>gi|76638907|ref|XP_883967.1|	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEAEKDS---GRRL-------------RPI
-DRQRYDENEDLSDVEEIVSARGFSLEEKLRSQLYQG-------------DFVHAMEGKD
FNYEYVQREALR--VPLVFRE-KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQK
GTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHT----KLEHLVKRPTVVDLVDWVDNMW
PQ--------HLKE-----KQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLHNLALY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VQPKFRYPFY-----YEMC-------WYVLERYVYCMTQR
SYLT-QEYQRESMLID-------APRKPSIDGFSSDSWLEMEEESCEQQPQ-EEKEEEEE
EEEEEEGADKTPRASTDGPASPTSTPSEDQEAPGKKPK--APAMRFLKRTLSNESEDSVK
SATMPTDYPKTPTGSPATEVSA--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEGVKNVL----------KEHAEDDPSLAITGVPVVTW-------
------------------------PK-----------KTPKNR-----------------
----------AV-----------------------------G------------------
--RPKGKL---------------------GPA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEEGKFNLM---------LMECSICNEIIHPGCL---
-----KIKESEGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE--HPKKVPP--DGILRRKSDDVHLRRK
RKYEKPQELSGRKR--------------------------------------LKPGKEDK
LFRKKRRSWK----NAEDRITLANKPLRRFKQEPEDDLPEAPPKTRESDHSRSSSPTAGP
STEGAEGP-EEKKKVK--MRRKRRLPNKELSKELSKE-----LNQEIQKTESSLAQENHQ
PIKSEPESENEEPKRPLG-LCERPH-----RFSKGLNGT-PRELR-HQ-LGPG---LRSP
PR--------VISRPPPSVS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMHREVWMAVFSYLSHQDLCVCMRVCKTWNRWCC----
---DKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW-LINRLPGLRD
LVLS-GCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKL
R--NIVELRLAGLDITD-ASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAV--GTTTR
DSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSSRRGRSQS
ATVWGMSEPGAFL---WSF----------
>gi|54607022|ref|NP_001003953.1	Mus musculus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEAEKDS---GRRL-------------RAI
-DRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG-------------DFVHAMEGKD
FNYEYVQREALR--VPLVFRD-KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQK
GTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHT----KLEHLVKRPTVVDLVDWVDNMW
PQ--------HLKE-----KQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLHNLALY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VQPKFRYPFY-----YEMC-------WYVLERYVYCVTQR
SYLT-QEYQRELMLID-------APRKTSVDGFSSDSWLDMEEESCEQQPQ-EEEEEEED
KEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPK--APAIRFLKRTLSNESEESVK
STSMPTDDPKTPTGSPATEVST--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEGVKNVL----------KEHVDDDPTLAITGVPVVSW-------
------------------------PK-----------KTAKNR-----------------
----------VV-----------------------------G------------------
--RPKGKL---------------------GPA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEEGKFNLM---------LMECSICNEIIHPGCL---
-----KIKESEGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE--HPKKVPA--DGILRRKSDDVHLRRK
RKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDK
LFRKKRRSWK----NAEDRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGP
STEGAEGP-EEKKKVK--MRRKRRLVNKELSKELSKE-----LNHEIQKTESTLAHESQQ
PIKSEPESENDEPKRPLS-HCERPH-----RFSKGLNGT-PRELR-HS-LGPG---LRSP
PR--------VMSRPPPSAS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMHREVWMAVFSYLSHRDLCVCMRVCRTWNRWCC----
---DKRLWTRIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW-LINRLPGLRD
LVLS-GCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKL
R--NIVELRLAGLDITD-VSLRLIIRHMPLLSKLQLSYCNHINDQSINLLTAV--GTTTR
DSLTEVNLSDCNKVTDLCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMS-------V
SVQFGQVEEKLLQ---KLS----------
>gi|148687711|gb|EDL19658.1|	Mus musculus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEAEKDS---GRRL-------------RAI
-DRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG-------------DFVHAMEGKD
FNYEYVQREALR--VPLVFRD-KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQK
GTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHT----KLEHLVKRPTVVDLVDWVDNMW
PQ--------HLKE-----KQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLHNLALY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VQPKFRYPFY-----YEMC-------WYVLERYVYCVTQR
SYLT-QEYQRELMLID-------APRKTSVDGFSSDSWLDMEEESCEQQPQ-EEEEEEED
KEEEGDGADKTPKPPTDDPTSPTSTPPEDQDSTGKKPK--APAIRFLKRTLSNESEESVK
STSMPMDDPKTPTGSPATEVST--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEGVKNVL----------KEHVDDDPTLAITGVPVVSW-------
------------------------PK-----------KTAKNR-----------------
----------VV-----------------------------G------------------
--RPKGKL---------------------GPA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEEGKFNLM---------LMECSICNEIIHPGCL---
-----KIKESEGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE--HPKKVPA--DGILRRKSDDVHLRRK
RKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDK
LFRKKRRSWK----NAEDRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGP
STEGAEGP-EEKKKVK--MRRKRRLVNKELSKELSKE-----LNHEIQKTESTLAHESQQ
PIKSEPESENDEPKRPLS-HCERPH-----RFSKGLNGT-PRELR-HS-LGPG---LRSP
PR--------VMSRPPPSAS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMHREVWMAVFSYLSHRDLCVCMRVCRTWNRWCC----
---DKRLWTRIDLNRCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW-LINRLPGLRD
LVLS-GCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKL
R--NIVELRLAGLDITD-VSLRLIIRHMPLLSKLQLSYCNHINDQSINLLTAV--GTTTR
DSLTEVNLSDCNKVTDLCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMS-------V
SVQFGQVEEKLLQ---KLS----------
>gi|125777158|ref|XP_001359514.	Drosophila pseudoobscura
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------NGNPSTNPKGVQRRQL-------------RER
KQRKLYLDEWSLGD-DDGEGARGFSVAEKLESSKFAQS------------GMVREMRGCD
LTVAFLQQHGFN--IPLLFRE-KNGLGLRMPDPQEFTVGDVRLCVGSRRLLDVMDVNTQK
NLQMTMKEWQQYYECP--QKDRLLNVISLEFSHT----RLDRFVQSPEIVRQIDWVDVVW
PK--------QLKD-----AQKEGTNLLGGMMYPKVQKYCLMSVKNCYTDFHIDFGGTSV
WYHILKGSKVFWLIPPTDRNLQLY--EKWVLSGKQADIFFGDTVEKCARVYLTAGNTFFI
PTGWIHAVYTPTQSLVFG-------------GNFLHSFGIVKQLRTATVEDITK------
--------------------VPQKFRYPFF-----TEML-------WYVLARYVYTLLGH
SHLE--------------------------------------------------------
---------------------------------G--------------------------
----------EPSASEAEMAAR--------PHIH---LTHYELFGLKEIVMYLYDLPP--
QKKNVPSLVLDPVALIKDVRTLV----------ERHCKDQQDQAVTGMSVLRT-------
------------------------AS--EEQAGFHLYDRTRVKQEIKQEIVRKNAEVIRE
QQQLEAGRDGAVAASGAVVAGIEYSNGVLKKEQLENGAGATGQGGGAQPEATFVLPTDTL
KYRPPKKMHLANAVAAAATSTSTTGGAGGGPSVGGTAANSNSLPTGGAGGAVTGNAISVI
ATCSNYNNLNSSEAASLDNNCASPVDGAKLSPHLTGTGQ-PRRRRTRCKNCAACQRSDC-
---------GTCPFCMDMVKFGGPGRAKQTCMMRQCLS----------------------
-PMLPVTAQCVYCHLDGWRQTPVSPQTKQLATV---DGPSALMECSVCYEIAHPDCALSQ
LDGTEDAADAKGI-VNEDLPNSWECPSCCRSGKNYD---------------YKVTYIYLS
VSLSKTNVSPIRSPQPRHFRARLKSSEVRRVSVSHGPGGEPTGHEGTSSLLPPPVGQYTD
FVFTSESEMESG------------------------------------------------
--------------SAGGHVTHWKHGMKRHHQ--------LEVKTDRNNSCDTPSPGISP
NAVGGDK-----------VKRRKSDDGTSVSS--------------------SMQESNDA
PCNSSIDARKKNSIRS--------------QLAQQMLNNSNRVLK--------------K
PQ--------YVVRPAASSS------SSGNNAIGGGGGSNGISNGTGQSGGGGLGSGGER
GANGSGTSGSNGINSLHHSSSLALDPTVLKIIFRYLQPETLVTCCSVCKVWSTAAV----
---DPDLWKSMNCSAHK-MSASLLTAIVRRQPEHLILDWTQIAKRQLAW-LVARLPALKN
LSLQ-NCPIQAVLALHTCLCPPLQTLDLSFVRGLNDAAVRDILSPPKDSRPGLSDSKTRL
R--DLKILKLAGTDISD-VAVRYITQSLPYLKHLDLSSCQRITDAGVAQIGT---SNTAI
ARLSELNLSACRLVSENALEHLSKCESLIWLDLRHVPQVSTQSVIRFASNSK----HDLC
VKDVKLVESRRLS---TSVRSVSLGSSWH
>gi|109105232|ref|XP_001107511.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEPEEERIRYSQRL-------------RGT
-MRRRY-EDDGISD-DEIEGKRTFDLEEKLHTNKYNA-------------NFVTFMEGKD
FNVEYIQRGGLR--DPLIFKN-SDGLGIKMPDP-DFTVNDVKMCVGSRRMVDVMDVNTQK
GIEMTMAQWTRYYETPEEEREKLYNVISLEFSHT----RLENMVQRPSTVDFIDWVDNMW
PR--------HLKE-----SQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSV
WYHIHQGGKVFWLIPPTAHNLELY--ENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVI
PSGWIHAVYTPTDTLVFG-------------GNFLHSFNIPMQLKIYNIEDRTR------
--------------------VPNKFRYPFY-----YEMC-------WYVLERYVYCITNR
SHLT-KEFQKESLSMD-----------LELNGLESG---NADEEAVDREPR---------
---------RLSSRRSVLTSPVANGVNLDYDGLGKT----CRSLPSLKKTLSGDSSSDSS
RGSHNGQVW-DPQCAPRKDRQV-----------H---LTHFELEGLRCLVDKLESLPL--
HKKCVPTGIEDEDALIADVKILL----------EELANSDPKLALTGVPIVQW-------
------------------------PK----RDKLKFPTRPKVRVPTIP------------
------ITKPHT-----------------------------M------------------
--KPAPRL---------------------TPV---RP-----A-----------------
--------------------AASP----------IVSG--ARRRRVRCRKCKACVQGEC-
---------GVCHYCRDMKKFGGPGRMKQSCVLRQCLA----------------------
-PRLPHSVTCSLCGEVDQNEETQD----FEKK---------LMECCICNEIVHPGCL---
-----QM-DGEGL-LNEELPNCWECPKCYQEDNSEK------------------------
AQKRKMEESDEEAVQAKVLR------PLRSCDEPLTPPPHSP--TSMLQLIHD-------
------------------------------------------------------------
--------------------------------------PVSPRGMVTR-----SSPGAGP
SDHHSASR-DER------FKRRQLLRLQATERTMVRE-------------------KENN
PSGKKELSEVEKAKIRGSYLTVTLQ-----RPTKELHGT-SIVPK-LQAITASSANLRHS
PR--------VLVQHCPART--------PQRGDEERLGGEEEEEEEEEEEDDSAEEGGAA
RLNGRGSWAQDG-------DESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCC----
---DKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTW-LVNRLPGLKD
LLLA-GCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPAD-KPGQ-DNRSKL
R--NMTDFRLAGLDITD-ATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAV--GSSTR
YSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHFISDLS-------I
NSLYCLSDEKLIQ---KIS----------
>gi|91084735|ref|XP_970863.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MAHRGKKLQRSDDRQSYISRM-------------RER
KQKKLYSEDWALGD-DEIEGRRSFNLQEKLENPLFATH------------NIVKEMHGNE
LNVAYFQKHGFN--TPLLFKE-KTGLGLRVPTS-NFTINDVRMCVGSRRILDVMDVNTQK
NSEMTMKEWQKYYEDP--AKDKLLNVISLEFSHT----KLENYVQSPTVVRQVDWVDCVW
PR--------HLKE-----SQTEATNLLEDMKYPKVQKYCLMSVKGCYTDFHVDFGGTSV
WYHILKGSKVFWLIPPTEHNLALY--ERWVLSGKQSDIFFGDTVDKCARIVLTEGNTFFI
PTGWIHAVYTPMDSLVFG-------------GNFLHSYGIDKQLKIAHVEDTTK------
--------------------VPQKFRYPFF-----TEML-------WYVLERYVHCLLGN
SHLT--------------------------------------------------------
--------------------------------TGHDVA----------------------
----------IPPDRPHV---------------H---LTQAELHGLKEIVMFLHMLPA--
NKKNVPDLIRDPVSLIQDVRTLI----------GHHRQDSRELAITGRPVLWL-------
------------------------PD---DHDRKSLYPRPYAK-----------------
----------SN-----------------------------G------------------
VRPPKPAF---------------------KSK---SGLG---G-----------------
--------------------GAG-----------DKGG--PRRRRTRCKKCEACQRSDC-
---------GECSFCLDMVKFGGPGRAKQTCNMRQCLQ----------------------
-PMLPVTAACVHCGLDGWNQTPVTPLQKGPQRC---ESASNLMECSVCYEIAHPSCV---
---QRLCPDFTGY-INEDMPNSWECPMCCKLGKNTD------------------------
-------------YRPRHFRARQKSSDMRRMSI--SSDASSA------------------
------------------------------------------------------------
----------------------------------------FDSKLHQEHYSDSGSENDNK
DNNKDLLP----------IKKRR-------------------------------SSEGTP
EIETSKSQASDLPRKTAFRM----------QLAHQIASNSTKMLK--------------K
PM--------VVVRPAPILM--------------------------MNPLP---------
-----------G-------NNLALDKRCVLNIFKYLSPKDLLNCALVCKTWATYSI----
---DPTLWRVMAFSRKH-ISSDILKGIVRRQPEVLRLDWCHINKFQLPW-LIQRLSNLKE
LSLV-SVNVKTAISLRTNHSAVLQHLDLSFISDFNDAALREILGPNNDSRRGLADEKIRF
R--NLRTLKLAGTDVTD-IAMRYVTQYLPNLQHLSLSLCPRISDAGIAQLTTK--PATTV
GSLVSLDLSHSKLVTETSLEHLAKCESLVRLDCRHSLQISTQALIKFAAKSD----KNLQ
VRDIKLVDKRLKA----------------
>gi|66504478|ref|XP_394324.2|	Apis mellifera
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MSTMADDSTSLPKRRQL-------------RER
-TRKLYTDDWTIGD-EEIEGRRTFQLDEKIECDRYNLSNFT---------GLFREMAGSE
LNLAYLQKHGLS--IPLLFRD-KSGLGLRVPSS-NFSVNDVRTCVGSKRILDVMDVNTQK
NEDMTMKEWQKYYEDS--NKERLLNVISLEFSHT----KLENYVQSPELVRQVDWVDVVW
PR--------HLKE-----AQVESTNLLEDMMYPKVQKYCLMSVKGCYTDFHVDFGGTSV
WYHILRGGKIFWLIPPTEKNLSLY--QEWVLSGKQSDVFFGDMVDRCGRISLTAGMTLFI
PTGWIHAVYTPQDSLVFG-------------GNFLHSFGIEKQLKVAQVEEHTK------
--------------------VPQKFRYPFF-----TEML-------WYVLERYVHVLLGR
SHLDISESQRQHS-----------------------------------------------
------------------------------------------------------------
----------VPQHHQHI---------------H---LTPFELHGLKAIVMYLHSLPS--
TKKNVPELIRDPVALIHDVRCLV----------EQHRHDNPEAAVTGNPVLPP-------
------------------------PP------ALTIAERERMR-----------------
----------IT-----------------------------K------------------
--KSFTKI---------------------QRH---HSQE---------------------
----------------------------------KSERAFPRRRRTRCKKCEACTRTDC-
---------GECIYCQDMVKFGGSGRAKQTCLMRQCLR----------------------
-PMLPVTAACKVCRLDGWGQPPAPLMGKPTPTA-----PSSLVECSICFDIVHPECI---
-----GL-DPQTITVSDDLPNSWECPQCCESGRNLD------------------------
-----------------------------------CRPRQPK------------------
------------------------------------------------------------
------------------------------------------ARARKLSVSSAASSAPTT
DSERATTP----------SKRSRPDPSDAW--------------------------NDRE
PAEGEQRTALRT------------------QLAVQLTGSSSKSLK--------------R
PH--------VVVRPVSL-------------------------PPVQRPGPD--------
---------FNG-------QSLAYDKTALLAIFRFLNAKDLANCALVCRTWARYSI----
---DPSLWRKLDMSHSH-LTALHLTGIIRRQPENLSLDWTNVTKRQLAW-LLSRLPQLRT
LSLQ-GCTWTGVCALRTCTCPPLVTLDLSHVSGLNDSSLREVLSPPTDSRPGLIDKTSRL
K--HLKNLSLAGCDITD-IALRYIVQHLPYLETLDLSSCGRVTDAGVAQLATP--PAQAV
TNLASLNLANCRLLTETTLDHLARCKVLKRLDLRHTTQVSTQSVIKFAAKSI----HNLH
VTDVKLVEEKKFKVEVKVT----------
>gi|58332054|ref|NP_001011176.1	Xenopus tropicalis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEEEQLR--YSRRL-------------RHT
-LRRRY-EDDGISD-DEIEGKRTFDLEEKLRSSKYNS-------------NFITYMEGKD
FNMKFIQEGGLR--DPIIFTK-SEGLGIKMPDP-NFSVNDVKMFVGSRRVVDVMDVGTQK
GIEMTMAQWAKYYETPEEEREKLYNVISLEFSHT----KLENLVQRPTTVDQIDWVDNIW
PR--------HLKD-----RQTESTNVIQEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSV
WYHILRGGKVFWLIPPTDQNLELY--ENWLLSGKQGDVFLGDRVTECQRIELKQGYTFVI
PSGWIHAVYTPQDTLVFG-------------GNFLHSFNIPMQLRIYSIEDRTR------
--------------------VPTKFRYPFY-----YEMC-------WYVLERYVYCMMRR
SHLT-KEFQRESLSIDLELNGRQRPDTPSSSSSSSSSGLSSSSDNDDSSDQ---------
DWEEEEGLRKRERDRCRVERELQRKRNRDRQQRDQERDRHGRTERIIIHTLPASLRPLTP
PPSLPLPTPDSPPSTSPF-------------------LTWFEVEGLRCLVLKLESLPP--
LKKCLPDGIHDPEALIFDIKRLL----------EDHAHDPPELALTGVPIIQW-------
------------------------PK----RSQYKVHLRPKIQ-----------------
------FTKPHT-----------------------------M------------------
--RPASRH---------------------STA---PPRTSGTP-----------------
--------------------SGTT----------ASSG--ARRRRVRCRKCQACVQREC-
---------GTCHYCKDMKKFGGPGRMKQSCVLRQCLA----------------------
-PRLPHSVTCALCGEVDQTNDTQD----FERK---------LMECSVCNEIVHPGCL---
-----EM-DGEGL-LSDELPNYWECPKCYEGQKHTV----------------EANHDRIL
LHSKRKAADNYESSHY-------------------YPAKVLR------------------
------------------------------------------------------------
--------------------------------PPLGQSPPSPPLLLLPPSPSSAPPT--P
PSAQTQVP---------LASREERAKRRQLARE-----------------------KENH
PTGCD-QSEGDRLRLRGPYLTVTLQ-----RPPKELSST-SIVPK-LQAITPN-------
PR--------QPIRAAPLHQ--------DEEREEEE------EEEEEEEETENVMLG---
---------QRK-------DSTSMQKDVWLSVFHYLTHEELCICMRVCKAWYKWGC----
---DKRLWSRIDVSRCKSLVPQALSGIIKRQPIYLDLSWTNVSKKQLIW-LINRLPGLKD
LILA-GCTWSAVSALASCSCPLLRTLDLRWTVGIKDTQIRDLLTPASD-KSGH-DSRSKL
R--LLTDLRLSGLDISD-VTLRLIIRHCPLLSKLDLSHCPLLSDQSVNLLTAV--GSSTR
GTLTHIHLAGCKGVTDESLLYLRRATNLSLIDLHGCKQVTRGACEEFISDLS-------V
STLYCLSDDKLIQ---RIS----------
>gi|54112382|ref|NP_115979.3|	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------MAGPQMGGSAEDHPPRKRHAAEKQK---KKTVIYTKCFEFESATQRPI
-DRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG-------------DFVHAMEGKD
FNYEYVQREALR--VPLIFRE-KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQK
GTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHT----KLEHLVKRPTVVDLVDWVDNMW
PQ--------HLKE-----KQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLHNLALY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VQPKFRYPFY-----YEMC-------WYVLERYVYCVTQR
SHLT-QEYQRESMLID-------APRKPSIDGFSSDSWLEMEEEACDQQPQ-----EEEE
KDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPK--APALRFLKRTLSNESEESVK
STTLAVDYPKTPTGSPATEVSA--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEGVKNVL----------KEHADDDPSLAITGVPVVTW-------
------------------------PK-----------KTPKNR-----------------
----------AV-----------------------------G------------------
--RPKGKL---------------------GPA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEEGKFNLM---------LMECSICNEIIHPGCL---
-----KIKESEGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE--HSKKVPP--DGLLRRKSDDVHLRKK
RKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDK
LFRKKRRSWK----NAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGP
STEGAEGP-EEKKKVK--MRRKRRLPNKELSRELSKE-----LNHEIQRTENSLANENQQ
PIKSEPESEGEEPKRPPG-ICERPH-----RFSKGLNGT-PRELR-HQ-LGPS---LRSP
PR--------VISRPPPSVS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCC----
---DKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW-LINRLPGLRD
LVLS-GCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKL
R--NIVELRLAGLDITD-ASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAV--GTTTR
DSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMS-------V
SVQFGQVEEKLLQ---KLS----------
>gi|149725472|ref|XP_001497145.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEPEEERIRYSQRL-------------RGT
-MRRRY-EDDGISD-DEIEGKRTFDLEEKLHTNKYNA-------------NFVTFMEGKD
FNVEYIQRGGLR--DPLIFKN-SDGLGIKMPDP-DFTVNDVKMCVGSRRMVDVMDVNTQK
GIEMTMAQWTRYYETPEEEREKLYNVISLEFSHT----RLENMVQRPSTVDFIDWVDNMW
PR--------HLKE-----SQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSV
WYHIHQGGKVFWLIPPTAHNLELY--ENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVI
PSGWIHAVYTPTDTLVFG-------------GNFLHSFNIPMQLKIYNIEDRTR------
--------------------VPNKFRYPFY-----YEMC-------WYVLERYVYCITNR
SHLT-KEFQKESLSMD-----------LELNGLESG---NGDEEAVDREPR---------
---------RLSSRRSVLTSPVANGVSLDYDGPGQT----CRSLPGLKKTLSGGSPSDSS
RGSHNGQVW-DPQCSPRKDRQV-----------H---LTHFELEGLRCLVDKLESLPL--
HKKCVPTGIEDEDALIADVKILL----------EELANSDPKLALTGVPIVQW-------
------------------------PK----RDKLKFPTRPKVRVPTIP------------
------ITKPHT-----------------------------M------------------
--KPAPRL---------------------TPV---RP-----A-----------------
--------------------AASP----------IVSG--ARRRRVRCRKCKACVQGEC-
---------GVCHYCRDMKKFGGPGRMKQSCVLRQCLA----------------------
-PRLPHSVTCSLCGEVDQNEETQD----FEKK---------LMECCICNEIVHPGCL---
-----QM-DGEGL-LNEELPNCWECPKCYQEDNAEK------------------------
AQKRKMEESDEEAVQAKVLR------PLRSCDEPLTPPPHSP--TSMLQLIHD-------
------------------------------------------------------------
--------------------------------------PVSPRGMVTR-----SSPGAGP
SDHHSASR-DER------FKRRQLLRLQATERTMVRE-------------------KENN
PSGKKELSEVEKAKIRGSYLTVTLQ-----RPTKELHGT-SIVPK-LQAITASSANLRHS
PR--------VLVQHCPART--------PQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAA
RLNGRGSWAQDG-------DESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCC----
---DKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTW-LVNRLPGLKD
LLLA-GCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPAD-KPGQ-DNRSKL
R--NMTDFRLAGLDITD-ATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAV--GSSTR
YSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHFISDLS-------I
NSLYCLSDEKLIQ---KIS----------
>gi|148233062|ref|NP_001085840.	Xenopus laevis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEAKKDS---ARRL-------------RSI
-DRTRYAEHEDLSDVEDMVSIRGFSLEQKVSCNAYRG-------------NFVRYMEGKD
FTYEYVQREALQ--TPLLFST-KEGLGIKMPEQ-DFTVRDVKLLVGSRRVVDVMDVNTQK
SIDMSMSQFVRYYETPEMEREKLYNVISLEFSHT----KLERVVKRPTVVDAVDWVDNMW
PR--------HLKE-----QQKESTNVIAEMKYPKVKKYCLMSVKGCYTDFHIDFGGTSV
WYHVFRGGKVFWLIPPTGHNLQLY--EEWLLSGKQTDIFLGDRSEGCQRIELKQGQTFFI
PSGWIHAVYTPADSLVFG-------------GNILHSFNIPMQLRVFEIEDRTR------
--------------------VNAKFRYPFY-----YEMC-------WYVLERYVCTLTKR
SHLI-KEYQRESMITD---------RKPSLDSHSSDSWLEMEEESCDIHIK---------
-EEKGNLVEKPSKQSGDESSTTNSTHSNGKDAAEKKQK--ATLMQQLKRTLSNDSDESSK
SIVHS-DFPKTPTGSPATDMPC--------KLTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEDMKTVL----------KEHADDDNNLAISGVPVVMW-------
------------------------PK-----------KPSKNR-----------------
----------AV-----------------------------G------------------
--RPKGKI---------------------ASS---PAVK---L-----------------
--------------------SANR----------TSAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDCVEGQEAKFNVM---------LMECSICNEIIHPGCL---
-----KTKESDGV-VNDELPNCWECPKCNHAGKTGKVYKQKRGPGF----KYASNLPGSL
LKEQKVNRDNKELTEIVKKKVEREETPKQIPEE--QPKKKPT--EGIIKKKPEDGHVRKK
RKFEKPPDPSVRKR--------------------------------------LKLVKEEK
LLRKKRRSWK----TPDERAMMA-KTLRRIKQEPDDDLTEAAPKAKESDQSRSSSPTAGP
STEGSE-P-KEKKKI----RRKRRVSNKELSKELSKE-----LNQEIQKTESSLASENHH
PIKSEPESDNEESKKCISTNGERMH-----NFSKGLNGT-PKELR-HE-LFPS---LKTT
PR--------ANNRPPPSLS--------PPKCMQME--RHVIRPPPISPPPDSLPL----
---------ANG-------AAHVMQREVWMAIFSYLSHRDLCICMRICRTWNRWCC----
---DKRLWTQIDLNRCKSITPLMLSGIIRRQPASLDLSWTNISKKQLSW-LINRLPALRD
LNLS-GCSWIAVSALCSSCCPLLRTLNVQWVEGLKDAQMRDLLSPPTDNRPGQIDNRSKL
R--NITELRLAGLDITD-ASLRLMIRHMPLLAKLDLSYCNHVTDQSINLLTAV--GTSTR
DTLLEMNLSDCNNVTDQCLTFFKRCGNICLIDLRFCKQVSKESCEQFIAEMS-------V
IVQFGQTEEKLLQ---KVS----------
>gi|118098507|ref|XP_415137.2|	Gallus gallus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKTEKDS---GRRL-------------RPI
-GRRRYDEHEDLSDVEEIVSVRSFNLEEKLKSKTYRG-------------DFVHSMDGKD
FTFEYVQREALR--VPLIFRN-KDGLGIKMPDP-DFTVRDVKLLVGSRRIVDVMDVNTQK
GVEMSMSQFVRYYETPEAQREKLYNVISLEFSHT----KLENIVKRPNVVDLVDWVDNMW
PQ--------HLKE-----RQTDATNAISEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLQNLELY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VHAKFRYPFY-----YEMC-------WYVLERYVSCVTQR
CHLS-KEYQKESMLID-------AKRKRSIDSYSSDSWLDMDEESCDAHIR---------
-EEKDDSLDKNSKSLVDGSSSPNSTHSEGKEGAGRKQK--ATVMRYLKRTLSNESDDSVK
STT-PTDYPKTPTGSPATEVST--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEDMKNIL----------KEHADDDQNLAISGVPVVSW-------
------------------------PK-----------KTPKNR-----------------
----------AV-----------------------------G------------------
--RPKGKL---------------------GAA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEESKFNLM---------LMECSICNEIIHPGCL---
-----KVKESDGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEVTDAAKRKGDCEETPRRKSEE--HSKKPQV--DSILRRKSDEVHLRRK
RKFEKPQEPSMRKRV--------------------------WQNPY------------KK
LFRKKRRSWK----ASDERTALL-KPLRRLKQEPEDELPEAPPRSKDSDQSRSSSPTAGP
STEGAE-P-RDKKKFK--MRRKRRLPNKELSKELSKE-----LNQEIQKTENSLANENHQ
PIKSEPESENEEPKRALN-NSERLH-----RFSKGLNGT-PRELR-HP-LIPS---LRST
PR--------GIARPPPSLS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMQREVWMAVFSYLSHRDLCICMRVCKTWNRWCC----
---DKRLWTKIDLNHCKSITPLMLSGIIRRQPVTLDLSWTNISKKQLSW-LINRLPGLRD
LLLS-GCSWIAVSALCSSSCPLLRTLDVQWAEGLKDAQMRDLLSPPTDNRPGQIDNRSKL
R--NIVELRLAGLDITD-ASLRLIIRHMPLLSKLNLSYCNHVTDQSINLLTAV--GTTTR
DSLTEINLSDCNKVTDQCLSYFKRCGNICQIDLRYCKQVTKEGCEQFIAEMS-------V
SVQFGQVEEKLLQ---KLS----------
>gi|125826112|ref|XP_699998.2|	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MSDGCRAHTGAVFTFGKSKIA-------------NNV
-PSRLWLKSDIPVHISCGQSHSAF-VTEQGRLFVFGDNNRG---------QLGLQIKGPV
TKPVCVKAQGEI--LAAGGNS-DGQLGLGHCND-SISFQRLRPFCDYAP-IKLLSAGDHT
SAALTEDGRLFLWGDNSAGQ--------LGFGND----SHALLPKELNMGQSIHWVSCGY
RH--------SALV-----TDSGDVYSFGESADGRL---GLSAHQLANHSYPQRVESLHS
VLQVACGGKHTLAL--TEDELYCFGGGEFGQLGLGTLVFVADSPVAVGH--FRKGRVTHV
TCGEQHSALITDSGLLYTFGDGRHGKLGHGDENFTNQFTPTVCQRFFEYSVMTVACGSS-
-----------------HMLVFARPRQQEN-----EEVCLEDEDVTYSYLDRCYTTMIQG
QPLE-HIPDPESALVS-------QSTSLSSPLPTSHRWSLSTRARRRQKES---------
--------SSAQFGPEFSNLPPLTTSYTALALTGTILQ--PRSAKGTPKHINTDAPVDTS
ITVLSKEPSFTPITKSPDDCQC--------VETSENSLSDKNSAGREENVFQ-QALPT--
ELQ-VASVSHPSITESQSSSNLMHKK-PRPGDAENNAEVEEQSSVTALQSKVQ-------
------------------------PKIVKTTIQKQETKSSSIKIPLTSSSVQEVEKVRTT
PTSTQEVQSPIS-----------------------------KEAGIPEKASKRVNSPIKV
QEMPTATN---------------------KSS---APKA---A-----------------
--------------------ESGKLFSSTSSSPQLRQSPLNKRKLKTVEDKEPVLVTETP
HQQSEQSLMGSVVSVLPAMAIAAPLLIKAAEVLSE-------------------------
-TSLEQSNEMSSCASASQETA-------GNKI---------LIEQEVEQDTTVQDIS---
--ATEETDDRNKQEIVEDLQNELVSDKVYTGGN---------------------------
---EKMDDDDDEDVKGHETEREEKESVAEEEDN--SEGCGKK--DNAFEDEPEGESENAP
KGGEDSEE----------------------------------------------------
-------------------------------EEGEEEESDAVGQEENGDDGGKSSEIEGE
KSKGGSGDMAESEEVEESEGQEEGETEDKDAEDEEEE-----RESEDEDSERQIEDEEKT
DAEEGESSNEGEPERSESEDVSKNDRSDEEEGESEENGS-EREEE-ED------------
----------VLEGEQEEKM-------KEENSSEDEGEESVREKEEQEVEEEKLSEEGSE
RQEGDEQIEEED-------EEGEKEGKMKSSEVKFREAETDDEENNEENTEDKSGSGEEE
D--DDETEKQEERHGRKDRETEEEEGGEEEEEEAEQKDTSEEEEQAEES-EEEEEETEQN
SGKT-RETSEEEEEQQENEEEEEEEEEAEWKEKKQRESNEEEEEEGEEEKEEEGEQKENV
E--KDKQNKEEEEEESE-EEE------------------GQEEDESEEENEKT--KKITK
QK-AKPNVLPARRQTGQTETQKTRPRGKQNVKIR--KQTDGAQDPQF-------------
---WNNVLPQYLN---LK-----------
>gi|157012496|gb|EAA01048.5|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------RER
KQKKLYSDDWTLGD-DDYEGARGFSVAEKLESPRFAQS------------GMVREMKGEN
LTVGFLQHNGFN--IPLLFKE-KTGLGLQVPTA-NFSISDVRMCVGSRRMLDVMDVNTQK
NVEMTMKEWEKYYEDP--VKKKLLNVISLEFSHT----KLENYVQSPAIVRQIDWVDVVW
PK--------QLKE-----SQVESTNLLNDMMYPKVQKYCLMSVKNCYTDFHVDFGGTSV
WYHILRGSKVFWLIPPTDKNLQLY--EKWVLSGKQSDVFFGDTVEKCARVYLTAGNTFFI
PTGWIHAVYTPTDSLVFG-------------GNFLHSFGIVKQLKITQVEDNTK------
--------------------VPQKFRYPFF-----TEML-------WYVLAKYVYTLLGH
SHLE-GEPGREHELV---------------------------------------------
------------------------------------------------------------
-------------GKPHV---------------H---LTHYELFGLKDIVMYLYDLPA--
QKKNVPELIKDPVALIKDVRTLV----------ERHCKDIPELAVTGVPVLHPDLNVSNN
SYIREHYEYYSGDGGGNRTTDNEGPR---------DNRRDRDEDEEDDEEGVEEAENRRR
NADHERQRLQEVEQQEGNKNGDNRMGNGSESLQRGYHDGTAGKVQQPSSGNGDDRNFVSP
QPTSGNRL--------------PSSGVGRGPYKKHGTGNSGHG-----------------
--------------------GEKR----------DGGGNGPRRRRTRCKNCEACQRSDC-
---------GECSFCLDMVKFGGPGRAKQTCMMRQCLQ----------------------
-PMLPVTAQCIHCNLDGWRQAPIMAPAQAKLQAQMQEGPSALMECSVCYEISHPDCA---
---QRAAPEAQGI-VNDDLPNSWECPSCCKSGKNTD---------------YRVRQIVTQ
FVDLTFVNLSFFFILPRHFRARQKSSDIRRMS---CSSDASSAHNAEFGRIGGSGHGGAG
SGGEGSMNSTGDGMMAGANVSAPRAPRF----------------------------QDDM
LYDFAVSGSAVIVGSKGGNILFERKPKIKDEDMSSGSEYDASGVGKKMHHSLNSSPGAGT
AMGGGSMK-VEVKDEPLDHHPNHGYPANHHATSVIKDGREMQREQALASSCGAINTHHHS
GGTGTGAADGNEAKNSHGGSLPRKKSSQRMQLAHQIHSTSTKPMK--------------K
PL--------YPIRPASVAH-----------------------TPTMSLS----------
-------------------GNYALDAPCLLAVFRYLPPETLVTCTMVCKTWANIAV----
---DPSLWKRMNCAEYK-LSPNLLSAIVRRQPEHLIMDWIGLGKRQVTW-LISRIPGLKN
LSLQ-GTHIQAVLGLHTCMCPPLQVLDLSFIAGLNDFAIREILSPPKDSRPGLADSKSRL
R--NLKMLKVAGADISD-VALRYITQGLPNLTHLDLSSCQRITDAAIAQIGTS--PAAIK
-TLVELDLSCCKLITELSLDHLAKCDALTRLDLSHVPQVSTQSMI---------------
-----------------------------
>gi|114647424|ref|XP_001164996.	Pan troglodytes
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------MAGPQMGGSAEDHPPRKRHAAEKQK---KKTVIYTKCFEFESATQRPI
-DRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG-------------DFVHAMEGKD
FNYEYVQREALR--VPLIFRE-KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQK
GTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHT----KLEHLVKRPTVVDLVDWVDNMW
PQ--------HLKE-----KQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLHNLALY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VQPKFRYPFY-----YEMC-------WYVLERYVYCVTQR
SHLT-QEYQRESMLID-------APRKPSIDGFSSDSWLEMEEEACDQQPQ-----EEEE
KDEEGEGRDRAPKPPADGSTSPTSTPSEDQEALGKKPK--APALRFLKRTLSNESEESVK
STTLAVDYPKTPTGSPATEVSA--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEGVKNVL----------KEHADDDPSLAITGVPVVTW-------
------------------------PK-----------KTPKNR-----------------
----------AV-----------------------------G------------------
--RPKGKL---------------------GPA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEEGKFNLM---------LMECSICNEIIHPGCL---
-----KIKESEGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE--HPKKVPP--DGLLRRKSDDVHLRKK
RKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDK
LFRKKRRSWK----NAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGP
STEGAEGP-EEKKKVK--MRRKRRLPNKELSRELSKE-----LNHEIQRTENSLANENQQ
PIKSEPESEGEEPKRPPG-ICERPH-----RFSKGLNGT-PRELR-HQ-LGPS---LRSP
PR--------VISRPPPSVS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCC----
---DKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW-LINRLPGLRD
LVLS-GCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKL
R--NIVELRLAGLDITD-ASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAV--GTTTR
DSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMS-------V
SVQFGQVEEKLLQ---KLS----------
>gi|118344152|ref|NP_001071898.	Ciona intestinalis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MS---ERYL-------------RHK
-SVPVYDDDDAVED--EIDGKRTYDIKEKLESSKYDG-------------EFLIDLKGHE
LTFERIQRYGLS--DPLRIKD-PDGLGMVMPDRSTFSVSDVRAFVGGRRMVDVMECKTQR
ALEMSMRDFERYFEGS--DRKYIYNVISLEFSQS----RLESLIQRPKVVDALDWIDLVW
PQ--------HLKH-----TQVEQTNRIHHMKYPKVQKYCLMSVAGCYTDFHIDFGGTSV
WYHILKGGKIFWLIPPTNENLQLY--ERWTLSGNQGDIFFADMVSRAQRLELVAGNSLMI
PSGWIHAVYTPYDSIVFG-------------GNFLNSFNIPMQLRIAQVEERLK------
--------------------VPGRFRFPFF-----SEVL-------WYALDRYLHCLTKK
TFLS-EEFKEENHCIV------------------------KEKPDVEKEEE---------
------------------------------------------------------------
------------------------------EYVH---LTPFEYKGLQKLIETLEFLPE--
GKQSIPDGILNPLELIKTGKSLL----------WNHSADDHEMSITGKSKVYW-------
------------------------PV--------TIKPRDLHK-----------------
----------LT-----------------------------R------------------
--KPR------------------------TPS---TSST---P-----------------
--------------------GTKK----------PNA---SRVRRVRCKQCEACQRGDC-
---------RECVFCKDMRKYGGPGTMKQTCILRRCIN----------------------
-PILPSTA---------REEPVT-------------------------------------
--------------VNQPTPFV-ESPVPPKPGKRGK------------------------
---------------------------KRLSSN---------------------------
------------------------------------------------------------
------------------------------------------------------------
--ESVVVP----------MKSTKLEEDVE---------------------------EEDD
DSDFSPPSKNQMPRVVIA------------RVSTGDLAK---------------------
----------YAVRPADSST-----------------------EEDLAKLP---------
---------TET-------ETLSMNRTLWMHVFKYLNHTDLCSCMLVCKDFLRWCA----
---SPSLWKSVNLTGKQ-INSSTLQCLVRRTPTSINFSESNISYRQLMW-LFERSPSLRE
LYLI-RCAWSTVAALNTAACPPLNLLDLSWAAGFTDPHLKQLLSAPTDVRPGQEICHTRL
R--FCRELSVAGTDITD-VGLKLISHYLPHLKSVNISFCS-VTSEGFGYLTSS--NSSMP
KILSVIISQHCHLMTDCALQNASKLPKISQLDFRGCTEVTEEACEDFIENFK--------
-LNLFMPEPLYLV---AQNT---------
>gi|47208500|emb|CAF90519.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MTM-------------ASL
-TKR-------------------------------------------------STAGGR-
--LTWRRKSTVR--GSV--------LNCRMPDP-DFTVNDVKMFVGSRRMIDVMDVSTQK
GTEMSMAQWTRYYETPLSQREKLYNVISLEFSHT----KLENLVRRPTTVDLIDWVDNMW
PR--------HLKE-----RQRDSTNSITDMQYPKVQKYCLMSVEGCYTDFHIDFGGTSV
WYHILRGSKVFWLIPPTPQNLELY--ENWVLSGKQGDVFLGDRASDCQRIELKQGYTFII
PSGWIHAVYTPVDSMVFG-------------GNFLHSFNIPTQLNICNIEDRTRVCRGTL
EESNKTGTFRIFKHIMLSLQVPTKFRYPFY-----YEMC-------WYVLERYVFSLTKT
SYLT-PEFQRHSLGIG--------LKKPC--KLANEKGILEDEESSEDEVQ---------
------------------------------------------------------------
--------------REHSDEAA--------AKIH---LTPLELEGLWNLLGKLEDLPP--
NKKCIPSGIHNFQALVAHIKALL----------KEHANDNPKLSYTGKPIITW-------
------------------------PK------RVRSSDISPER----------------L
IFHLFTSHVPYL-----------------------------TCFALVYQPSWYQPPPPPP
PPPPRPKL---------------------ATI---SIIP---R-----------------
--------------------PQKP----------ASSMSVLRRRRVRCKRCEACVRSEC-
---------GDCNFCRDMKKFGGPGKLKQTCVLRQCLSVSRLRPRLLRKRPRGDRLWVPF
QPGLPLSAVCEVCKEPNQDET-----GDTSLT---------LMECSNCAQIVHPACL---
-----TI-QGEGL-INKDLPSCWECPRCVQGVTDPEQSKGDRGDGLSLKRKSSTLLDARM
AKIYRQQRHSRDEDDSGSDDEDAVSQRRRMTLNVRGGAHSSR--RGFGANRRGLLRGGSS
HRGSRGALMGHGSF-------------------------------------RLKRGMAMR
ESGRRGRGVRLRGGSRMQRRGEDSEESEDDEEDDEEEEADSEDGGKERHRRRRRRRTDDQ
DDDGDDDE-EEEDEDD--SEGQDFDPEEEM--DMVED-----DEEEMDEEEEGLWDSDRE
P-PVLLMSDLNDDLLSGSYLTVTLQ-----RPDKAKKQTGSIVPKLEAAMGPRTAAGASG
PQHAFIQRRTALSKHIPARLGDGPNDWATPRGPGRKDFSALSSEEEHTVAPSLSLL----
---SLPSFKDVG-------NDSGGEKEVWVSVFTYLNRAELLACMTVCKAWYKWSC----
---DKRLWSHIDVSRCSPLSNQALAGIIKRQPYSLDLSWTPLAKRQLNC-LLTRLPGLRE
LRVA-GLAWSCLSALVSPTLPCLQLLDLRWCEGIKDAQIKDLIIP-----PGSESSRSRL
R--NLVTLRLSGLDISE-SILKLLQRHMTQLERLELSHCKNITDSSVALLAAP--GTHTR
NNLTELTLAGCNELTDCCLLYMKRLSSLTLLDLRGCKSVSRRACDAFIADLS-------H
ISLYCMMEEKLIQ---RI-----------
>gi|73994531|ref|XP_849903.1|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MEAEKDS---GRRL-------------RPI
-DRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG-------------DFVHAMEGKD
FNYEYVQREALR--VPLIFRE-KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQK
GTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHT----KLEHLVKRPTVVDLVDWVDNMW
PQ--------HLKE-----KQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLHNLALY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VQPKFRYPFY-----YEMC-------WYVLERYVYCVTQR
SYLT-QEYQRESMLID-------APRKPSIDGFSSDSWLEMEEESCEQQPQEEEKEEEEE
EEEEEEGADKVPKPPADGPPSPTSTPSEDQEAPGKKPK--APAMRFLQRTLSNESEESVK
STTVPTDYPKTPTGSPATGVSA--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEGVKNVL----------KEHADDDPSLAITGVPVVTW-------
------------------------PK-----------KTPKNR-----------------
----------AV-----------------------------G------------------
--RPKGKL---------------------GPA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEEGKFNLM---------LMECSICNEIIHPGCL---
-----KIKESEGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE--HPKKVPP--DGILRRKSDDVHLRRK
RKYEKPQELSGRKRASTLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDK
LFRKKRRSWK----NAEDRMALANKPLRRFKQEPEDDLPEAPPKARESDHSRSSSPTAGP
STEGAEGP-EEKKKVK--IRRKRRLPTKELSKELSKE-----LNQEIQKTENSLANENHQ
PIKSEPESESEEPKRPLG-LCERPH-----RFSKGLTGT-PRELR-HQ-LGPG---LRSP
PR--------VISRPPPSVS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCC----
---DKRLWTCIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW-LINRLPGLRD
LVLS-GCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKL
R--NIVELRLAGLDITD-ASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAV--GTTTR
DSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMS-------V
SVQFGQVEEKLLQ---KLS----------
>gi|115911471|ref|XP_780290.2|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------YCLMSVKGCYTDFHVDFGGTSV
WYHILRGSKVFWLIPPTEENLDTY--ETWVLSGKQGDIFLGDRVMECGRIRLEAGDTFMI
PTGWIHAVYTPEDSLVFG-------------GNILHTFNVRKQLGVWQLEDRTR------
--------------------VPNKFRYPFY-----FEIH-------WFALARYVEVLLGR
QHVR-NTGKSQS-------------NETIIEHANNGHSLLKQENGIDQEVK--------V
DEEEEDDVDIGPHHR--------NVKVEDEDEMSDAILKSLAMGQTMDMDESDDKDLSFG
ESKETFEKKPEPAGGGGGDFASTSSMGGVKKPIH---LSWAEMEGLINLVEFLESLPR--
SKRSVPELIDNPDKLLEDAREML----------ELHQEDDPAVGVTGVPIVKW-------
------------------------PD-----------PPPKPP-----------------
----------VI-----------------------------L------------------
--RPAPSK---------------------KRV---KKQK---------------------
---------------------KNK----------ALTM--NRKRRTRCKQCANCTRADC-
---------GECNFCIDMKKYGGPGKMKQSCIMRQCLT----------------------
-PILPGKSSCSVC-------KLEDTDSEGNTT---------LFECHVCHDITHPACL---
---KEQGFQAEGI-MNEDLTNSWECPKCMEVDDEDD------------------------
EEEDEEEEDDDGDESDSSSEKAVSSRGRKRKAE--SDVRTHE--AGTIGK----------
------------------------------------------------------------
---------------------------------------------RGSHAGKGPTMASTS
TYQGTLRT----------RLRQRKGNNQKLAKQKVRQ-----AKYHMQSSLK----KGRA
MLKRHP---LQQKKRRLG----RPP-----KLQAQVEPK-PIIMEKIP--------ACAA
PK--------FVVRPAPA-----------------------------NPPPAFVLM----
---------ADD-------TKHPIHRDDWMMIFQFLDKRALNECMAVCKTWNRWCI----
---HPSLWKRISY--KTPISKLALCGIVRRQPLSLNLSWTNISAKQLSW-LLPRLPNLKD
LGLG-GSTWPVVYSLASVVCPFFTSLDLQWVSGLNDSSLLSLLSSPMDHRPGYFDERSRL
S--NLERLCLLGADITD-ATMSSIVQFAPLLAHLDISFCGNLTDASIRILLDE--KSPVR
MTLKELNIAGCRKMTLSVFSQLESCPTLTKLIIHSCPNLAQEACLKFTEQKG--------
-VEMVTSKPSRVC---RPRRP--------
>gi|149063339|gb|EDM13662.1|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------MEAEKDS---GRRL-------------RAI
-DRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQG-------------DFVHAMEGKD
FNYEYVQREALR--VPLVFRD-KDGLGIKMPDP-DFTVRDVKLLVGSRRLVDVMDVNTQK
GTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHT----KLEHLVKRPTVVDLVDWVDNMW
PQ--------HLKE-----KQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSV
WYHVFRGGKIFWLIPPTLHNLALY--EEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFI
PSGWIHAVYTPVDSLVFG-------------GNILHSFNVPMQLRIYEIEDRTR------
--------------------VQPKFRYPFY-----YEMC-------WYVLERYVYCVTQR
SYLT-QEYQRELMLID-------APRKNSVDGFSSDSWLEMEEESREQQLQ-----EEED
KEEEGDGADKTPKPPTEGPTSPTSTQSEDQDSTGKKPK--APAMRFLKRTLSNESEESVK
STAMPVDYPKTPTGSPATEVST--------KWTH---LTEFELKGLKALVEKLESLPE--
NKKCVPEGIEDPQALLEGVKNVL----------KEHVDDDPNLAITGVPVVSW-------
------------------------PK-----------KTPKNR-----------------
----------VV-----------------------------G------------------
--RPKGKL---------------------GPA---SAVK---L-----------------
--------------------AANR----------TTAG--ARRRRTRCRKCEACLRTEC-
---------GECHFCKDMKKFGGPGRMKQSCIMRQCIA----------------------
-PVLPHTAVCLVCGEAGKEDTVEEEEGKFNLM---------LMECSICNEIIHPGCL---
-----KIKESEGV-VNDELPNCWECPKCNHAGKTGK---QKRGPGF----KYASNLPGSL
LKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE--HPKKVPT--DGILRRKSDDVHLRRK
RKYEKPQELSARKRASTLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDK
LLRKKRRSWK----NAEDRLSLANKPLRRFKQEPEDDLPEAPPKTRESDQSRSSSPTAGP
STEGAEGP-EEKRKVK--MRRKRRLPNKELSKELSKE-----LNHEIQKTESTLAHENHQ
PIKSEPESENEEPKRPLS-HCERPH-----RFSKGLNGT-PRELR-HS-LGPG---LRSP
PR--------VISRPPPSTS--------PPKCIQME--RHVIRPPPISPPPDSLPL----
---------DDG-------AAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCC----
---DKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW-LINRLPGLRD
LVLS-GCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKL
R--NIVELRLAGLDITD-VSLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAV--GTTTR
DSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMS-------V
SVQFGQVEEKLLQ---KLS----------
