>gi|148236349|ref|NP_001085771.	Xenopus laevis
---------------------------MKCE-----------------------------
NCTKTECSKKKKT--------EENGEILDAMALADGE--------------------EKS
EFHQLAEAKIFLSDCLACGNCVTSEEGAKIFAQNQKELFKVLNRN--KKC----DSSLHK
LVVASISPQSVPYFAVKFHLSVC-EASKKLCGFLKS-LGVHHVLDTT-----IAADFSIL
ETQKDFIQRFRRQTQ-DEHAFPMFASAC-------------------PGWVQYAERVLGD
SVTPHICTAKSPQQIMGSLVKGYFAS---------SKNVSPDKIFHLMVAPCYDRKLEAL
REDYYTELYNCR---DVDCVLTS-------------------------------------
---------GEVMQIMEQQNISVKEV--MEFPLE-NL----------------FGETSCV
F--V--RHEGTSSDGYLAHVFRHAAKELFDMDVQ--E-----ITYKALKNKDFLEV-SLE
KD---GETV-LRFAAAYGFRNIQNMVLKL-------RKGK--------------------
--------------------FHYH--FVEVLACPGGCLNGKGQAQ--TMD----------
-------GKVERALLHEMEEVYTRV---PIQNPESNPHIQAL-----YEDWLQGA-ESQK
TKQTLHTKIVAS-AQSAAR----LDMKW--
>gi|109119241|ref|XP_001113522.	Macaca mulatta
---------------------------MKCE-----------------------------
HCTRKECSKKTKT------DDQENVSADAPSPAQENG--------------------EKG
EFHKLADARIFLSDCLACDSCVTAEEGVQLSQQNAKDFFRVLNLN--KKC----DTSKHK
VLVVSVCPQSLPYFAAKFNLSVT-DASRRLCGFLKS-LGVHYVFDTR-----IAADFSIL
ESQKEFVRRYRQHSE-EERTLPMLTSAC-------------------PGWVRYAERVLGR
PITAHLCTAKSPQQVMGSLVKDYFAR---------QQNLSPEKIFHVIVAPCYDKKLEAL
QEGFPPALHGSR---GADCVLTS-------------------------------------
---------GEIAQIMDQGDLSVKDA--ASTLCK-------------------FGDLKED
K--VT-RHDGASSDGHLAHIFRHAAKELFNEDVE--E-----VTYRALRNKDFQEV-TLE
KN---GEVV-LRFAAAYGFRNIQNMILKL-------KKGK--------------------
--------------------FPYH--FVEVLACAGGCLNGRGQAQ--TPD----------
-------GHADKALLRQMEGIYADI---PVRRPESSAHMQEL-----YQEWLEGI-NSPK
AREVLHTTYQSQ-ERGAHS----LDIKW--
>gi|6324089|ref|NP_014159.1|	Saccharomyces cerevisiae
-------------MSALLSESDLNDFISPAL-----------------------------
ACVKPTQV-----------SGGKKDNVNMNGEYE-----------------------VST
EPDQLEKVSITLSDCLACSGCITSSEEILLSSQSHSVFLKNWGKL---------SQQQDK
FLVVSVSPQCRLSLAQYYGLTLE-AADLCLMNFFQKHFQCKYMVGTE-----MGRIISIS
KTVEKIIAHKKQKENTGADRKPLLSAVC-------------------PGFLIYTEKTK-P
QLVPMLLNVKSPQQITGSLIRATF-E---------SLAIARESFYHLSLMPCFDKKLEAS
RPESLDD--------GIDCVITP-------------------------------------
---------REIVTMLQELNLDFKSFLTEDTSLYGRL------------SPPGW-DPRVH
W--A--SNLGGTCGGYAYQYVTAVQRLHPGSQ----------MIVLEGRNSDIVEY-RLL
HD---DRII-AAASELSGFRNIQNLVRKL-------TSGSGSERKRNITALRKRRTGPKA
NSREMAAAT-------AATADPYHSDYIEVNACPGACMNGGGLLNG-EQN----------
-------SLKRKQLVQTLNKRHGEE--LAMVDPLTLGPKLEE-----AA-------ARPL
SLEYVFAPVKQAVEKDLVS----VGSTW--
>gi|45185025|ref|NP_982742.1|	Ashbya gossypii
-------------MSAKLSESDLNDFIGAQV-----------------------------
ACVKPTRTLHTAD------EGDEALEVGKE------------------------------
-PQEATKVSISLQDCLACAGCITSSEEILLSRQSHGVFLEAW------------RSLAPK
ALAVSVAPQSRLSLAQHFGLSVA-ELDQCLSGVLGSYFGAKYVVGTQ-----LGRELSVQ
QTNARLVERKQ-----QGVQGPLLCSVC-------------------PGFVLYAEKTK-P
GLVPYMLDVKSPQQITGALLHA-----------------ADPNIYHLSLMPCFDKKLEAA
REDCAR---------EVDCVLTP-------------------------------------
---------REFVALLDELQLDLHSFAGAAVPIA-QL------------TPPGW-DPRVS
W--C--SSAGSSSGGYAYQYILHMQRLHPGST----------IATQAGRNADLLEHRLLA
PS---GVLL-ASAGELYGFRNIQNLVRKLLSPAT--KRSA---------------KVVRR
--------RLPQASPAPPATDPCNADFIEVMACPSGCINGGGLLN-GGLG----------
-------PSQRRDLVSQLNEGYARL---PTLDIPMPTYSQPS-----YIYNLRPL-----
----------AP-TDDVLT----VANAW--
>gi|61557212|ref|NP_001013201.1	Rattus norvegicus
---------MASPFSGALQLTDLDDFIGPSQ-----------------------------
SCIKPVTVAKKPG------SGIAKIHIEDDGSYFQVN--------------------PDG
RSQKLEKAKVSLNDCLACSGCVTSAETILITQQSHEELRKVLDAN--KVA----APGQQR
LVVVSVSPQSRASLAARFQLDST-DTARKLTSFFKK-IGVHFVFDTA-----FARNFSLL
ESQKEFVQRFREQAN-SREALPMLASAC-------------------PGWICYAEKTHGN
FILPYISTARSPQQVMGSLIKDFFAQ---------QQLLTPDKIYHVTVMPCYDKKLEAS
RPDFFNQEYQTR---DVDCVLTT-------------------------------------
---------GEVFRLLEEEGVSLSEL--EPVPLD-GL----------------TRSVSAE
E--PT-SHRGGGSGGYLEHVFRHAAQELFGIHVA--D-----VTYQPMRNKDFQEV-TLE
RE---GQVL-LRFAVAYGFRNIQNLVQKL-------KRGR--------------------
--------------------CPYH--YVEVMACPSGCLNGGGQLK--APD----------
--------TEGRELLQQVERLYSMV---RTEAPEDAPGVQEL-----YQHWLQGE-DSER
ASHLLHTQYHAV-EKINSG----LSIRW--
>gi|50291209|ref|XP_448037.1|	Candida glabrata
-------------MSALLSEDYLNDYISPAL-----------------------------
ACTKPTEIKKEKF-------------VTEDGEFQ-----------------------VGV
EPQELEKVTISLSDCLACSGCITSSEEIMLSQQSHSVFLDAWRELGFDKCGSAGDAQCTN
KLVVSISPHCRASMARYYGVDVD-AADYAILRVFKEVFHATSVIGDG-----AGRLLSVK
RVVEELMERR------KASQGTALSSIC-------------------PGFLIYTEKTK-P
KLVPMLLNVKSAQQVTGALFKEIALEEGYDVDTSLKDGKRTNVQYHLTIVPCFDKKLEAS
RPDGEG---------EVNCVITP-------------------------------------
---------REVLAMLGEMGVSFRKYLGDWASLDKQLQQSQLGMLRAEMSPAGW-DPLLH
W--SIPANGDGYSDGYAYQYACTVRDAHVASGCA-AQ-----VVSVPGKNADVLEYRVVE
PSSEGGKVI-ARACVLSGFRNIQNLCRKL-------DPSGHKKRSVRRVAALRSRGRKDS
SSEDSTGTPSAISNALGGTANPAECDYVEVSACPSGSINGGGLLMELAPEREEMGETPLP
SSTIGGNARRRQQQLQELQAMYKAQIRITDETPTSLPPAALP--------------PLPP
QYTMQYTFYIQE-EDPAKPDIVTVGNTW--
>gi|149758758|ref|XP_001490420.	Equus caballus
---------------------------MKCE-----------------------------
HCTRKECSKKTKT------DDQENASVDVPSPAQENG--------------------EKG
EFHKLADAKIFLSDCLACDSCVTAEEGVQVSQQNAKDFFRVLNLN--KKC----NTSEHK
VLAVSVCPQSLPYFAAKFSLSVT-DASRRLCGFLKS-LGVHYVFDTT-----IAADFSIL
ESQREFVRRYHQHSE-GEPALPMLTSAC-------------------PGWVRYAERVLGH
PVTPHLCTAKSPQQIMGSLVKDYFAR---------RQNLSPDKIFHVVVAPCYDKKLEAL
RDDFPSALRSSR---GADCVLTS-------------------------------------
---------GEIVQIMEQSDVSV-----KDAAVD-TL----------------FGDCKEE
E--VR-RHGGASSDGCLVHVFRHAAKELFNEDVG--E-----VTYRTLRNKDFQEV-TLE
KN---GEVL-LRFAAAYGFRNIQNVILKL-------KKGK--------------------
--------------------SPYH--FVEVLACAGGCLNGRGQAQ--TED----------
-------GRADKALLRQMEGIYADV---PVRAPEASARVQEL-----YQEWLDGA-DSPR
VQEALHTAYQGP-GHPANS----RDIKW--
>gi|5538|emb|CAA49833.1|	Kluyveromyces lactis
-------------MSALLRDADLNDFISPGL-----------------------------
ACVKPAQPQKVEK------KPSFEVEVGIESS----------------------------
---EPEKVSISLQDCLACAGCITSSEEILLSKQSHKVFLEKWSEL--EEL----DE---R
SLAVSISPQCRLSLADYYSMCLA-DLDRCFQNFMKTKFNAKYVVGTQ-----FGRSISIS
RINATLKDRV------PENEGPLLCSVC-------------------PGFVLYAEKTK-P
ELIPHMLDVKSPQQITGNLLKQ-----------------ADPTCYHLSIMPCFDKKLEAS
REECEK---------EVDCVITP-------------------------------------
---------KQFVAMLGDLSIDFKSYMTEYDSSK-EL------------CPSGW-DYKLH
W--L--SNEGSSSGGYAYQYLLSLQSSNPESD----------IITIEGKNSDVTEYRLVS
KS---KGVI-ASSSEVYGFRNIQNLVRKLSQSASVKKRGI---------------KVKRR
GQSVLKSGETSEKTTKVLTADPAKTDFVEVMACPSGCINGGGLLNE-EKN----------
-------ANRRKQLAQDLSLAYTKV------HSVNIPDIVHA-----YD-------DKSN
DFKYNLRVIEPSTSSDVVA----VGNTW--
>gi|118791474|ref|XP_319772.3|	Anopheles gambiae
----------MSRFSSALQLTDLDDFITPSQ-----------------------------
ECIKPVKIETSKS------KTGAKITIQEDGSYVQES--------------------SSG
-IQKLEKVEITLADCLACSGCITSAEGVLISQQSQEELLRVMNAN--NLAKLNNQRDEIK
FVVFTVSQQPILSLARKYNLTPE-DTFEHIAGYFKK-LGADMVVDTK-----IADDLALI
ECRNEFIERYNT----NRKLLPMLASSC-------------------PGWVCYAEKTHGN
FILPYIATTRSPQQIMGVLVKQYLAK---------QLQTTGDRIYHVTVMPCYDKKLEAS
REDFFSEVENSR---DVDCVITS-------------------------------------
---------IEIEQMLNSLDLPSLQL-VERCAID-WP----------------WPTVRPS
A--FVWGHESSGSGGYAEYIFKYAARKLFNVQLD--T-----VAFKPLRNNDMREA-VLE
QN---GQVL-MRFAIANGFRNIQNMVQKL-------KRGK--------------------
--------------------STYD--YVEIMACPSGCLNGGAQIR--PEE----------
-------GRAARELTAELECMYRSL---PQSTPE-NDCVQTM-----YATFFDSEGDLNK
RQSLLHTSYHQI-EKINSA----LNIKW--
>gi|14336719|gb|AAK61251.1|AE00	Homo sapiens
---------MASPFSGALQLTDLDDFIGPSQVGSLQALLALAFLHTGNFSAAGCWEPDPW
ECIKPVKVEKRAG------SGVAKIRIEDDGSYFQINQEKLGELELEPTFGIFLPYSPDG
GTRRLEKAKVSLNDCLACSGCITSAETVLITQQSHEELKKVLDAN--KMA----APSQQR
LVVVSVSPQSRASLAARFQLNPT-DTARKLTSFFKK-IGVHFVFDTA-----FSRHFSLL
ESQREFVRRFRGQAD-CRQALPLLASAC-------------------PGWICYAEKTHGS
FILPHISTARSPQQVMGSLVKDFFAQ---------QQHLTPDKIYHVTVMPCYDKKLEAS
RPDFFNQEHQTR---DVDCVLTT-------------------------------------
---------GEVFRLLEEEGVSLPDL--EPAPLD-SL----------------CSGASAE
E--PT-SHRGGGSGGYLEHVFRHAARELFGIHVA--E-----VTYKPLRNKDFQEV-TLE
KE---GQVL-LHFAMAYGFRNIQNLVQRL-------KRGR--------------------
--------------------CPYH--YVEVMACPSGCLNGGGQLQ--APD----------
--------RPSRELLQHVERLYGMV---RAEAPEDAPGVQEL-----YTHWLQGT-DSEC
AGRLLHTQYHAV-EKASTG----LGIRW--
>gi|149637614|ref|XP_001513248.	Ornithorhynchus anatinus
---------------------MLSGPLIAAS-----------------------------
SAFPPGRAKQRGD----KGATLRRPPSSPGGCFLDDSV------------------APKS
EFHKLADAKIFLSDCLACDSCVTEEEGARVFQQNQKEFFRVLNLN--KKC----DTSKHK
VLAASICPQSLPYFAAKFNLCVT-DTSRRLCGFLKS-LGVHYVFDTT-----IAADFSIL
ESQKEFVQRYRRREQ-EEHALPMLTSAC-------------------PGWVRYAERVLAN
PVTLHICTAKSPQQIMGSLVKDYFAR---------QKNLSPDKIFHIIVAPCYDKKLEAL
REDFYTSLYDSQ---DVDCVLTS-------------------------------------
---------GEIVQILEQSGLSLNEL--EEASVD-TL----------------FGATTEG
E--VV-RHDGTRSDGYLEHVFKHAAKELFDMDVQ--E-----ITYRTLKNKDFQEV-TLE
RD---GEVL-LRFAAACGFRNIQNLVLKM-------KRGR--------------------
--------------------FPYH--FVEVLACPGGCLNGKGQME--AGS----------
-------GKPDGALLRRLEEAYAGI---PVRLPEANAHVQRL-----YRDWLQGT-DSPK
VQAALHTSYGAA-EPPAPG----PHIKW--
>gi|23664246|gb|AAN39277.1|	Neocallimastix frontalis
------------------------------------------------------------
------------------------------------------------------------
----------------------TERNEVI-------EVLRQLDSK--R-----------K
ILVCSTAPAIRVALAEEFNADPDFNFTGKMVAGLRK-LGFDYIFDTN-----FSADLTIM
EEGTELINRLN-----NGGKFPMFTSCC-------------------PGWINMVEKSY-P
ELRENLSTCKSPQQMIGALIKSYFAK---------KLGVSTEDIIHVSVMPCTAKKGEAK
RPEFVQKGKDGKNYPDIDYVLTT-------------------------------------
---------RELLTLMKLKKVNPAEL--ADDKLD-SP-------------------LGIS
S--SA-GNLFGVTGGVMEAAVR-TAQIITGVENPIPL-----GELKAVRGLEGIKAATVP
LKTKEGKDINVRAAVVSGGANIQKFLEKI-------KNKE--------------------
--------------------VEFD--FVEMMMCPGGCINGGGQPK---------------
-------SADPKIVTKKMQRMYTMDEQATLRLSHENEEVKQI-----YKEFLIEP-NGHL
SHELLHTHYNDR-SKAIQD----MSLHEKK
>gi|108871353|gb|EAT35578.1|	Aedes aegypti
----------MSRFSGALQLTDLDDFITPSQ-----------------------------
ECIKPVKIETNKS------KTGSKITIQDDGSYMQAT--------------------SSG
-LQKLEKVEITLADCLACSGCITSAEGVLITQQSQEELLKVMNEN--NLAKLNNQLDSVR
YIVFTVAQQPILSLAKRYNLGPE-ETFERVAGYFKK-LGADMVVDTK-----IADDLSLI
ESRNEFVERFNT----NRQSMPMMASSC-------------------PGWVCYAEKTHGN
FILPFIATTRSPQQIMGVLVKKYLAK---------ILGVPGDRIYHVTVMPCYDKKLEAS
REDFFSDVDNCR---DVDCVITS-------------------------------------
---------IEIEQMLDGTGIQFLQT-VEPSPID-WP----------------WPTPRPS
A--FVWAHESSGSGGYSEYIFKYAARKLFNINID--Q-----AEFKILRNNDLREA-ILE
IN---GEVL-LRFAIANGFRNIQNMVQKL-------KRGK--------------------
--------------------CNYH--FIEIMACPSGCLNGGAQVR--PNS----------
-------GQTPRELTAELEAMYKML---PQSNPE-NEAVEMV-----YTTFLDNAGDNNK
RKEFLHTSYHQI-EKMNTA----LNIKW--
>gi|126309437|ref|XP_001368190.	Monodelphis domestica
---------------------------MKCE-----------------------------
NCTKKECIKKTKI------DDHQSISVDTLNFYSEHE--------------------EKS
EFHKLADAKIFLSDCLASDTCVTAEEGIRVFQQNQKEFFRILNLN--KKC----DSSHHK
VLAVSICPQSLPYFAAKFNLSIT-DASKRLCGFLKS-LGVHYVFDSA-----IAADFSIL
ESQKEFVYRYRQQNQ-KEHSLPMFASAC-------------------PGWIRYAERVLGN
PVTPHICTAKSPQQIMGSLVKDYFAR---------QQNLSPAKIFHIIVAPCYDKKLEAL
REDFYTASYNSH---DVDCVLTS-------------------------------------
---------GEIIQIMEQKKELV-----KEAAVD-NL----------------FGEIKEG
D--IV-QDGRTRSDGYLEHIFKYAAKELFDMDIK--E-----ITYKALKNKDFQEI-SLE
KN---GEIV-LRFAAAYGFRNIQNMVLKL-------KKGK--------------------
--------------------FPYH--FVEVLACPGGCLNGKGQTQ--TED----------
-------GKPDKALLRRMEEVYAEI---PVQLPETNTHVQRL-----YQEWLDGI-DSPK
VLEALHTTYSAA-EPPTDN----VDIKW--
>gi|73959191|ref|XP_547207.2|	Canis familiaris
---------MASPFSGALQLTDLDDFIGPSQ-----------------------------
DCIKPVKVDRRPG------SGVAKIHIEDDGSYFQVS--------------------PDG
GTQRLEKAKISLDDCLACSGCVTSAETVLITQQSHEELRKVLDAN--KTA----APGQQR
LVVVSVSPQSRASLAARFQLSPT-DTARKLTAFFKK-IGVHYVFDTA-----FSRNFSLL
ESQREFVQRFREQTN-STQALPVLTSAC-------------------PGWICYAEKTHGN
FLIPYLSTARSPQQVMGSLVKDFFAQ---------QQHLTPDRIYHVTVMPCYDKKLEAS
RPDFFNQEHQTR---DVDCVVTT-------------------------------------
---------GEVFKLLEEEGVSLSEL--EPAPLD-SL----------------CSSMSAQ
E--PS-SHRGGGSGGYLEHVFQHAARELFGIHVD--E-----VTYRPLRNKDFQEV-TLE
KE---GRVL-LHFAAAYGFRNIQNLVQKL-------KRGR--------------------
--------------------CPYH--YVEVMACPAGCLNGGGQLK--APD----------
--------MPSKELLQQVEMLYGMV---RTEVPENVPGVQEL-----YRSWLQGE-GSEQ
AGRLLHTSYHAV-EKASSS----LSIRW--
>gi|47218040|emb|CAG11445.1|	Tetraodon nigroviridis
---------MASHFSGVLQLTDLDDFITPSQ-----------------------------
ECVKPVKVEKKQG------KSVAKIQIEEDGSYIQIN--------------------QDG
GKQKLEKAKITLNDCLACSGCITSAESVLITQQSHEELFRVLQHN--KA-----SETEKK
VVVVSVSPQSRASIAARYGLSST-EAGRRLTSFFKG-LGVHHVFDTT-----FTRTFSLL
ESQREFVERFQRKEQ-DNKSLPMMTSACPGT----------------PGWICYAEKTHGD
LILPYISTTRSPQQMMGSLVKGYFAE---------QQGLSPQQIYHVAVMPCYDKKLEAS
RSDFHMNEAQTR---EVDCVITS-------------------------------------
---------GEVQLMLEEKNVSLSDV--EPAPLD-TV----------------FSNVNGD
E--FL-SHAGSSSGGYLHHVFTYAAKHLFGEEVK--E-----LTYKTLKNKDFQEV-TLE
KD---GVVL-LCFASTYGFRNIQNLVQKF-------KRGK--------------------
--------------------CPYH--FVEVMACPSGCLNGGGQLK--ALP----------
-------GQNPKELLQKVEEIYRAE---RSMVPEDNTRVAEL-----YHSWLHSV-GEER
AKELLHTRYHTV-EKMKNG----LTMKW--
>gi|114671181|ref|XP_511766.2|	Pan troglodytes
-------MARAARASGAGRVETKGAVMGPGQ-----------------------------
---------------------------TGATGFAQAL--------------------CKG
EFHKLADAKIFLSDCLACDSCVTAEEGVQLSQQNAKDFFRVLNLN--KKC----DTSKHK
VLVVSVCPQSLPYFAAKFNLSVT-DASRRLCGFLKS-LGVQVSVGSGPKISCQVSKFCDV
LMRSDWAVRLRERTLQGRSHFPVASRPAGSHDPQPGHRGWVLGPAQAPGWVRYAERVLGR
PITAHLCTAKSPQQVMGSLVKDYFAR---------QQNLSPEKIFHVIVAPCYDKKLEAL
QESLPPALHGSR---GADCVLTS-------------------------------------
---------GEIAQIMEQGDLSV-----RDAAVD-TL----------------FGDLKED
K--VT-RHDGASSDGHLAHIFRHAAKELFNEDVE--E-----VTYRALRNKDFQEV-TLE
KN---GEVV-LRFAAAYGFRNIQNMILKL-------KKGK--------------------
--------------------FPFH--FVEVLACAGGCLNGRGQAQ--TPD----------
-------GHADKALLRQMEGIYADI---PVRRPESSAHVQEL-----YQEWLEGI-NSPK
AREVLHTTYQSQ-ERGAHS----LDIKW--
>gi|156545553|ref|XP_001605725.	Nasonia vitripennis
---------MASRFSGALQLTNLDDFITPSQ-----------------------------
ECIKPVEIKKNKS------KPGSKIKIQDDGSYAEVL--------------------EGG
PLTKLTKVEITLADCLACSGCITSAESVLVTQQSQEELLKVFKDK--IEKQKA-GDENVK
FIVVSLSIQPILSLAERYKLTPE-EAALHLTGYFKS-MGADMVLDMT-----VAEDLSLV
ESAKEFVERYKAAKEGSKNQLPMLASSC-------------------PGWVCYAEKTHGN
FILPYISVTKSPQQIMGSLVKYHLAD---------VQGLSPEQVYHVTLMPCYDKKLEAS
REDFYNSLKETR---DVDCVITS-------------------------------------
---------IELEQMLTQQDKSLQDF--DKGEIE-KP----------------FKTMELE
NSGVLLGHQGSGSGGYADFIFHYAAKYLFQVTDA--K-----LEYKSLRNPDFQEA-VLE
KD---GQVL-LKFAIANGFRNIQNLVQKL-------KRGK--------------------
--------------------SPYD--YVEVMACPTGCLNGGAQIR--PQD----------
-------GTQPRELALKLENEYHQL---PKSDPEKNQAVADL-----YKTWLEGE-NSDK
ANAYLHTQYHEI-EKMNVA----LSIKW--
>gi|14165461|ref|NP_114174.1|	Homo sapiens
---------------------------MKCE-----------------------------
HCTRKECSKKTKT------DDQENVSADAPSPAQENG--------------------EKG
EFHKLADAKIFLSDCLACDSCMTAEEGVQLSQQNAKDFFRVLNLN--KKC----DTSKHK
VLVVSVCPQSLPYFAAKFNLSVT-DASRRLCGFLKS-LGVHYVFDTT-----IAADFSIL
ESQKEFVRRYRQHSE-EERTLPMLTSAC-------------------PGWVRYAERVLGR
PITAHLCTAKSPQQVMGSLVKDYFAR---------QQNLSPEKIFHVIVAPCYDKKLEAL
QESLPPALHGSR---GADCVLTSEISQAWWCTPVITATREAAARESLEPGRQRLQRDKIA
PLDSSLGGGGEIAQIMEQGDLSV-----RDAAVD-TL----------------FGDLKED
K--VT-RHDGASSDGHLAHIFRHAAKELFNEDVE--E-----VTYRALRNKDFQEV-TLE
KN---GEVV-LRFAAAYGFRNIQNMILKL-------KKGK--------------------
--------------------FPFH--FVEVLACAGGCLNGRGQAQ--TPD----------
-------GHADKALLRQMEGIYADI---PVRRPESSAHVQEL-----YQEWLEGI-NSPK
AREVLHTTYQSQ-ERGTHS----LDIKW--
>gi|116007464|ref|NP_001036428.	Drosophila melanogaster
----------MSRLSRALQLTDIDDFITPSQ-----------------------------
ICIKPVQIDKARS------KTGAKIKIKGDGCFEE----------------------SES
GNLKLNKVDISLQDCLACSGCITSAEEVLITQQSREELLKVLQEN--SKNKASEDWDNVR
TIVFTLATQPILSLAYRYQIGVE-DAARHLNGYFRS-LGADYVLSTK-----VADDIALL
ECRQEFVDRYR-----ENENLTMLSSSC-------------------PGWVCYAEKTHGN
FLLPYVSTTRSPQQIMGVLVKQILAD---------KMNVPASRIYHVTVMPCYDKKLEAS
REDFFSKANNSR---DVDCVITS-------------------------------------
---------VEVEQLLSEAQQPLSQY--DLLDLD-WP----------------WSNVRPE
F--MVWAHEKTLSGGYAEHIFKYAAKHIFNEDLK-TE-----LEFKQLKNRDFREI-ILK
QN---GKTV-LKFAIANGFRNIQNLVQKL-------KREK--------------------
-------------------VSNYH--FVEVMACPSGCINGGAQIR--PTT----------
-------GQHVRELTRKLEELYQNL---PRSEPE-NSLTKHI-----YNDFLDGF-QSDK
SYDVLHTRYHDVVSELSIS----LNINW--
>gi|150866595|ref|XP_001386245.	Pichia stipitis
-------------MSAILSADDLNDFISPGV-----------------------------
ACIKPPAQNSDQKFNSLNENGEVEIQIDSEGNPLEISK-------------------IDG
KQTNLSPAQISLADCLACSGCITSAEEVLVAQHSHEELIKALNEK--V------DNNSTK
VFVASISHQSRASLATAYNLSIE-EIDKLLINLFINQMGFKYIVGTS-----IGRKLSLI
NEAQNLIEKKE-----SEFDGPVLSSIC-------------------PGWVLYAEKTH-P
YVLPRMSTVKSPQQITGCLLKTLAAH---------ELGVTRNDIYHLSIMPCFDKKLESA
RPEKYGEQNTSN---DVDCVLTA-------------------------------------
---------KELVTLLEQHSDKFQLI--PPQAHTITNSAIPVVDLYSKCAPRTWPLVQYS
W--S--NDSGSASGGYGYNYLKMYQNHLIMKHPTKYQQEGFSIDYVKGRNTDLTEM-RLM
YG---SEKL-ASSAIVNGFRNIQNLVRKLKPTV---KPGS-------TTGKGNALVARRR
ARVAGGITKASSPAGSDESADASKCDYVEIMACPNGCINGGGQIN--PPE----------
-------DVSEKDWLSASLEKYNSI---PLLDLAAMENVDTVAEIMQWSCLFREE-FGVS
ENRLLKTWFNEV-EKPTDSASILLGARW--
>gi|38146740|gb|AAR11770.1|	Pichia pastoris
-------------MSAILRADDLNDFIMPGV-----------------------------
ACIKPVESGKKGS------GEDLEIQIDSEGNALEVT--------------------KEG
HERKLDKAQISLSDCLACSGCITSAEEVLIAQHSHKELLNALETD-----------GNRK
VFVASISHQTRASLASAFDVQIE-AMDKVLIYLLKNVMKFKYVIGTE-----TGRRLSHI
FTTLDLQNRS------PHSEKPLINSTC-------------------PGWVLYAEKTH-P
FILPRISTIKSTQQITGHLLKNIVSK---------DLGIEKSQIYHLSVMPCFDKKLEAA
RDSDVP---------DVDCVITA-------------------------------------
---------RELVQVIEELNIDLQTI-LKESVLDNTD----IYSVYRSSSPPGWYQPEQS
W--L--NNKGSASGGYAMQYLLDVQQRHADSE----------IITIEGRNSDIYEHRLVL
RD---GQVV-ASSAVVNGFRNIQNLIRKL-------KPNH---------KATGGGISARR
RSRKLKEDQTGDQGQSNAVVDPSKCDYVEIMACPGGCINGGGQIA---------------
-------------------------------APADQNS----------------------
------------------------------
>gi|74211319|dbj|BAE26421.1|	Mus musculus
---------MASPFSGALQLTDLDDFIGPSQ-----------------------------
NCIKPVKVAKKPG------SGIAKIHIEDDGSYFQVN--------------------QDG
RTQKLEKAKVSLNDCLACSGCVTSAETVLITQQSHEELRKVLDAN--KEA----APGQQR
LVVVSISPQSRASLAARFRLDPT-DTARKLTSFFKK-IGVHFVFDTA-----FARNFSLL
ESQKEFVQRFREQAN-SREALPVLASAC-------------------PGWICYAEKTHGN
FILPYISTARSPQQVMGSLVKDFFAQ---------QQLLTPDKIYHVTVMPCYDKKLEAS
RPDFFNQEYQTR---DVDCVLTT-------------------------------------
---------GEVFRLLEEEGVSLTEL--EPAPLD-GLDLSCVAPPALTRPSPRTSSVSAE
E--PS-SHRGGGSGGYLEHVFRHAAQELFGIHVA--E-----VTYQPLRNKDFQEV-TLE
RE---GQVL-LRFAVAYGFRNIQNLVQKL-------KRGR--------------------
--------------------CPYH--YVEVMACPSGCLNGGGQLK--APD----------
--------TEGSELLQQLERLYSMV---RTEAPEDAPGVQEL-----YQHWLQGE-DSER
ASRLLHTQYHAV-EKPSSG----LSIRW--
>gi|152941142|gb|ABS45008.1|	Bos taurus
---------MASPFSGALQLTDLDDFIAPSQ-----------------------------
DCIKPMKVDRRPG------SGVAKIHIEDDGSYFQVS--------------------QDG
GMKKLEKAKISLDDCLACSGCVTSAETVLITQQSHEELRKVLGAN--KTA----APDQQK
LVVISVSPQSRASLAVRFQLNPT-DTARKLTAFFKK-IGAHYVFDTA-----FSRNFSLL
ESQREFVRRFRGQAD-PEQALPVLTSAC-------------------PGWICYAEKTHGS
TLLPHISTARSPQQVMGSLVKDFFAQ---------QQHLTPDKVYHATVMPCYDKKLEAS
RPDFFSQEHQTR---DVDCVITT-------------------------------------
---------GEVFKLLEEGGVSLSEL--EPAPLD-SL----------------CSSASAQ
E--PT-SHQGGGSGGYLEHVFRHAAQELFGIHVT--E-----VTYRPLRNKDLQEV-ILE
RE---GQVL-LHFAAAYGFRNIQNLVQKL-------KRGR--------------------
--------------------CPYH--YVEVMACPAGCLNGGGQLK--APD----------
--------MPGKELLQQVERLYGLV---RTEAPEDAPGIQEL-----YERWLQGA-GSER
AGRLLHTSYHAV-EKAGSG----LSIRW--
