>gi|149731543|ref|XP_001500077.	Equus caballus
------------------------------------------------------------
----------------------------MPPVPGS--RGGEGQLEARDPES---------
SLEPKCLNICTSG-SATS--CEECLLIHPKCAWCSKEDF-GSPRSVTSRCDLKA-NLIKN
G---CGGE-FESPASSTQVLRSLPLSSK-----GSSSAGS--------------------
---------------------DVIQMTPQEIAVNLRPGDKTAFQLQVRQVEDYPVDLYYL
MDLSLSMKDDLDSIRNLGTKLAEEMR-KLTSNFRLGFGSFVDKNISPFSYTA-PRYQTNP
CI-GYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVC-
---------------------------KEKIGWRK--DALHLLVFTTDDVPHIALDGK--
LGGLVQPHDGQCHL--------NEANE-YTASSQMDY----PSLALLGEKLAENNINLI-
------------------------------------FAVTKNHYM--------LYKNFTA
LI---PGTTVEILYGDSKNIIQLIINAYNSIRSKVELS-VWDQPEDLNLVFTATCQD-GV
SYPG----QRKCEGLKI--GDTASFEVSVEARS-------C--PGRHAE--HTFTLRPVG
FRDSLEVGVTYNCK-CGCSAGR----EPASSRC-SGNGTYVCGLCECNPS-YLGTRCECQ
EGE-SPS--GYQNLC--REAEGKPL-CSGRGECSCNQCSCFESE---F---GKIYGPFCE
CDNFSCARNK-GVLCSGH--GECH-CGE------CKCHAGYIGD----NCN--CSTDIST
CQAKDGQ----ICSDRGHCVCGQCQC---TEPG-AFGETCEKCP--TC-PDA---CSTK-
-RDCVECLLLHSGSPADNQT-CQSLCKDEVI-TRVDTI---VKDDQEA---VLCFYKTA-
K-------------DCVMMFTYAEL-PSGK------SNLTVLR---EPECGTAPN-AMTI
LLAVVGSILLIGIALLAIWK---------LLVTIHDRREFAKFQSE--------------
------------RSRA-RYEMASN------------------------------------
------------------------------------------------------------
------------PL--------YRKPISTHTVDFTFNKFNKSYN--------------GT
VD---------------
>gi|17386066|gb|AAL38579.1|AF44	Sigmodon hispidus
------------------------------------------------------------
---------------------------MLGPHLLL--PALAGLLFLTSAFS---------
-------EECTKY-KVSS--CRDCVQSGPGCAWCQKLNFTGPGQPDSLRCSTRA-QLLQN
G---CPADEIMDPRSFAEPQIDRQG-----------------------------------
---------------------ERKQLFPQKVTLHLRPGQAAAFNVTFRRAKGYPIDLYYL
MDLSYSMLDDLNNVKKLGGDLLRALN-EITESGRIGFGSFVDKTVLPFVNTH-PEKLKNP
CP-S--KEKDCQPPFAFRHVLKLTDNSNQFQTVVGKQLISGNLDAPEGGLDAIMQVAAC-
---------------------------PEEIGWRN---VTRLLVFATDDGFHFAGDGK--
LGAILTPNDGRCHL--------EDN-M-YKKSNEFDY----PSVGQLAHKLSESNIQPI-
------------------------------------FAVTKKMVK--------TYEKLTE
II---PKSAVGELSDDSSNVVQLIKNAYYKLSSRVFLD-HTTLPDTLKVTYDSFCSN-GA
SSIGKS--RGDCDGVQI--NVPVTFQVKVTASE-------C--IQE-----QSFVIRALG
FTDTVTVKVLPQCD-CQCRDQS-----QAQGLC-KGKGVMECGICRCEAG-YIGKNCECQ
TQGRSSQ--ELEGSC--RKDNTSIV-CSGLGDCICGQCVCHTSD-TPN---KVIFGQYCE
CDNVNCERYD-GQVCGGSDRGSCF-CGQ------CKCKDGFEGS----ACQ--CKRSTDG
CLNTRLV----ECSGRGRCHCNQCKC----EDG-YQPPLCEECI--GC-PSP---CSEY-
-ISCAECRKFEKGPFEKN---CSVQCANVTL-Q--------PIPLKGK----LCKERDS-
Q-------------GCWITYTLQQKDGKNI------YDIHVED---DRECVKGPN-VAAI
VGGTVLSVVLIGVLLLVIWK---------ALTHLTDLREYRHFEKE--------------
------------KLKS-QWN-NDN------------------------------------
------------------------------------------------------------
------------PL--------FKSATTTV-MNPKFAES---------------------
-----------------
>gi|148728583|gb|ABR08706.1|	Camelus bactrianus
------------------------------------------------------------
------------------------MNLQLIFWIGL----ISSVCCVFGQAD---------
------EDRCLKA-NAKS--CGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLE-ALKKK
G---CHPNDTENPRGSKDIKKNKNVTNR-----SKGTAEKLQPE----------------
---------------------DITQIQPQQLVLQLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMR-RITSDFRIGFGSFVEKTVMPYISTT-PAKLRNP
CT-N---EQNCTSPFSYKNVLSLTDKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVC-
---------------------------GSLIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGQCHL--------KND-V-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEEFQP--------VYKELKN
LI---PKSAVGTLSANSSNVIQLIIDAYNSLSSEVILE-NSKLPEGVTINYKSYCKN-GV
NGTGEN--GRKCSNISI--GDEVQFEISITANK-------C--PDKNS---ETIKIKPLG
FTEEVEIILQFICE-CECQGEG----IPGSPKCHDGNGTFECGACRCNEG-RVGRHCECS
TDEVNSE--DMDAYC--RKENSSEI-CSNNGECVCGQCVCRKRD-NTN---EIYSGKFCE
CDNFNCDRSN-GLICGGN--GVCK-CRV------CECNPNYTGS----ACD--CSLDTTS
CMAVNGQ----ICNGRGVCECGACKC---TDPK-FQGPTCEMCQ--TC-LGV---CAEH-
-KECVQCRAFNKGEKKDT---CAQECSHFNI-TKVENRDKLPQPGQVD-PLSHCKEKDV-
D-------------DCWFYFTYSVN-GNNE------ATVHVVE---TPECPTGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------RMNA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKSAVTTV-VNPKYEGK---------------------
-----------------
>gi|75064586|sp|Q863C4|ITB6_SHE	Ovis aries
------------------------------------------------------------
--------------------------------MGI--ELLCLFFLFLGRND---------
----HVQGGCAMG-GAET--CEDCLLIGPQCAWCSQENF-THLSGVGERCDTPA-NLLAK
G---CQLTFIENPVSQVEILTNKPLSIG-----RQKNSS---------------------
---------------------NIVQISPQSLALKLRPGLEQTLQVQVRQTEDYPVDLYYL
MDLSASMDDDLNTIKELGSLLSKEMS-KLTSNFRLGFGSFVEKPISPFMKTT-PEEIANP
CS-S--IPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVC-
---------------------------KEKIGWRN--DSLHLLVFVSDADSHFGMDSK--
LAGIVIPNDGLCHL--------DSKNE-YSMSTILEY----PTIGQLIDKLVQNNVLLI-
------------------------------------FAVTQEQVH--------LYENYAK
LI---PGATVGVLQKDSGNILQLIISAYEELRSEVELE-VLGDTEGLNLSFTAICNS-GV
PFPH----QKKCSHMKV--GDTASFNVTVSLPN-------C--ERRS----RHVILKPVG
LGDALEILVSPECS-CDCQKEV----EVNSSKCSNGNGSFQCGVCACNPG-HVGHHCECG
EDTLSTE------SC--KEAPELPS-CSGRGDCYCGQCVCHLSP---Y---GNIYGPYCQ
CDNFSCVRHK-GLLCGDN--GDCD-CGE------CVCRSGWTGE----YCN--CTTSTDP
CVSEDGI----LCSGRGDCVCGKCIC---TNPG-ASGPACERCP--TC-SDP---CNSK-
-RNCIECYLSADGQAQEE---CVDKCKLAG--ATINEEEDFSKDSSVS-----CSLQGE-
N-------------ECLITFLLTTD-NEGK------TVIHSIE----KDCPKPPN-IPMI
MLGVSLAILLIGVALLCIWK---------LLVSFHDRKEVAKFEAE--------------
------------RSKA-KWQTGTN------------------------------------
------------------------------------------------------------
------------PL--------YRGSTSTF-KNVTYKHKEKQKVDL------------ST
DG---------------
>gi|75042916|sp|Q5VI41|ITB2_CAP	Capra hircus
------------------------------------------------------------
---------------------------MLPQRPQL--LLLAGLLALQSVLS---------
-------QECTKY-KVST--CRDCIESGPGCAWCQKLNFTGQGEPDSTRCDTRA-QLLSK
G---CPADDIMEPKSLAETRQSQAG-----------------------------------
---------------------KQKQLSPEEVTLYLRPGQAAAFNVTFQRAKGYPIDLYYL
MDLSYSMVDDLANVKKLGGDLLRALN-DITESGRIGFGSFVDKTVLPFVNTH-PEKLRNP
CP-N--KEKQCQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAAC-
---------------------------PEEIGWRN---VTRLLVFATDDGFHFAGDGK--
LGAILTPNDGRCHL--------EDN-L-YKSSNEFDY----PSVGQLAHKLAESNIQPI-
------------------------------------FAVTKKMVK--------TYEKLTE
II---PKSAVGELSEDSKNVVELIKSAYNKLSSRVFLD-HNTLPDTLKVAYDSFCSN-GV
SQVDQP--RGDCDGVQI--NVPITFQVKVTATE-------C--IQE-----QSFTIRALG
FTDTVTVRVLPQCE-CQCRDAS-----RDRSVC-GGRGSMECGVCRCDAG-YIGKNCECQ
THGRSSQ--ELEGSC--RKDNSSII-CSGLGDCICGQCVCHTSD-VPN---KKIYGQFCE
CDNVNCERYD-GQVCGGEKRGLCF-CGT------CRCNEQHEGS----ACQ--CLKSTQG
CLNLDGV----ECSGRGRCRCNVCQC----DPG-YQPPLCIDCP--GC-PVP---CAGF-
-APCTECLKFDKGPFAKN---CSAACGQTKL-LSS------PVPGGRK-----CKERDS-
E-------------GCWMTYTLVQRDGRNR------YDVHVDD---MLECVKGPN-IAAI
VGGTVGGVVLVGILLLVIWK---------ALTHLSDLREYHRFEKE--------------
------------KLKS-QWN-NDN------------------------------------
------------------------------------------------------------
------------PL--------FKSATTTV-MNPKFAES---------------------
-----------------
>gi|7025426|gb|AAF35883.1|	Ictalurus punctatus
------------------------------------------------------------
-----------------MNCRRSIRTEMKVMVVLM--TVLLGFFSFCSAQL---------
-----DGNDCTKA-SAQS--CGECIQVGEKCGWCTYESFLKQGESKSTRCDEIE-ALIKK
G---CPTNNVENPRGTVVANENKTVTNR-----KKDVVEKLKPD----------------
---------------------QITQIQPQKLTLNLRAGEPQKFSLKFKRAEDYPIDLYYL
MDWSYSMKDDLENVKNLGTDLMREMQ-SVTSDFRIGFGSFVEKTVMPYISTT-PAKLLNP
CT-S---DQNCTSPFSYKNVLSLTEDGRQFNSLVSRQQISGNLDSPEGGFDAIMQVAVC-
---------------------------GEQIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGECHL--------KDN-L-YTMSHYYDY----PSIAHLVQKLSDNNIQTI-
------------------------------------FAVTEEFQP--------VYKELKN
LI---PKSAVGTLSANSSNVIKLIIDAYNSLSSEVILE-NSKLPEGVSISYVSHCIN-GV
SETGDN--GRKCSNISI--GDEVTFDIAITSKG-------C--PSHGT---SEVKIKPLG
FNEEVVVVLNFICE-CECSKKG----IPKSPDCHFGNGTLECGACRCNEG-RIGRVCECS
KDDVRAE--DLDANC--RMDNGTDI-CSNNGDCICGTCECKKRD-NPE---ERYEGKYCE
CDNFNCDRSS-NKLCGGH--GQCV-CRV------CVCDANYTGS----ACD--CPLDKQP
CVASNGQ----ICNGRGTCDCGVCKC---TDPK-FQGPTCEICP--TC-PGV---CTEH-
-KPCVQCRAFNTGEMKDE---CEEKCNYFKL-TMVKEKEDLPQPNSKP-YLSHCKERDA-
N-------------DCWFFFIYATKNVS--------VEVYVVE---QLECATGPD-IIPI
VAGLVAGIVLIGLALLFIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDAGEN------------------------------------
------------------------------------------------------------
------------PI--------YKSAVTTV-VNPKYEGK---------------------
-----------------
>gi|147905868|ref|NP_001086588.	Xenopus laevis
------------------------------------------------------------
------------------------MERSARSRVLL---AVSLLCCLVPSLG---------
-----GPNVCTTR-SATSASCHECLLTHPQCAWCSQEEF-GGSRTVTSRCDFVH-NLISR
G---CKKDFIEGPGSSVTITKNLPLSTK-----ESSSSQT--------------------
---------------------NFIQVAPQKISLSLRPGAAASFKVHVRQVEDYPVDLYYL
MDLSLSMKDDLDTIRNLGTKLAAEMK-KLTSNFRLGFGTFVDKNMSPYSYTA-PKYQNNP
CT-GYKYFPVCVPSFGFRHLLSLTDKANSFNAEVQKQRVSRNRDAPEGAFDAILQAAVC-
---------------------------GDRIGWRK--EASHLLLITTDDVPHVALDGK--
LAGVVQPHDGQCHL--------NENNE-YSASDKLDY----PSLALLGDKLSENNINLI-
------------------------------------FAVTKSNYV--------LYKNFTA
LI---PGTTAEILDQDSQNIIQLIVSAYNNIRSKVELM-VSDSPEDLGLSFTATCQD-GV
SYPG----VKKCGELKI--GDTVSFEVSVEARN-------C--HPPGTE--HTFTIKPVG
FRDTLEVTVTYNCS-CSCTQQV----ETASSKC-SSNGTYTCGVCDCDTG-FLGARCECG
EEEISSD--VSQNTC--REAEGKTV-CNGRGRCLCGLCVCYESE---F---GIISGSFCQ
CDDFSCARYK-GILCSGH--GECD-CGE------CKCHAGYIGD----NCN--CTIETSS
CLSDDGQ----MCSGKGNCVCGRCQC---IEPG-AFGETCEKCP--TC-PDA---CGTK-
-RDCIECRLYQTGRLADNQT-CQKLCKDQII-TVEEL----NTDNPEA---AVCIYKTE-
S-------------DCVMRFTYSEE--SGR------SVLRVLK---EPECASAPD-TLTV
LLAVVGSILLIGLVLLAVWK---------LLVTIHDRREFSRFQSD--------------
------------RSRA-RYEMASN------------------------------------
------------------------------------------------------------
------------PL--------YRPAVSTHNVDEMYNMLSKSYN--------------GT
T----------------
>gi|13365501|dbj|BAB39130.1|	Cyprinus carpio
------------------------------------------------------------
----------------------------MLQAVCL--RGLFLLLVVRQVYM---------
------EEQCLKA-SVNT--CGDCIKSGSGCAWCKDLNFTKAGEQEAARCNTAA-MLRDK
G---CSSNGIINPKNDFIKTKDKPLAPG-----A--------------------------
---------------------NPVQIQPQEVQLNLRPGLPQTFQLHFKRAIGYPVDLYYL
MDLSYSMKDDLENVKQLGNNLLTELT-RITGNARIGFGSFVDKTLLPYTDTN-EAKLQRP
CS-D--KSEPCQPAFGFQHVLSLTKDGTKFRDMVAKQHISGNLDPPEGSLDAIMQVAVC-
---------------------------VKDIGWGN---STRLLVLATDDGFHMAGDGK--
LAAILEPNKETCEL--------VKN-K-YSKSNLWDY----PSVGQIARKLEEQNIQPI-
------------------------------------FAVTKKMET--------VYTELSK
LI---PKSAVGVLSEDSSNVVKIIVDAYNNLTSEVILA-HEALPDFISVKYTSDCKG-GE
SPSE----KGKCDNVNI--GKEVIFNVTVTVDR-------C--ITS-----QSFLIGPLG
FSEKMRVNIRTRCE-CECDDSN----QP-HPHC-GGNGKVVCGSCSCDPG-FLGQRCECK
LGQKDEA--SLKAQC--RKDNGTE--CEGKGDCLCGRCQCYSTD--SG---GNFYGEFCE
CDDEHCEKAN-NTQCAGH--GKCK-CGK------CECDQGYEGP----ACD--CIKSDKD
CMTDEG-----VCHERGKCECNVCKC----ERG-YSGAKCKTCS--SC-QRP---CKES-
-GSCVECLAFGTGPFEKN---CSKACNHLKQ-ETVERLLK-----------YDCRVRDK-
E-------------GCWMLFTMTEQRGFDK------YFVKVLQ---ARECPEGPN-IAAI
VGGSLAAVALIGLLILLIIK---------GVLYASDLREWKRFEKD--------------
------------RKHE-K-TSGTN------------------------------------
------------------------------------------------------------
------------PL--------FQNATTTI-QNPTFSGDS--------------------
-----------------
>gi|55638059|ref|XP_509093.1|	Pan troglodytes
------------------------------------------------------------
-----------------------MVALPMVFVLLL--VLSRGESELDAKIPSTGDATEWR
NPHLSMLGSCQ---PAPS--CQKCILSHPSCAWCKQLNFTASGEAEARRCARRE-ELLAR
G---CPLEELEEPRGQQEVLQDQPLSQG-----ARGE-----------------------
---------------------GATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYL
MDLSYSMKDDLERVRQLGHALLVRLQ-EVTHSVRIGFGSFVDKTVLPFVSTV-PSKLRHP
CP-T--RLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALC-
---------------------------QEQIGWRN---VSRLLVFTSDDTFHTAGDGK--
LGGIFMPSDGHCHL--------DSNGL-YSRSTEFDY----PSVGQVAQALSAANIQPI-
------------------------------------FAVTSAALP--------VYQELSK
LI---PKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLE-HSSLPPGVHISYESQCEG-PE
KREGKAEDRGQCNHVRI--NQTVTFWVSLQATH-------C--LPEP----HLLRLRALG
FSEELIVELHTLCD-CNCSDTQ-----PQAPHCSDGQGHLQCGVCSCAPG-RLGRLCECS
VAELSSP--DLESGC--RAPNGTGPLCSGKGHCQCGRCSCS----------GQSSGHLCE
CDDASCERHE-GILCGGF--GRCQ-CGV------CHCHANRTGR----ACE--CSGDMDS
CISPEGG----LCSGHGRCKCNRCQC----LDG-YYGALCDQCP--GC-KTP---CERH-
-RDCAECGAFGTGPLATN---CSTACAHTNV-TLA------LAPILDD---GWCKERTL-
D-------------NQLFFFLVEDD-ARGT------VVLRVRP------QEKGADHTQAI
VLGCVGGIVAVGLGLVLAYR---------LSVEIYDRREYSRFEKE--------------
------------QQQL-NWKQDSN------------------------------------
------------------------------------------------------------
------------PL--------YKSAITTT-INPRFQEADSPTL----------------
-----------------
>gi|2293521|gb|AAB65421.1|	Homo sapiens
------------------------------------------------------------
-----------------------MAGPRPSPWARL---LLAALISVSLSGT---------
-----LANRCKKA-PVKS--CTECVRVDKDCAYCTDEMF------RDRRCNTQA-ELLAA
G---CQRESIVVMESSFQITEETQIDTT-----L--------------------------
---------------------RRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYIL
MDFSNSMSDDLDNLKKMGQNLARVLS-QLTSDYTIGFGKFVDKVSVPQTDMR-PEKLKEP
WP-------NSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVC-
---------------------------TRDIGWRP--DSTHLLVFSTESAFHYEADGANV
LAGIMSRNDERCHL--------DTTGT-YTQYRTQDY----PSVPTLVRLLAKHNIIPI-
------------------------------------FAVTNYSYS--------YYEKLHT
YF---PVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIR-ALDSPRGLRTEVTSKMFQ---
--------KTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQK---GNIHLKP-S
FSDGLKMDAGIICDVCTCELQK----EVRSARC-SFNGDFVCGQCVCSEG-WSGQTCNCS
TGSLSD-----IQPC-LREGEDKP--CSGRGECQCGHCVCYGE--------GRYEGQFCE
YDNFQCPRTS-GFLCNDR--GRCS-MGQ------CVCEPGWTGP----SCD--CPLSNAT
CIDSNGG----ICNGRGHCECGRCHC---HQQSLYTDTICEINYSAIH-PGL---CEDL-
-RSCVQCQAWGTGEKKGR---TCEECNFKVK-MVDEL----KRAEEVV---VRCSFRDED
D-------------DCTYSYTMEGDGAPGPN-----STVLVHK---KKDCPPGS--FWWL
IPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHL
DTPMLRSGNLKGRDVV-RWKVTNN--MQRPGFATHAASINPTELVPYGLSLRLARLCTEN
LLKPDTRECAQLRQEVEENVRTQELGLAGDVAERGLQADLRCTQAPADQVPAAAQCREKA
RPHHCGHSADGAPLGQAGPAEAYREAGGTE-GLPRPQGGPRLLHPHCRPGRPGHGGVPGG
RGAGGRTGAPLYPA---
>gi|3789801|gb|AAC67503.1|	Biomphalaria glabrata
------------------------------------------------------------
--------------------------------MKL--VVVLIVACLGTLAQ---------
---GNEINPCLSADAQKS--CASCIATSKECAWCVSVSY---EQENRLRCDTHENHLRGL
Y---CDPGDIQFPTDEVEKLKNQDVGDG-----DNPE-----------------------
---------------------DAVQVQPQKVRIKIRPNKPVEVKLTFRQAENYPVDLYYF
MDLSNSMEDDKEKLALLGNKIAEQMS-AITKNFRLGFGSFVDKVVSPYVSTV-PQKLKMP
CK-TY-NGEPCEAPYGFKNQLSLDLETTKFSQKVKEARVSGNLDAPEGGFDAIMQAVAC-
---------------------------EDEIGWRP--ISRRMLVFSTDAGFHHAGDGK--
LGGIVTPNDGQCHL--------KNN-L-YSESSNLDY----PSVSQIANKIKEKSVSVI-
------------------------------------FAVTDLQFD--------IYEKLSK
YI---ESSTTGRLANDSSNIVTLIEDNYKKITSKVTLK-ADGLGENITVDFFSRCFG-GE
EIK-----TNECGSLKI--GQSVEFRAEVMLTA-------C--PKDRKKWLKEFSIRPLG
YQEKLTVELEMICE-CQCENAE--NEELNSDKCSNGNGTFECGKCSCHPG-RYGKFCECK
ADDLTSK--DSIKQC--TAPNATLP-CSGRGSCVCGECLCNTRSSDSA---QTFSGPYCE
CDDYSCNQFN-EQICGGPERGKCN-CGK------CECKLGYNGT----ACE--CELSMEK
CTTDKGL----VCNGHGNCTCGKCVC----ENQ-YTGFKCEQCP--AC-PDK---CLEY-
-TPCVQCKAFKFGKLIQER--CLRECKMEIF-FHDK-----IREGHGI---QLCPIKDD-
D-------------ECWAYYTYEYD-RNGK------VVIKAQI---TKVCPDQLN-VLAI
VGGVVGGIVAVGLFLLLLWK---------LLTFIHDTREFAKFEKE--------------
------------RQNA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKQATSTF-KNPTYGSQ---------------------
-----------------
>gi|130502124|ref|NP_001076305.	Danio rerio
------------------------------------------------------------
-MCRCDLGRMDKEKTSVTRCGRMWKLCSSTRHPAL--LVCIVLEIFIHSVK---------
-----GLNVCMSG-SATS--CEECLLIHPSCAWCAQEDF-GQARTLTSRCDFSQ-NLQKR
G---CDAPFIENPRSGSSVLQSKPLSYK-----GSGVTQY--------------------
---------------------DVIQIYPQKISLSLRPGDQASFEVQVRPVEDYPVDLYYL
MDLSLSMKDDLDTIRNLGTKLAEEMR-KLTSNFRLGFGSFVDKNISPFSYTA-SKYQDNP
CN-GYKLFPNCVPTFGFRHLLSLTDKVDRFNEEVQKQMVSRNRDAPEGGFDAILQAAVC-
---------------------------REKIGWRK--EAYHLLVFATDDVPHLALDGK--
LGGLVHPHDGQCHL--------NDKNE-YSASTKMDY----PSLALLGEKLAENNIFLI-
------------------------------------FAVIKRHYV--------LYKNLTA
LI---PGTTVEILDQDSKNIIQLIVNAYNNIRSKVELS-VWDHPEDLSLAFSATCQD-GQ
PLTG----LRKCADLKI--GDTVSFNVTVDARG-------C--PPKGTR--KSFTIRPVG
FKDRLEVSVDYRCD-CRCTYHT----KPNSSRC-NSAGTYNCGLCRCEPG-YLGARCECQ
EGEVDHQ---HLSAC--REAEGKQV-CSGRGECSCNQCLCYESE---F---GKIYGTFCE
CDDFSCARHK-GILCSGH--GECH-CGE------CKCHAGYIGD----NCN--CSTETAS
CVSDDGK----ICSGRGSCVCGRCQC---TEPG-AFGDTCEKCP--TC-PDA---CGTK-
-RECIECRLFNTGRLADNQT-CQRMCKDEI--TTVETL---KTDDPNA---VQCVYKTE-
N-------------DCVMKFTYSEH-ANGQ------SVLTALK---EPECAVAPN-AMTV
LLAVVGSILLMGIVLLALWK---------LVITVHDRREFARFQSA--------------
------------RSRA-RYEMASN------------------------------------
------------------------------------------------------------
------------PV--------YKRSVPME-TDFDMHGI-KSLN--------------GG
VH---------------
>gi|50978890|ref|NP_001003162.1	Canis lupus
------------------------------------------------------------
----------------------------MRARPLW--AAVLLLGALAGTGV---------
----GVSNICTTR-GVHS--CQQCLAVSPVCAWCSDEAL----PLGSPRCNLKE-NLLKD
N---CALESIEFPISEVRILEARPLSNK-----GSGDSS---------------------
---------------------QITQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYL
MDLSYSMKDDLSSIQNLGTRLASQMH-KLTSNLRIGFGAFVDKPVSPYMYISPPEALKNP
CY-D--MKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVC-
---------------------------DEKIGWRN--DASHLLVFTTDAKTHIALDGR--
LAGIVQPNDGQCHI--------GSDNH-YSASTTMDY----PSLGLMTEKLSQKNINLI-
------------------------------------FAVTENVVN--------LYQNYSE
LI---PGTTVGILSTDSSNVLQLIVDAYGKIRSKVELE-VRDLPEELSLSFNATCLN-NE
VIPG----LKSCVGLKI--GDTVSFSIEAKVRG-------C--PQEKE---KSFTIKPVG
FKDSLTIQVTFDCD-CACQAQA----EPSSHRCNNGNGTFECGVCLCGPG-WLGSQCECS
EED-YHP--SQQDEC--SPREGQPA-CSQRGECLCGQCVCHSSD---F---GKITGKYCE
CDDFSCVRYK-GEMCSGH--GQCS-CGD------CLCDSDWTGY----YCN--CTTRTDT
CMSSNGL----LCGGRGKCECGSCVC---IQPG-SYGDTCEKCP--TC-PDA---CTFK-
-KECVECKKFDRGTLHDDNT-CNRYCRDEIE-SVKEL----KDTGKDA---VNCTYKNE-
D-------------DCVVRFQYYED-SSGK------SILYVVE---EPECPKGPD-ILVV
LLSVMGAILLIGLATLLIWK---------LLITIHDRKEFAKFEEE--------------
------------RARA-KWDTANN------------------------------------
------------------------------------------------------------
------------PL--------YKEATSTF-TNITYRGT---------------------
-----------------
>gi|47228128|emb|CAF97757.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------MDLRLLLIAAL--SALLTVSWAQQEGS---------
--------ICIKA-NAQS--CGECIQVSELCGWCTDISFLGEGESKSARCDDLE-SLKNR
N---CQTVDIENPRGSVVVNKDKPVTNR------KNEPGELKPE----------------
---------------------QITQIQPQKLTLTLRSGEPLSFRLKFKRAEDYPIDLYYL
MDLSFSMKDDLENVKNLGTDLMTRMK-KITSDFRIGFGSFVEKTVMPYISTT-PARLINP
CT-S---NQNCTSPFSYKNVLKLTDKGEEFNRLVSQQQISGNLDSPEGGFDAIMQVAVCE
VGGVSRGLPLRLPLRSVPLLTTACSLLQNEIGWRD---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGKCHL--------ENN-M-YTMSHYYVRPGRRPACGHLRARFSLGSVAFAG
LPLHRPSGAETERPQHPDHLRRHRGVPARLQGGRELWCTSDTHPARSYRLPSGLFQELKN
LI---PKSAVGTLSSNSSNVINLIIDAYNALSSEVILE-NTKLPEGVSISYKSICKN-GA
EATGDN--GRKCSNISI--GDEVFFQISVQADK-------C--PADGRS--ETIKIKPQG
FTEEVEIVLNFICD-CPCASSG----EPRSPKCDSGNGIFECGACKCNQG-RIGRVCECS
KDDVHAE--DLDANC--RKDNGTDI-CSNNGDCVCGTCECKKRL-NPA---ESYSGKYCE
CDNFNCDRSN-NMLCGGH--GRCE-CRK------CICDANYTGS----ACD--CSMDTST
CMAKNGQ----LCNGRGSCECGTCKC---TDVK-FQGPTCEICP--TC-PGV---CQEH-
-KDCVLCRAFPS---EKP---CA-NCSYFDL-VKVADRDKLPQPTDQTFPLSHCKVRDE-
N-------------DCWVYYTFAIKNQT--------KMVYVVE---KPGCTEGPD-IVPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKSAVTTV-VNPKYEGK---------------------
-----------------
>gi|149060639|gb|EDM11353.1|	Rattus norvegicus
------------------------------------------------------------
--------------------------MPRVPATLY--ACLLGLCALVPRLA---------
-----GLNICTSG-SATS--CEECLLIHPKCAWCSKEYF-GNPRSIISRCDLKA-NLIRN
G---CGGE-IESPASSTHVLRNLPLSSK-----GSSAMGS--------------------
---------------------DVIQMTPQEIAVSLRPGDQATFQLQVRQVEDYPVDLYYL
MDLSLSMKDDLDNIRSLGTKLAEEMR-KLTSNFRLGFGSFVDKDISPFSYTA-PRYQTNP
CI-GYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVC-
---------------------------KEKIGWRK--DALHLLVFTTDDVPHIALDGK--
LGGLVQPHDGQCHL--------NEANE-YTASDQMDY----PSLALLGEKLAENNINLI-
------------------------------------FAVTKNHYM--------LYKNFTA
LI---PGTTVEILHGDSKNIIQLIINAYSSIRAKVELS-VWDQPEDLNLFFTATCQD-GL
SYPG----QRKCEGLKI--GDTASFEVSVEARS-------C--PGRHTT--QSFTLRPVG
FRDSLQVEVAYNCT-CGCSAGL----EPNSARC-SGNGTYVCGLCECDPS-YLGTRCECQ
EGE-NQS--GYQNLC--REAEGKPL-CSGRGECSCNQCSCFESE---F---GRIYGPFCE
CDSFSCARNK-GVLCSGH--GECH-CGE------CKCHVGYIGD----NCN--CSTDIST
CRAKDGQ----ICSDRGRCVCGQCQC---TEPG-AFGETCEKCP--TC-PDA---CSSK-
-RDCVECSLLHQGKPDNQT--CHHQCKDEVI-TWVDSI---VKDDQEA---VLCFYKTA-
K-------------DCVMMFSYTEL-PNGK------SNLTVLR---EPECGSAPN-AMTI
LLAVVGSILLVGMALLAIWK---------LLVTIHDRREFAKFQSL--------------
------------KP----------------------------------------------
------------------------------------------------------------
------------PV--------QKAHLHTY-CRFCLQQVQQILQWLSGL---SSWMAGGG
LRTKTGVSRTPWTICSR
>gi|88954311|gb|AAI14108.1|	Bos taurus
------------------------------------------------------------
------------------------MNLQLIFWIGL----ISSVCCVFGQAD---------
------ENRCLKA-NAKS--CGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLE-ALKKK
G---CHPNDIENPRGSKDIKKNKNVTNR-----SKGTAEKLQPE----------------
---------------------DITQIQPQQLVLQLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMR-RITSDFRIGFGSFVEKTVMPYISTT-PAKLRNP
CT-N---EQNCTSPFSYKNVLSLTDKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVC-
---------------------------GSLIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGQCHL--------END-V-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEEFQP--------VYKELKN
LI---PKSAVGTLSANSSNVIQLIIDAYNSLSSEVILE-NSKLPEGVTINYKSYCKN-GV
NGTGEN--GRKCSNISI--GDEVQFEISITANK-------C--PNKNS---ETIKIKPLG
FTEEVEIILQFICE-CECQGEG----IPGSPKCHDGNGTFECGACRCNEG-RVGRHCECS
TDEVNSE--DMDAYC--RKENSSEI-CSNNGECVCGQCVCRKRD-NTN---EIYSGKFCE
CDNFNCDRSN-GLICGGN--GVCK-CRV------CECNPNYTGS----ACD--CSLDTTS
CMAVNGQ----ICNGRGVCECGACKC---TDPK-FQGPTCEMCQ--TC-LGV---CAEH-
-KECVQCRAFNKGEKKDT---CAQECSHFNI-TKVENRDKLPQPGQVD-PLSHCKEKDV-
D-------------DCWFYFTYSVN-GNNE------ATVHVVE---TPECPTGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTQEN------------------------------------
------------------------------------------------------------
------------PI--------YKSPINNF-KNPNYGRKAGL------------------
-----------------
>gi|45383197|ref|NP_989814.1|	Gallus gallus
------------------------------------------------------------
---------------MPRRGGLPAPAAARRPPPLL--RLLLRLLLLAAPLQ---------
--PGRGLNLCTSG-SASS--CEECLLIHPKCAWCSKEEF-GSTKSVPSRCDFLK-NLIAN
G---CAGA-IENPRSSSSVAKNVPLSSK-----GSGQTHL--------------------
---------------------DVTQITPQKVALSLRPGDRTSFRVQVRQVEDYPVDLYYL
MDLSLSMNDDLDNIRNLGTKLAEEMR-KLTSNFRLGFGSFVDKNISPFSYTA-PRYQNNP
CI-GYKLFPSCVPSFGFRHLLSLTDKVDRFNEEVQKQKVSRNRDAPEGGFDAILQAAVC-
---------------------------KEKIGWRK--EASHLLVFTTDDVPHIALDGK--
LGGLVQPHDGQCHL--------NEANE-YSASSQLDY----PSLALLGEKLAENNIHLI-
------------------------------------FAVTKSHYV--------LYKNFTA
LI---PGTTVEILHKDSKNIIELIVKAYNSIRSKVELT-VWDSPEDIGLTFTATCQD-GL
SYPG----LRKCGDLKI--GDTVSFEVSVEARS-------C--PAEDTS--HVFTIKPAG
FRDTLEVTVTYNCL-CGCTGLA----EPASGKC-SGNGTYACGLCECDAG-YLGARCECE
EGA-GGE--TQPGLC--REVEGKPV-CSGRGECSCNQCVCYESE---F---GNIYGPFCE
CDDFSCARYK-GVLCSGH--GECH-CGE------CKCHTGYIGD----NCN--CSTETAS
CVSSDGQ----MCSGRGNCICGRCQC---TEPG-AFGETCEKCP--TC-PGV---CSTK-
-RDCIECKLFNSGRLDNQT--CQKHCKDELI-TTVDVL---KTDDPNA---ILCAYPVN-
--------------NCVMKFTYSEL-ASGK------SNLTVLK---EPACSSAPS-AVTI
VLAVIGSVVLIGTILLGLWK---------LLVTIHDRREFDRFQSE--------------
------------RTRA-RYEMASN------------------------------------
------------------------------------------------------------
------------PL--------YRKPISTHNVEFTFNKLNKSYN--------------GT
VD---------------
>gi|148353986|emb|CAL90974.2|	Oncorhynchus mykiss
------------------------------------------------------------
---------------------------MYKCVSLL--LLLMGRGVLSQEVE---------
--------VCSKT-VINS--CRDCIRSGAYCTWCKQLNSTKPGEQEAARCDTRA-QLEER
G---CMGKDIVSPLNILTVTKNTALSTN-----AFVKD----------------------
---------------------EPIQLRPQEVNPKLRPGLPRTFKLDFRRVEGYPVDLYYL
MDLSYSMEDDLRSIKTLGNELFKALQ-GITKQGRIGFGSFVDKTVLPFTNTN-PEKLKKP
CE-E--KELFCQPAFGYRHVLSMTENKADFNREVDKQRISGNLDSPEGRLDAIMQAAVC-
---------------------------GDRIGWRN--SSTRLIVLTTDDGFHMAGDGK--
QAGILEPNDERCYM--------DNK-L-YTKSNDMDY----PSVGQVASQLEKNNIQPI-
------------------------------------FAVTKNMEN--------VYRELSR
MI---PKSEVGVLSEDSKNVVELIQAAYNRLSSKVTVT-HDALPDNVRVTYTPLCPG-RG
TRRD----KGVCGNVKV--GDLVSFNVTVTADE-------C--IDR--E--RSFLIGPLG
IKDKLKVSLSTRCE-CECDDPK----EENHKDC-DGKGKVKCGMCSCNAG-FVGQKCECA
IGEKDES--SLRAAC--RKDNGTE--CEGRGDCVCGICQCYAQQ--GG---STYYGTHCE
CENESCEKFQ-NKLCGGN--GKCR-CKI------CECNPEYEGT----ACQ--CKKSDEQ
CRTPSGS----VCSGRGTCQCNQCKC----IEG-YQRPYCLTCP--AC-QTP---CITK-
-GKCIECLGFQTGPFSKN---CSQTCKSINEFEMVE-----TLPPGKP-----CDVRDV-
E-------------NCRVFFIIKQLDGEDN------YSAQILK---TRECPELPN-IYAI
IGGSIAGVALIGLLILLIIK---------AILYMRDVKEFRRFENE--------------
------------QKKG-KWSPGDN------------------------------------
------------------------------------------------------------
------------PL--------FMNATTTV-ANPTFTGE---------------------
-----------------
>gi|126723613|ref|NP_001075535.	Oryctolagus cuniculus
------------------------------------------------------------
------------------------MRARARPRPLW--AAVLALGALAGVGV---------
----GGPNICTTR-GVSS--CQLCLAVSPMCAWCSDEAL----PVGSPRCDLRE-NLLQD
N---CAPESIEFPVSEAQILEARPLSDK-----GSGDSS---------------------
---------------------QVIQVSPQRIALRLRPDDSKTFSIQVRQVEDYPVDIYYL
MDLSYSMKDDLRSIQNLGTKLASQMR-KLTSNLRIGFGAFVDKPVSPYMYISPPEALRNP
CY-D--MKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQNVSRNRDAPEGGFDAIMQATVC-
---------------------------DEKIGWRN--DASHLLVFTTDAKTHIALDGR--
LAGIVRPNDGQCHI--------GGDNH-YSASTTMDY----PSLGLMTEKLSQKNINLI-
------------------------------------FAVTENVFN--------LYQNYSE
LI---PGTTVGVLSTNSSNILQLIVDAYGKIRSKVELE-VRDLPEELSLSFNATCLN-NE
VIPG----LKSCVGLKI--GDTVSFSIEAKVRG-------C--PQEKE---KSFTIKPVG
FKDSLTVQVTFDCD-CACQAHA----EPHSHRCNNGNGTFECGVCRCGPG-WLGSQCECS
EED-YSP--SQQDQC--SPKEGQPI-CSQRGECLCGQCVCHSSD---F---GKITGKYCE
CDDFSCVRYK-GEMCSGH--GQCS-CGD------CLCDSDWTGY----YCN--CTTRTDT
CMSSNGL----LCSGRGKCECGSCVC---IQPG-SYGDTCEKCP--TC-PDA---CTFK-
-KECVECKKFERGVLHEENT-CSRYCRDEME-SVKEL----RDTGKDA---VNCTYKNE-
D-------------DCVVRFQYYED-SSGK------SILYVVE---EPECPKGPD-ILVV
LLSVMGAILLIGFALLLIWK---------LLITIHDRKEFAKFEEE--------------
------------RARA-KWDTANN------------------------------------
------------------------------------------------------------
------------PL--------YKEATSTF-TNITYRGT---------------------
-----------------
>gi|1771447|emb|CAA67357.1|	Pacifastacus leniusculus
------------------------------------------------------------
-----------------------MRHRGILVWAVVSVVWLVVVGVVTAQQH---------
---QQVVDKCN---AQRK--CVDCIQT-PDCMWCSKL--KNESEQRVARCQHIR-ADPPP
S---AAPDHLENITNSVFITQDTPLTVA-----GNENRGTTGEAD---------------
---------------------KIVQLKPQRMKLKLRKGVPINITLTYRQARDYPVDLYYL
MDLSNSMSDDKKQLAALGSELAKLMK-GLTSQFTLGFGSFVDKVLMPYADTS-PQKLLQP
CP-G------CAPPYSFRNDLPLDDDPKQFTIKVNEAPISGNMDSPEGGFDALMQVMVC-
---------------------------TDQIGWRE--QARRIVIFSTDAKFHHAGDGR--
LAGIVAPNDETCHL--------NNLQE-YTDFDKYDY----PSIAQINKIAKEKNINVI-
------------------------------------FAVSSHEL---------LYKELSG
MI---ETSSYGMLDADSGNVVELVRDQYNKISSTMRLT-DNSTNSAVSVRYFSSCKE-GG
APVL----TRECGDIKE--NDTIDFLLEITAVE-------C--PKDANT--TYVEVKTL-
-QDNLVLEIEFKCS-CGCADPE--FVEENAAGC-KGKGDLVCGVCACQEG-YRGEVCQCS
NEYSDNS-ESDTLLC--MAKEGDKV-CSGLGYCSCGLCICNDKP--------VVHGTYCE
CNSRKCQSGV-GMACSGH--GTCD-CNK------CRCDQGYTGD----LCQ--CR-DDSA
CRLQGTQE---TCSGHGKCECGKCKCSQQHGIT-YTGQYCEDCP--TCTAGK---CFEF-
-RDCVQCQQFNTGKLKDT---ACLNCSINSN-KID------SLDGQVATGARLCTFEDE-
E-------------GCLFNFTYRYIDSASDTKPQQ-YQIFVQK---DRQCPQPPP-VLGI
VFGLVAAIVAIGLLTLLIWK---------LLTTLHDRREYAKFEKE--------------
------------RKLP-SGKRAEN------------------------------------
------------------------------------------------------------
------------PL--------YKSAKTTF-QNPAFAQSK--------------------
-----------------
>gi|45361049|ref|NP_989160.1|	Xenopus tropicalis
------------------------------------------------------------
------------------------MARYSVLTFGL--LTCLALCINAQQGG---------
-------TECLKA-NAKS--CGECIQAGPNCGWCTKVNFLQEGEPTSARCDDLA-ALKNK
G---CPEEDIQNPRGRKQKLKDIPITNK-----GKG--ERMDPA----------------
---------------------NITQIRPQQLVFELRSGEPQTFNLTFRRAEDYPIDLYYL
MDLSFSMKDDLENVKSLGTALMTEME-KITSDFRIGFGSFVEKTVMPYISTT-PAKLINP
CT-S---DQNCTSPFSYKNVLNLTSDGKLFNDLVGKQQISGNLDSPEGGFDAIMQVAVC-
---------------------------GEQIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGKCHL--------HGN-M-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEDFQP--------VYQELKN
LI---PKSAVGTLSSNSSNVIQLIIDSYNSLSSELILE-NSKLPEGVTISYKSFCKN-GV
KGTGED--GRKCSNISI--GDQVEFEISVTAHK-------C--PKKGQA--ESIKIKPLG
FTEEVEIVLQFICE-CDCQEKG----TPNSPECHHGNGTFECGACRCNEG-RIGKECECS
TDEVNSE--DMDAYC--RRENSSEI-CSNNGDCICGQCVCKKRD-NPN---EVYSGKYCE
CDNFNCDRSN-GLICGGK--GVCK-CRV------CECFPNYSGS----ACD--CSEDTST
CMAKNGQ----ICNGRGICDCGRCKC---TDPK-FQGPTCELCQ--TC-VGV---CTEH-
-KECVQCRAFQKGEKQEV---CLEQCMHFNI-SLVESREDLPQPGQAE-ALTHCKEKDA-
E-------------DCWFYFTYSVD-SKNE------VLVHVVK---EPECPSGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKSAVTTV-VNPKYEGK---------------------
-----------------
>gi|24640486|ref|NP_524793.2|	Drosophila melanogaster
------------------------------------------------------------
----------------------MILERNRRCQLAL--LMIAILAAIAGQTD------AQK
AAKLTAVSTCA---SKEK--CHTCIQT-EGCAWCMQPDF-----KGQSRCYQNTSSL---
----CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFY
SQSSSGSSSASGYEEYSAG--EIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYL
MDLSKSMEDDKAKLSTLGDKLSETMK-RITNNFHLGFGSFVDKVLMPYVSTI-PKKLEHP
CE-------NCKAPYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIAC-
---------------------------RSQIGWRE--QARRLLVFSTDAGFHYAGDGK--
LGGVIAPNDGECHL--------SPKGE-YTHSTLQDY----PSISQINQKVKDNAINII-
------------------------------------FAVTASQLS--------VYEKLVE
HI---QGSSAAKLDNDSSNVVELVKEEYRKISSSVEMK-DNA-TGDVKITYFSSCLS-NG
PEVQ----TSKCDNLKE--GQQVSFTAQIQLLK-------C--PEDPRDWTQTIHISPVG
INEVMQIQLTMLCS-CPCENPGSIGYQVQANSC-SGHGTSMCGICNCDDS-YFGNKCECS
ATDLTSK-FANDTSC--RADSTSTTDCSGRGHCVCGACECHKRP-NPI---EIISGKHCE
CDNFSCERNR-NQLCSGPDHGTCE-CGR------CKCKPGWTGS----NCG--CQESNDT
CMPPGGGE---ICSGHGTCECGVCKC-TVNDQGRFSGRHCEKCP--TC-SGR---CQEL-
-KDCVQCQMYKTGELKNGDD-CARNCTQFVP-VGVEKVE--IDETKDE---QMCKFFDE-
D-------------DCKFMFKYSEQ---GE------LHVYAQE---NKECPAKVF-MLGI
VMGVIAAIVLVGLAILLLWK---------LLTTIHDRREFARFEKE--------------
------------RMNA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKQATSTF-KNPMYAGK---------------------
-----------------
>gi|46250721|dbj|BAD15077.1|	Halocynthia roretzi
------------------------------------------------------------
-----------------MAFYGGISFLQCLFSLGI--IFILFPLSREQMTT---------
--ADELDAICEEA-SITT--CDACIRADPRCSWCVQGRL----GAKIKRCRA---ATKQT
D---CALGQEQNPRNVFNKTENREFSAI-----GTDITQ---------------------
---------------------AVVQLRPQKIDLELRKGAPIKFNITYRKVSDYPVDLYYV
MDLSHSMTDDLVVLQKLGTTLANDIRNNVTQNIQLGFGTFVDKVMMPFTSTV-PEQLKNP
CVKNPGGGDQCAPPFGFRHQQSISSDLDKFRTAVESTKISGNIDSPEGGFDALMQIAVC-
---------------------------SKDIGWRD--EATHLVVFTTDASFHMALDGK--
LAAILEMNDLKCHLTAGANKYLNPSDIVYSKSKELDY----PSIGQLRHVFSEYKIQPI-
------------------------------------FAVTGDVLP--------LYEGLKE
LI---PNSYVDQLASDSSNIIDIIKDAYNNLKGKLEMN-YNNKPPNVDLKYRVLCPSEPD
WKLQ----SLRCDNITI--GSEVVYEFEITATS-------C--PPDGVTY-PPMTFTSSS
LQESVTINFGFKCS-CDCTNQP----IQNSPQC-NTNGSLVCGICSCYSP-HEGAQCQCT
RES-DDV--SLIDKCKKGGPQSNDEICEGNGICECGTCNCD----------EGYSENFCQ
CSNKGCPKND-KGLCGGPVRGTCHNCGGDGR---CICMDGWTLHPTLGTCS--CNINFCK
VNATDVK----NCTGNGECACDRCRC---DDPLIWSGEFCETCIHPSC-KEVQPECQGSA
VRQCAECVHTARRNRKNADETCKETCGNLQY-LAVAEFPACGSCGTDENCARICDDIDQ-
DIVTPRDCLSPLTSECDIKFKVVWKRSTND------YHLLVKEFDKNSDCRDPIN-PLLY
VLPIVAGIVLIGLIALAVWK---------VYQTMRDKKEWENFERE--------------
------------MKQS-RWTKDIN------------------------------------
------------------------------------------------------------
------------PV--------FVNPSAKF-ENPSYGGDM--------------------
-----------------
>gi|91091112|ref|XP_969214.1|	Tribolium castaneum
------------------------------------------------------------
----------------------------MLVHITL--LIGALLAGIQGQIL---------
--QQFTQNPCD---SRST--CHECIAT-PSCAWCYDTVN----INTTKRCFQPSYPLPPL
DK--CDPSKIYNPDNEMIIISNRALSSR-----TEGEGGTLITEEEQTGGFGGGGGAGGG
INQGGGAWESGG---------TITQVRPQRIKLKLRARQTYSVNMYYTQAEDYPVDLYYL
MDLSKSMEDDKEKLSALGDHLAQTMR-NMTSKFMLGFGSFVDKVVMPYVSTI-PEKLRHP
CT-G------CVAPYGFRNHMTLSTNTTSFSHMVKRASVSGNLDAPEGGFDAIMQAVVC-
---------------------------REQIGWRD--QARRLLVFSTDAGFHYAGDGK--
LGGIVKPNDGECHL--------DQRGY-YTMSSKQDY----PSISQINTYVKKNAINVI-
------------------------------------FAVTAEKKE--------IYEQLKE
HI---EGSSCGKLSNDSSNVVDLITEQYQAISSTVQMK-HNA-SGSVKVRFFSKCLDSKG
REIE----TNKCGNIKV--GSLVQFRVQLEVVE-------C--PSDPRDTKQLIQIYPVG
LNESLLIDLTMLCD-CPCEHEG---FERNSPKC-HNHGTYMCGICDCIEP-AYGPYCECN
KDGTSAN--ISTANC--INPKNGLE-CSGRGNCICGKCECEQRN-NPE---EAISGELCQ
CDNFSCERHN-GLICSGPEHGTCV-CGV------CECKEGWMGD----NCA--CRNATNL
CIKPDSEDPTLICSGNGECECGICKC-RETDEGRYFGRFCEHCPFKNC-SDD---CEKY-
-KECVQCQQYQTGNLTEE---ECRKCPFTPTSARVVE----VDEKNGE---VLCPFYDE-
D-------------DCRFSFVYYFD-EENK------IQVRAQE---ERECPATVF-LLGI
VLGVIAAVVLLGMAILLLWK---------LFTTIHDRREFAKFEKE--------------
------------AMMA-RWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKQATSTF-KNPTYAGKS--------------------
-----------------
>gi|149634688|ref|XP_001508202.	Ornithorhynchus anatinus
------------------------------------------------------------
------------------------MNLQHIFFVLA----SCSICKVFGQTG---------
------GNECLKA-NAKS--CGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLA-ALKSK
G---CLPEDIENPRGSKNIRKNKNVTNR-----SKGTAEKLQPE----------------
---------------------DITQIQPQQLVLKLRSGEPQTFALKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMYEMK-RITSDFRIGFGSFVEKTVMPYISTT-PAKLRNP
CT-G---DQNCTSPFSYKNVLNLTDKGEVFNELVGKQHISGNLDSPEGGFDAIMQVAVC-
---------------------------GSLIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGRCHL--------ENN-V-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEEFQA--------VYKELKN
LI---PKSAVGTLSANSSNVIQLIIDAYNSLSSEVILE-NSKLPEGVTINYKSYCKN-GV
NGTGEN--GRKCSNISI--GDEVQFEISVTANK-------C--PKKGQN--ETIKIKPLG
FTEEVEINLQFICE-CECQNEG----IPESSKCHGGNGTFECGACRCNEG-RVGRHCECS
TDEVNSE--DMDAYC--RKENSSEI-CSNNGECVCGQCVCRKRD-NTN---EVYSGKFCE
CDNFNCDRSN-GLICGGN--GVCK-CRV------CECNPNFTGS----ACD--CSLDTSS
CLASNGQ----ICNGRGICECGSCKC---TDPK-FQGPTCEMCQ--TC-LGV---CAEH-
-KECVQCRAFDKGEKKDT---CVQECSHFNM-TLVENRDKLPQPGQVD-PLSHCKEKDA-
D-------------DCWFYFTYSVN-GNNE------AIVHVVE---TPECPTGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTQEN------------------------------------
------------------------------------------------------------
------------PI--------YKSPINKF-KNPNYGRKAGL------------------
-----------------
>gi|29650243|gb|AAO85806.1|	Pseudoplusia includens
------------------------------------------------------------
---------------------MYIHRSSVLRLCVW--VSLLALCWGQRAEQ---------
---LLAQNPCS---SKTT--CSDCIRT-ASCAWCFASDF------NGPRCFNP--AMERG
GTAGCDEAYIFNPDNQRSVDPRYNMELS-----RAKSRMGMAGGSFEESMSSKGSSFSGS
SASGSAAAAAGSGE-------SLVQMKPQRVSLNLRMNQMQKLTFAYSRAQDYPVDLYYL
MDLSRSMKNDKEKLSTLGSLLSDTMK-NMTSNFWIGFGSFVDKLVMPYVSTV-PKNLISP
CD-G------CAAPYGYQNQMSLSNDTNFFVKAVANADVSGNLDAPEGGFDAIMQAVVC-
---------------------------KQQIGWRD--QARRLLVFSTDAGFHYAGDGK--
LGGIVQPNDGECHM--------KGNT--YTHSTLQDY----PSISQINHKVKKHAINVI-
------------------------------------FAVTAEQIS--------VYEQLSK
HI---EGSSTGVLSNDSDNIVDLVREQYNKITSAVEMK-DSS-SDAVQIVYYSSCLS-GK
ELIQ----TNKCDGLKV--GDVVEFTAEITLKE-------C--PKDRSKWRQTLDISPVG
ISDSLVVDLEMVCD-CPCEQPGHHAYNDSPLVC-SGEGVSACGVCVCAPG-RFGKSCECS
AHGGVSA--EQERGCRPTNASSGPL-CSNRGTCICGVCECNKMD-DPL---KVISGPFCE
CDNFTCDMNK-GLLCSGPDHGECV-CGK------CSCTADYTGP----ACQ--CLKDQTP
CRSPENNE---ICSGNGQCVCGQCMCNSDDDRH-YSGKYCEKCP--TC-PGR---CGEF-
-KDCVLCEVHKRGPKYNADTDTCGDCALFPI-VEEGKIE--ANESRNE---HLCSFYDD-
E-------------DCLYVYVYSYN-ENQQ------LVIRAQK---ERECPKKVP-IPGI
VLGVIAAIVLVGLALLMLWK---------MATTSHDRREFARFEKE--------------
------------RMMA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKQATSTF-KNPTYAGK---------------------
-----------------
>gi|47551111|ref|NP_999730.1|	Strongylocentrotus purpuratus
------------------------------------------------------------
-------------------MKLHRRPQLLFQWTISAVIFFLSLHVFLDAQS---------
---TGTNSACL---QAKN--CGDCIITDPSCAWCAQPDF--QDAENFPRCDNPD-TLRER
G---CQELHIENPQSTMNITGKTPLSKA-----GDPVE----------------------
---------------------NLVQVYPQVVDLTMRPGEKISIDLQIRQAEDFPVDLYYL
MDLSDSMSDDLVQLRSLGGILAGEMK-NITNNFRLGYGAFIDKTVMPYVDIY-PAKLENP
CL-----NKRCGPAFSF-HILPLTLETDRFTEEISKVNSSGNLDSPEGGMDALMQATVC-
---------------------------TDEIGWRE--RARHLLVYTTDASFHIAGDGK--
LGGIVKPNDGKCHM--------DSTGFEYTMANEMDY----PSISKLSQKMETLSILPI-
------------------------------------FAIGKAEVDKQDPFV--FYEDLPQ
YF---HESKAARLSADSSNIVDLIKNIYLNITSEVTVE-TRLGADLFEVDYVAHCLD-GS
ITKD----KQTCMGLKL--GDQISFDVGITMKN-----LSCTVQQWNA---HDSVGRPV-
FTENLVLNVKALCE-CDCSSSE---QEPNSTKC-NFHGTFTCGACMCNEG-RSGRTCECD
TVE--AE--GLDPSC--VQPNSTVE-CSSRGTCVCGECECDTRG-DPN---RIITGEYCQ
CDNYLCPRSG-GEVCGGSDKGTCL-CDEDVG-NFCGCLEGYQGS----ACE--CPTSNDT
CRAPNGE----ICNGVRTCDCGKCQC---NDPK-YSGATCQICP--DC-AGE---CDIN-
-QPCVQCRAFHTGAYNKS---QCKNCPHPIY-VVKELR---REEGHQE-----CRFTDD-
D-------------ECHVIFTYEIL-PNGT------YYIEVQE---DKICPGAPE-MLWV
ILGIIIGVFLVGLALLLIWR---------LLTYIHDRREFQNFEKE--------------
------------RANA-TWEGGEN------------------------------------
------------------------------------------------------------
------------PI--------YKPSTSVF-KNPTYNIK---------------------
-----------------
>gi|73948624|ref|XP_535143.2|	Canis familiaris
------------------------------------------------------------
-MRMLPTLGEELSKEVWKGCRKLLMNLQLIFWIGL----IGSICCVFGQAD---------
------ENRCLKA-NAKS--CGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLE-ALKKK
G---CHPDDIENPRGSKDIKKNKNVTNR-----SKGTAEKLQPE----------------
---------------------DITQIQPQQLVLQLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMR-RITSDFRIGFGSFVEKTVMPYISTT-PAKLRNP
CT-S---EQNCTSPFSYKNVLSLTDKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVC-
---------------------------GSLIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGQCHL--------END-V-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEEFQP--------VYKELKN
LI---PKSAVGTLSANSSNVIQLIIDAYNSLSSEVILE-NSKLPEGVTINYKSYCKN-GV
NGTGEN--GRKCSNISI--GDEVQFEISITSNK-------C--PNKNS---ETIKIKPLG
FTEEVEVILQFICE-CECQSEG----IPSSPKCHEGNGTFECGACRCNEG-RVGRHCECS
TDEVNSE--DMDAYC--RKENSSEI-CSNNGECVCGQCVCRKRD-NTN---EIYSGKFCE
CDNFNCDRSN-GLICGGN--GVCK-CRV------CECNPNYTGS----ACD--CSLDTTS
CLATNGQ----ICNGRGVCECGACKC---TDPK-FQGPTCEMCQ--TC-LGV---CAEH-
-KECVQCRAFNKGEKKDT---CAQECSHFNI-TKVENRDKLPQPGQVD-PLSHCKEKDV-
D-------------DCWFYFTYSVN-GNNE------AIVHVVE---TPECPTGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTQEN------------------------------------
------------------------------------------------------------
------------PI--------YKSPINNF-KNPNYGRKAGL------------------
-----------------
>gi|47522764|ref|NP_999133.1|	Sus scrofa
------------------------------------------------------------
------------------------MNLQLIFWIGL----ISSVCYVFGQAD---------
------ENRCLKA-NAKS--CGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLE-ALRKK
G---CHPDDIENPRGSKNIKKNKNVTNR-----SKGTAEKLQPE----------------
---------------------DITQIQPQQLVLQLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMR-RITSDFRIGFGSFVEKTVMPYISTT-PAKLRNP
CT-S---EQNCTSPFSYKNVLSLTDKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVC-
---------------------------GSLIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGHCHL--------END-V-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEEFQP--------VYKELKN
LI---PKSAVGTLSANSSNVIQLIIDAYNSLSSEVILE-NSKLPEGVTINYKSYCKN-GV
NGTGEN--GRKCSNISI--GDEVQFEISITANK-------C--PNKNS---ETIKIKPLG
FTEEVEIILQFICE-CECQSEG----IPSSPKCHDGNGTFECGACRCNEG-RVGRHCECS
TDEVNSE--DMDAYC--RKENSSEI-CTNNGECVCGQCVCRKRD-NTN---EIYSGKFCE
CDNFNCDRSN-GLICGGN--GVCK-CRV------CECNPNYTGS----ACD--CSLDTTS
CMAVNGQ----ICNGRGVCECGVCKC---TDPK-FQGPTCEMCQ--TC-LGV---CAEH-
-KECVQCRAFNKGEKKDT---CAQECSHFNI-TKVENRDKLPQPGQVD-PLSHCKEKDV-
D-------------DCWFYFTYSVN-GNNE------ATVHVVE---TPECPTGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKSAVTTV-VNPKYEGK---------------------
-----------------
>gi|15004986|dbj|BAB62173.1|	Crassostrea gigas
------------------------------------------------------------
-----------------------------MVSTVWFLCFTTIFCSLNPIGKLSAQDLRSD
TLTPTQENPCLKE-KTTT--CGECIAISTLCAFCTDAEY---DANNYPRCDLLT-THQKL
INNKPRCKDIVNPSSTLVKSRDDRLIDG-----DRDR-----------------------
---------------------YAVQIRPQQIDLELRPNDPQTFNLTFRLAENYPVDLYYL
MDLSNSMADDKEKLASLGVKIAEDMS-TITKNFKLGFGSFVDKVVMPYVSTA-PNKINSP
CP-G------CEKAYGFRNVHPLDPNATLFRDKVNAAKVSGNLDAPEGGFDAIMQAIAC-
---------------------------ETEIGWRN--RSRRMLLFSTDAGFHYAGDGE--
LGGIIQPNDGNCHL--------SPDGM-YTESSNQDY----PSISQVAVKAKEKNVNII-
------------------------------------FAVTNDQKN--------IYDQLKP
II---AGSETGVLASDSQNVVKLVRDNYLAITSKVEMI-VEN-SDNLEVKFRTKCK--GT
EEKE----TNKCENLAI--GGSVDFSVTVEVKS-------C--PPKGEE-ERTLRIKPVG
LYDDLTVKLKLMCQ-CDCESPKQMEDNKNHEKC-NGNGTYVCGMCVCNEP-YFGDYCDCD
KGTGTIA--DKESEC-IQDKNTTII-CNGRGECNCGTCTCRERQKGTN---HFYTGRYCE
CDDYSCPYYA-GLICGGLGRGQCD-CGN------CKCNAGFNGT----NCG--CNTDNST
CM-YNGL----LCNDKGTCECGKCTC---TDPK-YFGPQCQECD--NCGQEQ---CRTH-
-QDCALCNRTNAGVLTKEQ--CEKECSHT---TAVDK----IRNGITN-----CEYVDQ-
N-------------GCFIYFTYFYD-DDGT------LRVEVQK---EPECPPEVN-VLAI
VLGVIAGIVFFGIILLLIWK---------LFTTISDKRELARFEKE--------------
------------AMNA-RWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKQATSTF-VNPTYRQ----------------------
-----------------
>gi|58381607|ref|XP_311354.2|	Anopheles gambiae
------------------------------------------------------------
--------------------------MLPRAGPMAAGALLLLVALVADTTL--------G
QLSNYQLTTCP---GKTT--CSQCIQT-TNCRWCTMPNF------THPRCH----GQIEK
Y---CPEEYTVDPSNTFQLVQGRELTKP-----SRRVLEGQSERESYYS----SSHYQSS
SSSSSSSSFQQSSYESESAAGSIVQISPQRVSLKLRLNEAFRFNVNYAQAEDYPVDLYYL
MDLSKSMEDDKTILSTLGADLASEMR-KITSNFKLGFGSFVDKVLMPYVSTV-PKNLREP
CP-G------CVAPYGYHNLMPLSTDANLFSQEVQRANVSGNLDAPEGGFDAIMQAIVC-
---------------------------REQIGWRE--KARRLLLFSTDAGFHYAGDGK--
LGGVITPNDGECHL--------DHNGR-YTHSTTQDY----PSISQINLKVKQNAINVI-
------------------------------------FAVTAEELS--------VYEQLSR
LV---EGSSAAKLSNDSSNIVSLVRDQYNKISSSVEMK-DNRTDNVIDVKYYSRCRNTNG
ALQQ----TNRCEGLKV--GDVVTFEAHITLLK-------C--PTDPRDWQQVLQIYPVG
INESLTVDIEMLCS-CPCEHPSDPEYRERADEC-SNAGTYKCGICECDGT-YHGQRCECS
AMESLLE-PGMVDAC--RMSNASEE-CSGRGQCVCGVCVCERRP-NPD---ELIDGRYCE
CDNFSCDRPG-GLLCSGPDHGRCV-CGQ------CECREGWTGP----ACD--CRASNET
CMPPGGGE---LCSGHGTCECGTCRC-TVTEDGRYTGRYCEKCP--TC-AGR---CNEF-
-KHCVQCQQYKTGPLAEANE-CATNCTLFVP-IPVEKVT--IDEERND---NKCTFFDE-
D-------------DCRFEFSYNDS-DQDK------VVVTAQE---NRECPPKVF-MLGI
VLAVIAVVVLIGMAVLLLWK---------VLTSIHDRREFARFEKE--------------
------------RMMA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKQATTTF-KNPTYAGK---------------------
-----------------
>gi|148665440|gb|EDK97856.1|	Mus musculus
------------------------------------------------------------
--------------------------MPRVPATLY--ACLLGLCALVPRLA---------
-----GLNICTSG-SATS--CEECLLIHPKCAWCSKEYF-GNPRSITSRCDLKA-NLIRN
G---CEGE-IESPASSTHVLRNLPLSSK-----GSSATGS--------------------
---------------------DVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYL
MDLSLSMKDDLENIRSLGTKLAEEMR-KLTSNFRLGFGSFVDKDISPFSYTA-PRYQTNP
CI-GYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVC-
---------------------------KEKIGWRK--DALHLLVFTTDDVPHIALDGK--
LGGLVQPHDGQCHL--------NEANE-YTASNQMDY----PSLALLGEKLAENNINLI-
------------------------------------FAVTKNHYM--------LYKNFTA
LI---PGTTVEILHGDSKNIIQLIINAYSSIRAKVELS-VWDQPEDLNLFFTATCQD-GI
SYPG----QRKCEGLKI--GDTASFEVSVEARS-------C--PGRQAA--QSFTLRPVG
FRDSLQVEVAYNCT-CGCSTGL----EPNSARC-SGNGTYTCGLCECDPG-YLGTRCECQ
EGE-NQS--GYQNLC--REAEGKPL-CSGRGECSCNQCSCFESE---F---GRIYGPFCE
CDSFSCARNK-GVLCSGH--GECH-CGE------CKCHAGYIGD----NCN--CSTDVST
CRAKDGQ----ICSDRGRCVCGQCQC---TEPG-AFGETCEKCP--TC-PDA---CSSK-
-RDCVECLLLHQGKPDNQT--CHHQCKDEVI-TWVDTI---VKDDQEA---VLCFYKTA-
K-------------DCVMMFSYTEL-PNGR------SNLTVLR---EPECGSAPN-AMTI
LLAVVGSILLIGMALLAIWK---------LLVTIHDRREFAKFQSL--------------
------------KP----------------------------------------------
------------------------------------------------------------
------------PV--------QKAHLHTH-CRFRLQQVQQILQWLSGLRLLDGWR--GT
KDEDSGVPWTSWTICSR
>gi|108871137|gb|EAT35362.1|	Aedes aegypti
------------------------------------------------------------
---------------------MTILISRKRPLAVMTLAAILLVCVVTLAAA---------
--QSSSQLTCP---GKTT--CRECIQT-SNCRWCTQANF------TKPRCHGHDIGY---
----CPEEYTVDPSNEAITLIARELSKP-----TKVGGGGAGGGYEAEMSGSSHWSSSSS
SHSSSSSSSSSSGHMSASGH-NIVQIYPQRVQLEV-----YRLGVKYSQAEDYPVDLYYL
MDLSKSMEDDKEKLSSLGAQLAEEMQ-KITSNFRLGFGSFVDKVLMPYVSTV-PKKLEHP
CD-G------CEAPYGYKNHMSLSVDTSRFSEEVERAAVSGNLDAPEGGFDAIMQAVVC-
---------------------------REQIGWRE--MARRLLVFSTDAGFHYAGDGK--
LGGVITPNDGECHL--------DKTGR-YTHSTIHDY----PSISQINLKVKQNAINVI-
------------------------------------FAVTQNELS--------VYERLSK
LV---EGSSAAMLSNDSSNIVSLVRDEYNKISSSVEMK-DNRTDSLIDVKYYSRCKG-DG
PLVQ----TSKCDGLKV--GDIVNFEAHITLLK-------C--PENPRDWNQILQIYPIG
INESLTVDIEMLCS-CPCELPGNPDYKEYAEEC-SGVGTYKCGICDCDEF-HHGHKCECS
ATDIHTE-SGFAENC--RQTNTSIE-CSGRGQCVCGVCDCDKRV-NPE---EIISGTFCE
CDNFSCDRNN-GLLCSGPKQGVCS-CGE------CVCAEGWTGA----ACD--CKATNES
CIPPSGGE---ICSGHGTCECGSCRC-KITEEGRYSGRFCEKCP--TC-SGR---CNEF-
-KHCVQCQMYKTGPLADPDD-CATNCTLFVP-TGVKKVE--IDEEKDD---NKCTFFDE-
D-------------DCRYEFSYND--SGEK------IVVKAQE---ERECPPKVF-MLGI
VLAVIAAVVLIGLAVLLLWK---------LLTTIHDRREFARFEKE--------------
------------RMMA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKQATTTF-KNPTYAGK---------------------
-----------------
>gi|122138000|sp|Q2VJ42|ITB2_OV	Ovis canadensis
------------------------------------------------------------
---------------------------MLPQRPQL--LLLAGLLSLQSVLS---------
-------QECTKY-KVST--CRDCIESGPSCAWCQKLNFTGQGEPDSTRCDTRA-QLLSK
G---CPADDIMEPKSLAETRQSQAG-----------------------------------
---------------------RQKQLSPEEVTLYLRPGQAAAFNVTFQRAKGYPIDLYYL
MDLSYSMVDDLANVKKLGGDLLRALN-DITESGRIGFGSFVDKTVLPFVNTH-PEKLRNP
CP-N--KEKECQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAAC-
---------------------------PEEIGWRN---VTRLLVFATDDGFHFAGDGK--
LGAILTPNDGRCHL--------EDN-L-YKSSNEFDY----PSVGQLAHKLAESNIQPI-
------------------------------------FAVTKKMVK--------TYEKLTE
II---PKSAVGELSEDSKNVVELIKSAYNKLSSRVFLD-HNTLPDTLKVAYDSFCSN-RV
SQVDQP--RGDCDGVQI--NVPITFQVKVTATE-------C--IQE-----QSFTIRALG
FTDTVTVRVLPQCE-CQCREAS-----RDRGVC-GGRGSMECGVCRCDAG-YIGKNCECQ
THGRSSQ--ELEGSC--RKDNSSII-CSGLGDCICGQCVCHTSD-VPN---KKIYGQFCE
CDNVNCERYD-GQVCGGDKRGLCF-CGA------CRCNDQYEGS----ACQ--CLKSTQG
CLNLNGV----ECSGRGRCRCNVCQC----DPG-YQPPLCIDCP--GC-PVP---CAGF-
-APCTECLKFDKGPFAKN---CSAACGQTKL-LSS------PVPGGRK-----CKERDS-
E-------------GCWMTYTLVQRDGRNR------YDVHVDD---MLECVKGPN-IAAI
VGGTVGGVVLVGILLLAIWK---------ALTHLSDLREYHRFEKE--------------
------------KLKS-QWN-NDN------------------------------------
------------------------------------------------------------
------------PL--------FKSATTTV-MNPKFAES---------------------
-----------------
>gi|126341190|ref|XP_001366613.	Monodelphis domestica
------------------------------------------------------------
------------------------MSLQLIFWVGL---VSCSIYQVFGQTG---------
------GNDCLKA-NAKS--CGECIQAGPNCGWCTNSSFLQEGMPTSARCDDLE-ALEKK
G---CRPQDIENPRGYKDIRKNKNVTNR-----SKDTAEKLQPE----------------
---------------------DITQIQPQQLTLKLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMK-RITSDFRIGFGSFVEKTVMPYISTT-PAKLRNP
CT-G---DQNCTSPFSYKNVLPLTDKGEVFNDLVGKQHISGNLDSPEGGFDAIMQVAVC-
---------------------------GSLIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGRCHL--------ENN-V-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEEFQA--------VYKELKN
LI---PKSAVGTLSANSSNVIQLIIDAYKSLSSEVILE-NGKLPEGVTINYKSYCKN-GV
NGTGEN--GRKCSNISI--GDEVQFEISVTSNK-------C--PKKDT---ETFKIKPLG
FTEEVEITLQFICE-CECQSEG----LPNSPECHEGNGTFECGACRCNEG-RVGRHCECS
TDEVNSE--DMDAYC--RKENSSEI-CSNNGECVCGQCVCRKRD-NTN---EIYSGKFCE
CDNFNCDRSN-GLICGGN--GVCK-CRV------CECNPNFTGS----ACD--CSLDTSS
CMASNGQ----ICNGRGVCVCGSCKC---TDPK-FQGATCEMCQ--TC-LGV---CAEH-
-KECVQCRAFDKGEKKDT---CLKDCPYFNI-TKVKSREDLPQPGQRE-ALSHCKEKDV-
D-------------DCWFYFTYSVN-GNNE------VVVHVVE---TPECPTGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTQEN------------------------------------
------------------------------------------------------------
------------PI--------YKSPINNF-KNPNYGRKAGL------------------
-----------------
>gi|156541142|ref|XP_001601489.	Nasonia vitripennis
MRDVLRVIDLLAFGILKVRASMYGVMVPQVRNSQRTDAAELLMLLVMVVAGFEVICDKGE
KTFPISDEQDSALLSGFYQSFGKYLRKKMVGSSRW-GLILLLLTWISSSAA--------Q
YSKPTGANPCI---GKQS--CHDCIQT-PTCAWCSRPNF------EYNRCFSP--YLSKK
IDEACP--DAFNPDNVYIKRRAKEIWKG-----NYTVGTAIEEHIEVSAGGSHSSSGSFN
INSSSGTKTSSVIGGKN----EAVQLYPQHIELKLRINEAQKIKIQYAQAEDYPVDLYYL
MDLSNSMKDDKQKLSDLGQLLVESMK-NITSNFALGFGSFVDKVAMPYVSMS-GDNLKSP
CD-G------CAAPYGYRNHMPLSRKPKEFAEQVRNASVSGNLDAPEGGFDAIMQAIVC-
---------------------------RDEINWRE--RARKLLLFSTDAGFHFAGDGK--
LGGIVKPNDGCCHL--------DHNGL-YTHSTLQDY----PSISQINLKVKENSVNII-
------------------------------------WAVTEEQLK--------IYQSLTN
HI---EGSYAAMLSEDSSNIVDLVREQYNAISSTVELK-DTA-SNWVNINYYSNCLG-GG
EMVE----TNKCEGVKV--GNKIEFTAEIIIPA-------C--PKDRSEWKQKFLIYPVG
INESLTVDLEMICD-CGCENPDSPSYIPNAFEC-NYNGDLSCGICICKPG-FFGKKCECG
VNDKVQT-VKNEFVC--RPDNTSTVDCSGRGICECNQCNCYPRE-NPD---EIVDGEFCE
CDNFSCDRRN-KTLCSGH--GKCN-CGH------CECNPNWTGP----ACD--CNTDKTP
CIKF-GL----ECSGHGTCECGKCKCHAEGETI-YKGTHCQICT--NC-PNR---CEEL-
-KPCVLCTVFKAGNLTEAE--CNSTCDEYDI-QIVETLE--INADEDE---TGCWGYDE-
Q-------------DCKYYFGYLFNMTTHK------LQVKVQE---ARECPPQVY-VLGI
VLGVIAAVVLVGLALLLVWK---------VATSIHDRREFARFEKE--------------
------------RMMA-RWDASEN------------------------------------
------------------------------------------------------------
------------PI--------YRQATSTF-KNPTYTASGAHMSMHK-------------
-----------------
>gi|109033501|ref|XP_001113909.	Macaca mulatta
------------------------------------------------------------
--------------------------MPRAPAPLY--ACLLGLCALLPGLA---------
-----GLNICTSG-SATS--CEECLLIHPKCAWCSKEDF-GSPRSITSRCDLRA-NLVRN
G---CGGE-IESPASSFHILRSLPLSSK-----GSGSAGW--------------------
---------------------DVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYL
MDLSLSMKDDLDTIRNLGTKLAEEMR-KLTSNFRLGFGSFVDKDISPFSYTA-PRYQTNP
CI-GYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVC-
---------------------------KEKIGWRK--DALHLLVFTTDDVPHIALDGK--
LGGLVQPHDGQCHL--------NEANE-YTASNQMDY----PSLALLGEKLAENNINLI-
------------------------------------FAVTKNHYM--------LYKNFTA
LI---PGTTVEILDGDSKNIIQLIINAYNSIRSKVELS-VWDQPEDLNLFFTATCQD-GV
SYPG----QRKCEGLKI--GDTASFEVSVEARS-------C--PSRHTE--HVFALRPVG
FRDSLEVGVTYNCT-CGCSVGL----EPNSARC-SGSGTYVCGLCECSPG-YLGTRCECQ
DGE-NHS--VYQNLC--REAEGKPL-CSGRGECSCNQCSCFESE---F---GKIYGPFCE
CDNFSCARNK-GVLCSGH--GECH-CGE------CKCHAGYIGD----NCN--CSTDIST
CRGKDGQ----ICSERGHCLCGQCQC---TEPG-AFGEMCEKCP--TC-PDA---CSTK-
-RDCVECLLLHSGKPDNQT--CHSLCRDEVI-TWVDTI---VKDDQEA---VLCFYKTA-
K-------------DCVMMFTYTEL-PSGK------SNLTVLR---EPECGNTPN-AMTI
LLAVVGSILLVGLALLAIWK---------LLVTIHDRREFAKFQSE--------------
------------RSRA-RYEMASN------------------------------------
------------------------------------------------------------
------------PL--------YRKPISTHTVDFTFNKFNKSYN--------------GT
VD---------------
>gi|3089557|gb|AAC15066.1|	Lytechinus variegatus
------------------------------------------------------------
-------------------MRLHRRQELLLQWIFS--VFIISLHVFSDAQS---------
---TGTSSSCL---QART--CGDCIITDPSCAWCAQPDF--QDAENYPRCDSPD-TLRER
G---CMEEHIENPQSTINITQKTPLSKA-----GASVD----------------------
---------------------NLVQVYPQEIDLTLRPGEKVSIDLQIRQAEDFPVDLYYL
MDLSDSMSDDLVQLRSLGGILAAEMQ-NITNNFRLGYGAFIDKTVMPYIDIF-PAKLQNP
CL-----NKKCGPAFSFHNILPLTLETGRFTEEVSKVNSSGNLDSPEGGMDALMQATVC-
---------------------------TEEIGWRD--RARTLLVYTTDASFHIAGDGK--
LGGIVKPNDGRCHM--------DDTGFRYTKADEMDY----PSISKLSQKMEALSILPI-
------------------------------------FAIGKAGVDKQDPFV--FYEDLPQ
YF---HESKAARLSADSSNIVDLIKNVYENITSEVTVG-DKADKDLFELDYVAHCLD-GS
VTKD----KKTCAGLKL--GDQISFDVSITMKN-----LSC--TVNDGM--HTISIGPTT
FTENLVLNVKALCE-CECSNDV---PEPNSSKC-SFHGTFTCGACVCNEG-RSGKICECD
RAE--AE--GLDESC--VAPNSTVE-CSGRGDCVCGLCECDTRG-DPN---RVITGEFCQ
CDNYLCPRSG-GKVCGGSDRGTCE-CDEDRNINFCTCAEGYKGS----ACX--CPISNDT
CRAPNGE----ICNGVGTCNCGKCDC---NDPK-YSGATCQICP--DC-AGA---CEIN-
-QPCVQCRAFHTGAFNKS---QCKNCPHPIY-VVTELR---KAEGHQE-----CRFTDD-
D-------------ECEVIFIYEIL-PNGT------FYIEVQE---EKICPGAPE-MLWV
ILGIIIGIILVGLALLLIWR---------LLTYIHDRREFQNFEKE--------------
------------RANA-TWEGGEN------------------------------------
------------------------------------------------------------
------------PI--------YKPSTSVF-KNPTYNIK---------------------
-----------------
>gi|56785948|gb|AAW29104.1|	Bubalus bubalis
------------------------------------------------------------
---------------------------MLRQRPQL--LFLSGLLALQSVLS---------
-------QECTKY-KVST--CRDCIESGPGCAWCQKLNFTGQGEPDSLRCDTRA-ELLSK
G---CPADDIMEPKSLAETRDSQAD-----------------------------------
---------------------RQKQLSPQEVTLYLRPGQAAAFNVTFRRAKGYPIDLYYL
MDLSYSMVDDLINVKKLGGDLLRALN-DITESGRIGFGSFVDKTVLPFVNTH-PEKLRNP
CP-N--KEKECQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAAC-
---------------------------PEEIGWRN---VTRLLVFATDDGFHFAGDGK--
LGAILTPNDGRCHL--------EDN-L-YKSGNEFDY----PSVGQLAHKLAESNIQPI-
------------------------------------FAVTKKMVK--------TYEKLTE
II---PKSAVGELSEDSKNVVELIKNAYNKLSSRVFLD-HSTLPDTLKVTYDSFCSN-RV
SQVDQP--RGDCDGVQI--NVPITFQVKVTATE-------C--IQQ-----QSFTIRALG
FTDTVTVRVLPQCE-CQCRDAS-----RDGSIC-GGRGSMECGVCKCDAG-YIGKNCECQ
TQGRSSQ--ELEGSC--RKDNSSII-CSGLGDCICGQCVCHTSD-VPN---KKIYGQFCE
CDNVNCERYD-GQVCGGEKRGLCF-CGT------CRCDEQYEGS----ACQ--CLKSTQG
CLNLDGV----ECSGRGRCRCNVCQC----DPG-YQPPLCSECP--GC-PVP---CAGF-
-APCTECLKFDKGPFAKN---CSAACGQTKL-LSS------PVPGRK------CKERDS-
E-------------GCWMTYTLVQRDGRDR------YDVHVDD---MLECVKGPN-IAAI
VGGTVGGVVLVGILLLVIWK---------ALTHLSDLREYHRFEKE--------------
------------KLKS-QWN-NDN------------------------------------
------------------------------------------------------------
------------PL--------FKSATTTV-MNPKFAES---------------------
-----------------
>gi|110749786|ref|XP_001120851.	Apis mellifera
------------------------------------------------------------
----------------------------MPGWTILFFCVQLSSFIFCEYKD---------
-----SEILCA---SQQS--CKNCLQT-PRCVWCSTPVSNQSVNNPLIRCVTRE-KFSNE
GDHWCRTSDVIIETNKMLILENRPLSLT-----KGT------------------------
---------------------DPVQIQPQKIDLRLRLGEEYRLTLKYSQAEDYPVDLYYL
MDLSKSMEDYRDQLSELGFQLAEAMR-NLTSNFRLGFGSFVDKVVLPMTSTQ-PDKLKSP
CN-LDKTKKPCAPPYGYKNQMPLTENIALFKTRVQEAPVSGNLDSPEGGLDAMMQAMVC-
---------------------------TKEIGWRQ--NARHFIVFSTDANFHIAGDGR--
LAGIIEPNDCLCHL--------DSEGF-YTYSLLQDY----PSIFQINKVARENNMNII-
------------------------------------FAVTSNRNE--------TYQLLSR
SI---RGSSIGTIERNSRNVVALVSGEYEKLVNTIIMT-DDA-PKMIDVKYFSRCLDKNG
ELKE----RQECGGLRV--GNIVEFEVTLQAIE-------C--PKDSNEWQTSMHIKPRG
INESLTINLSIACD-CPCERPGHPGYTPASENC-RGNGTLVCGICSCDDG-FYGKQCECE
GNDARAESAAAMSDC--RADNETTEICSDHGVCKCGVCECVKRP-NPQ---EVFYGKYCE
CDNFSCKRKE-GLVCGGR--GKCE-CGT------CNCFPGWGGE----MCD--CKETNST
CISSNSETME-ICSGRGDCICGSCYCHEKDNIR-YSGRYCEECP--VC-PDQR--CEQL-
-KNCVECVVHKSGPLARSE--KCDECMHQID-IVDKIVEDSEKDQNKT---RICRTPGD-
A-------------GCTFVFKYEYY-RDGTGGDIKIFKILAER---EKSCPVPIN-VLGV
AVGLIISTVIIGFAILLTWK---------ILTMIRDNREFKKFERE--------------
------------RILANKWNRRDN------------------------------------
------------------------------------------------------------
------------PL--------YKEATSTF-KNPTFNTNTIR------------------
-----------------
>gi|10998792|gb|AAG25994.1|AF30	Podocoryne carnea
------------------------------------------------------------
---------------------------MHFFQIIS--ILLLHLGYIKFTAA---------
------VHECN---TKLT--CSDCISSSPKCSWCEDIYYNKTEKYFHKKCDLVE-THQRQ
L---CSK--INNPLSNSVLVKTSPLV----------------------------------
---------------------GETRVSPQEITLKLRPEQPTKVDIKVKTPKNFPIDLYYL
MDLSRSMRDDLAQIKTLGDILSREMA-DVTSNFRLGFGGFVDKPIGPYTRTK-KEEIETA
VE------PGMQNTFGFRNYLPLDKDTTKFGNVLNNVNISYNVDVPEGSLEALMQVIVC-
---------------------------NDEIGWRKKKKARRIVIITTDATFHYAGDGL--
LGGVVIPNDEKCYL--------NPEGL-YTAWNMFDY----PSLSQIRSKMIENQMIPI-
------------------------------------FATTGNTA---------LYQKVAE
FFGEASGAVADALNSNSSNVVPLIKDAYQKIAKTVSIK-ADA-SDGIDVKFQAKC---GK
EELKD---SAFCNNIQI--GEEVTFVTEVVASD-------C--RHAGKA--TSFKLETP-
-FDDVVVNVELLCE-CNCTDPI-----INSTHC-TARGNLSCGMCFCDRDLYGGRFCQCT
AEEAKNQ-----TLC--RVPGSNKPICSGKGTCDCGECVCDEPQKNKNNEMEYIYGDQCQ
CSNTTCPRSNLNQVCGGLERGSCE-CGK------CNCTESWQGD----ACEDRCLAGEDR
CFDNAGV----MCSGKGTCKCNQCKC----IDG-YIGDFCQECV-TNC-PDP---CQNY-
-RECVKCRVFDTSDLSTAE--CEVECARWNI-TSHIVVD--KVPDDRR-----CIARDE-
D-------------DCSFVFTYNKDNITDT------VQLVVQR---DRICPAEPD-ILAI
ILGVIAGIVGIGLALLLIWK---------LLATIQDRREFAKFEKD--------------
------------RQNP-KWDSGEN------------------------------------
------------------------------------------------------------
------------PI--------YKKATSTF-QNPMYGNKPEEEEPLTT------------
-----------------
>gi|124963|sp|P05556|ITB1_HUMAN	Homo sapiens
------------------------------------------------------------
------------------------MNLQPIFWIGL----ISSVCCVFAQTD---------
------ENRCLKA-NAKS--CGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLE-ALKKK
G---CPPDDIENPRGSKDIKKNKNVTNR-----SKGTAEKLKPE----------------
---------------------DIHQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMR-RITSDFRIGFGSFVEKTVMPYISTT-PAKLRNP
CT-S---EQNCTTPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVC-
---------------------------GSLIGWRN---VTRLLVFSTDAGFHFAGDGK--
LGGIVLPNDGQCHL--------ENN-M-YTMSHYYDY----PSIAHLVQKLSENNIQTI-
------------------------------------FAVTEEFQP--------VYKELKN
LI---PKSAVGTLSANSSNVIQLIIDAYNSLSSEVILE-NGKLSEGVTISYKSYCKN-GV
NGTGEN--GRKCSNISI--GDEVQFEISITSNK-------C--PKKDS---DSFKIRPLG
FTEEVEVILQYICE-CECQSEG----IPESPKCHEGNGTFECGACRCNEG-RVGRHCECS
TDEVNSE--DMDAYC--RKENSSEI-CSNNGECVCGQCVCRKRD-NTN---EIYSGKFCE
CDNFNCDRSN-GLICGGN--GVCK-CRV------CECNPNYTGS----ACD--CSLDTST
CEASNGQ----ICNGRGICECGVCKC---TDPK-FQGQTCEMCQ--TC-LGV---CAEH-
-KECVQCRAFNKGEKKDT---CTQECSYFNI-TKVESRDKLPQPVQPD-PVSHCKEKDV-
D-------------DCWFYFTYSVN-GNNE------VMVHVVE---NPECPTGPD-IIPI
VAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKE--------------
------------KMNA-KWDTGEN------------------------------------
------------------------------------------------------------
------------PI--------YKSAVTTV-VNPKYEGK---------------------
-----------------
