>gi|5174511|ref|NP_005892.1|	Homo sapiens
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSAGGSGGAG-GGEQNGQEEKWCEKAVKSLVKKLKK-TGRLDELEKAITTQNCNTKCV
TIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELKAIENCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTHSIPENTNFPAGI------------------------------------------
-------------------------EPQSNY-----------------------------
-IPETPPPGYISED--GETSDQQLNQS-MDTGSPA--ELSPTTLSPVNHS------LDLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|47230677|emb|CAF99870.1|	Tetraodon nigroviridis
-------------------------------------------MSILP-FTPPIVKRLLG
WKK----------G-EQNGQEEKWCEKAVKSLVKKLKK-TGQLDELEKAITTQNINTKCI
TIPRLRHPKWTLDAPELELQHKQTRV------SGS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLQSHHELRAVELCEYAFHTKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEIP----------------SEFP----------------------V
LDDYSHSIPENTNFPAGI------------------------------------------
-------------------------EPHSNY-----------------------------
-IPETPPPGYLSED--GETSDHQMTHS-MDTSSPN---LSPNPVSPTHSN------LDLQ
PVTYCEPAFWCSISYYELNQRVGEIFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNSAVELTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAASAGAVGQPGLRGRVPAHQDVHHPHELRQRLGSRVQVSGSVSAG
QPLGPQKQNSPCNIRRVTPRPFPSEAFCVNTDNLNKRNSDSLIVRKKGDGIKVELKVGPA
LEGFLPRGNLCELVSRLDPDLRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSV
S---
>gi|109120486|ref|XP_001084638.	Macaca mulatta
------------------------------------MHSTTPISSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEFPFGSKQ-KEVCINPYHYRRVE----------TP-------
-VLPP--VLVPRHSEYN-------------PQLSLLAKFR------------------SA
SLHSEPLMPHNATYPDSF-QQP-PCSAL----------PPSP--SHAFSQSP-----CTA
SY-------PHSPG--------SPSEPESPY-------------------------QH--
-SVDTPPLPYHAT----EASETQSGQP-VDATADR--HLVLSIPN-----------GDFR
PVCYEEPQHWCSVAYYELNNRVGETFQASS-------RSVLIDGFTDPSNNRNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCK
IPSGCSLKVFNNQLFAQLLAQSVHHGF-------EVVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|33303616|gb|AAQ02337.1|	Danio rerio
----------------------------------------MNVTSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDALVKKLKKKKGAMEELERALSCPGQPSNCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKALECCEFPFGSKQ-KDVCINPYHYKRVD----------SP-------
-VLPP--VLVPRNSEFN-------------AKLSMLPRFR------------------NP
LHQTEPPMPQNATFPDSFPQQPANALPFT---------PNSP--TNSYPSSPNSGTGSTA
TF-------PHSPS---------SSDPGSPF-----------------------------
QMPETPPPAYMPPE---EPMTQDCPQP-MDT---N--LLAPNLPLEISNR------TDVH
PVAYQEPKHWCSIVYYELNNRVGEAFLASS-------TSVLVDGFTDPSNNRNRFCLGLL
SNVNRNSTIENTRRHIGKGGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCK
IPSRCSLKIFNNQEFAELLAQSVNHGF-------EAVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAKYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|91087663|ref|XP_973637.1|	Tribolium castaneum
------------------------------------------MSGMLPSFTPPVVKRLLG
WKK----------G---TDADDRWCEKAVKSLVKKLKK-SGALEELERAISSQNHNTKCV
TIP------------------------------RVRPAAELGNVQ-QQRKGLPHVIYCRL
WRWPELQSHHELRPLENCEYAYNLKK-EEVCVNPYHYTRIE----------SP-------
----A--ILVPRH-PLS-------------DENNLFP---------------------HS
LEDLSTSVPENTSFPHN------------------------PNSLGLHMQHSGGYMDAVG
IC-------PNGA----------PANMESPH-----------------------NAAP--
-PTETPPPGYMSED--GDPIDPNDNMS-MSRITPS-------------PP------VDAQ
PVLYCEPAFWCSISYYELNTRVGETFHASQ-------PSITVDGFTDPSN-SERFCLGLL
SNVNRNTVVEQTRRHIGK-GVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLSQSVSQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSM
S---
>gi|146335602|gb|ABQ23403.1|	Branchiostoma belcheri
----------------------------------------MTMASLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGAMEELEKALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLEHCNYPFGAKDTKEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEFV-------------PSQTLLP----------------------Y
HNVPEPPMPHNATFPQSFQNSP----------------------GMQSPHSPGL------
----------HSPA---------SSGPSSPY-----------------------SMQPGN
QPADTPPPAYMPP---GEDQNRNNEEQ-MDTSSQL--SPASSLGSPAVPNVPTAVSGDVQ
PVTYQEPVYWASIAYYELNNRVGEPFHAKS-------HSIIVDGFTDPSNSGDRFCLGLI
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSAIFVQSRNCNHHHGFHPTTVCK
IPPGCSLKIFNNQEFAQLLSQSVNHGF-------EAVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDRVLTQMGSPHNPISSV
S---
>gi|126320707|ref|XP_001365064.	Monodelphis domestica
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSAGGSGGAG-GGEQNGQEEKWCEKAVKSLVKKLKK-TGRLDELEKAITTQNCNTKCV
TIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELKAIENCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTHSIPENTNFPAGI------------------------------------------
-------------------------EPPSNY-----------------------------
-IPETPPPGYISED--GETSDQQLNQS-MDTGSPA--ELSPSTLSPVNHS------LDLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|11464653|gb|AAG35265.1|AF21	Schistosoma mansoni
-----------------------------------MSTPISSLNSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGALEALERALSNPGEPSECV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLDFCRFPFSAKE-NEVCINPYHYQRVE----------SP-------
-VLPP--VLVPRHSEYP-------------SLSTVTPSPGLSHCGSSGMSSSRSASNLGM
FPMTDSAMPYNVNYPHNFSHSP-----------------------SLPPGNSGTSTDSTV
AG-------PIHSL--------NSSNLQSGY-------------------------QT--
-QPNQDPASSGQT---------------------------------------------MH
PVNYQEPKYWCSIVYYELNNRVGEAFNASQ-------LSIIIDGFTDPSNNSDRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHNFHPTTVCK
IPPGCSLKIFSNQEFAHLLSRTVHHGF-------EAVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWVEIHLNGPLQWLDRVLTQMGTPRNPISSV
S---
>gi|58332038|ref|NP_001011168.1	Xenopus tropicalis
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSPSGTTGAG-GGEQNGQEEKWCEKAVKSLVKKLKK-TGQLDELEKAITTQNCNTKCV
TIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELKAIENCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTHSIPENTNFPAGI------------------------------------------
-------------------------EPQSNY-----------------------------
-IPETPPPGYISED--GETSDQQLNQS-MDTGSPA--ELSPSTLSPVNHN------LDLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|45331050|gb|AAS57861.1|	Carassius auratus
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSASGSSGAGGGGEQNGQEEKWCEKAVKSLVKKLKK-TGQLDELEKAITTQNCNTKRV
TIPSNCSEIWGLSTPNTIEQWDTSGLYSYPDQTRS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELRAIETCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTNSIPENTNFPTGI------------------------------------------
-------------------------EPPNNY-----------------------------
-IPETPPPGYISED--GEASDQQMNQS-MDTGSPA--ELSPSTLSPVNHG------MDLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYDWHPATVCK
IPPGCNLKIFNNQEFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|72134872|ref|XP_801746.1|	Strongylocentrotus purpuratus
------------------------------------------MASLFS-FTSPVVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGAMEELERALSRPGELSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKALDCCDYAFGKKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSESI-------------PSHSLLP----------------------Y
RGLPEPAYPHNATYPQSF-QQQ-NSPP-----------PPPP----THPGSPH----GTS
QP-------QPSPA---------SSNPNSPY-------------------------GL--
-PADTPPPAYMPPDEGGPNQNDNSSTP-MDTNPPS--CVVPNQILAVEGR-------DVA
PVTYQEPQSWCSIAYYELNNRVGEPFHATT-------TSVIVDGFTDPSNNHDRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSSIFVQSRNCNHRHGFHPTTVCK
IPPGCSLKIFNNQEFAALLSQYVNHGF-------EMVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLNGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|118790893|ref|XP_318870.3|	Anopheles gambiae
---------------------------------------------MLP-FTPPIVKRLLG
WRK----------VSPDDSAEGKWGEKVIKSLAKKMKK-SSALEELERALTAQSSHTKCI
PIS------------------------------RN--ASAIGENGVALKKGLPHVICCRL
WRWPDLNSHTELKPLDVCEYAYHLKK-DEVCINPYHYARNESHSQHSQQQQSPQQQQSSQ
QLQQPLTILVPKNLSNS-------------QGENSVT---------------------YT
LDDLSNTVPVNTQYNALNDNYVTSPQPSQVTSRQLQQQQLQPNQLHQQLQQQQQQQQLSS
PCYMEATLGQQIPTNTTIMDSVSVGVPNIP------------------------------
-NTETPPPGYMSED--GDPLDQNDNMTDLSRMSP--------------SE------MDTQ
PVMYHEPTFWCSISYYELNLRVGETFHASQ-------PSITVDGFTDPSN-SERFCLGLL
SNVNRNEVVEQTRRHIGK-GVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFATLLSQSVSMGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSM
S---
>gi|147906869|ref|NP_001084355.	Xenopus laevis
----------------------------------------MNVTSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGRPSNCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEYPFGSKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEYN-------------PQHSLLAQFR-------------------N
LEPSEPHMPHNATFPDSF-QQP-NSHPF----------PHSP--NSSYPNSPG----SGS
TY-------PHSPA---------SSDPGSPF-------------------------QI--
-PADTPPPAYMPPE---DQMTQDNSQP-MDT---N--LMVPNISQDI-NR------ADVR
AVAYEEPKHWCSIVYYELNNRVGEAFHASS-------TSVLVDGFTDPSNNRNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCK
IPSGCSLKIFNNQEFAQLLAQSVNHGF-------ETVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
SLMD
>gi|157110270|ref|XP_001651031.	Aedes aegypti
MTHPQNNDINRFDLSSLSRPADYFFTMDTDDVESSSSSTMSSLNSLFS-FTSPAVKKLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPIETCQYPFSAKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEFA-------------PGHSLLP----------------------F
HQMNEPNMPHNVSYTNSGFNNSHMGGGG----------PNSPISSHMGPNSP-----ISS
VS-------SPGPI---------NSNPQSPY-------------------------GS--
-LPETPPPAYSPPEDGNNVSSQDNNQ--MDTNQMH---------------------GEVA
PVSYQEPPYWASIAYYELNCRVGEVFHCNS-------TSVIVDGFTNPSNNSDRFCLGQL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSAIFVQSRNCNHHHGFHPSTVCK
IPPGCSLKIFNNQEFAQLLSQSVNHGF-------EAVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLIQMGSPHNAISSV
S---
>gi|13633872|sp|P97588|SMAD1_RA	Rattus norvegicus
----------------------------------------MNVTSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEFPFGSKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEYN-------------PQHSLLAQFR-------------------N
LGQNEPHMPLNATFPDSF-QQP-HSHPF----------AQYP--NSSYPNSPGS---SSS
TY-------PHSPT---------SSDPGSPF-------------------------QM--
-PADTPPPAYLPPE---DPMAQDGSQP-MDTNMTN--MTAPTLPAEINR-------GDVQ
AVAYEEPKHWCSIVYYELNNRVGERFHASS-------TSVLVDGFTDPSNNKNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCK
IPSGCSLKIFNNQEFAQLLAQSVNHGF-------ETEYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|37992038|emb|CAD68074.1|	Echinococcus multilocularis
-----------------------------------MSTPISSLNSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGALESLEKALSNPGEPSECV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLDICRFPFSAKE-NEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEYPCMGSVSAGPPADSTRISIMP---------LQAAPLLVASSYGQ
PTSGGPSMPYNVTYPQGFTQTS----------------PLPP------------------
-----------------------ATPISSGA-------------------------SP--
-STSLPPP------------------------------------------------SDTH
PINYQEPKYWCSIVYYELNTRVGEAFFASQ-------PSIVIDGFTDPSNNSDRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVFAECLSDSSIFVQSRNCNHRHNFNLTTVCK
IPPGCSLKIFSNQEFAQLLRRTVSHGF-------EAVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWVEIHLNGPLQWLDRVLTQMGTPRNPISSV
S---
>gi|115343499|gb|ABI94728.1|	Ctenopharyngodon idella
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSASGSTGAGGGGEQNGQEEKWCEKAVKSLVKKLKK-TGQLDELEKAITTQNLNTKCV
TIPSNCSEIWGLSTPNTIEQWDTSGLYSYPDQTRS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELRAIETCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTNSIPENTNFPTGI------------------------------------------
-------------------------EPPNNY-----------------------------
-IPETPPPGYISED--GEASDQQMNQS-MDTGSPA--ELSPSTLSPVNHG------MDLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|67514583|ref|NP_001019997.1	Gallus gallus
------------------------------------MHSSTPISSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGAMEELERALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEFPFGSKQ-KEVCINPYHYRRVE----------TP-------
-VLPP--VLVPRHSEFN-------------PHLSLLAKFR------------------NT
SLHSEPLMPHNATYPDSF-QHP-PCTPF----------PPSP--SHMFSQSP-----NSI
SY-------PNSPG--------SSSGPGSPY-------------------------QL--
-TVETPPPPYHARE---TPGSHNGRS--MDAIAES--QLVLSLPNGGKSADGET--ENFR
PVCYEEPQHWCSVAYYELNNRVGETFQASS-------RSILIDGFTDPSNNKNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCK
IPSGCSLKIFNNQLFAQPLAQSVNHGF-------EVVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|114051079|ref|NP_001039683.	Bos taurus
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSAGGSGGAG-GGEQNGQEEKWCEKAVKSLVKKLKK-TGRLDELEKAITTQNCNTKCV
TIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELKAIENCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTHSIPENTNFPAGI------------------------------------------
-------------------------EPQSNY-----------------------------
-IPETPPPGYISED--GETSDQQLNQS-MDTGSPA--ELSPTTLSPVNHS------LDLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQGFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|66506782|ref|XP_392819.2|	Apis mellifera
---------------------------MDDEEGSSSSGPMSSLNSLFS-FTSPAVKKLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGTPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLELCQYPFSAKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEYA-------------PGHSLLP----------------------F
QQIAEPTMPHNVSYSSSGFNAGSTGGVN----------PTSPMSSVGSVPSPGSTT----
-----------------------SPNPQSPY-------------------------GTNG
-LPETPPPAYSPP----EDGSQSGQSPPPDP-----------VAMDTSGS------AEVA
PVCYQEPPYWASIAYYELNCRVGEVFHCHS-------HSVIVDGFTNPSNNSDRFCLGQL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSAIFVQSRNCNHHHGFHPSTVCK
IPPGCSLKIFNNQEFAQLLSQSVNHGF-------EAVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEAHLHGPLQWLDKVLTQMGSPHNAISSV
S---
>gi|47522758|ref|NP_999130.1|	Sus scrofa
----------------------------------------MNVTSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEFPFGSKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEYN-------------PQHSLLAQFR-------------------N
LGQNEPHMPLNATFPDSF-QQP-NSHPF----------PHSP--NSSYPNSPGS---SSS
TY-------PHSPT---------SSDPGSPF-------------------------QM--
-PADTPPPAYLPPE---DPMTQDGSQP-MDT---N--MMAPALPSEI-NR------GDVQ
AVAYEEPKHWCSIVYYELNNRVGEAFHASS-------TSVLVDGFTDPSNNKNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCK
IPSGCSLKIFNNQEFAQLLAQSVNHGF-------ETVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|1407782|gb|AAB03612.1|	Mus musculus
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSAGGSGGAG-GGEQNGQEEKWCQKAVKSLVKKLKK-TGRLDELEKAITTQNCNTKCV
TIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELKAIENCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTHSIPENTNFPAGI------------------------------------------
-------------------------EPQSNY-----------------------------
-IPETPPPGYISED--GETSDQQLNQS-MDTGSPA--ELSPTTLSPVNHS------LDLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|149635771|ref|XP_001510888.	Ornithorhynchus anatinus
------------------------------------MHPSTPISSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGAMEELERALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLEGCEFPFGSKQ-KEVCINPYHYRRVE----------TP-------
-VLPP--VLVPRHSEFN-------------PQLSLLAKFR------------------NA
SLHSEPLMPHNATYPESF-QQP-PGSAF----------SSSP--SHMFIQSP-----STI
SY-------PNSPG---------SSGPGSPY-------------------------QL--
-TVDTPPPPYHTTE---TPGNQSGRT--LDPAADS--HLVLSLPNGGNPRM-----MNFR
PVCYEEPQHWCSVAYYELNNRVGETFQASS-------RSVLIDGFTDPSNNRNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCK
IPSGCSLKIFNNQLFAQLLAQSVNHGF-------EVVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|73993251|ref|XP_848882.1|	Canis familiaris
------------------------------------MHSSTPISSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEFPFGSKQ-KEVCINPYHYRRVE----------TPGEFSSRY
HVLPP--VLVPRHSEYN-------------PQLSLLAKFR------------------ST
SLHSEPLMPHNATYPDSF-QQP-PCSAF----------PPSPGPGHVFSQSP-----CTA
GY-------PHSPG--------SPSEPESPY-------------------------QH--
-SVDTPPLPYHATG---APGTQNG-QP-VDATTDS--HLVWEAPHDGSDVLSALFLSDFR
PVCYEEPQHWCSVAYYELNNRVGETFQASS-------RSVLIDGFTDPSNNRNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCK
IPSGCSLKIFNNQLFAQLLAQSVHHGF-------EVVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|118343986|ref|NP_001071815.	Ciona intestinalis
----------------------------------------MAMTSLFG-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGSMEELERALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLEICSYPFDAKQ-KDVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEFV-------------PSHSMIHGNG------------------GG
HNHNHNHMPPNANYPQNNSYNRPVPQ------------LNHPTIPNQGPSSPYGGSQSTD
VYSPNSFQPPQSPD-------GSVSGPNSPY-------------------------SI--
-PADTPPPAYMPPE--GDKVVPGSEA--MET--------NRTMISPNNRG------IEV-
PVAYSEPNHWCTIVYYELNNRVGEAFPATS-------TSIIVDGFTNPSSTSNRFCLGQL
SNVNRNSTIENTRRHISK-GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCK
IPPSCSLKIFNNQEFAALLSQSVNHGY-------EAVFELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLNGPLQWLDKVLTQMGSPNNAISSV
S---
>gi|114596279|ref|XP_001148109.	Pan troglodytes
----------------------------------------MNVTSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEFPFGSKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEYN-------------PQHSLLAQFR-------------------N
LGQNEPHMPLNATFPDSF-QQP-NSHPF----------PHSP--NSSYPNSPGS---SSS
TY-------PHSPT---------SSDPGSPF-------------------------QM--
-PADTPPPAYLPPE---DPMTQDGSQP-MDT---N--MMAPPLPSEI-SR------GDVQ
AVAYEEPKHWCSIVYYELNNRVGEAFHASS-------TSVLVDGFTDPSNNKNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCK
IPSGCSLKIFNNQEFAQLLAQSVNHGF-------ETVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|4519908|dbj|BAA75798.1|	Halocynthia roretzi
----------------------------------------MAMTSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDALVKKLKKKKGSMEELERALSCPGTPSQCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCLYPFDSKQ-KDVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEFV-------------SSHSMIHGP--------------------G
ERRNHNHMPPNRVYDSGGMFNS--GRPPPLSHHPVLSGPVSPHNQFGGPNSPDSYNANSP
FQ-------PPMSP------DGSTTSPGSPY-------------------------NV--
-PADTPPPAYHANE--SDRGNEN-----MDT---------NSTIHGNHNG------IDVR
SVHYTEPKDWCTIVYYELNNRVGEAYIANA-------TSIIVDGFTDPSAKSNRFCLGQL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECLSDSAIFVQSRNCNYHHGFHPTTVCK
IPPGCSLKIFNNQEFAALLSQSVNHGY-------EAVFELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLNGPLQWLDKVLVQMGSPTNPISSV
S---
>gi|125981529|ref|XP_001354768.	Drosophila pseudoobscura
---------------------------------------------MLP-FTPQVVKRLLA
LKK----------GNEDNTVEGKWSEKAVKNLVKKIKK-NSQLEELERAISTQNCQTRCV
TVP------------------------------RS----KPVPPGEHLRKGLPHVIYCRL
WRWPDLQSQNELKPLDHCEYAFHLRK-DEICINPYHYKKIE----------LS-------
-ILVP--KSLPT------------------PPDSIVD---------------------YP
LDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGG----GSGPVTSSSASASASVSVSATS
SSSSSSYQQPLSFG--------QNMDSQSSV----------------------LSVGSSI
PNTGTPPPGYMSED--GDPIDPNDNMN-MSRLTPP---------------------ADAA
PVMYHEPAFWCSISYYELNTRVGETFHASQ-------PSITVDGFTDPSN-SERFCLGLL
SNVNRNDVVEQTRRHIGK-GVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLSQSVSQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSM
S---
>gi|149730149|ref|XP_001495487.	Equus caballus
------------------------------------MHSSTPISSLFS-FTSPAVKRLLG
WKQ----------G----DEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLECCEFPFGSKQ-KEVCINPYHYRRVE----------TP-------
-VLPP--VLVPRHSEYN-------------PQLSLLAKFR------------------SA
SLHSEPLMPHNATYPDSF-QQP-PCSAF----------PPSP--GHVFSQSP-----CTA
SY-------PHSPG--------SPSEPESPY-------------------------QH--
-SVDTPPPPYHAAE---APGTQNG-QP-VDATVDS--HLVLSMPN-----------GDFR
PVCYEEPQHWCSVAYYELNNRVGETFQASS-------RSVLIDGFTDPSNNRNRFCLGLL
SNVNRNSTIENTRRHIGK-GVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCK
IPSGCSLKIFNNQLFAQLLAQSVHHGF-------EVVYELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSV
S---
>gi|156552286|ref|XP_001602991.	Nasonia vitripennis
---------------------------MDDDERSPRSGPMASLNNLFS-FTSPAVKKLLG
WKQ----------G----DEDEKWAEKAVESLVKKLKKKKGAFEELERAVSNPGTPSKCI
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRV
WRWPDLQSHHELKPLEICQYPFSAKQ-KEVCINPYHYKRVE----------SP-------
-VLPP--VLVPRHSEFA-------------PGRLPVN----------------------F
SQHSESTMPQNMSYYSDDFNTGRM--------------SNNTSSIDGSANSP-----VSS
YG-------SVSSP-------INAANNHNPY-------------------------GTNN
GLSETPPPAYSPSE--------DGSQY-VQSPSPN-----SMMAMDISNT------QDVA
PVPYHEPRYWASIAYYELNSRVGEVFHCQS-------PSVIVDGFTDPRNNSARFCLGQL
SNVNRNSTIENTRRHIGK-GVQLHYVSGALFAECNSDSAIFVQSRNCNTQRGFHQSTVIK
IPPTCSLKIFDNQLFADLLGQSVNHGF-------EAVFELTKM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYH----
---------------------RQDVTSTPCWIEMHLNGPLQWLDNVLTRMGSPHNAISSV
S---
>gi|73961177|ref|XP_866228.1|	Canis familiaris
------------------------------------------MSSILP-FTPPVVKRLLG
WKKSAGGSGGAG-GGEQNGQEEKWCEKAVKSLVKKLKK-TGRLDELEKAITTQNCNTKCV
TIP------------------------------RS----LDGRLQVSHRKGLPHVIYCRL
WRWPDLHSHHELKAIENCEYAFNLKK-DEVCVNPYHYQRVE----------TP-------
-VLPP--VLVPRHTEI----------------LTELP----------------------P
LDDYTHSIPENTNFPILV------------------------------------------
---------------------------SSSY-----------------------------
GEKVFSSMSKLSNS--YYPSGKCKSKP-QEPASPLLSELSPTTLSPVNH--------NLQ
PVTYSEPAFWCSIAYYELNQRVGETFHASQ-------PSLTVDGFTDPSN-SERFCLGLL
SNVNRNATVEMTRRHIGR-GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLAQSVNQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSM
S---
>gi|17530843|ref|NP_511079.1|	Drosophila melanogaster
---------------------------------------------MLP-FTPQVVKRLLA
LKK----------GNEDNSVEGKWSEKAVKNLVKKIKK-NSQLEELERAISTQNCQTRCV
TVP------------------------------RS----KPAPAGEHLRKGLPHVIYCRL
WRWPDLQSQNELKPLDHCEYAFHLRK-EEICINPYHYKKIE----------LS-------
-ILVP--KSLPT------------------PPDSIVD---------------------YP
LDNHTHQIPNNTDYNAAIIRSASLSPPQ-----YMELGGAGPVSVSSSASSTPATAAGGG
GG-------PSSSS-------SSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIP--
-NTGTPPPGYMSED--GDPIDPNDNMN-MSRLTPP---------------------ADAA
PVMYHEPAFWCSISYYELNTRVGETFHASQ-------PSITVDGFTDPSN-SERFCLGLL
SNVNRNEVVEQTRRHIGK-GVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCK
IPPGCNLKIFNNQEFAALLSQSVSQGF-------EAVYQLTRM-----------------
-----------CTIRM---------SFV--------------------KGWGAEYR----
---------------------RQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSM
S---
