>gi|115762659|ref|XP_780045.2|	Strongylocentrotus purpuratus
--------------------MTSIIKLTPFSGVLDESPPCYMLQVDEFRFLLDCGWD--E
HFTMENIEGLKKH-IHQVDAVLLSYPDNLHLGALPYL----VGKCNLTCPIYATVPVYKM
GQMFMYDLYQSKHNYE--------EFD--LFNLDDVDAAFDRIIQLKYSQSVTLKGK---
---------------------GHGLTITPLSGGHMIGGTIWKIVKDGEEEIIYAVDYNHK
KERHLNGAVL--------ETISRPSLLITDCFNATYVQARRRARDEKLMDIILNTMRNEG
NVLISVDTAGRVVELSLLLDQL-WRNQDSGLGN-YNLAMLNNVSYNVVEFAKSQVEWMSD
KVMRAFEDR------------RN-NPFQFKHLKLCHNLKELAKVP-DPKVVLASVPDLEC
GYSRELFIQWSGDAKNSVILT----NRT-SHGTLARRL-------------IETPNP---
-NQLKLRVSKRVKLEKEELDEYRIHEKEKERQRKVDEAAQRLEG----------------
-------------------------DSSDESEEEME--VD--------------------
---DMGRSRTK--H-DLMMNTDTGK---------KGTSFFKTVKKS-YPMFPFHEERLRW
DDYGEVI-----------KPEDYMIKETVQ-------------------------TEEEK
E------VKVGSGQRTGKK----------------------KIDK-DQCDIPTKCIAS--
---QI----IVDVK-CSITFIDFEGRSDGESMKKLITQVKPRQLVLVRGQMNATQHLAEY
CHLQLAG-VKVFIPRMNEICDATMESHIYQVKLKDSLVSSLLFSKTR--DTELSWIDGCL
DLQSAGDKLAGKAIKGSDSSPNGDEKSFG------------------------------D
EKKKTPGLGLGNESEDSSDDEDDIIPVLDAVQTNE--VTPHRQVYVNPPR---FLDFKQV
LAKNG-IRAE------------------------FTG--GVL-VCNNTVAIKRNEKGHLT
L--EG-----AVCDDYYTVREL---------LYEQYAIV---------------------
-------------
>gi|114654445|ref|XP_001147204.	Pan troglodytes
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDIEED--ID--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------------------------------------------------
------------------------------------------------------------
-------------K-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VEAPSDSSV
IAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|91094147|ref|XP_969300.1|	Tribolium castaneum
MSNKRKPDSQV------PAEESDLLTIRPLGAGQEVGRSCIMLEFKGKKIMLDCGIH-PG
LSGMDALPFVDLIEADEIDLLLISHFHLDHCGALPWF----LQKTSFKGRCFMTHATKAI
YRWLLSDYVKVSNIAT--------EQM--LYTEADLEASMDKIETINFHEEKD-------
---------------------VLGIKFWAYNAGHVLGAAMFMIEIAGVK-ILYTGDFSRQ
EDRHLMAAEI--------PTVH-PDVLITESTYGTHIHEKREERESRFTNLVHDIVNRGG
RCLIPVFALGRAQELLLILDEY-WSQHPD-LHD-IPIYYASSLAKKCMAVYQTYINAMND
KIKRQIA--------------IN-NPFVFKHISNLKGIDHFEDI--GPCVIMASPGMLQN
GLSRELFESWCTDAKNGVIIA----GYC-VEGTPAKTI-------------LSEPEE---
----------ITTMVGQKL-------PLKMS---VDYISFSAHT----------------
-------------------------DYQQTSEFIRILKPPH-------------------
---VVLVHGEQ--NEMNRLKAALQREYEDDPN--TTIHLHTPRNTH-AVELYFRGEKTA-
KVMGSLA---------VEKP--------------------------------------KP
G-------NVLSGVLVKRN---------------FNYHLLAANDLPKYTDMSMSQIMQ--
---RQ----SIHYS-GNVGVLRHLLTQVAGLLEPVEGDKKTRAFNA--------------
I----------------------------DITIENKIVT-LEWVANPV-NDMYADAIVAA
ILQADLLD----------------------------------------------------
----------------------------TPIKNLSTSVKVDRMHFKECL----IEMLQDM
FGEDS-VPKM------------------------FKGEKLYV-TVNDKKADIDLSTLEVT
CPEDE-----TFRQIVETAVSK---------LYQSLAPPQI-------------------
-------------
>gi|67969643|dbj|BAE01170.1|	Macaca fascicularis
-------------MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIH-PG
LEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWF----LQKTSFKGRTFMTHATKAI
YRWLLSDYVKVSNISA--------DDM--LYTETDLEESMDKIETINFHEVKE-------
---------------------VAGIKFWCYHAGHVLGAAMFMIEIAGVK-LLYTGDFSRQ
EDRHLMAAEI--------PNIK-PDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGG
RGLIPVFALGRAQELLLILDEY-WQNHPE-LHD-IPIYYASSLAKKCMAVYQTYVNAMND
KIRKQIN--------------IN-NPFVFKHISNLKSMDHFDDI--GPSVVMASPGMMQS
GLSRELFESWCTDKRNGVIIA----GYC-VEGTLAKHI-------------MSEPEE---
----------ITTMSGQKL-------PLKMS---VDYISFSAHT----------------
-------------------------DYQQTSEFIRALKPPH-------------------
---VILVHGEQ--NEMARLKAALIREYEDNDE--VHIEVHNPRNTE-AVTLNFRGEKLA-
KVMGFLA---------DKKP-----------------------------------EQGQR
V----------SGILVKRN---------------FNYHILSPCDLSNYTDLAMSTVKQ--
---TQ----AIPYT-GPFNLLYYQLQKLTGDVEELEIQEKP------------ALKVFKN
ITV-----------------------------IQEPGMVVLEWLANPS-NDMYADTVTTV
ILEVQSNP----------------------------------------------------
-------KIRKGAVQK---------------------VSKKLEMHVYSKR---LEIMLQD
IFGEDCISVK-------------------------DDSILSV-TVDGKTANLNLETRTVE
CE-EGGEDDESLREMVELAAQR---------LYEALTPVH--------------------
-------------
>gi|157018137|gb|EAA08192.4|	Anopheles gambiae
--------------------MTSIIKMHAISGAMDESPPCYILQVDDVRILLDCGWD--E
KFDQGFIKEIKKY-VHTIDAVLLSYPDGSHLGALPYL----VGKLGLNCPIYATIPVYKM
GQMFMYDMFMSHYNMH--------DFD--LFSLDDVDAAFDKIVQLKYNQSVAMKGK---
---------------------GYGITITPLPAGHLIGGTIWKIVKVGEEDIVYATDFNHK
KERHLNGCEL--------EKLQRPSLLITDAYNARYQQARRRARDEKFMTNILQTLRNNG
NVLVTVDTAGRVLELAHMLDQL-WKNKESGLMA-YSLALLNNQSYNVVEFAKSQIEWMSD
KLMKSFEGA------------RN-NPFTFKHLRLCHTMADLAKVP-SPKVVLASSPDLES
GFSRELFIQWAPNASNSIIIT----SRS-SPGTLARDL-------------IENGGN---
GRKIEMDIRRRVELEGAELEEYMRTEGEKLN---RSIKKRDLD-----------------
-------------------------ESSSDSDDELE------------------------
----MNVITGK--H-DIVVRPEGRS---------HT-GFFKSSKKN-YAMFPFHEEKIKY
DEYGEII-----------QPDDYRMVDLGPET-----------------------NGGDD
N-------KENGGIKTEDI-------------------KKEKEDEVTVLDKPTKCVQS--
---RK----PIEVN-AQVQFIDFEGRSDGESLLKILSQLRPRRVVVVRGSPANTSHIAEH
CQQNIG--ARVFTPNRGEIIDATTETHIYQVRLTEALVSQLEFQKGK--DAEVAWVDAQI
VIRNKRID----------------------------------------------------
-------TMEVDDVDTIDDKMDKQILTLEPLAQED--LPPHNPVFINELK---LIDFKQI
LMKSN-IASE------------------------FSG--GVLWCSNGTVALRRVDTGRVT
I--EG-----CISEDYYKIREL---------LYEQYAII---------------------
-------------
>gi|28461235|ref|NP_787002.1|	Bos taurus
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KVTEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDAEED--ID--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCIST--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDAPSDSSV
IAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|150865856|ref|XP_001385241.	Pichia stipitis
-----------MNTENQDQDESESFKFFGLGGCNEVGRSCHIIEYKNKVIMLDAGVH-PA
LTGHSSFPFYDEYDLSKVDILLISHFHLDHAASLPYV----MQHTTFKGRVFMTHATKAI
YRWLLQDFVRVTSIGAGSRAEGSDETSTNLYTDDDIISSFDRIETIDYHSTME-------
---------------------IDGIRFTAYHAGHVLGACMYFVEIGGLK-VLFTGDYSRE
ENRHLHAAEV--------PP-TRPDILITESTFGTGTLEPKADLEKRLVQNIHATLTKGG
RVLMPVFSLGNAQELLLILDEY-WEKNED-LQN-ISVFFASKLARKCMAVYQTYTSIMND
NIR--LSSRIGQ---------KS-SPFDFKYIKSIKDLGKFSDM--GPSVVVASPGMLQA
GVSRQLLEKWAPDPKNLVVMT----GYS-VEGTMAKDL-------------LNEPHTIKS
AVNPDITIPRRINVS---------------------EISFAAHV----------------
-------------------------DFQQNSEFIEKVAPSK-------------------
---IILVHGDS--VPMGRLKSALLSKYSARKGTEQEVKVFNPKNCE-PLKIPIKGLRVAA
RVLGTLA-----------EEQLHLLKAEIENKVAESNLKIEELDDEENEKMEIGQPKEEG
K-------EDDSKVKEGEDTKTENEDPDAFKTGQLMSGVLVSMDF-DLDLLQLQDLHE--
---YT----QLSTS-IVKSKMSLKINADITLMKWHLEQM-FGFINIVNDDEDEWECIIMD
M-------IDLLVDRSK----------------TDSLYITLEWINDNLMSDSMADSVIAI
LYSIDSSP----------------------------------------------------
---------ASVKLSSRSHNHNHDNIEKESTPPTKKSAHANSEISSRIHR---ISSLLKA
QFGDS-LNN-------------------------LEDNKAVI-TIGKNEAKINYLDLTVD
CG-SR-----VLRDRIENIIKRGCGLAAPLSQYQEVYKI---------------------
-------------
>gi|126282070|ref|XP_001365385.	Monodelphis domestica
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQVDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDSKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKE-----ALIIQADI----------------
-------------------------DSSDESDVEED--ID--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEIINLSFYREIEEEDYENFLVPELQA-------------------------TEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCISA--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDTPSDASV
IAQQKAMKSLFGDDDKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNLVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|121700651|ref|XP_001268590.	Aspergillus clavatus
MAAKRKASAMN-AVDDEPVDPSDELAFYCLGGGNEVGRSCHIIQYKGKTVMLDAGMH-PA
KEGFSALPFFDEFDLSTVDILLISHFHVDHSSALPYV----LSKTNFKGRVFMTHATKAI
YKWLIQDNVRVSNTASSS------DQRTTLYTENDHLSTLPLIETIDFNTTHT-------
---------------------INSIRITPFPAGHVLGAAMFLVSIAGLN-ILFTGDYSRE
EDRHLIPAEV--------PKGIKIDVLITESTFGISTNPPRLEREAALMKAITGVLNRGG
RVLMPVFALGRAQELLLILEEY-WETHPD-LQK-IPIYYIGNTARRCMVVYQTYIGAMND
NIKRLFRQRMAEAEASGDKSASA-GPWDFRFVRSLRSLERFDDV--GGCVMLASPGMLQT
GTSRELLERWAPNERNGVVMT----GYS-VEGTMAKQL-------------LNEPDQIPA
VMSRAPGGLSRRGLASGDEEQ-KIMIPRRCT---VDEISFAAHV----------------
-------------------------DGVENRNFIEQVAAPV-------------------
---VILVHGEK--HQMMRLKSKLLSLNADK-T-VKV-KVYTPANCE-EVCIPFRKDKIA-
KVVGKLA--------------QLAAP-----------------------------SEQDD
G-------RLMSGVLVQNG---------------FNLSLMAPDDLREYAGLTTTTITC--
---KQ----HITLSSASMDLIKWALEGTFGAIEELGSS--DKALDKEASSKGDSSKDVNG
ELQTKEEPADEEIPMQDTQTYLVMGCVIIRYHARTREVE-LEW-EGNMMNDGVADAVMAV
LLTVESSP-ASVKQSAKLNHDHHHHGELE------------------------LPNPHSH
QGPEERFENLLMMLEAQFG--SDIAPIEQPRIPPQALTNGTTKEEAVKSESDAADETSAK
VKTED-KEDE--EDQKREEIEAAELARLEALGIPYPG--IEI-KVDKHVARVWLEDLEVE
CV-NP-----VLRDRVRMVIER---------AVETVASMWLEGPPSVPVANGTKSHK--E
TPIQKSAEIEAEA
>gi|47224566|emb|CAG03550.1|	Tetraodon nigroviridis
--------------------MTSIIKLTAVSGVQEESALCYLLQVDEFRFLLDCGWD--E
NFSMDIIDAMKRY-VHQVDAVLLSHPDPIHLGALPYA----VGKLGLNCTIYATIPVYKM
GQMFMYDLYQSRNNSE--------DFT--LFTLDDVDSAFDKIQQLKYSQIVSLKGKLAS
KRLFTWSKLPKYVMAFYATGKGHGLSITPLPAGHMIGGTIWKIVKDVTSTVAH---WR--
------------------ALVVLPYLSQTPSMQHMYNH----------------------
-----VASSGTRCSLI-------WRTKDAGLGV-YPLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLTLCHSLADLARVP-SPKVVLCSQPDLES
GFSRELFIQWSKDSKNSIILT----YRT-TPGTLARYL-------------IDNPGE---
-KHLDLEVRKRVRLEGRELEEYLEKDRIKKEAAKKLEQAKEVDV----------------
-------------------------DSSDESDMDDDDDLD--------------------
---QPTTVKSK--HHDLMMKSEGSR---------KG-SFFKQAKKS-YPMFPTHEERIKW
DEYGEII-----------RLEDFLVPELQA-------------------------TEEEK
S-------KLDSGLTNGDE----------------------PMDQ-DLSVLPTKCISN--
---VE----SLEIR-ARVTYIDYEGRSDGDSIKKIINQMKPRQLVIVHGPPEASLDLAES
CKAFS-KDIKVYTPKLQETIDATSETHIYQVRLKDSLVSSLQFCKAK--DTELAWIDGVL
DMRVVKVD-TGVMLEDG-VKEEAEDSELG----------------MEITPDLGIEASSIA
VAAHRAMKNLFGEEEKEVSEESDIIPTLEPLPTPE--VPGHQSVFINEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNMVAVRRTEAGRIS
L--EG-----CLCEDYYKIREL---------LYQQYAVV---------------------
-------------
>gi|47125306|gb|AAH70095.1|	Homo sapiens
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSG
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDIEED--ID--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCIST--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELRDDGEDSEMQ----------------------VEAPSDSSV
IAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|66508341|ref|XP_394940.2|	Apis mellifera
--------------------MTSIIKLHAVSGAMDESPPCYILQVDELRILLDCGWD--E
NFDQEFIRELKRH-VHQIDAVLLSYPDPLHLGALPYL----VGKCGLNCPIYATIPVYKM
GQMFMYDMYQSRHNME--------DFD--LFTLDDVDAAFDKIVQLKYNQSISMKGK---
---------------------GYGVTLTPLPAGHMIGGTIWKIVKVGEEDIIYAVDFNHK
KERHLNGCEL--------ERLQRPSLLITDAFNATYQQARRRTRDEKLMTNILQTLRGGG
NVLVSVDTAGRVLELAHMLDQL-WRNKESGLLA-YSLALLNNVSYNVVEFAKSQIEWMSD
KLMRSFEGA------------RN-NPFQFKHLQLCHSMAELNQVP-SPKVVLASTPDMEC
GFSRELFLQWCGNPQNSIILT----SRT-SPGTLARDL-------------VEKGGN---
-RNITLEVKRRIKLEGLELEEYQRKEKLKQE---QLKQEQMETA----------------
-------------------------DVSSESEDEIE------------------------
----VGGGRGK--H-DLLVKQE--S---------KP-GFFKQSKKQ-HPMFPFVEEKIKI
DEYGEII-----------RPEDYKIAETMPE------------------------VDDNK
E-------NLETKQEDTAH----------------------HPEI--PTDIPTKCIQV--
---TR----TMTVN-ASVTYIDFEGRSDGESLQKILAQLRPRRVVLVRGSQRDTEILAQQ
AQSAG---ARVFIPGRGETLDATTETHIYQVRLTDALVSGLNFSKGKG-DSEVAWVDAMI
TARDQICR----------------------------------------------------
-------DAVAGTESNDAIDQSDKILTLEPLPLNE--VPGHQTTFINELK---LSDFKQI
LNKSN-IPSE------------------------FSG--GVLWCCNNTIAVRRHEAGKVI
L--EG-----CISEDYYKVREL---------LYEQYAIV---------------------
-------------
>gi|109478568|ref|XP_216766.4|	Rattus norvegicus
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSVDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPFA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KVTEIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDVEED--VD--------------------
---QPTAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGEE----------------------PMDQ-DLSDVPTKCVSA--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDAPSDSSV
IAQQKAMKSLFGDDEKELGEESEVIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|6323144|ref|NP_013216.1|	Saccharomyces cerevisiae
--------------------MTYKYNCCDDGSGTTVGS---VVRFDNVTLLIDPGWNPSK
VSYEQCIKYWEKV-IPEIDVIILSQPTIECLGAHSLLYYNFTSHFISRIQVYATLPVINL
GRVSTIDSYASAGVIG--------PYDTNKLDLEDIEISFDHIVPLKYSQLVDLRSR---
---------------------YDGLTLLAYNAGVCPGGSIWCISTYSEK-LVYAKRWNHT
RDNILNAASILDATGKPLSTLMRPSAIITTLDRFGSSQPFKK-RSKIFKDTLKKGLSSDG
SVIIPVDMSGKFLDLFTQVHELLFESTKINAHTQVPVLILSYARGRTLTYAKSMLEWLSP
SLLKTWENR------------NNTSPFEIGSRIKIIAPNELSKYP-GSKICFVSEVG---
ALINEVIIKVGNSEKTTLILTK--PSFE-CASSLDKILEIVEQDERNWKTFPEDGKSFLC
DNYISIDTIKEEPLSKEETEAFKVQLKEKKRDRNKKILLVKRESKKLANGNAIIDDTNGE
RAMRNQDILVENVNGVPPIDHIMGGDEDDDEEEENDNLLNL-------------------
---LKDNSEKSAAKKNTEVPVDIII---------------QPSAASKHKMFPFNPAKIKK
DDYGTVV-----------DFTMFLPDDSDNVNQNSRKRPLKDGAKTTSPVN----EEDNK
N-------EEEDGYNMSDPISKRSKHRASRYSGFSGTGEAENFDNLDYLKI-DKTLSK--
---RTISTVNVQLK-CSVVILNLQSLVDQRSASIIWPSLKSRKIVLSAPKQIQNEEITAK
LIKKN---IEVVNMPLNKIVEFSTTIKTLDISIDSNLDNLLKWQRISD-SYTVATVVGRL
V-----------------------------------------------------------
-------KESLPQVNNHQKTASRSKLVLKPLHGSSR-SHKTGALSIGDVR---LAQLKKL
LTEKN-YIAE------------------------FKGE-GTL-VINEKVAVRKINDAETI
I--DG-----TPSELFDTVKKL---------VTDMLAKI---------------------
-------------
>gi|18029276|gb|AAL56454.1|	Oikopleura dioica
--------------------MTSIVKFQSLSGFDDEAPHCHLLQIDDFKFLLDCGWA--E
QHHEKIIDGLKRH-GRQIDAILISHPDLLHCGMLPY-----LSKLGITCPIYMTMPACKM
GQMFLYDFVLSRTAVE--------DFD--MFTLDDVDAVFDRATQLKHNQTEAVRGQ---
---------------------DYGIQIMPVQAGHMIGGTTWKIMKDEEEEYVYCVDVNHK
RETHLNGIQL--------DAFDKPTLMITDCSTYGYQQERRAKRTERLVQRIQNTTSKGG
NVLITTDTAGRSLEMALMLEGI-WNDERYGLGR-VNLVMVSNVATSTIEAAKGMIEWMSE
KIISKFTHK------------RE-NIFDLTKMKLRSSIQEIARIP-EPKVILATPMDMDT
GFSRELFVMMAAHPKNAVIMS----GRS-TKGSLCRKI-------------IENEGM---
-SSITLEMNKRLPLVGPELEEYEKQKEQERN----ANLIKRLEE----------------
-------------------------ESSDESENEMSETISV-------------------
---RKKTVKGKRTH-DIIMPHHVQK---------KEGGFFKKARKEKFPLFPFNENRIKW
DDYGEII-----------NPDDYKTHELIPESEPVNINNL---------------TENQQ
S---VTFGRHKPNDSRKKQ----------------------KEEPVEEEKAPTKCIKT--
---RE----QVSIR-CSIEFINFEGRVDGESQLQLLSTIKPKELILIRTKEKYKEKLFKD
IKSRVQG-IRIHMPVHHELIDATKESFIYQLKLKDSLLSNLNFVRVGSKDIEVARIRGRV
DYFGGRLE----------------------------------------------------
------LEAENGENDEPKKLEIDDIPTLQPVTNNY--SSGHDSIFINDTK---LTELKSN
LIDCG-MQAE------------------------FIG--GNL-VCNNKVSIKRSANGVIQ
V--EG-----TLSEDYFIVRKM---------VYDNYAIV---------------------
-------------
>gi|125774535|ref|XP_001358526.	Drosophila pseudoobscura
-------MSQATNDVRVPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIH-PG
LSGMDALPYVDLIEADEIDLLFISHFHLDHCGALPWF----LMKTSFKGRCFMTHATKAI
YRWMLSDYIKISNIST--------EQM--LYTEADLEASMEKIETINFHEERD-------
---------------------VMGVRFCAYNAGHVLGAAMFMIEIAGIK-ILYTGDFSRQ
EDRHLMAAEV--------PPMK-PDVLITESTYGTHIHEKREDRENRFTSLVQKTVLQGG
RCLIPVFALGRAQELLLILDEF-WSQNPE-LHE-IPIYYASSLAKKCMAVYQTYINAMND
RIRRQIA--------------VN-NPFVFRHISNLKGIDHFEDI--GPCVIMASPGMMQS
GLSRELFESWCTDPKNGVIIA----GYC-VEGTLAKTI-------------LSEPEE---
----------ITTLSGQKL-------PLNMS---VDYISFSAHT----------------
-------------------------DYQQTSEFIRLLRPTH-------------------
---VVLVHGEQ--NEMSRLKLALQREYEADAS--TDIKFYNPRNTH-AVDLYFRGEKTA-
KVMGNLA---------AKNP-----------------------------------EVGSK
L----------SGVLVKRD---------------FKYHLLAPSDLGKYTDMSMSVVTQ--
---RQ----SIPWT-SSLGTLELLLDRIGAGCVEVVE-------------PERKLRVFNC
IELTV-----------------------------EQKIIVMEWQATHV-NDVYADAVLAC
IMQSELGG----------------------------------------------------
-------TSLKGATKQTKSESSRFRECL-------------------------IETLQDT
FGDSC-VPKM------------------------FKGDLLPV-TVSGKRAEINLETLAVH
CAEDD-----ILRQMLNTTVHK---------LHQTLVSA---------------------
-------------
>gi|109084634|ref|XP_001092942.	Macaca mulatta
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDIEED--ID--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCIST--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDAPSDSSV
IAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|118088995|ref|XP_419942.2|	Gallus gallus
-MAKRKAEALI------PAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIH-PG
LEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWF----LQKTSFKGRTFMTHATKAI
YRWLLSDYVKVSNISA--------DDM--LYTETDLEESMDKIETINFHEVKE-------
---------------------VAGIKFWCYHAGHVLGAAMFMIEIAGVK-LLYTGDFSRQ
EDRHLMAAEI--------PNIK-PDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGG
RGLIPVFALGRAQELLLILDEY-WQNHPE-LHD-IPIYYASSLAKKCMAVYQTYVNAMND
KIRKQIN--------------IN-NPFVFKHISNLKSMDHFDDI--GPSVVMASPGMMQS
GLSRELFESWCTDKRNGVIIA----GYC-VEGTLAKHI-------------MSEPEE---
----------ITTMSGQKL-------PLKMS---VDYISFSAHT----------------
-------------------------DYQQTSEFIRALKPPH-------------------
---VILVHGEQ--NEMARLKAALIREYEDNDE--VHIEVHNPRNTE-AVTLNFRGEKLA-
KVMGSLA---------DKKP-----------------------------------EQGQR
I----------SGILVKRN---------------FNYHILSPCDLSNYTDLAMSTVTQ--
---TL----AIPYT-GPFNLLFYQLQKLTGDVEEIEIQQKP------------ALKVFKS
ITV-----------------------------IQEPGMVVLEWVANPA-NDMYADTVTTV
ILEVQSNP----------------------------------------------------
--------------------------KIQKAAVHK--VSTKVDMEEYRKR---MEMMLQD
MFGEDCVSSK-------------------------EGSILCV-TVDGKTANLSLETRTAD
CE-PGSEDDESLREMVELAAQR---------LYDALSPVYC-------------------
-------------
>gi|89267474|emb|CAJ83498.1|	Xenopus tropicalis
MSVKRKAESAI------PAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIH-PG
LEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWF----LQKTSFKGRTFMTHATKAI
YRWLLSDYVKVSNISA--------DDM--LYTETDLEESMDKIETINFHEVKE-------
---------------------VAGIKFWCYHAGHVLGAAMFMIEIAGVK-LLYTGDFSRQ
EDRHLMAAEI--------PNVK-PDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGG
RALIPVFALGRAQELLLILDEY-WQNHPE-LHD-IPIYYASSLAKKCMAVYQTYVNAMND
KIRKQIN--------------IN-NPFVFKHISNLKSMDHFDDI--GPSVVMASPGMMQS
GLSRELFESWCTDKRNGVIIA----GYC-VEGTLAKHI-------------MSEPEE---
----------IATMSGQKL-------PLKMS---VDYISFSAHT----------------
-------------------------DYQQTSEFVRALKPPH-------------------
---VILVHGEQ--NEMARLKAALIREYEDNDE--VEIEVHNPRNTE-AVTLNFRGEKLA-
KVMGLLA---------DKKP-----------------------------------EQGQR
I----------SGILVKRN---------------FNYHILCPSDLSSYTDLAMSTVTQ--
---KQ----AIPYT-GPFNLLSCQLQQLIGDVEEIEVNEK------------DALRVFKA
VTV-----------------------------VRDAGMVYLEWVANPA-NDMYADTVITV
ILELQS------------------------------------------------------
----------------------------NPKANKAVATRASKEVDMDAYRKRLEMMLQDI
FGDDC-VNCE------------------------DAG--SITVTVDGKSAILSMETRTVE
YE-EGIDEDETLREMVQQAAQR---------LYDALCPASL-------------------
-------------
>gi|50308971|ref|XP_454491.1|	Kluyveromyces lactis
--------------------MTYTIETCRDEKKRFEGT---IVRFNNVIVLLDPGWN-GE
GSYEECEEFWTQY-ISEVDIVLISQPTIECLGSYAMMFKQFLPHFRSRIQVYGTLPVSNL
GRVNSVDLLTSVGILG--------PFSNAVMDLEDIESSFDLIETVKYSQTVDLKNK---
---------------------FDGLSLEAHNSGYAPGGTIWTIITSSEK-ILYAPRWNHT
RDTILNSADLLDNTGNPTSSMMHPTSVITNLSIIGSAEPQRK-RVEHFTDTMKRAIQMNN
SLLVPVEVGGKLLEVLVLVNNFLYENMRGGLKYDIPVFLISYSRGRSLTYAKSMLEWLSS
QVIKTWESR------------DNRSPFDVVSRLRIITPEELGGYT-GQKICLVSEVD---
DILSQTINKLCSKDKVTIILTERHPNTP-AQHPLRKLNDKWQQAIKNGSRSALDGNPISI
SDSMSLRIMKRTILNKKDAEKVREMIKTRNEVREKIIEEYTAKTNDKAQTKTILF-----
-------------------------DVDDESSDEEG--VDS-------------------
---MDARGKNGSGNVKVEIPVDITS---------ND-SVSTNEK---HLMFPFHPAKLKS
DDYGDVV-----------NLKRFLPQEESYDQAQSLKQSYSNNDYD---------EDDDD
DTYEVLDSRINKSKKRKTD---------------HNPRKQENNDDISYLDPLKSDIYK--
---RAIVETKVNIR-CSLVYIDLTSIVNARSIAIIWPAIKPRKVIVLPSAAPVDNQVVVN
LTKRN---IDILVTEFNNSVEMDTSVKAIDISIDPSLDQLLNWQRISK-SFTVAHVVGKL
L-----------------------------------------------------------
-------------TETDPKAPHREKVILKPLSNPLA-LHSGSSLRIGDVR---LPELKRR
LTAEN-HKAE------------------------FQGE-GTL-VIDGKVLVRKINDAETI
V--DG-----SPSDVFYKVKSA---------VSDMLANV---------------------
-------------
>gi|19173576|ref|NP_597379.1|	Encephalitozoon cuniculi
-------------------MSSSFVSLTPLIK-TETGVYCHMLEIDNTKILVNCGAP--Y
AMDMSMYTPVLPQ-ILSCDAILLTSFNINCIGGLPY-----VLRNNYYNKVFSSVPIKVL
GKICLDEHLRGMGLES--------SVD---------TGCFERISEIKYSQPTA-------
---------------------VNNVEICAYNSGNSIGGCLYKISK-GPERIIVGFNVNHR
KENHLDGMSF--------SGIGDCSLCVFNGNHVLAENISIAKRDDVFRDMVGGALDSGR
KVVLPVKYS-RFLEVALILNGL-MAQRNGKIAC------LSYFGQRFVERAKSMIEWAGE
KVSSMFSEE------------KV-NPFEFERIEFMKYYQDVSRFD----VVVVVDECVHG
AMLTTTLHEF-NDEDNVILLI---------------------------------------
----DPRMDEILRRESGAMKWYNFRLVEKASEKKGMDGDEVLED----------------
-------------------------SVGDGSDVE--------------------------
---GVETHWSEVRH-EIWCEDE-------------------------DEVFPSVARRRAY
DDYGEYM-----------DRSLFVKEILPV-------------------------EEVSE
E-------EIEEETTIEER---------------------------EVGGE---------
---------GITLR-YRVEKVDLVGISDLSSCKMIIETLSPRKLVCV-GEDGDTERFFYH
TFKYLPCFEDVYMCRSKIILSSDVSMGM--VKLDKGFDA-LNYRAIG--TDSVASFRGVR
D-----------------------------------------------------------
-----------GDMVRCIGEGPRM-------------VIGHAD----------INEMRRM
IVEGS-MRVE-------------------------QEENGLL--VEDCVWIRVSGDG-VT
I--DG-----RDSGVFYAVRDV---------VYRSSAFI---------------------
-------------
>gi|73962299|ref|XP_848582.1|	Canis familiaris
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKD-------------------
----------------------------DESDVEED--ID--------------------
---QPSAHKMK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCIST--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDAPSDSSV
IAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|70996586|ref|XP_753048.1|	Aspergillus fumigatus
MATKRKASALNAAVDDEPVDPSDELAFYCLGGGNEVGRSCHIIQYKGKTVMLDAGMH-PA
KEGFSALPFFDEFDLSTVDILLISHFHVDHSSALPYV----LSKTNFKGRVFMTHATKAI
YKWLIQDNVRVSNTASSS------DQRTTLYTEHDHLSTLPLIETIDFNTTHT-------
---------------------VNSIRITPFPAGHVLGAAMFLISIAGLN-ILFTGDYSRE
EDRHLIPAEV--------PKGIKIDVLITESTFGISTNPPRLEREAALMKSITGILNRGG
RVLMPVFALGRAQELLLILDEY-WETHPE-LQK-IPIYYIGNTARRCMVVYQTYIGAMND
NIKRLFRQRMAEAEASGDKSASA-GPWDFKFVRSLRSLERFDDV--GGCVMLASPGMLQT
GTSRELLERWAPNERNGVVMT----GYS-VEGTMAKQL-------------LNEPEQIPA
VMSRSAGGVSRRGLAGTDEEQ-KIMIPRRCT---VDEISFAAHV----------------
-------------------------DGVENRNFIEEVAAPV-------------------
---VILVHGEK--HQMMRLKSKLLSLNADK--AVKV-KVYTPANCD-EVRIPFRKDKIA-
KVVGKLA---------QVAPP----------------------------------SDQDD
G-------RLMSGVLVQNG---------------FDLSLMAPDDLREYAGLTTTTITC--
---KQ----HITLSSASMDLIRWALEGTFGAIEELGSNERSKV-------KEESTKAVNG
EQEIKEEPADEEIPMEETQTYLVMGCVLIRYHSRTREVE-LEW-EGNMMNDGVADAVMAV
LLTVESSP-ASVKQSAKLKHHHHHHSDLE------------------------LPNPHAH
QGPEETFENLLMMLEAQFG--SNIAPIERPRIPSG--IRANRTTKADPSV---SAAVKTK
SDAAGETPAESQEDESTEEIEAAELARLQALGIPYPG--IEI-KVDKHVARVWLENFEVE
CA-NT-----VLRDRVRVVIER---------AVETVSSMWGEGHPAARASNGTQGNK--E
VAVSKSNEIEARA
>gi|21358013|ref|NP_651658.1|	Drosophila melanogaster
--------------------MTSIIKLHTISGAMDESPPCYILQIDDVRILLDCGWD--E
KFDANFIKELKRQ-VHTLDAVLLSHPDAYHLGALPYL----VGKLGLNCPIYATIPVFKM
GQMFMYDLYMSHFNMG--------DFD--LFSLDDVDTAFEKITQLKYNQTVSLKDK---
---------------------GYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHK
KERHLSGCEL--------DRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNG
NVLIAVDTAGRVLELAHMLDQL-WKNKESGLMA-YSLALLNNVSYNVIEFAKSQIEWMSD
KLTKAFEGA------------RN-NPFQFKHIQLCHSLADVYKLPAGPKVVLASTPDLES
GFTRDLFVQWASNANNSIILT----TRT-SPGTLAMEL-------------VENCAP---
GKQIELDVRRRVDLEGAELEEYLRTQGEKLN---PLIVKPDVEE----------------
-------------------------ESSSESEDDIE------------------------
----MSVITGK--H-DIVVRPEGRH---------HS-GFFKSNKRH-HVMFPYHEEKVKC
DEYGEII-----------NLDDYRIADATGYEFVPM-------------------EEQNK
E----NVKKEEPGIGAEQQ----------------ANGGIVDNDV-QLLEKPTKLISQ--
---RK----TIEVN-AQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARH
CEQNVG--ARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGK--DAEVAWVDGRL
GMRVKAIE----------------------------------------------------
-------APMDVTVEQDASVQEGKTLTLETLADDE--IPIHNSVLINELK---LSDFKQT
LMRNN-INSE------------------------FSG--GVLWCSNGTLALRRVDAGKVA
M--EG-----CLSEEYYKIREL---------LYEQYAIV---------------------
-------------
>gi|156551217|ref|XP_001601407.	Nasonia vitripennis
--------------------MTSIIKLHAISGALDESPPCYILQVDELRILLDCGWD--E
KFDPDFIKELKRH-VHQIDAVLLSYPDPLHLGALPYL----VGKCGLSCPIYATIPVYKM
GQMFMYDIYQSRHNME--------DFN--LFTLDDVDAAFDKIVQLKYNQSISMKGK---
---------------------GYGVTLTPLPAGHMIGGTIWKIVKVGEEDIIYAVDFNHK
KERHLNGCEL--------ERLQRPSLLITDSFNATYQQARRRTRDEKLMTNILQTLRGGG
NVLVGVDTAGRVLELAHMLDQL-WRNKESGLLA-YSLALLNNVSYNVVEFAKSQIEWMSD
KLMKSFEGA------------RN-NPFQFKHLQLCHSMAELNQVP-SPKVVLASTPDMEC
GFSRDLFLQWCSNPQNSIIIT----SRT-SPGTLARDL-------------VENGGN---
-RNITLEIKKKVRLEGAELEEYMKKEKVKQE---QLKQEKMETA----------------
-------------------------DVSSESEDEIE------------------------
----VGGAKGK--H-DLLVKQE--H---------KP-GFFKQSKKQ-HPMFPFVEEKIKV
DEYGEII-----------KPEDYKIAEVL--------------------------PEAED
N-------KENIEVKQEEQ-------------------VQHPAE--TMSDIPTKCVQT--
---TR----TIAVN-ASVTYIDFEGRSDGESLQKILAQLRPRRIVLVRGSPKDTELLAAQ
ARNVG---ARVFIPSRGETLDATTETHIYQVRLTDALVSGLNFSRGKG-DSEVAWVDALI
TARDQVCR----------------------------------------------------
-------DVFMDNENEDLIDRTEKILTLEPLPLNE--VXXXQTTFINELK---LSDFKQI
LTKAN-IPSE------------------------FSG--GVLWCCNNTIAVRRHEAGKII
M--EG-----CLSEDYYRVKEL---------LYEQYAIV---------------------
-------------
>gi|45200915|ref|NP_986485.1|	Ashbya gossypii
--------------------MTYTFTYCKDESGSTTGT---ILSFDNCTLLIDPGWS-GG
CSYDECMAYWKEW-IPQVDIILLSQPIQECIGAYAALFFDYISHFNSRIQVYSTLPVANL
GRVATVDLYASLGIIG--------PFDTNRIDIEDIDTAFDHLNTVKYSQLVDLKSR---
---------------------FDGLSLVAYSSGFAPGGTIWCANTYSEK-VLYAPRWNHT
RDTILNSADLLDKGGKPSTALMRPSAVIMSAAHVGPSTPYRK-RSQKFKEVIKKALSANT
SVILPSAIGGKFLELFVLVHDILHENKKSGLQADAPVLLLSYSRGRTLTYARSMLEWLSS
QLVKTWESR------------DNKSPFDLGNRLKIVNVNDLANYP-GTKICFISQVE---
TLINDALSKVCTKEKAMLVLTEKPTYYSHTIAILAKAYAKWERALNSNNLNAVEGNPIAY
SESLSLQFSKTKPLTGSDLEEFKERIEARRKERAELLSSFQSNDNPAGASAFT-------
-------------------------AIEDDDDEEED------------------------
---VLRPHGAGALSTKVEIPTDLII---------------QPNALPKHKMFPFQPGKVAH
DDYGELV-----------DFERFLPQSAPSSAKRGATN-----------------EEDEE
SYDPHDFRDIRTNDSGGKR------RRREQD---ALQRQMNQDNL-SYLDTLTKPQHR--
---TSNTQ-KVVIR-CTMAFVDLAGLVDERSMSIIWPALKPRKMVLLPSDAASVSPVAQQ
LQKKG---LDVIEPELNKSLVINTSLRSLDIFIDAEMDQMLNWQRISE-VYTVAHVVGRL
T-----------------------------------------------------------
-------------KEKDTKVSHRDKWVLKPLPNASARMQTTDSLRIGDVR---LAELKRK
LTAAS-HVAE------------------------FRGE-GTL-VVDGRVIVRKISESETV
V--DG-----TPSDLFYKVKSA---------VADMLAKV---------------------
-------------
>gi|149531954|ref|XP_001507374.	Ornithorhynchus anatinus
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLKKH-VHQVDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDVEED--ID--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------AEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCIST--
---TE----SLEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEESEMQ----------------------VDPPSDSST
LAQQKAMKSLFGDDDKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNLVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|149737455|ref|XP_001497134.	Equus caballus
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDVEED--ID--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCIST--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDAPSDSSV
LAQQKAMKSLFGDDEKDTGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|83765848|dbj|BAE55991.1|	Aspergillus oryzae
MATKRKASALNASVDDEPVDPSDELGFYCLGGGNEVGRSCHIIQYKGKTVMLDAGMH-PA
KEGFSALPFFDEFDLSTVDILLISHFHVDHSSALPYV----LSKTNFKGRVFMTHATKAI
YKWLIQDNVRVSNTASSS------DQRTTLYTEHDHLSTLPLIETIDFNTTHT-------
---------------------INSIRITPFPAGHVLGAAMFLISIAGLN-ILFTGDYSRE
EDRHLIPAEV--------PKGIKIDVLITESTFGISSNPPRLEREAALMKSITGVLNRGG
RVLMPVFALGRAQELLLILDEY-WEKHPE-LQK-VPIYYIGNTARRCMVVYQTYIGAMND
NIKRLFRQRMAEAEASGDKSISA-GPWDFRFVRSLRSLERFDDV--GGCVMLASPGMLQT
GTSRELLERWAPNERNGVVMT----GYS-VEGTMAKQL-------------LNEPEQIPA
VMSRAASGLARR---GGNDEEQKVMIPRRCT---VDEISFAAHV----------------
-------------------------DGVENRNFIEEVSAPV-------------------
---VILVHGEK--HQMMRLKSKLLSLNAEKT--VKV-KVYTPANCE-EVRIPFKKDKIA-
KVVGKLA---------QIAPP----------------------------------SEQDD
G-------HLMAGVLVQNG---------------FNLSLMAPDDLREYAGLTTTTITC--
---KQ----HITLSSASMDLIKWALEGTFGAIEEIGPKTDVKEELV------ENEKVSKE
ISKLKEEAADEEIPIENEQAYLVMGCVVIRYFPRTREVE-LEW-EGNMMNDGVADAVMAV
LLTVESSP-ASVKQSAKQKHHHHHHQDTL-----------------------ELPNPHSQ
LGSEERFARLLMMLEAQFG--SDISPIERPRLPTTQLTNGAAKNETSAQ----LSAAEQT
LKEEEEDDDE-----SLAELEAAELARLHALGIPVPG--IEI-RVDKHIARVWLEDLEVE
CA-NA-----VMRDRVRVVIER---------AVETVASMWAEGPPPATVTNGETKEKLKD
VLASNGAEIDATA
>gi|50539828|ref|NP_001002384.1	Danio rerio
--------------------MTSIIKLTALSGVQEESALCYLLQVDEFRFLLDCGWD--E
TFSMDIIDSLKRY-VHQVDAVLLSHPDHVHLGALPYA----VGKLGLNCTIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDSAFDKIQQLKYSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIIYGVDFNHK
REIHLNGCSL--------ESLSRPSLLITDSFNASYVQPRRKQRDEQLLTNVMETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHSLSDLARVP-SPKVVLCSQPDLES
GFSRELFIQWCQDAKNSVILT----YRT-TPGTLARYL-------------IDNPGE---
-KRIELEIRKRCRLEGRELEEYMEKERMKKEAAKKLEQAKEVDL----------------
-------------------------DSSDESDMEDD--LE--------------------
---QPAVVKTK--HHDLMMKGEGGR---------KG-GFFKQAKKS-YSMFPTHEERIKW
DEYGEII-----------RPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGEE----------------------PMEQ-DLSDVPTKCTST--
---TQ----TLDIR-ARVMYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPDASQDLAES
CKAYSGKDIKVYIPKLQETVDATSETHIYQVRLKDSLVSSLQFCKAR--DTELAWIDGVL
DMRVEKVD-TGVIVELGEAKDEAEEGGEQGM--------------EVTEELNTEP-STAA
AANQRAMKTLFGEDEKEISEESDVIPTLEPLPAHE--VPGHQSVFINEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNLVAVRRTEAGRIC
L--EG-----CHCDDYYRIREL---------LYEQYAVV---------------------
-------------
>gi|147901518|ref|NP_001081123.	Xenopus laevis
--------------------MTSIIKLTTLVGAQEESAVCYLLQVDEFRFLLDCGWD--E
NFSMDIIDSVKKY-VHQVDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFS--LFSLDDVDCAFDKIQQLKYNQIVHLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMINRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLTLCHGYSDLARVP-SPKVVLASQPDLEC
GFSRELFIQWCQDPKNSVILT----YRT-TPGTLARFL-------------IDHPSE---
-RIIDIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADL----------------
-------------------------DSSDDSDVEED--ID--------------------
---QITSHKAK--H-DLMMKNEGSR---------KG-SFFKQAKKS-YPMFPAPEDRIKW
DEYGEII-----------KPEDFLVPELQV-------------------------TEDEK
T-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCVST--
---TE----SMEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPDATQDLAEA
CRAFGGKDIKVYTPKLHETVDATSETHIYQVRLKDSLVSSLKFCKAK--DTELAWIDGVL
DMRVSKVD-TGVILEERELKDEGEDMEMQ---------------------VDTQVMDAST
IAQQKVIKSLFGDDDKEFSEESEIIPTLEPLPSNE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IHAE------------------------FVG--GVL-VCNNMVAVRRTETGRIG
L--EG-----CLCEDFFKIREL---------LYEQYAIV---------------------
-------------
>gi|73962293|ref|XP_537353.2|	Canis familiaris
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSMDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPYA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPSE---
-KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDVEED--ID--------------------
---QPSAHKMK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGDE----------------------PMDQ-DLSDVPTKCIST--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDAPSDSSV
IAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|8393762|ref|NP_058552.1|	Mus musculus
--------------------MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWD--E
HFSVDIIDSLRKH-VHQIDAVLLSHPDPLHLGALPFA----VGKLGLNCAIYATIPVYKM
GQMFMYDLYQSRHNTE--------DFT--LFTLDDVDAAFDKIQQLKFSQIVNLKGK---
---------------------GHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHK
REIHLNGCSL--------EMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDG
NVLIAVDTAGRVLELAQLLDQI-WRTKDAGLGV-YSLALLNNVSYNVVEFSKSQVEWMSD
KLMRCFEDK------------RN-NPFQFRHLSLCHGLSDLARVP-SPKVVLASQPDLEC
GFSRDLFIQWCQDPKNSIILT----YRT-TPGTLARFL-------------IDNPTE---
-KVTEIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADI----------------
-------------------------DSSDESDVEED--VD--------------------
---QPSAHKTK--H-DLMMKGEGSR---------KG-SFFKQAKKS-YPMFPAPEERIKW
DEYGEII-----------KPEDFLVPELQA-------------------------TEEEK
S-------KLESGLTNGEE----------------------PMDQ-DLSDVPTKCVSA--
---TE----SIEIK-ARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAEC
CRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK--DAELAWIDGVL
DMRVSKVD-TGVILEEGELKDDGEDSEMQ----------------------VDAPSDSSA
MAQQKAMKSLFGEDEKELGEETEIIPTLEPLPPHE--VPGHQSVFMNEPR---LSDFKQV
LLREG-IQAE------------------------FVG--GVL-VCNNQVAVRRTETGRIG
L--EG-----CLCQDFYRIRDL---------LYEQYAIV---------------------
-------------
>gi|157112944|ref|XP_001657690.	Aedes aegypti
--------------------MTSIIKLHAISGAMDESPPCYILQVDEVRFLLDCGWD--E
KFDPNFIKELKKY-VHTIDAVLLSYPDGLHLGALPYL----VGKLGLNCPIYATIPVYKM
GQMFMYDLFMSHYNMY--------DFD--LFTLDDVDAAFDRIIQLKYNQSVSLKGK---
---------------------GYGITITPLPAGHLIGGTIWKVMKVGEEDIVYATDFNHK
KERHLNGCEL--------EKLQRPSLLITDAYNAKYQQARRRARDEKFMTNILQTLRNNG
NVLVTVDTAGRVLELAHMLDQL-WKNKESGLMA-YSLALLNNVSYNVVEFAKSQIEWMSD
KLMKSFEGA------------RN-NPFQFKHLRLCHTMAELAKVP-SPKVVLASSADMES
GFSRELFVQWASNVNNSIIIT----CRS-SPGTLARDL-------------IENGGN---
GRKIELDVRRRVELEGAELEEYMRTEGEKHN---RSIIKSDMDL----------------
-------------------------DSSSDSDDELE------------------------
----MSVITGK--H-DIVVRPEGRS---------HT-GFFKSSKKQ-YAMFPFHEEKIKF
DEYGEII-----------QPDDYKMIDLGPDGGF---------------------EDNKE
N-------QIKPEDIKKEK----------------------DEEL-SVLDKPTKCISS--
---RK----LVEVN-AQVQFIDFEGRSDGESMLKILSQLRPRRVVVIRGSPQNTAHIAEH
CQLNIG--ARVFTPNRGEIIDATTETHIYQVRLTEALISQLEFQKGK--DAEVAWIDAQI
VIPAASDT----------------------------------------------------
-------PMDVDQVEGNDDKSDRQILTLEPMKNDE--LPAHHSVFINELK---LIDFKQV
LMKAN-ISSE------------------------FSG--GVLWCNNGTVALRRVDTGKVT
V--EG-----CLSEEYYKIREL---------LYEQYAIV---------------------
-------------
>gi|50286175|ref|XP_445516.1|	Candida glabrata
--------------------MTYSFKCCDDGSGIASGS---ILRFDNVTILLDPGWSSYK
VSYEDSVAFWSNI-IAEVDIILISQPTTECLGAYTFLYYNFISHFISHIQVYATLPVANL
GRVSTIEFYVTKGIIG--------PYQTNQLDIDDVEKAFDFIDVLKYSQLVDLRSK---
---------------------YDGLSLFAYNSGYAPGGAIWCITTYSEK-LIYAPRWNHT
RDTILNAANLLDNTGKPLSSLMRPSAIVTNFDHFGSSQPFRK-RAKSFKDILKTKLSNNG
NILIPVDIGGKFLDLFVLVHDFLYENGRNNKLANIPIVLLSYTKARSLTYAKSMTEWFSS
ISAKTWENR------------NQKTAFDLDTPFSVVDSNELANLK-GPKICFVSNVE---
TLVNDALSILGSDNNTLLVLTT--DNRQEVPALHTIYD---YWKENNTESSIESANVLKL
NQKITINTTTFKELQNEELDAYLSKLEQRKRKQLITEITTRKGL-KKGAAVALPTNLASD
EGQKTEVDLVDDITNTEDLEKLLEEEEEDEDEDNEDNLINI-------------------
---LEDEDRAD--GIEESIPVDIII---------------TPGVNNKHKIFPFQPLRQKK
DDYGIVV-----------KFDQFVPAEDKDDITPSKRHIN---------------GDNEE
DMDDDYVIKEASNKKIKSD------------------SVNQPTKETKFSDDINHLRNSNR
PGIREFKATEVNLN-MSLTFINMESLVDRRSCGVIWPLFKSRKLILMGPSNVQDKHVTGI
ITSKT---MEVTSLAYNQSIDFDTTIKALDITISPELDALLKWQRISN-DYTLAHVTGRL
VKESAHQS----------------------------------------------------
---------SAVPVTDNTTSSGREKYVLKPLNGNVG-VQTNGSLAIGDVR---LIKLKQN
LNATN-HTAE------------------------FKGE-GIL-VVDDKVIIRKISDSETI
I--DG-----PPSALFYSVKKL---------VMDMLAKI---------------------
-------------
