>gi|147903006|ref|NP_001079435.	Xenopus laevis
------------------------------------------------------------
----------------------------------------------------MELLRNIA
YQPSSGGKMCEQALGR---------------------------VCDPDRRWKVPGDGEP-
------IHHSCSATDVSRIITDPGTGRRYCRGKVLGKGGFAKCYEMKDLTTNKIYAAKII
PHSRVSK-PHQREK------------------------------IDKE-IELHRTLNHRH
VVQFYHYFEDKENIYILMEYCGRRSMAHILKTRKVLTDPEVRYYLKQIVSGLKYLHEQEI
LHRDLKLGNFFINESMELKVGDFGLAARLEPLEQRRRTICGTPNYLSPEVL---NKQ--G
HGCESDIWALGCVMYTMLLGRPPFETTNLKETYKCIREARYSLP-SS--LMTSAKHLIAS
MLSRNPEDRPSLDEITQHDFFTQGFT--PERLPTTCCH----TAPD-FHLSSPAKNFFKK
AAAALFGGKKE-------------KSKYLDNH-NKLPKEDEVIYKLRQGLQKNTIS----
-------------------------HQRHNPRTDEEIKTISK-------SDVLVERAD--
KQHMGDTIHMIV------RGTLGSCSS--------------------SSECLEDSTMGTV
ADTVARVLKDCLEKM-------PDADAIPKEQ-----------IDTSFH-----------
---------------WVTKWV----DYSNKYGFGYQLSDHTVGVLFNNGAHMSFLPDKKT
VHYYAELGQC----SVF-------PA--TEAPEQFISQVTVLKYFSHYM----EENLMDG
GDLPS--VTDVCRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIIANQ-NDEYVL
TYINEDRMSTTFHLSTLLISGG-----SSDLKNRMEYALNMLLQRCNEVA----------
---------------------------------------
>gi|6323643|ref|NP_013714.1|	Saccharomyces cerevisiae
------------------------------------------------------------
-----------------------------------------MSLGPLKAINDKQLNTRSK
LVHTPIKGNTADLVGK-------------ENHFKQTKRLDPNNDHHHQPAQKKKREKLS-
-----------ALCKTPPSLIKTR-GKDYHRGHFLGEGGFARCFQIKD-DSGEIFAAKTV
AKASIKS-EKTRKK------------------------------LLSE-IQIHKSMSHPN
IVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRV
IHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVL---MGKHSG
HSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFP-RDKPISDEGKILIRD
ILSLDPIERPSLTEIMDYVWFRGTF---PPSIPSTVMS----EAPN-FEDIPEEQSLVNF
KDCMEKSLLLE-------------SMSSDKIQ-RQKRDYISSIKSSIDKLEEYHQN----
-----------------------RPFLPHSLSPGGTKQKYKE-VVDIEAQRRLNDLAR--
EARIRRAQQAVL------RKELIATST---------------------NVIKSEISLRIL
ASECHLTLNGIVEAEAQYKMGGLPKSRLPKIK-------------HPM------------
---------------IVTKWV----DYSNKHGFSYQLSTEDIGVLFNNGTTVLRLADAEE
FWYISYDDREGWVASHY-------LL--SEKPRELSRHLEVVDFFAKYM----KANLSRV
STFGR---EEYHKDDVFLRRYTRYKPFVMFELSDGTFQFN-FKDHHKMAISDG---GKLV
TYISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTVD--------
---------------------------------------
>gi|24667346|ref|NP_524179.2|	Drosophila melanogaster
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MAAKPEDKS-
-----------T--DIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIV
SKKLMIK-HNQKEK------------------------------TAQE-ITIHRSLNHPN
IVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRI
IHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEIL---TKK--G
HSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVP-SY--LRKPAADMVIA
MLQPNPESRPAIGQLLNFEFLKGSKV--PMFLPSSCLT----MAPR-IGSNDTIEDSMH-
------------------------RKPLMEMN----------------------------
-----------------------------GIRPDDTRLESTF------LKANLHDAIT--
ASAQVCRHSEDY------RSDIESLYQ----------------------------QLTNL
INGKPRILQGNL----------GDENTDPAAQ--------------PLF-----------
---------------WISKWV----DYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQIN
VHFIDKDGKE----TYM-------TT--TDYCKSLDKKMKLLSYFKRYM----IEHLVKA
GANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLN-FSDHMKLILCPR---MSAI
TYMDQEKNFRTYRFSTIVENGV-----SKDLYQKIRYAQEKLRKMLEKMFT---------
---------------------------------------
>gi|109475363|ref|XP_342889.3|	Rattus norvegicus
------------------------------------------------------------
--MTLDLAYVTRSPQPLRAWLPERGGAGDDETPGRGQAFIDKNAGLSPASARSQRRETRQ
RHPRPGPGGTENKLGRRCAAPRRAVRMEPAAGFLSPRPFPRAAAPSSPPAGPGPPASAS-
PRSEPGVLAGPQTPDASRLITDPRSGRTYIKGRLLGKGGFARCYEATDTETSIAYAVKVI
PQSRVAK-PHQREK------------------------------IINE-IELHRDLQHRH
IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI
LHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL---LRQ--G
HGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLP-AS--LSLPARQLLAA
ILRASPRDRPSIEQILRHDFFTKGYT--PDRLPVSSCV----TVPD-LTPPNPARSLFAK
VTKSLFG-----------------RRKSKNKN---HSEEQDNVSCLVSGLMRTSIG----
---------------------------HPDVRPEAPAASALA--------------PV--
SLVETAAEDSSP------RGTLASSGD----------------------GFEEGLTVTTV
VESALCALRNCVAFM-------PPAEQNPAPL----------AQPEPLV-----------
---------------WVSKWV----DYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKT
VHYNPTSTKH----FSF-------SV--GSVPRALQPQLGILRYFASYM----EQHLMKG
GDLPSVEEVEVPAP-PLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGW--EPLLV
TFVARNRSACTYLASHLRQLGC-----SPDLRQRLRYALRLLRDRSPA------------
---------------------------------------
>gi|66553034|ref|XP_396707.2|	Apis mellifera
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------MSKDEKEC-
--------------VIPDVIYDVNSGKSYIKGRFFGKGGFAKCYEIRESKSHRVFAGKIV
PKSQITK-SNQREK------------------------------MTQE-ISIHQTLNHKN
IVGFYGFFDDPQNVYIILELCRKRSMMELHKRRKALTECETRYYMKQILDGVNYLHQNKI
IHRDLKLGNLFLSDDLQVKIGDFGLATRLEHEGERKKTVCGTPNYIAPEIL---TKA--G
HSYEVDIWSIGCIMYTLLVGKPPFETSSLKETYARIKQVQYKIP-TH--INTIAMNMISN
MLQGNPSKRPSITKLMKDPFFTCGFM--PLSLPLSCLT----MAPR-LDMLEMHNQ----
------------------------RKPLSEMN-TNVGGEGQDF-----------------
----------------------------VFRVPNSPVRKTKP----------ADAISE--
VQKLNLDIRK-M------LQTLREQLS-------------------------------AV
LKAKPSRETTSS----------ADEMTDPAAQ--------------PVV-----------
---------------WISKWV----DYSDKYGFGYQLSDDGVGVMFNDGTRLIMLANCFN
IHYINREGNE----LYY-------TV--KEYPSELEKKMRLMNFFLKYM----KEHLMKA
GCSFAVKPCDAMSRIPYMHQWFRTQSAVVMQLTNGTVQIN-FLDHTKIIMCPL---MAAV
TYIDTEKNFRTYRFQTIQENGC-----CKGLAKNLAYAHEKLVLMLSNPQTR--------
---------------------------------------
>gi|67969022|dbj|BAE00866.1|	Macaca fascicularis
------------------------------------------------------------
------------------------------------------------------------
----------MSAAVT--------------AGKLARAPADPGKAGVPGVAAPGAPAAAP-
-----------PAKEIPEVLVDPRGRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIV
PKSLLLK-PHQREK------------------------------MSME-ISIHRSLAHQH
VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV
IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL---SKK--G
HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP-KH--INPVAASLIQK
MLQTDPTARPTINELLNDEFFTSGYI--PARLPITCLT----IPPR-FSIAPSSLDPSN-
------------------------RKPLTVLN-KGLED----------------------
------------------------------PLPERTREKEEP------------------
VVRETGEVVDCH------LSDMLQQLH-------------------------------SV
NASKPSERGLVR----------QEEAEDPACI--------------PIF-----------
---------------WVSKWV----DYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDS
LQYIERDGTE----SYL-------TV--SSHPNSLMKKITLLKYFRNYM----SEHLLKA
GANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPL---MAAV
TYIDEKRDFRTYRLSLLEEYGC-----CKELASRLRYARTMVDKLLSSRSASNRLKAS--
---------------------------------------
>gi|50305027|ref|XP_452471.1|	Kluyveromyces lactis
------------------------------------------------------------
----------------------------------------------MSAPPLQIINDKQL
NARSNNIHTPIKAKRVVTELHHIDRLTTNGKPTNNNNNNNNNNINRQQPPQKKKKEKLS-
-----------SLCKTPPSLIKTR-GRDYHRGHFLGEGGFARCFQMKD-DKGKVFAAKTV
AKLSIKS-EKTRRK------------------------------LLSE-IQIHKSMKHPN
IVQFTDCFEDDTNVYILLEICPNGSVMELLRQRKHLTEPEVRFCMIQIIGAIRYMHSRRV
IHRDLKLGNIFFDKEYNLKIGDFGLAAVLANDKERKYTICGTPNYIAPEVL---TGKHTG
HSYEVDIWSIGVMLYALLFGKPPFQAKEVETIYERIKCRDFIFP-ADKPVSSDAKNLISH
LLQLNPAARPSLYEITDNVWFRNTF---PSRLPSTITK----EIPN-FDHLSFSESLINL
KQCMLNSGLLKSSQTHSYDGS---KNPIELVR-TEIEEERNRA-----------------
-------------------------VLPQSLSPGGTKNKYKEVIDLDGHRKFNEMAYQ--
NRLKKAGENLFF------KPELVATST---------------------NMIKSEMSLKIL
ASECHMTLRGIKSAEIDKR---QSNYPSPDST-----------VQDPI------------
---------------VVTKWV----DYSNKHGFAYQLSTDDIGVLFNNGTTVLKLADAEE
FWYINYDTKEGWVASHY-------KL--ESKPIELTRHLEVVDFFSNYM----NSNLSRI
STLVR---ETYHKDDVFLRRYTRYKQFVMFELSDGTFQFN-FKDHNKFALSHG---GKFL
TFISSDRKTITLLLSSVLIDGCVPGFPSIDIFEKLELMKEGLRDKASVLTIH--------
---------------------------------------
>gi|109077303|ref|XP_001102530.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
--------MCEQALGK--------------GCGGDSKKKRPPQPPEESQPPQSQAQVPP-
AAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKII
PHSRVAK-PHQREK------------------------------IDKE-IELHRILHHKH
VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI
LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL---NKQ--G
HGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP-SS--LLAPAKHLIAS
MLSKNPEDRPSLDDIIRHDFFLQGFT--PDRLSSSCCH----TVPD-FHLSSPAKNFFKK
AAAALFGGKKD-------------KARYIDTH-NRVSKEDEDIYKLRHDLKKTSIT----
-------------------------QQPSKHRTDEELQPPTT----TVARSGTPAVEN--
KQQIGDAIRMIV------RGTLGSCSS--------------------SSECLEDSTMGSV
ADTVARVLRGCLENM-------PEADCIPKEQ-----------LSTSFQ-----------
---------------WVTKWV----DYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT
VHYYAELGQC----SVF-------PA--TDAPEQFISQVTVLKYFSHYM----EENLMDG
GDLPS--VTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQ-NEEYLL
TYINEDRISTTFRLTTLLMSGC-----SLELKNRMEYALNMLLQRCN-------------
---------------------------------------
>gi|126323633|ref|XP_001372994.	Monodelphis domestica
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MELRVPRRRGAHEP-
---------------VASFLRDPNTGRIYRRGRLLGTGAFGRCYKLTDMSTNRVFALKVV
PWGRLSGGPPSRRQ------------------------------VERE-IELHSQLRHRN
VVGFHGHFADRDNVYLVLEYCSRKSLAHVLKARKTLTEPEVRYYLRGIAAGLRYLHQQGI
IHRDLKLSNFFITKNMEVKIGDLGLATKVGPGGHCHGGLCGTPNYLAPEVV---SRK--G
HSFQSDIWALGCIMYTALTGFPPFKASPLPEMYQNIRDARYPVP-GH--LSANARRLIAR
LLAPNPADRPSLDQVLQDDFFTQGFT--PDQLPPRSCH----TAPI-FTIPQPLDKLFQK
ATQLFLAMAQR-------------RAPRSFVP----------------------------
-------------------------KMPTTPAPEDPQKTPGE------------ADNE--
VRDPEIPIHLLL------RRSLRSHPP------------------------GTEGELALR
AEVAARLLKNCLDFM-------PAGEQDPPGQ------------QQPVL-----------
---------------WVTKWV----DYSNKYGFGYELSDGSTGVLLRDGTHISLRPALGC
ISYCPAQGEV----ATF-------SW--RDIPDSLGTKVAVLQLFTRYM----QRWLLEG
GAVPS-QPGLSPGPGFSLLHFLKSDQALLLLFSDQTMQVNFYHDHTKLLLNWA-GEEPLL
TYIDPERLATSHPLSILQGHGC-----SEALRQRLHYTLHLLQAF---------------
---------------------------------------
>gi|68473738|ref|XP_718972.1|	Candida albicans
------------------------------------------------------------
--------------------------------------------MSALRSQPLQPLNSGQ
LNARANNITPVKSIRR-----------------------PKENVQPTDQKQKKKKEKLS-
-----------ALCKTPPSIVRTRNGRDYRRGNFLGEGGFARCFQMKD-ASGQIYAAKTV
AKASIKN-EKTKTK------------------------------LLSE-IKIHKSLRHPN
IVNFVDCFEDDVNVYILLEICPNQSLMELLKTRKRVSEPEVRFFMVQIVGAIKYLHSRRV
IHRDLKLGNIFFDPEMNLKIGDFGLASVLPSTDSRKYTICGTPNYIAPEVL---GGKNTG
HSFEVDIWAIGIMMYALLVGKPPFQAKDVNVIYERIKKTEYYFP-EDKPISESAKQLIKD
LLSLNPLHRPTIDEILSYDWFKGPF---PDKTYEVSLQ----TLPPGLDQITRAQSSANF
KYAKDSAGIYTPKN----------KNPVEILR-ADLHSEQPRT-----------------
-------------------------LLPSSLSPNDTRNKYQE--------------VD--
PGQLGRPRRVNF------SSNFSTAIK-------------------------------RL
NQVCFETYQTMRRLEHSRH-DEVDASEFPNCE-------------NPT------------
---------------LISKWV----DYSNKYGFSYQLNNDDIGVLFNDENTLLKRHNSDR
FLELIYHENEGWTCIEN-------SL--ANPPAQAKRQLEIVDFFAKYM----NSNLSKV
S------EIEERKETVFLRRYTRTPDYIMFEMTNGNFQFN-FKDHHKICISKT---GLAI
THISPGRLTQTQPLISVLKQGNFQHENVPDCMEKIMVIKEAIKKKAFKEA----------
---------------------------------------
>gi|47228254|emb|CAG07649.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
--MNADIFKPVPERGT-------------------------HQPSAAAKTIKNKGDQAK-
-----------A--ELAQVVTDSKTGRSYSKGKLLGKGGFARCYEMTDLSNNKMYAVKVI
PQSRVSK-PHQREKVGALNMSASGPSLIRGGLTNGGGGISFVEQIMNE-IELHRTLSHKH
VVKFSHHFEDQENIYIFLELCSRKSLAHIWKARHTLTEPEVRYYLRQIISGLKYLHSRGI
LHRDLKLGNFFVNENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVL---NRQ--G
HGTESDVWSLGCVMYTLMCGNPPFETLDLKETYKCIKEVQYRLP-ST--ISHPAQKLISG
ILQKNPSDRLTLDQILSHEFF-KGFT--PDKLPASSCM----MVPE-LHPPSPAKKFFTK
MAKSLFG-----------------KKKSKVEKTPCEEKEEKDISKLVSGIVKCSIN----
-----------------------RQISYKTVGPSEVASPAGQ----MANSAPQEQTPA--
EEESRKSISRSF------KGTMASSTEPAILWNSLPPARRSHPGLVFSSACEDVATPAAV
AESAAKVLGGCLASM-------PAASRNPPCL----------SRPQSFL-----------
---------------WVTKWV----DYSNKYGFGYQLSNHSVGVLFNEGTHLSLCNQRNT
VHYCLTNNKH----FTF-------PA--SSLPEQLHSQKEIVELMANYM----EQNLMEG
GDLLC--GDQVSGPPPLLLQWVKTEHALVMLFNNGTLQVNFYTDHTKIILCKSSDDSYLL
TYITRERVSYTYLLSMLTEMGC-----TAELRHRLRYVVQLLQHHSDA------------
---------------------------------------
>gi|72158731|ref|XP_784826.1|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MASRHKEDLRV-
-----------K--EVPDVVTDPSTGKTYTKGRFLGKGGFAKCYELTDDATKQIFAGKVV
SKALLVK-PHQKDK------------------------------MTME-IHIHKSLHHRH
VVGFHSFFEDKENVYVLLELCRRRSLMELHKRRKAITEPETRYFMRQCILACQYLSKTKV
IHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVL---SKK--G
HSYEVDLWSLGCIMYTLLVGKPPFETQSLKDTYQRIKRNEYRVP-SH--VSTPARNLIVK
LLKNDPTQRPHIDILLQDEFFTTGYL--PPQLPTTCLT----MAPR-FQVPVSSG-----
------------------------RRPLLEVN----------------------------
-------------------------GQDENVPPGREQSGKPH---------RKHSDRK--
ENGGGKPKVYQP------KEDHLASLK---------------------------VHLTSV
VAAKPSEKADIR----------LDEAEDPAAA--------------PIL-----------
---------------WVSKWV----DYSDKYGLGYQLCDGSVGVLFNDSTRLLLHANADT
LEYIERDGNE----KYC-------RL--GSYDSTLHKKVTLLKYFRNYM----SEHLLKA
GAAMTPRESDSMARLPFLQSWFRTKSAIVLHLSNGTVQINFFEDHTKLIVCPM---MGAA
TYIDAKRNFRTFRLNLIEKHGC-----TPDLYDRIKYANNMVKNMLDKKTTTTTAAAVPA
H--------------------------------------
>gi|108870134|gb|EAT34359.1|	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MSSIKPDDKS-
-----------S--DIPEKLYDATARRTYKRLRFFGKGGFAKCYEIMDVVTGEVYAGKIV
SKKLMMK-HNQKEK------------------------------MTQE-ITIHKSLNHRN
IVGFHSFFDDPLNIYIVLELCKKRSMMELHKRRKVITDYECRYYIHQVLTGVKYLHDRHI
IHRDLKLGNLFLNDELHVKIGDFGLATKIEFEGERKKTLCGTPNYIAPEIL---NKK--G
HSYEVDVWSIGCVMFTLLVGQPPFETKSLKDTYTKIRKCDYRLP-ST--IRTNAAEMICS
MLQSDPIKRPSVTQMFDFDFMCSAHI--PASLPISCLT----MAPR-ADQLENADRMG--
------------------------RKPLSEVN----------------------------
---------------------------------DDTRLESSF------LKNNLHDAIT--
ASGTMSRHNEGY------RTDIENLYK----------------------------QLSSL
IASKPPKLATNL----------DDENTDPAVQ--------------PLF-----------
---------------WVSKWV----DYSDKYGFGYQLCDEGMGVMFNDTTKLIMLANGLN
VHFIDKEGVE----TYM-------DI--HNYPPQMEKKMKLLSYFKRYM----TEHLVKA
GAGAVNIESDQISRIPHLHTWFRTMCAVVMHLTNGTVQLN-FSDHQKIILCPL---MRAV
TLMDNNKNFRTYRFSTIQEQGC-----SSDLYQKIRYAHEKLKKLLEKLA----------
---------------------------------------
>gi|22779889|ref|NP_690017.1|	Mus musculus
------------------------------------------------------------
----------------------------------------------------MELLRTIT
YQPAAGTKMCEQALGK--------------ACGGDSKKKRPQQPSEDGQPQAQVTPAAP-
---HHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKII
PHSRVAK-PHQREK------------------------------IDKE-IELHRLLHHKH
VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI
LHRDLKLGNFIINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL---NKQ--G
HGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP-SS--LLAPAKHLIAS
MLSKNPEDRPSLDDIIRHDFFLQGFT--PDRLSSSCCH----TVPD-FHLSSPAKNFFKK
AAAALFGGKKD-------------KARYNDTH-NKVSKEDEDIYKLRHDLKKVSIT----
-------------------------QQPSKHRADEEPQPPPT----TVARSGTSAVEN--
KQQIGDAIRMIV------RGTLGSCSS--------------------SSECLEDSTMGSV
ADTVARVLRGCLENM-------PEADCIPKEQ-----------LSTSFQ-----------
---------------WVTKWV----DYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT
VHYYAELGQC----SVF-------PA--TDAPEQFISQVTVLKYFSHYM----EENLMDG
GDLPS--VTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQ-SEEYLL
TYINEDRISTTFRLTTLLMSGC-----SLELKNRMEYALNMLLQRCN-------------
---------------------------------------
>gi|118783668|ref|XP_313155.3|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MSSVAKPDEKA-
-----------V--DIPEKLYDAGTKRTYRRMRFFGKGGFAKCYEIVDVATNEVFAGKIV
SKKLMMK-HNQKEK------------------------------MTQE-ITIHRSLNHKN
IVGFHSFFDDPLNIYIVLELCKKRSMMELHKRRKIITDYECRYYMHQVMTGVKYLHDKHI
IHRDLKLGNLFLNDELHVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEIL---NKK--G
HSYEVDIWSIGCVMYTLLVGQPPFETKSLKDTYNRIRKCDYRLP-PT--LRNTAAEMICA
MLQSDPMKRPRIHKLFEFEFLSGSHI--PNSLPISCLT----MAPR-ADQLEQAERMN--
------------------------RKPLSEMN----------------------------
------------------------------GAGDETRFESSF------LKNNLHDPIT--
ASGMISRHNDTY------RADIETLHR----------------------------ELTKL
FLAKPARLASNL----------DDENTDPAVQ--------------PLF-----------
---------------WVSKWV----DYSDKYGFGYQLSDEGMGVMFNDTTKLIMLANGHN
VHFIDKEGQE----SYW-------DV--NSFPPYLEKKMKLLTYFKRYM----MEHLVKA
GAGVMNVESDQISRIPHMHTWFRTMCAVVMHLTNGTVQLN-FSDHQKIILCPL---MRAV
TLMDNNKNFRTYRFQTIIEHGC-----SHDLYTKIRYAHEKIKKLLEKLS----------
---------------------------------------
>gi|91082205|ref|XP_972118.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MSKVDDYVV-
---------------VPDYIYDENTKIRYKKGQFFGKGGFAKCYEITNVANSQTFAGKVV
SKKLIVK-ENQKEK------------------------------MTQE-IQIHKSLKHKN
IVGFYSFFEDTDNIYIVLELCRKRSMMELQKRRKMLTEPETRFYMRQILNGVSYLHQRRI
IHRDLKLGNLFLNDELTVKIGDFGLAATIEYEGERKKTLCGTPNYIAPEIL---QKK--G
HSFEVDIWSIGCIMYTLLVGKPPFETRSLKETYSRIKKCEYHFT-TT--ISPAAKSMIML
MLQSDPKSRPKVTELLQHPFITDGYC--PSSLPVSSLT----MAPR-FQKYDVSM-----
------------------------RKPLINTN--GLLGDAV-------------------
--------------------------------ANPELRAQQD-----SITAHLTGAPN--
HHMFDAKENFVT------LRNMLGRLL-------------------------------KI
KPAKNHVF--------------LDEMTDPAAQ--------------PMI-----------
---------------WVSKWV----DYSDKYGFGYQLSDECVGVMFNDTTKLIMLPNGIN
VHYIDKNGDE----VYM-------TM--DNYPRSYDKKMKLLSYFSRYM----REHLIMT
GASVV-REVDSLSRTPHLHQWCRSTSGVLMQLNNGTVQMN-FSDHTKIIMCPL---MAAI
TYIDEEKQFRTFRFSSLETNGY-----NIALYEKMRYAYDKISLLLNPENNYMN------
---------------------------------------
>gi|47076901|dbj|BAD18393.1|	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MEDRKELLTEIPVAGIIKKNGEKYIT-
-----------ELDETKTKIVD-----RYRVGKQIGKGGFAIVYELTSIRTGKKYAGKVV
EKAGLTK-PKYLEK------------------------------FMSE-IRIHQSLDHPH
ICKMYKHFEDNRYHYLILELCSNETLAHLLRVRECLTEPEVQYFLLQIIDAVSYLHKRCI
IHRDLKLGNIFLDENLEVKVGDLGLAAQLNEPNERKKTMCGTPNYIAPEILQSNDKR--A
YSYEVDIWAVGVITYTMLIGKAPFDGGSKEITYRKIRENELSFPIKDHHISHQARMFIRS
ILNPDPTQRLTLEQMVQHPFFTDSPIDPPKSLPLYILREPFLLSARLPTEPTPVLQRAQR
LPAEDTGVGEAK------------RIRMADLP----------------------------
--------------------------APRLPAPATVSSPSPAVGTVGQATGEVGGNAY--
TAHLFRPQAAEYDLDGNGRNNLNRFSL----------------------TGDRAREMEGR
LDYVNRSFHDARGLLPSEVFEGLPTGIVPSIT--VPRGRFEEKEGSPLLQAHAANLYTAM
NNPGLMVPANHVQVTRTANWIVDEYDFTRKYGIGYMFSNGNIGILFNDKTSIVLSADGMF
FEYHPRISITQWNAKQTFPPSVSGSI--DDYPDELAKKITLIKYFRTNFRDRAENRMLSK
EEVEDTARGGPKVNMPFALKWLKKEDASICMLSTGAIQVR-YDGGTILNLESP---FDDV
TYLDKYGVVTAMPLARAISLK------RDDLMRRLDYVESNIQDIVTHLSKAHH------
---------------------------------------
>gi|41152008|ref|NP_958465.1|	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
--MNPDMFKASPA------------------------------APPPAKPSRSKSEHVK-
-----------P--ELAQVVVDAKTGRSYCKGKLLGKGGFARCYEMTDLANNKMYAVKVI
PQSRVSK-PHQREK------------------------------IINE-IELHKSLQHKH
VVKFSHHFEDQDNIYIFLELCSRKSLAHIWKARHTLTDPEVRYYLRQIISSLKYLHNKGI
LHRDLKLGNFFVNENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVL---NRQ--G
HGTESDVWSLGCVMYTLLCGNPPFETLDLKETYKCIKEVKYSLP-SS--LTPSAQKLISS
ILQKNPCDRLTLDQILAHDYFTKGFT--PEKLPPSSCV----MVPE-LNPPSPAKKFFTK
MAKSLFG-----------------KKKSKTVE-KTTSEEKDDISKLVSGMVKHSIG----
-----------------------RQMSYKTMGVNEATSPTVQ-----LASSGPLDTPA--
EEESRKSASRSF------KGTVASSTD----------------------GCDDIPTPSAV
AESAMKVLNSCLSSM-------PTASRNPPCL----------VKTKPFI-----------
---------------WVTKWV----DYSNKYGFGYQLSNQNVGVLFNEGTHLSLCDQRRT
VHYCLTNNKH----FSF-------PA--NALPEKLQSQKHIVDLMANYM----EQNLMEG
GDINR--EDQSSSSSPLLLQWIKTDHALVMLFDNRTLQVNFYTDHTKIILCKPSDASYLV
TFISKERVSYSYPLNVLSELGC-----SPELRQRLHYVVQLLQHYTNA------------
---------------------------------------
>gi|57042806|ref|XP_535242.1|	Canis familiaris
------------------------------------------------------------
----------------------------------------------------MELLRTIT
YQPAAGTKMCEQALDK--------------ACGGDSKKKRPPQPPEEPPPPPQPAGQGPP
AAPHHHHHHAHSGAEVSRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKII
PHSRVAK-PHQREK------------------------------IDKE-IELHRILHHKH
VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI
LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL---NKQ--G
HGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP-SS--LLAPAKHLIAS
MLSKNPEDRPSLDDIIRHEFFLQGFT--PDRLSSSCCH----TVPD-FHLSSPAKNFFKK
AAAALFGGKKD-------------KARYIDTH-NRVSKEDEEIYKLRHDLKKTSIT----
-------------------------QQPSKHRTDEELQPPTT----TVARSGTPAVEN--
KQQIGDAIRMIV------RGTLGSCSS--------------------SSECLEDSTMGSV
ADTVARVLRGCLENM-------PEADCIPKEQ-----------LSTSFQ-----------
---------------WVTKWV----DYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT
VHYYAELGQC----SVF-------PA--TDAPEQFISQVTVLKYFSHYM----EENLMDG
GDLPS--VTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQ-NEEYLL
TYINEDRISTTFRLTTLLMSGC-----SSELKNRMEYALNMLLQRCN-------------
---------------------------------------
>gi|50291573|ref|XP_448219.1|	Candida glabrata
------------------------------------------------------------
------------------------------------------MMGPLKNVDDKQLNVRIA
RTPVKTNPTASHNHYE-------------EGKENYVVNQHHKRIDQQGQQHKRKKEKLS-
-----------SLCKTPPSLIKTR-GRDYHRGQFLGEGGFARCFQIKD-DSGKIFAAKTV
AKISIKS-EKTRKK------------------------------LLSE-IQIHKSMSHTN
IVQFIDCFEDNVNVYILLEICPNGSLMELIKKRKTITEPEVRFFMTQICGGIQYMHSNRV
IHRDLKLGNIFFDEHYNLKIGDFGLAAVLANDRERKFTICGTPNYIAPEVL---MGKHSG
HSYEVDIWSIGVMLYALLIGKPPFQAKDVNTIYERIKQRNFAYP-KDKKISQDAKYLIDD
ILSLNPMERPSIQEIMDYVWFRGTF---PPYTLNSVMT----TVPD-YSHITPQESFMNF
QNCLEASGLLSVHQNHMVANISERTVPTNKLHIAPAHKYSSNPYMTEYNNAGNSIGNNGY
PDTVQTSASKRFHMEKFQQQEQFQPILPHSLSPGGTKNKYKE-VIDLEAQRKLNDLAR--
EARIRKARQSMA------RKELIPTST---------------------NLIKSDISLRIL
ASECQLTLNGILEAEAQKRMGGLPKSRLPSIK-------------NPM------------
---------------VVTKWV----DYSNKHGFSYQLSTEDIGVLFNNGSTVLRLADADE
FWYITYDEREGWVASHY-------LL--DEKPKELSRHLEVVDFFAKYM----RANLSRV
SNFVR---EEYHKDDVFLRRYTRYKEFVMFELSDGTFQFN-FKDHHKLAISDG---GKLV
TYISPDHESETYPLVELLRIGEIPGHTDCNFESKLMLVKEGLKQKASIITVDH-------
---------------------------------------
>gi|149243893|ref|XP_001526542.	Lodderomyces elongisporus
------------------------------------------------------------
--------------------------------------------MSTLRSQPLQPLNGGQ
LNARTNNNNNNNNNNN-ITPIKSVRISKENLPQLDQDENQNQKQKVQPQTQKKKKEKLS-
-----------ALCKTPPSIVRTRNGRDYRRGNFLGEGGFARCFQMKD-AAGQIYAAKTV
AKASIKN-EKTKTK------------------------------LLSE-IKIHKSLKHPN
IVNFVDCFEDDINVYILLEICPNQSLMELLKNRKRVTEPEVRFFMVQVVGAIKYLHSRRV
IHRDLKLGNIFFDPEMNLKIGDFGLASVLPSNDSKKYTICGTPNYIAPEVL---GGKNTG
HSFEVDIWAIGIMMYALLVGKPPFQAKDVNVIYERIKKTEYYFP-EDKPISDSAKQLIKD
LLSLNPLNRPTIDEVLSYDWFKGPF---PDRTREISLM----EAPEGIDCISRAQSSINF
KAAKDMAGIYTPKS----------KNPVEILK-SDLHSEQPRA-----------------
-------------------------LLPQSLSPNDTRNKYQE--------------VD--
LDQLGRPRKVNF------NSHFSTTIK-------------------------------RL
NQVCFETYQNMRRLEYSR----HEEFELPLCE-------------TPT------------
---------------LISKWV----DYSNKYGFSYQLTNDDIGVLFNDENTLLKLYNSDK
FLELIYHDEEGWTCIEN-------SL--SHPPAQAKRQLEIVDFFAKYM----NSNLSKV
S------ENEERKEIVFLRRYTRTPEYIMFEMTNGNFQFN-FKDHHKICISKS---GLAI
THISPDRLTQTHPLQHVMELENFPTEQVPDCLQKIAIIKEAIKRRAFKEI----------
---------------------------------------
>gi|149633975|ref|XP_001508038.	Ornithorhynchus anatinus
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MDLRGSRRRERDT-
---------------LGRFIRDPGTGRIYKRGKLLGKGAFGRCYKLTDMSTNRVFALKVV
PRTHTGH-LEQRGK------------------------------VERE-IELHSCLRHRN
VVGFHRHFADHDHIYMVLEYCSRKSLAHILKARKTLTEPEARYYLRGIVGGLRYLHQQGI
IHRDLKLSNFFVNKNMEVKIGDLGLATRAEPGGRCRGVLCGTPNYLAPEVI---SRK--G
HSVQSDVWALGCIMYTVLTGSSPFKVSHLREMYQSIREARYPVP-AH--LSPHARHLVAC
LLAPNPANRPSLDQILAHDFFTQGFT--PDRLPTRSCY----AAPI-FAVTQPLGKLFQK
ATQRFLGGTAL-------------PLPAQQAR-PPVQESPANH-----------------
---------------------------CLRPAPQGPKSQNIEIVHPYGGDPSSGARLE--
PPTLDPPIRLLM------RGTLGSPLD--------------------GREARPEGSSGLG
VHPATRILQCCLDSG-------PPAEPILWGQRWRQQRWWQQRQQRPVL-----------
---------------CVTKWV----DYSNKYGFGYQLSDGGFAVLLRDGTHMALRPPLGC
VCYSTGQGEP----MTF-------SR--TEVPRFLAGKLAVLQFFTRYM----QQQLLEG
GNPPTPPLADIAVPGVSLQHFLKSDQALLMLFSDGTLQVNFYRDRTKLVLSWM-GEGPLL
TYIDQERRATSYQPGTLQREGC-----ASPLRQRLSYALRLLQKL---------------
---------------------------------------
>gi|11463874|dbj|BAB18588.1|	Hemicentrotus pulcherrimus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MASRHKEDLRV-
-----------K--EVPDVVTDPSTGKTYTKGRFLGKGGFAKCYELTDDATKQIFAGKVV
SKALLVK-PHQKDK------------------------------MTME-IHIHKSLHHRH
VVGFHSFFEDKENVYVLLELCRRRSLMELHKRRKAITEPETRYFMRQCILACQYLAKTKV
IHRDLKLGNLFIDDNMELKVGDFGLATKVDFSGERKKTLCGTPNYIAPEVL---SKK--G
HSYEVDLWSLGCIMYTLLVGKPPFETQSLKDTYQRIKRNEYRVP-SH--VSTPARNLIVK
LLKNDPTQRPHIDTLLQDEFFTTGYL--PPQLPTTCLT----MAPR-FQVPVSSG-----
------------------------RRPLLEVN--GQDENVP-------------------
--------------------------------PSREQSGKPH----RKHSDRKENGGG--
KPKVFQPKED-H------LASLKVHLT-------------------------------SV
VAAKPSEKADIR----------LDEAEDPAAA--------------PIL-----------
---------------WVSKWV----DYSDKYGLGYQLCDGSVGVLFNDSTRLLLHANADT
LEYIERDGNE----KYC-------RL--GSYDSTLHKKVTLLKYFRNYM----SEHLLKA
GAAMTPRESDSMARLPFLQSWFRTKSAIVLHLSNGTVQINFFEDHTKLIVCPM---MGAA
TYIDAKRNFRTFRLNLIEKHGC-----TPDLYDRIKYANNMVKNMLDKKTTTAAAH----
---------------------------------------
>gi|24475525|dbj|BAC22692.1|	Asterina pectinifera
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MSARAREDLRV-
-----------KDSCIPEFVVDPRSQRRYKKGRFLGKGGFAKCYELIDTATNTTYAGKIV
SKALLVK-PHQKEK------------------------------MSME-IAIHRSISHPH
IVGFHGFFEDSDNVYILLELCRRRSLMELHKRRRAITEPETRYFMRHAILAMQYLHKNQI
IHRDLKLGILFINDDMDLKLGDFGLATKIEREGERKKTLCGTPNYIAPEVL---AKK--G
HSYEVDTWSLGCIMYTLLVGKPPFETSCLKDTYLRIKRNEYSIP-SHCKVSPTARSLISR
LLKNNPHERPSINTLLEDSFFTSDYL--PPKLPTTCLT----IAPR-FAPMAMP------
------------------------RKPLKEIN-AKDENVSPLFGAMKTGTD---------
-------------------------MLHKATVPKSSQGNNEN-----PDRPAVSAIPSAR
LPSTKAEEDCSY------LTELLGQLV-------------------------------SV
VHSKPQDIKDMR----------MDDAEDPAAA--------------PVL-----------
---------------WISKWV----DYSDKYGLGYQLSDGSFGVLFNDSTKLLLQTNGDN
MEYIERDGTE----KIF-------TI--DTFSESMRKKVTLLKYFRNYM----SEHLLKT
GAGVK-LESDNLARLPFLRTWFRTRSAIVLHLNNGTLQINFFQDHTKIILCSL---MGAV
TYIDETRQFRTYRLSLIEKYGC-----CKELASRLQYARIMTERLLAPKTQSTKPHKESA
SSAVSSKETAVAAIR------------------------
>gi|150866257|ref|XP_001385791.	Pichia stipitis
------------------------------------------------------------
-----------------------------------------MSNLRTQSLQPLQPLSGGQ
LNNRVNNVTPIKQPVR-------------RLKENVETIAPPPSNTAKPQQQKKKKEKLS-
-----------ALCKTPPSIVRTRNGRDYRRGNFLGEGGFARCFQMKD-SSGQIYAAKTV
AKASIKN-EKTKTK------------------------------LLSE-IKIHKSLKHAN
IVNFIDCFEDDVNVYILLEICPNQSLMELLKTRKRVSEPEVRFFMVQIVGAIKYLHSRRV
IHRDLKLGNIFFDPDMNLKIGDFGLATVLPSNSTRKYTICGTPNYIAPEVL---GGKNTG
HSFEVDVWAIGIMMYALLVGKPPFQAKDVQVIYERIKKTEYGFP-EDKPISDSAKALIKD
LLSLNPIHRPTIDEILSYEWFKGPF---PEKTHELSLN----GTPSGLDQISLAQSALNF
NNTKTNAGIYTPKN----------RNPVEILR-SDLHSEQPRA-----------------
-------------------------MLPQSLSPNDTKNKYEE--------------VD--
PTSLGRPRKINL------SSNYSTTLK-------------------------------RL
NNICLETYQNMRRLQYSQH-ESIDVMELPRCE-------------NPT------------
---------------LISKWV----DYSNKYGFSYQMNNDDIGVLFNDGNTLLKLHNSDR
FLELIYHENEGWTCIEN-------SS--SHPPTQTRRQLEIVDFFAKYM----NSNLSKV
S------ENEERKETVFLRRYTRTPEYIMFEMTNGNFQFN-FKDHHKICVSKN---GLAI
THISPSRAIQTHPLILILKQGNFPSEEVPECLEKIAVIKDAIKKKAFKET----------
---------------------------------------
>gi|55742294|ref|NP_001006766.1	Xenopus tropicalis
------------------------------------------------------------
------------------------------------------------------------
-METACYIQSHPYQCN--------------ALGADLYRTTHQHGPAVPRSPKPEPQRSP-
-----------Q--QPCKLITDPLTGKAYTKGRLLGKGGFARCYEMTEVATNKTYAVKVI
PHSRVAK-PHQREK------------------------------IVNE-IDLHRELHHKH
VVKFSHHFEDSENIYIFLEICSRKSLAHIWKARHTLLEPEVRYFLKQIISGLKYLHLKGI
LHRDLKLGNFFINESMELKVGDFGLAARLEPPEQRKKTICGTPNYLAPEVL---YRQ--G
HGPESDIWSLGCVMYTLLCGTPPFETSDLKETYRCIKQVKYTLP-AC--LSSAAKHLLMG
ILKRTPGERLTLDQILEHEFFTKGYT--PDKLPPSSCV----MVPD-LHPPNPAKSLFTK
VAKSLFG-----------------KTKSKTKK--SPTEEKDDISKIVTGLVKTSIC----
-----------------------RQLSYKTVDGNEVAPVTSH---AVSANSSPVDTLT--
EEASGKSVSRSI------RGSLVSSSD----------------------AFEDCVTASGV
IETALAVLKDSLSSM-------PAVEGNPTSL----------AKPEHFV-----------
---------------WVSKWV----DYSNKYGFGYQLSNRSIGVLFNSGTHMVLPAHRRH
VHYNLTNSRH----FVF-------PT--SAVPEQLQGQMSILQYFATYM----EKNLMKG
GDLPC--HEEGSQTPLLLLQWVKTEHALLMLFSNGTLQVNFYNDHTKIILCKP-QDAYLL
TYINRDRNSQTFLLNTLTQTGC-----SSEMYHRLRYTVKLLQQKAES------------
---------------------------------------
>gi|55274739|gb|AAV49163.1|	Schistosoma mansoni
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MAANDSAKP-
-----------K--DPPEVIVDVTRKREFLRGRFLGKGGFAKCYELVDKKTGEKYAGKVI
NKSALVK-ESQKEK------------------------------MRQE-ISIHRSLKHEN
VVRFYGNFEDSEFIYILLELCNRRSLLELHKRRKYVTEPEARYFMKQIVHGCQYLHQNKV
MHRDLKLANLFLDDNLKIKIGDFGLASRISHEGEKKKTLCGTPNYIAPEIL---SKG--G
HSFEVDSWSLGCILYTLLVGSPPFETTKLEETYARIKQNEYRIP-IR--VSTNASMLIRS
LLHADPERRPNMFNVLDHDFF-KDFT--PNGLPVSCLS----TCPR-FDTMHRPQTG---
------------------------RRPLSDIN----------------------------
------------------------------PVEDVPITSGGG-------ALGNVGGAA--
VDKAVQPDDC-W------LGLLKHKLG--------------------------------R
VLEEPKEFDDSSPKA-------MEESEVPAAC--------------PIY-----------
---------------WVSKWV----DYSDKYGLGYQLCDNSYGVVFNDVTRLLLTTNEQN
LQYIDEHGTE----RLF-------TL--SKHPEYLSKKVTLLTCFKAYM----HQNLLKA
GENIARPDTDAMTRLPFLRRWFRTRSAIVLHLSNGTLQINFFDDHAKIILCPL---MRAV
TYIDANREFRTYRFKHLREFGL-----SKDLANRLRYAQEMIERLIPKCGTTSSNVNDPN
TKMTVDNGKSNKPVSADVQKTNATGTGAATKKITRPTNQ
>gi|114661620|ref|XP_001163585.	Pan troglodytes
-MAMLLFPGPEVEEDLSKSFLEEAQVNRRSFPGRPRKGETPKEFLLSRGWVSASTPGLVS
QAIPRVLASVSIRFSPAGSGFKGCCCAGRSHGAARRAGLDFKSPRPISGAQAFVTFPAPR
LNSGRSGAVRSFCSDPGLQSSFGSMSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAP-
-----------PAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIV
PKSLLLK-PHQREK------------------------------MSME-ISIHRSLAHQH
VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV
IHRDLKLGNLFLNEDL--------------------------------EVL---SKK--G
HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP-KH--INPVAASLIQK
MLQTDPTARPTINELLNDEFFTSGYI--PARLPITCLT----IPPR-FSIAPSSLDPST-
------------------------RKPLTVLN-KGLEN----------------------
------------------------------PLPERPREKEEP------------------
VVRETGEVVDCH------LSDMLQQLH-------------------------------SV
NASKPSERGLVR----------QEEAEDPACI--------------PIF-----------
---------------WVSKWV----DYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDS
LQYIERDGTE----SYL-------TV--SSHPNSLMKKITLLKYFRNYM----SEHLLKA
GANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPL---MAAV
TYIDEKRDFRTYRLSLLEEYGC-----CKELASRLRYARTMVDKLLSSRSASNRLKAS--
---------------------------------------
>gi|118094529|ref|XP_422425.2|	Gallus gallus
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MEHAGLFPPLLATCLPAQPAPTPAPPSARP-
-----------A--EPTRIITDPLSGRSYCKGRLLGKGGFARCYEMTDLSSNKTYAVKVI
PHSRVAK-PHQREK------------------------------ITNE-IELHRDLHHKH
IVKFSHYFEDAESIYIFLEHCSRKSLAHIWKARHTLLEPEVRYYLKQIISGLKYLHLKGI
LHRDLKLGNFFINENMELKVGDFGLAAYQDASDQKKKTICGTPNYLAPEVL---LRQ--G
HGPESDVWSLGCVMYTLLCGNPPFETLDLKETYRYIKQVDYILP-TF--LSLPARHLIAG
ILKRNPQDRLTLDEILDHEFF-KGYT--PEKLPPSSCV----MAPE-LCAPNPAKSLFAK
VTKTLF------------------RKKKPKAK-KGSLEDKDDISKLVTGLVKTSIC----
-----------------------RQMSCKAATPVSCCSAGSS----------PVETLV--
EETSRKSTSPSV------RGTMASSCE----------------------AFEDCITTSAI
IESAVQLLRTCLSCM-------PPAERNPASL----------ARHEQFV-----------
---------------WVSKWV----DYSNKYGFGYQLSNHSIGVLFNNGTHMMLSPNHKT
VHYNPTNSKH----FAF-------PV--SAVPEQLRGQMSVLRYFASYM----EQHLMKG
GDLPS--IDDLGQPALLLLQWVKTDQALLMLFSNGTLQVNFYNDHTKVIISKP-DHSCLV
TYINRERNSYTYKLCSIQELGC-----SPELQHCLRYILKLLQEWADA------------
---------------------------------------
>gi|45185682|ref|NP_983398.1|	Ashbya gossypii
------------------------------------------------------------
------------------------------------------------MSAPLQIVNEKQ
LNTRSNANVHTPVKQH---------------HAKRADLERGHHDNNRQPPQKKKKEKLS-
-----------ALCKTPPSLIKTK-GRDYHRGMFLGEGGFARCFQMKD-DSGKVFAAKTV
AKISIKS-EKTRKK------------------------------LLSE-IQIHKSMKHPN
IVQFTDCFEDDTNVYILLEICPNGSLMDLLKQRKQLTEPEVRFFTTQIVGAIKYMHSRRI
IHRDLKLGNIFFDKHFNLKIGDFGLAAVLANDRERKYTICGTPNYIAPEVL---TGKHTG
HSFEVDIWSIGVMIYALLIGKPPFQAKEVNTIYERIKVCDFSFP-KDKPISSEAKVLIKD
ILSLDPLERPSLAEIMEYVWFRNVF---PARINGDILN----FVPE-FHDLDLQESLINF
KNCMAKCGLMNPSAAAAAVAAKEYDQRLPSYS-KNSNNNNNQINQNNEQLSEAKKS----
-------------------------VLPQSLSPGGTRSSPGN--CYVETQRKLNDLAR--
EARIRRAQQSML------KQSLVASST---------------------NFIKSEISLRIL
ASECHMTLNGLLEAEAQKRMGGLPRSRLPEIQ-------------HPI------------
---------------VVTKWV----DYSNKHGFAYQLSTDDIGVLFNNGTTVLNLADAEE
FWYISYDDREGWVANHY-------SL--AEKPKELNRHLEVVDFFSNYM----NSNLSRI
STFVR---ESYHKDDVFLRRFTRYKQFVMFELSDGTFQFN-FKDHHKFAISQS---GKLT
TYISPDRQSFTFPTVEILKAEKIPGHPELGFMEKFAMIKEGLKQKSAIVSVAQQ------
---------------------------------------
>gi|13507375|gb|AAK28550.1|AF33	Sus scrofa
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------DPRSRRRYLRGRFLGKGGFAKCFEISDADTKEVFAGKIV
PKSLLLK-PHQKEK------------------------------MSME-ISIHRSLAHQH
VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV
IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL---SKK--G
HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP-KH--INPVAASLIQK
MLQTDPTARPTIHELLNDEFFTSGYI--PARLPITCLT----IPPR-FSIAPGSLDPSS-
------------------------RKPLTVLN-KGMEN----------------------
------------------------------PMPERPREKEEP------------------
VVRETSEAADGH------LGDMLQQLH-------------------------------SV
NASKPSERGLVR----------QEEAEDPACI--------------PIF-----------
---------------WVSKWV----DYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDS
LQYIERDGTE----SYL-------TV--SSHPNSLIKKITLLKYFRNYM----SEHLLKA
GANITPREGDELARLPYLRTWFRTRSAIILHLSNGCVQINFFQDHTKLILCPL---MAAV
TYIDEKRDFRTYRLSLLEEFG---------------------------------------
---------------------------------------
>gi|125978571|ref|XP_001353318.	Drosophila pseudoobscura
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MAAKPEDKS-
-----------T--DIPDRLFDSNQRRTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIV
SKKLMIK-HNQKEK------------------------------TAQE-ITIHRSLNHPN
IVKFHSYFEDVQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRI
IHRDLKLGNLFLNDMLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEIL---TKK--G
HSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVP-SY--LRKPAADMVIS
MLQPNPESRPAIGQLLNYDFLKGSKV--PTFLPSSCLT----MAPR-IGINDTIEDSIH-
------------------------RKPLMEMN----------------------------
-----------------------------GIR-DDTRLESTF------LKANLHDAIT--
ASAQVCRHNEDY------RSDIESLHQ----------------------------QLTNL
INNKPRILQGNL----------GDENTDPAAQ--------------PLF-----------
---------------WISKWV----DYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQIN
VHFIDKDGKE----SYM-------TT--TDYCKTLDKKMKLLSYFKRYM----IEHLVKA
GANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLN-FSDHMKLILCPR---MSAI
TYM---------------------------------------------------------
---------------------------------------
>gi|119913077|ref|XP_587229.3|	Bos taurus
------------------------------------------------------------
----------------------------------------------------MELLRTIT
YQPAASTKMCEQALGK--------------ACGGDSKKKRPQPPPEEPQPPQPPAQVQP-
AAPHHHHHHSHSGAEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKII
PHSRVAK-PHQREK------------------------------IDKE-IELHRILHHKH
VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI
LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL---NKQ--G
HGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP-SS--LLAPAKHLIAS
MLSKNPEDRPSLDDIIRHDFFLQGFT--PDRLSSSCCH----TVPD-FHLSSPAKNFFKK
AAAALFGGKKD-------------KARYIDTH-NKVSKEDEEIYKLRHDLKKTSIT----
-------------------------QQPSKHRTDEELQPPTT----TVARSGTPAVEN--
KQQIGDAIRMIV------RGTLGSCSS--------------------SSECLEDSTMGSV
ADTVARVLRGCLENM-------PEADCIPKEQ-----------LSTSFQ-----------
---------------WVTKWV----DYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT
VHYYAELGQC----SVF-------QA--TDAPEQFISQVTVLKYFSHYM----EENLMDG
GDLPS--VTDVRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQ-NEEYLL
TYINEDRISTTFRLTTLLMSGC-----SLELKNRMEYALNMLLQRCN-------------
---------------------------------------
>gi|149035547|gb|EDL90228.1|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
MEPAAGFLSPRPFPRA-------------------AAPSSPPAGPGPPASASPRSEPGV-
-----LAGPQTP--DASRLITDPRSGRTYIKGRLLGKGGFARCYEATDTETSIAYAVKVI
PQSRVAK-PHQREK------------------------------IINE-IELHRDLQHRH
IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI
LHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL---LRQ--G
HGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLP-AS--LSLPARQLLAA
ILRASPRDRPSIEQILRHDFFTKGYT--PDRLPVSSCV----TVPD-LTPPNPARSLFAK
VTKSLFG-----------------RRKSKNKN---HSEEQDNVSCLVSGLMRTSIG----
---------------------------HPDVRPEAPAASALA--------------PV--
SLVETAAEDSSP------RGTLASSGD----------------------GFEEGLTVTTV
VESALCALRNCVAFM-------PPAEQNPAPL----------AQPEPLV-----------
---------------WVSKWV----DYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKT
VHYNPTSTKH----FSF-------SV--GSVPRALQPQLGILRYFASYM----EQHLMKG
GDLPSVEEVEVPAP-PLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGW--EPLLV
TFVARNRSACTYLASHLRQLGC-----SPDLRQRLRYALRLLRDRSPA------------
---------------------------------------
