFREPIICKNIPKLVNSWIRPIIIGRHA
HADQYKAVDFIIPGPGKLEITWIG-DNEQKIQHIVHNFK-GPGIAQAQYNTDESIHAFAH
SSFQYALSRNYPLYLSTKNTILKQYDGKFKDIFHEIYEKEYKAQFEAKNIWYEHRLIDDM
VAYAMKSDGGFVWSCKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGRTVEAEAAHGTVTR
HYRQYQQ-GKETSTNPIAS-------------IFAWTR-----GLLHRAKLDDNKD---L
KQFSETLEAVCINTI-ESGFMTKDLAICIKG-MNNVTRSD-YLETFEFIDKLAENLQKQI
KVN-------
>gi|47217869|emb|CAG02362.1|	Tetraodon nigroviridis
------------------------------------------------------------
--------------------------------------------------ATERIKVEQP
VVEMDGDEMTRIIWEFIKEKVLKSSKRCRFFGGPAWFFPSPCVRPQLIL-P-NVDVELKY
FDLGLPYRDQTDDQVTIDSALATKKYNVAVKCATITPDEARV------------------
---------EEFNLKKMWKSPNGTIRNILGGTVFREPILCKNIPRLVPGWTQPITIGRHA
FGDQYRATDFTVNQPGKFKIIFAPADGGQQKEWEVYDFK-SGGCGMGMYNTDESIWGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIYEKDYQAEFEKLKIWYEHRLIDDM
VAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQR-GKPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNPD---L
IRFCQTLERVCVETV-ESGVMTKDLAGCIHG-LANCKLNEHYVNTTDFLDAIRTNLDRSL
GK--------
>gi|126337907|ref|XP_001365492.	Monodelphis domestica
------------------------------------------------------------
--------------------------------------------------MSQKINGG-S
VVEMQGDEMTRVIWDLIKQK--------------------------LIF-P-YVNLDLHS
YDLGIEHRDETDDQVTIDAAEAIKKYNVGIKCATITPDEKRV------------------
---------EEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVNGWVKPIVIGRHA
YGDQYRATDFVVPGPGKVEISYTPRDGSKTVTYLIHNFEDCGGVAMGMYNLDQSIMDFAH
SSFQMALTKGWPLYMSTKNTILKKYDGRFKDIFQKIYDTHYKSKFEAKKIWYEHRLIDDM
VAQALKSEGGFVWACKNYDGDVQSDSIAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTR
HYRMYQK-GQETSTNPIAS-------------IFAWTR-----GLAHRAKLDDNKE---L
GTFATILEEVCIETI-ESGFMTKDLAACIKG-LPNVQRSD-YLNTFEFMDKLAENLKAKL
AQAKL-----
>gi|52345502|ref|NP_001004799.1	Xenopus tropicalis
-----------------------------------------------MAGYLRAVSTI--
--CRAS-AAALGKNPGVLAPALSQ--QQLQQQRNY--------------AD-KRIKVANP
VVEMDGDEMTRIIWEFIKEK--------------------------LIL-S-NVDVELKY
FDLGLPYRDQTNDQVTIDSALATLKYNVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFRDPIICKNIPRLVPGWTQAITIGRHA
HGDQYKATDFVVDQAGTFKLVFAPANGTATKEWEVFNFP-AGGVGMGMYNTDESISGFAH
SCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQDIFEKHYKPEFDKLKIWYEHRLIDDM
VAQVLKSTGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNQD---L
INFSLTLEKVCVETV-ESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLDKAL
GKN-------
>gi|149632357|ref|XP_001507484.	Ornithorhynchus anatinus
--------------------------------------------MEDEVGPSEADLGV--
--IRVE---AERKLGEKVNTRSEC--HLLMD------------------AD-KRIKVAKP
VVEMDGDEMTRIIWQFIKEK--------------------------LIL-S-HVDVQLKY
FDLGLPHRDQTDDQVTIDSALATQKYSVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTRAITIGRHA
HGDQYKATDFVVDRSGSFKMVFTPKDGSGVKEWEVYNFP-GGGVGMGMYNTDESISGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTEFDKNKIWYEHRLIDDM
VAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLNL--CVLVCSSGESVEYDNLLDPISR
HEGAHGSFGRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDSNQD---L
INFAQTLEKVCVQTV-ESGAMTKDLAGCIHG-LSNVKLNEHYLNTTDFLDAIKNNLDKAL
GKS-------
>gi|125980137|ref|XP_001354101.	Drosophila pseudoobscura
-----------------------------------------------MFAIRRTATLM--
-------TARRPPLIRAVFQANFA--SSAV--------------------MAQKIRAG-P
VVDVLGDEMTRIIWQSIKDK--------------------------LIL-P-FLDIELHT
FDLGIEYRDQTEDKVTIDCAEAIKKYNVGIKCATITPDEKRV------------------
---------EEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVSGWQKPIVIGRHA
HADQYKAVDYVVPGPGKLTLTWKGNDG-QVIDEVINDFK-GPGVALGMFNTDDSIVDFAH
ASFKFALDRKLPLYMSTKNTILKKYDGRFKDIFEDIYNKEYKKQYEAAGIWYEHRLIDDM
VAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTR
HFRFYQQ-GKETSTNPIAS-------------IFAWTR-----GLLHRAKLDDNVP---L
QQFAETLEQVCIDTI-EGGAMTKDLAICIKGSISAVERKD-YQETFEFMDTLAKNLEAAL
AKSAAAAK--
>gi|93115142|gb|ABE98244.1|	Oreochromis mossambicus
-----------------------------------------------MAGYLKVLSSL--
--SRSA-GAAFSRNPAVLAPAANC--QTLQQ-RNY--------------AD-KRIKVANP
VVEMDGDEMTRIIWEFIKEK--------------------------LIL-T-NVDVELKY
FDLGLPYRDQTDDQVTIDSALATKKYSVAVKCATITPDEARV------------------
---------EEFGLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHA
FGDQYRATDFVVDQPGKFKIVFSPADGSTSKEWEVFDFP-AGGCGMGMYNTDESITGFAH
SCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDM
VAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNPD---L
IKFAQTLEQVCVATV-ESGTMTKDLAGCIHG-LSNVKLNEHYVNTTDFLDAIKTNLDKAL
GK--------
>gi|146416617|ref|XP_001484278.	Pichia guilliermondii
--------------------------------------------MLRSIGYTKPLSG---
-------GSRMTQATTISNGIRYL-------------------------ATGSKIKVKNP
IVELDGDEMTRIIWQRIKDK--------------------------LIH-P-YLDVDLKY
YDLGIEARDKTDDQITIDAAHAIQKYGVGVKCATITPDEARV------------------
---------KEFGLKKMWLSPNGTIRNILGGTVFRESIVIPRVPRLVPGWKLPIVIGRHA
HGDQYKATDLVVSGPGKLELKFTPKDGGESETRVVYDYQ-GPGVGLAMYNTDESIRGFAH
SSFKMALSKKLPLYMLTKNTILKKYDGRFKDIFAEVY-QEYQSEFEAQGLWYEHRLIDDM
VAQMMKSQGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKAFESEAAHGTVTR
HFRQHQQ-GKETSTNSIAS-------------IFAWTR-----GLAQRGRLDNTPE---V
VEFAERVEKATVDTVDKQGIMTKDLAIA----CGNLDRSA-YVTTTEFLDAVADSVANSK
----------
>gi|872121|emb|CAA49208.1|	Homo sapiens
-----------------------------------------------MAGYLRVVRSL--
--CRAS-GSRPAWAPAALTAPTSQ--EHPR--RHY--------------AD-KRIKVAKP
VVEMDGDEMTRIIWQFIKEK--------------------------LIL-P-HVDIQLKY
FDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHA
HGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDM
VAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNQD---L
IRFAQMLEKVCVETV-ESGAMTKDLAGCIHG-LSNVKLNEHFLNTMDFLDTIKSNLDRAL
GRQ-------
>gi|87248165|gb|ABD36135.1|	Bombyx mori
------------------------------------------------------------
--MANT---STTKILKCVNQFASL--TS-----NY--------------GTAKSVVAAKP
VVEMDGDEMTRIIWAKIKES--------------------------LMF-P-YVKVDCLY
FDLGLPHRDATDDQVTIDSAHAILKHNVGIKCATITPDEQSV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPMLCQSIPSVVPGWTKPIVMGRHA
HGDQYKAQDFVVPKPGKVELVYTTQDG-TTESRVLYDFK-TPGVAMGMYNTDESIRSFAH
SSFQVALQKKWPLYLSTKNTILKRYDGRFKDIFEEVFQSDYKTKFDEAKMWYEHRLIDDM
VAQAIKGSGGFVWACKNYDGDVQSDIVAQGYGSLGMMTSVLMCPDGRTVESEAAHGTVTR
HYRMHQQ-GKPTSTNPVAS-------------IYAWTS-----GLAHRAKLDGTPE---L
ERFALALEEACVECI-DSGKMTKDLVICMHG-LANTKEGM-FLHTEDFLEAIAEQLERKL
GGK-------
>gi|149248138|ref|XP_001528456.	Lodderomyces elongisporus
------------------------------------------------------------
------------MISSSAINRTSMLLRHLRSFSTSS-------------RIANKITVKNP
IVELDGDEMTRIIWQKIKDD--------------------------LIH-P-YLNVDLKY
YDLGIESRDATNDQITVDAAHAIQKYGVGVKCATITPDEARV------------------
---------KEFGLKKMWLSPNGTIRNILGGTVFRESIIIPCIPRLVPGWKEPIVIGRHA
FGDQYKATDLVIQEPGTLELRFTPDNGGETQTHKVYQYS-GPGVGLAMYNTDESIRGFAH
ASFKMAINKGLPLYMSTKNTILKKYDGRFKDIFQEIYDSEYKQEFEKKGIWYEHRLIDDM
VAQMIKSKGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSALMTPDGSAYESEAAHGTVTR
HYRQHQQ-GKETSTNSIAS-------------IFAWTR-----GIAQRGRLDNTPE---V
VEFANKLEKATIDTVQEDRIMTKDLALA----MGKTDRSS-YVTTTEFLDAVANRLKQ--
----------
>gi|48476117|gb|AAT44354.1|	Crassostrea gigas
---------------------------------------------MNSARGASSVANV--
--GRLF--WRSSNKLQRFAAPVAL--NATQQ-RDY--------------GT-KRIKVANP
VVEMDGDEMTRIIWEKIKET--------------------------LIL-P-YVDVDLKY
YDLGLPYRDQTDDQVTIDAAPATKKYNVAVKCATITPDEERV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPIICQKVPRLVPGWTRPIVIGRHA
HGDQYKATDMVIPGNGKLELIYTP-EGVRSKERPCSTSKMVVDVPWPCHNTDESITAFAH
TCFQYAIMKKWPLYMSTKNTILKRYDGRFKDIFEEVYQQGYKAKFDELKIWYEHRLIDDM
VAQALKSDGGFVWACKNYDGDVQSDVVAQGYGSLGLMTSVLXCPDGKTVESEAAHGTVTR
HYREHQK-GNPTSTNPVAS-------------IYAWTR-----GLEHRGKLDGNND---L
ITFSQKLEKACVDTI-DSGKMTKDLAGCIYG-LKNVKPEH-YLNTMDFLQAIRETQEKM-
----------
>gi|73951496|ref|XP_536192.2|	Canis familiaris
MTSRSSGLNFGREAEEKRCQLLTRGIPERGVQAADRGRQRPAPARASRSGAVGASRGLPP
QAVRANGGARHGRGGGSAAAAPLE--ESGS--RPASFGGVTHCVCPVLDAD-KRIKVAKP
VVEMDGDEMTRIIWQFIKEK--------------------------LIL-P-HVDVQLKY
FDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHA
HGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFP-GGGVGMGMYNTDESISGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKNKIWYEHRLIDDM
VAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNQD---L
IRFAQTLEKVCVQTV-ESGAMTKDLAGCIHG-LSNVKLNEHFLNTSDFLDTIKNNLDKAL
GQ--------
>gi|109891934|sp|Q04467|IDHP_BO	Bos taurus
-----------------------------------------------MAGYLRVVRSL--
--CRAS-GSGSAWAPAALTAPNLQ--EQPR--RHY--------------AD-KRIKVAKP
VVEMDGDEMTRIIWQFIKEK--------------------------LIL-P-HVDVQLKY
FDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHA
HGDQYKATDFVVDRAGTFKVVFTPKDGSGPKEWEVYNFP-AGGVGMGMYNTDESISGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDM
VAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNQD---L
IRFAQTLEKVCVETV-ESGAMTKDLAGCIHG-LSNVKLNEHFLNTSDFLDTIKSNLDRAL
GQQ-------
>gi|118788400|ref|XP_316694.3|	Anopheles gambiae
------------------------------------------------------------
-------------------------------------------------EMASKIKAG-P
VVDILGDEMTRIIWDSIKEK--------------------------LIL-P-FLDIELHT
YDLGIEHRDATNDQVTIDCAEAVKRYNVGIKCATITPDEARV------------------
---------EEFKLKQMWRSPNGTIRNILGGTVFREAIICKNVPRLVPGWEKPIIIGRHA
HGDQYKATDFVVPVPGKLEMKFTPADGSEPTTYVVNEYK-SAGVAMGMYNLDDSICDFAH
SSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYDKDYKKQFEALGIWYEHRLIDDM
VAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGRTVESEAAHGTVTR
HYRQHQQ-GKETSTNPIAS-------------IFAWTR-----GLLHRAKLDDNAE---L
KRFAETLEKVCIDTI-ESGFMTKDLAICIKG-MANVKRTD-YMETFEFMNKLGENLQAAL
TQSRL-----
>gi|71000064|ref|XP_754749.1|	Aspergillus fumigatus
---------------MSSLRLSSAFARRSLHACAPPRSAPLYSSAVRFSSLSSSTSSVSS
TSSSSFSTSAAVSRPQRTLASSSL--PASS--RWSGVTSFRLNQSRTMATEGTKIKVKNP
VVELDGDEMTRIIWQEIREK--------------------------LIL-P-YLDIDLKY
YDLGIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVPGWNKPIIIGRHA
FGDQYRATDIVVPGPGKLELVYTPENG-EPQAIKVYDFT-GGGVAQTQYNTDDSIRGFAH
SSFKMALMKGLPLYMSTKNTILKKYDGRFKDIFQEIYESTYKKEFDAKGIWYEHRLIDDM
VAQMIKSEGGFVMALKNYDGDVQSDVVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTR
HYREHQK-GRETSTNPIAS-------------IFAWTR-----GLIQRGKLDETPD---V
VTFAEELERACIDVVNEEGIMTKDLALA----CGRKEREA-WVTTKEYLAAVERRLKSNL
KARL------
>gi|157109449|ref|XP_001650675.	Aedes aegypti
------------------------------------------------------------
--------------------------------------------------MAAKIKAG-P
VVDILGDEMTRIIWDSIKEK--------------------------LIL-P-FLDIELHT
YDLGMEHRDKTDDQVTIDCAEAVKKYNVGIKCATITPDEARV------------------
---------KEFNLKKMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWEKPIVIGRHA
HGDQYKATDFVVPGAGDLEIKFTPKAGGEPISYVVHQYK-GPGVAMAMYNLDDSIVDFAH
SSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYEKEYKTQFEAAGIWYEHRLIDDM
VAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCPDGKTVEAEAAHGTVTR
HYRQYQQ-GKETSTNPIAS-------------IFAWTR-----GLLHRAKLDNNAE---L
KKFAETLEKVCIDTI-ESGSMTKDLAICIKG-MANVTRAD-YLETFEFMTKLGDNLKAAL
A---------
>gi|118093509|ref|XP_421965.2|	Gallus gallus
------------------------------------------------------------
--------------------------------------------------MSKKIHGG-S
VVEMQGDEMTRVIWELIKEK--------------------------LIF-P-YVDLDLHS
YDLGIEHRDATNDKVTVEAAEAIKKYHVGIKCATITPDEKRV------------------
---------EEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIVIGRHA
YGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESCGGVAMGMYNLDQSIKDFAH
SSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFEAKKIWYEHRLIDDM
VAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTR
HYRMHQK-GQETSTNPIAS-------------IFAWTR-----GLAHRAKLDNNTS---L
KTFATALEEVCIETI-ESGFMTKDLAACIKG-LPNVTRSD-YLNTFEFMDKLAANLKGKL
ASLPKL----
>gi|121705246|ref|XP_001270886.	Aspergillus clavatus
------------------------------------------------------------
-----------------------------------------------MATEGTKIKVKNP
VVELDGDEMTRIIWQEIKEK--------------------------VSC-PFYLDIDLKY
YDLGIEYRDQTDDKVTVDAAEAIKKYGVGVKCATITPDEARV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPIVIDRIPRLVPGWTKPIIIGRHA
FGDQYRAADRVIPGPGKLELVYTPKGG-EPESITVYDFP-GGGVAQTQYNTDESIRGFAH
SSFQMALMKGLPLYMSTKNTILKRYDGRFKDIFQEIYEADYQKEFEAKGIWYEHRLIDDM
VAQMIKSEGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSTLTTPTGEAFESEAAHGTVTR
HYREHQK-GRETSTNPIAS-------------IFAWTR-----GLIQRGKLDETPD---V
VAFAEELERACIDVV-NDGVMTKDLALA----CGRKDREA-WVTTKEYMAAVERQLKSNL
KARLMRAFLE
>gi|83766186|dbj|BAE56329.1|	Aspergillus oryzae
---------------------MMNSLRLHSASVRRAVASPLSAPLSSSAYRSISCSSSSY
ISSSSSSSFSTAATPRAQRPLASSQLPRIVSPRQTGIYPLQWTQARTMATEGPKIKVKNP
VVELDGDEMTRIIWQEIREK--------------------------LTSESSYLDIDLKY
YDLGLEYRDQTDDQVTVEAAEAIKKYGVGVKCATITPDEARV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPIIIPRVPRLVPGWTKPIIIGRHA
FGDQYRATDRVIPGPGKLELVYTPVNG-EPETVKVYDFQ-GGGVTQTQYNTDESIQGFAH
ASFQMALLKGLPLYMSTKNTILKKYDGRFKDIFQEIYESTYKKDFEAKNIWYEHRLIDDM
VAQMIKSEGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSTLTTPSGEAFESEAAHGTVTR
HYREHQK-GRETSTNPIAS-------------IFAWTR-----GLVQRGKLDETPD---V
VAFAEELERACIEVVNDEGIMTKDLALA----CGRKDRDA-WVTTKEYMAAVERRLKTNL
KSRL------
>gi|119177488|ref|XP_001240510.	Coccidioides immitis
------------MPALRASSVPSRLSLTRLARNNSQPAPRLLSTFSIRPAPPLPLNSSTA
RSCLPSTSSIHNTSAATTRFQSSFAPLRAVSWTAASSPSLSHTQKRNMSTGRKKIKVKNP
VVELDGDEMTRIIWQDIKDK--------------------------FIY-P-YLDVDLKY
YDLGLEYRDQTDDKVTVDAAEAIKKYGVGVKCATITPDEARV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVPGWKKPIIIGRHA
FGDQYRATDRLVPGPGKLELVYTPTNG-EPERITVYDFQ-GAGIAQVQYNTDDSIRGFAH
ASFKLALLKGLPMYMSTKNTILKKYDGRFKDIFEEVYEAEYKKAFEAKGIWYEHRLIDDM
VAQMIKGDGGCVIAMKNYDGDVQSDIVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTR
HYREHQK-GRETSTNPIAS-------------IFAWTR-----GLIRRGQLDETPD---V
VTFAEQLERACIEVVDEEGIMTKDLALS----CGKKERDA-WVTTREYMDAVERRLRSNL
ANAKL-----
>gi|6647567|sp|Q9Z2K9|IDHC_MICM	Microtus mexicanus
------------------------------------------------------------
--------------------------------------------------MSKKIHGG-S
VVEMQGDEMTRIIWELIKEK--------------------------LIL-P-YVELDLHS
YDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRV------------------
---------EEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHA
YGDQYRATDFVVPGPGKVEITFTPKDGSQKVTYLVHSFEEGGGVAMGMYNQDKSIEDFAH
SSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDM
VAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTR
HYRMHQK-GQETSTNPIAS-------------IFAWSR-----GLAHRARLDNNTE---L
SFFAKALEEVCIETI-EAGFMTKDLAACIKG-LPNVQRSD-YLNTFEFMDKLGENLKAKL
AQAKL-----
>gi|27370516|ref|NP_766599.1|	Mus musculus
-----------------------------------------------MAGYLRAVSSL--
--CRAS-GSARTWAPAALTVPSWP--EQPR--RHY--------------AE-KRIKVEKP
VVEMDGDEMTRIIWQFIKEK--------------------------LIL-P-HVDVQLKY
FDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHA
HGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFP-AGGVGMGMYNTDESISGFAH
SCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNKIWYEHRLIDDM
VAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNQD---L
IRFAQTLEKVCVQTV-ESGAMTKDLAGCIHG-LSNVKLNEHFLNTTDFLDTIKSNLDRAL
GKQ-------
>gi|57164307|ref|NP_001009276.1	Ovis aries
------------------------------------------------------------
--------------------------------------------------MSHKIQGG-S
VVEMQGDEMTRIIWELIKEK--------------------------LIF-P-YVDLDLHS
YDLSIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRV------------------
---------EEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHA
YGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNFTESGGVAMGMFNQDKSIEDFAH
SSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWYEHRLIDDM
VAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTR
HYRMYQK-GQETSTNPIAS-------------IFAWTR-----GLAHRAKLDNNKE---L
SFFAKALEEVCIETI-EAGFMTKDLAACIKG-LPNVQRSD-YLNTFEFMDKLGENLQLKL
AQAKL-----
>gi|6647566|sp|Q9Z2K8|IDHC_MICO	Microtus ochrogaster
------------------------------------------------------------
--------------------------------------------------MSKKIHGG-S
VVEMQGDEMTRIIWELIKEK--------------------------LIL-P-YVELDLHS
YDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRV------------------
---------EEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHA
YGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHSFEEGGGVAMGMYNQDKSIEDFAH
SSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDM
VAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTR
HYRMHQK-GQETSTNPIAS-------------IFAWSR-----GLAHRARLDNNTE---L
SFFAKALEEVCIETI-EAGFMTKDLAACIKG-LPNVQRSD-YLNTFEFMDKLGENLKAKL
AQAKL-----
>gi|50303483|ref|XP_451683.1|	Kluyveromyces lactis
------------------------------------------------------------
-------MKAAVMSINRQFSSSAA-------------------------TGLRKIKVQTP
VVELDGDEMTRIIWDKIKSK--------------------------LIL-P-YLDVDLKY
YDLSVTNRDATNDQVTVDSANAIKKYGVGVKCATITPDEGRV------------------
---------KEFNLKKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPGWEKPIVIGRHA
HGDQYKATDLVVPGPGKLELVYKPTDGSETKTLEVYDYK-GPGIALAMYNTDESIRGFAH
ASFKLAITKKLNLYLSTKNTILKKYDGRFKDIFQEIYDSEYKSEFEKLGIWYEHRLIDDM
VAQMIKSKGGFILAFKNYDGDVQSDIVAQGFGSLGLMTSVLVTPDGKAFESEAAHGTVTR
HYRQYQQ-GKETSTNSIAS-------------IFAWTR-----GLAKRGELDNTPE---V
VEFANLLEKSTLNTVQEDGIMTKDLALA----CGNTDRSS-YVNTDEFLDAVEKRFRNDV
KSLQ------
>gi|156543824|ref|XP_001608101.	Nasonia vitripennis
------------------------------------------------------------
--------------------------------------------------MAAKIKAG-P
VVDILGDEMTRIIWDLIKQK--------------------------LIL-P-YLDIELHT
YDLGMENRDATDDKVTVDCAEAIKKYNVGIKCATITPDEKRV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREAIICKNIPRLVGGWEKPIIIGRHA
HADQYKAVDFVVPGPGKLELTWTSPSG-EKIQHTVNEFK-GAGIAQAQFNTDESIQAFAH
SSFKYALARKYPLYLSTKNTILKQYDGRFKNIFQEIYEKEYKSQFEALNIWYEHRLIDDM
VAYCMKSNGGYVWACKNYDGDVQSDSVAQGFGSLGLMTSVLLCPDGKTVEAEAAHGTVTR
HYRMHQQ-GKETSTNPIAS-------------IFAWTQ-----GLLHRAKLDNNAP---L
KKFAETLEKVCVSTI-ESGFMTKDLALCIKK-ADDVKRSD-YLNTFEFLDKLAENLKKSL
DA--------
>gi|13928690|ref|NP_113698.1|	Rattus norvegicus
------------------------------------------------------------
--------------------------------------------------MSRKIHGG-S
VVEMQGDEMTRIIWELIKEK--------------------------LIL-P-YVELDLHS
YDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRV------------------
---------EEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHA
YGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAMGMYNQDKSIEDFAH
SSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFEAQKIWYEHRLIDDM
VAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTR
HYRMYQK-GQETSTNPIAS-------------IFAWSR-----GLAHRAKLDNNTE---L
SFFANALEEVCIETI-EAGFMTKDLAACIKG-LPNVQRSD-YLNTFEFMDKLGENLKAKL
AQAKL-----
>gi|3023999|sp|P79089|IDHP_ASPN	Aspergillus niger
----------------------MSSVRFSSALARRSFAVASPPLSAPLSSSARRFLSSSS
STISSSSSSVSTRSPRSLTSASSLLSSRTASARWTGLSSLNLTQSRTMATEIPKIKVKNP
VVELDGDEMTRIIWQEIREK--------------------------LIL-P-YLDVDLKY
YDLGLEYRDQTDDQVTVEAAEAIKKYGVGVKCATITPDEARV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPIIIPAIPRLVPGWNKPIIIGRHA
FGDQYRATDRVIPGPGKLELVYTPVNG-EPETVKVYDFQ-GGGIAQTQYNTDESIRGFAH
ASFQMALLKGLPLYMSTKNTILKRYDGRFKDIFQEIYESTYQKDFEAKNLWYEHRLIDDM
VAQMIKSEGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSTLVTPTGEAFESEAAHGTVTR
HYREHQK-GRETSTNPIAS-------------IFAWTR-----GLIQRGKLDETPD---V
VTFAEELERACIEVVNDEGIMTKDLALA----CGRKEREA-WVTTREYMAAVERRLKANL
KSRL------
>gi|115697799|ref|XP_001176537.	Strongylocentrotus purpuratus
-----------------------------------------------MAGSLAKI-----
--GRAFVAATRTDSPRCVQSGVAL--SSTQE-RNY--------------SDRKRIEVAKP
VVELDGDEMTRVIWEKIKET--------------------------LIF-P-YLNVECLY
YDLGLPYRDQTNDQVTVDAAVAIKEHNVGIKCATITPDEERV------------------
---------VEFNLKEMWKSPNGTLRNILGGTVFREPILCDTIPRLVPGWTKAITIGRHA
FGDQYRATDMVIKEPGKFELVFSPASGAEPTRTEVFNFP-GGGCGMAMYNTDESITGFAH
SCFQYALAKKWPLYLSTKNTILKRYDGRFKDIFEEIFVANYKKDYDSAGIWYEHRLIDDM
VAQALKSSGEFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIESEAAHGTVTR
HFREHQK-GNATSTNPIAS-------------IFAWTR-----GLEHRAKLDNNPD---L
KHFCTTLEKVCVDTV-DSGMMTKDLAGCIHG-LKNVKPEH-YLNTMDFLNAISVNLDKAL
K---------
>gi|149755011|ref|XP_001505172.	Equus caballus
------------------------------------------------------------
--------------------------------------------------MSQKIRGG-S
VVEMQGDEMTRIIWELIKEK--------------------------LIF-P-HVELDLHS
YDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRV------------------
---------EEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHA
YGDQYRATDFVVPGPGRVEITYTPSDGSQKRTYLVHNFEEGGGVAMGMYNQDKSIEDFAH
SSFQMALSKSWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYRSQFEAQKIWYEHRLIDDM
VAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTR
HYRMYQK-GQETSTNPIAS-------------IFAWTR-----GLAHRAKLDNNKE---L
GFFAKALEDVCVETI-EAGFMTKDLAACIKG-LPNVQRSD-YLNTFEFMDKLGENLKIKL
AQAKL-----
>gi|3023996|sp|O13285|IDH1_CANT	Candida tropicalis
------------------------------------------------------------
-MIRASAIQRTAMLLRQLRGFSTS------------------------ATLADKIKVKNP
IVELDGDEMTRIIWQKIKDQ--------------------------LIL-P-YLDVDLKY
YDLGIESRDATDDQITIDAANAIKEYGVGVKCATITPDEARV------------------
---------KEFHLKKMWLSPNGTIRNILGGTVFRESIIIPCIPRLIPGWEKPIVIGRHA
FGDQYKATDLVINEPGRLELRFTPASGGEAQTQKVYDYT-GPGVGLAMYNTDESITGFAH
ASFKMALAKGLPLYMSTKNTILKKYDGRFKDIFQQIYEQDYAAEFEKQGLWYEHRLIDDM
VAQMIKSKGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSALMTPDGKAYEAEAAHGTVTR
HYRQHQQ-GKETSTNSIAS-------------IFAWTR-----GLAQRGKLDETPD---V
VDFASKLEQATIDTVEVDRIMTKDLALA----MGKTDRSA-YVTTTEFLDAVADRLKK--
----------
>gi|21356561|ref|NP_652044.1|	Drosophila melanogaster
-----------------------------------------------MFALRRTAAMMTS
VHRQPHLSQAVFRANFAISAADPK--THKISMDNERMSAVS--------EMAQKIKAG-P
VVDVLGDEMTRIIWDSIKSQ--------------------------LIL-P-FLDIELHT
YDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRV------------------
---------EEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHA
HADQYKAVDYVVPGPGKLTLTWKGTDG-QVIDEVINDFK-GPGIALGMFNTDDSIVDFAH
ASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDM
VAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTR
HFRFYQQ-GKETSTNPIAS-------------IFAWTR-----GLLHRAKLDNNEP---L
KQFADTLEQVCIDTI-ESGAMTKDLAICIKGNINAVTRRD-YQETFEFINTLAKNLEGAL
AKNAVAAK--
>gi|41054651|ref|NP_955858.1|	Danio rerio
-----------------------------------------------MAGYLKVLSSL--
--SRSA--ATLSKSPAVLAPA--C--QSLQQ-RNY--------------AD-KRIQVAQP
VVEMDGDEMTRIIWEFIKEK--------------------------LIL-T-NVNVDLKY
YDLGLPYRDQTDDQVTIDSAIATKKYNVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHA
FGDQYKATDFVVNQPGKFKMVFTPADGSKNKEWEVYDFP-GGGCGMGMYNTDESITGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDM
VAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNPD---L
IKFSQTLERVCVETV-ESGVMTKDLAGCIHG-LANCKLNEHYVNTTDFLDAIKTNLDKAL
GK--------
>gi|114658858|ref|XP_001168261.	Pan troglodytes
-----------------------------------------------MAGYLRVVRSL--
--CRAS-GSRPAWAPAALTAPTSQ--EQPR--RHY--------------AD-KRIKVAKP
VVEMDGDEMTRIIWQFIKEK--------------------------LIL-P-HVDIQLKY
FDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEGQWCFCYTLALTVVGVI
GDRAEEEEEEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHA
HGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDM
VAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNQD---L
IRFAQTLEKVCVETV-ESGAMTKDLAGCIHG-LSNVKLNEHFLNTTDFLDTIKSNLDRAL
GRQ-------
>gi|109082346|ref|XP_001095686.	Macaca mulatta
-----------------------------------------------MAGYLRVVRSL--
--CRAS-GSRPAWAPAALTAPTSQ--EQTR--RHY--------------AD-KRIKVAKP
VVEMDGDEMTRIIWQFIKEK--------------------------LIL-P-HVDIQLKY
FDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARV------------------
---------EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHA
HGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAH
SCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDM
VAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRGKLDGNQD---L
IRFAQTLEKVCVETV-ESGAMTKDLAGCIHG-LSNVKLNEHFLNTTDFLDTIKSNLDRAL
GRQ-------
>gi|157017733|gb|EAA08466.5|	Anopheles gambiae
------------------------------------------------------------
------------MVPSRARSSDT------------------------------RIQAVKP
IVEMDGDEMTRIIWQFIKDK--------------------------LIF-P-YVKVEALY
YDLGLPYRDQTNDQVTIDAAHAMLKHNVGIKCATITPDEQRV------------------
---------EEFKLKKMWLSPNGTIRNILGGTVFREPIICNNIPRIVPGWTKPIVIGRHA
HGDQYKAQDYVVRKPGTVKMVYTGEDG-TVEEIQLYKYT-SPGVALAMYNTDESISAFAH
SSFQVALGKRWPLYLSTKNTILKRYDGRFKDIFQEIYEKDYKKQFEEAKIWYEHRLIDDM
VAQALKSSGEFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTVESEAAHGTVTR
HYREHQK-GRPTSTNPIAS-------------IFAWTR-----GLEHRAKLDNTPE---L
ARFSKALEKACVDTV-ESGKMTKDLALCIHG-SRNLKDSM-YLNTQDFLEAISEQLERTW
KK--------
