>gi|115663057|ref|XP_782471.2|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
--------------------MSMKAPRGRAAATFS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------SGLNSCPKVKEMLAGE------------
-PS---------------SPR---------------------------------------
------------TGRNNRQR----------------------------------------
----------------------------------SPSTPNAPDPKMLQRGL---------
-----------------------DPGGRDTTKFSL------IIELDGNKETIRL------
-------------------------------PARKDHDLKEVLEETLGKKGLT-----LD
DIEIYIQNTKTN------------------------------------------------
-----------------------------------------------------PLPKNDK
GLRVPTEPL----GGLEVFILPALEK------------------------TPESENRTVT
ATKRKKDLSAFLGVKDDVNPKVGT------------------------------------
------GRDRRMSVPAIVSDGTAGNTDGE-DENDDD-----------------GFEDDDV
AYGE--DEIEYNDGFYDDD-DVIVGILYMCCLLNLQTAAILNEIETEKIFSNITVLELA-
-HTKFWKENLL-----KIVEKARDSG------KPMDPHDIATAFEDFSD---QFSAYFKF
CAEEDSCIHYVREK--RQENNILRAFFEWCEGHNITRQMRLRGLGDLLIYPMQRVTKYHL
MVDRVQKNCED-EVPKAA--LKKTFEHIVEFVTHINHEIKKEQERKKMEKVAGILEGYEV
PNAPTGCDELSRLMEAHSV-FDVSSPMPYAS-QIHPRWLLLEGALKLQ--EKTGRSTLYA
FLFTDALVLAKQN--------------RTGEKYRVVRSPMRVDQLEVIELK-DGTGFAVL
CVDDYD-CAMTGFVAWPEKEKMVAV------WMEKISQAKDLYNKCCSIDDDVEYFDEMQ
PD-----------DPQTPIAALMEDHHLHPQQ---------------GFSYGSSPT---A
SPHQSPQMER-------------------------------------SNRWSSNSPSSHG
SS----------SSLQRMTEEEEYAVQ---------------------------------
--------------NGDKKLVMNGTGVQENNSNNQSTGEP-------------------N
SGPPKTMPKPYPKLN---------LRAPLTKNTSYQETDFPSDSSLLGSILPE-------
-----IATEENK-----------------SGLKAAMRRLSTGSPPEEVVP-------KSP
MMSPTRETQQRIMSFESDDDDDEGEIPSVTTDIYYQPPKNKKEKSPQRQKGTV-------
------------LSATPAKSKHH---RPSMPNIHVLEKKEHSKTNGEGTLKKKKIWEKMQ
SKIK--------
>gi|114640825|ref|XP_508820.2|	Pan troglodytes
------------------------------------------------------------
---------------------------------------------MRAGVQTGDRIIKVN
GTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQ-IPLADSEVEPSVIGHMSPIMTSPH
SPGA----SGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQ
RLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTD
CSSGDVSRPSSDNADSPKSGPKERIYLEENPEKSETI--------------QDTDTQSLV
GSPSTRIAPHIIGAEDDDFGTEHEQI------NGQCSCFQSIELLKSR------------
-PAHLAVFLHHVVSQF--DPA---TLLC--------YLYSDLYKHT--NSKETRRIFLEF
HQFF--------LDRSAHLK---VSVPDEMSADLEKRRPELI------------------
----------------------------------PEDLHRHYIQTMQERVH---------
---------------PEVQRHLEDFRQKRSMGLTL--AESELTKLDAERDKDRLTLEKE-
----------RTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVK-----VK
EPRNLEHKRGRI-----------GFLPKIKQSMKKDKEGEEKGKRRG-------------
----------FPSILGPPRRP-SRHDNSAIGRAMELQKARHPKHLSTPSSVS-PEPQDSA
KLRQSGLAN----EGTDAGYLPANSM-SSVASGASFSQEGGKENDTGSKQVGETSAPGDT
LDGTPRTLNTVFDFPPPPLDQVQEEE-CE------------------------------V
ERVTEHGTPKPFRKFDSVAFGESQSEDEQ-FENDLE-TDPPNWQQLVSREVLLGLKPCEI
KRQEVINELFYTERAHVRT-LKVLDQVF---YQRVSREGILSPSELRKIFSNLEDILQL-
-HIGLNEQMKA-------VRKRNETS------VIDQIGEDLLTWFSGPGEEKLKHAAATF
CSNQPFALEMIKSR--QKKDSRFQTFVQDAESNPLCRRLQLK---DIIPTQMQRLTKYPL
LLDNIAKYTEW-PTEREK--VKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSL
KLSEY------PNVEELRN-LDLTK-----------RKMIHEGPLVWKV-NRDKTIDLYT
LLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVI
SMSDNG-AQIYELVAQTVSEKTV--------WQDLICRMAASVKEQSTKPIPLPQSTPGE
GD-----------NDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHS---L
STSGKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLG
LL---KQLLVQQLGLTEKSVQEDWQHF----------PRYRTASQGPQTDSVIQNSENIK
AYHSGEGHMPFRTGTGDIATCYSPRTSTESFAPRDSVGLA----PQDSQASNILVMDHMI
MTPEMPTMEPEGGLDDSGEHFFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDG
YDPVQESSTDEEVASSLTLQPMTGI-PAVESTHQQQHSPQNTHSDGAISP-------FTP
EFLVQQRW--GAMEYSCFEIQSPSSCADSQSQ--IMEYIHKIEADLEHLKKVE-------
-----------------ESYTIL---CQRLAGSALTDKHSDKS-----------------
------------
>gi|45550660|ref|NP_649182.2|	Drosophila melanogaster
------------------------------------------------------------
------------------------------------------------------------
--------------MATSTASTTATTAGGTGATTG-------------------------
----------LFATTGAPGSLGRQANVTEKGERTGVCLSPSAPQPSSHASPH--------
------------------------------------------------------------
---------------------------------------------------HPPTIYTQA
PQVVRRMPSLMLSPTLDETTT-----------TASSSCFGTGHPSAGS------------
-------FHQHQHHHHHHQPT---GSVS--------TASCTATSTTSTHAVPSSKHFQSV
GEAAA-------TSSSSTLS----------------------------------------
----------------------------------PHSATSATLGGGGGGGG---------
---------------AGGGGLTSPVGCSTSSGSTVKKKSSFMKRKKPLLTRSEVSS----
----------SEFFSVSFCLDSSQQPDEEFIPATKGVTLLNALSHALRRRNLS-----FT
QITITDNNPTPS------------------------------------------------
-----------------------FLDAGPSLLPVSVDEQTDVESLAGHHLCI-TERGSNR
KPLQKAASFGS--RQPPPRLLPSVST------------------------EETSESGVAP
GKQIKQRWSSIFGIKNPQQSQLCELL-NS------------------------------Y
AKNGVPQRPDSMSFDHPDLVN---------SLAYLQ-YMHKSWRDFVNSD---SMSESEV
KIQTAIWELVTTEVYYIHA-LQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAVCEA-
-NIKFWTLWLY-----PMVAHSAITH------EPLRCAFFQEGFLSFAS---IFAPYKIY
CAEQSTCQFYCKEL--NHNNALFTSYLAWCESQKMCNRLRLA---DIVVRPMQRLTKYSL
LLAAIKKHMSD-VEEIEA--IDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDV
VDTNN--EVLDKMIKQNSQMFDLCAPMRGCP-AYHVRHLFMEGDHKFK--DNLGKSDVHC
FLLTDLLLVCKTIAK------------RGLGALKVIRQPYLTDQLIVQLA--PNNTLNCV
YLNEFQ-VATTAFTLQCTEAKN---------WYDALWRAKTIYQRLKRGGGGGGSGSGTV
GG---------------------------GDSFRFGGS---------ATSGGTADS---L
GVRKSPMNSS-------------------------------ICSHVSSANNSHSGSVEWN
DS---RNISVDFEKTNSVSSDEGSSIM---------------------------------
--------------TGNHGVNLKGKQQLISGLHKTKMGII--------------------
---GQMGSKSANTLS---------VQPMNHLGQSLPNLNMHHSHT---------------
---------------------------------VPLRRGMAFSTSTKNPP-------LRK
TRNITS---QNSINWHQIPATPTPPSPRSQY---QSPGVVCMQKSLPLLLPTN-------
------------------TDEGQ---GPTQPPPPLQKQLSHQAPLPTTIHNQSSTETDV-
------------
>gi|108996220|ref|XP_001092760.	Macaca mulatta
------------------------------------------------------------
------------------------------------------------------------
-------------------MNSVLTKHGSPPPSWL-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------KLCSGTDDQSPAEKK-------GLRCQNPACMDKGRAS------------
------KVCHHADCQQLHRRG---PLNL--------CEACDSKFHSAMHYDGHVRFDLPP
QGSV--------LARNVSTR----SCP---------------------------------
----------------------------------PRTSPAVDLEEEDEESS---------
---------------------VDGKGDRKSTGLKL----------SKKKARRRHTDDPS-
----------KECFTLKFDLNVDI--ETEIVPAMKKKSLGEVLLPVFERKGIA-----LG
KVDIYLDQSNTPLSLSFEAYRFGGHYLRVKAPAKPGDEGKVEQGVKD-------------
----------SKSLSLPILRP-----AGTAPPALERVDPQSRRESLDILAPG-RRRKNMS
EFLGEASI-----PGQEPPTPSSCSL-----------PSGSSGSTSSGDSWKNRAASRFS
GFFSSGPSTSAFGREVDKMEQLEGKL-HT------------------------------Y
SLFGLPRLPRRLRFDHDSWEEDDEDEDEDNACLRLE----DSWRELIDGH--EKLTRRQC
HQQEAVWELLHTEASYIRK-LRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQL-
-HRRLWAGVMA-----PVLEKARLTR------ALLQPGDFLKGFKMFGS---LFKPYIRY
CMEEEGCMEYMRGL--LRDNDLFRAYITWAEKHPQCQRLKLS---DMLAKPHQRLTKYPL
LLKSVLRKTEE-PRAKEA--VVTMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV
VESSS--DEVDKLLKEFLH-LDLTAPIPGAS-PEETRQLLLEGSLKMKE-GKDSKMDVYC
FLFTDLLLVTKAV--------------KKAERTRVIRPPLLVDKIVCRELR-DPGSFLLI
YLNEFH-SAVGAYTFQASGQALCRG------WVDTIYNAQNQLQQLRAQEPPGSQQPLQS
LE-----------EEEDEQEEEEEEEEEEGEES--------------GNSAASSPT---I
MRKSSGSPDS------------------------------QHCASDGSTETLAMVVVEPG
ET----LSSPEFDGGPFSSQSDETSLS-----------------------------TIAS
SATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPG----------PVAELVPRPP
DSPQAPSPPPSPRLR---------RRTPVQLLTCPPQLFKSKSEASLLQLLVG-------
-----TGTH--------------------GTSSAPSRSLSELCLAVPAPG-------IRT
QGSPQ----EAGPSWNCRGNPSPGGGP-------RLASCLAGEPAGSHRKRYG-------
--------------DLPSGASPR---VQPEPPPGVSTQHRKLTLAQLYRIRTTLLLNSTL
TAS---------
>gi|148683406|gb|EDL15353.1|	Mus musculus
------------------------------------------------------------
---------------------------------------------MRAGVKEGDRIIKVN
GTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSSIG-VSGLQQNPSLSGGPRVNPTIPPPP
PPPP----LPPPQHITGPKPLQDPE--VQKHATQILRNMLRQEEKELQRICEVYSRNPAS
LLEEQIEGARRRVTQLQ-------------------------------------------
---------------------------------------------------LKIQQETGG
LVGIDQSPKPLIIGPEEDYDPGYFN-------NESDIIFQDLEKLKSH------------
-PAYLVVFLRYIFSQA--DPG---PLLF--------YLCSEVYQQT--NPKDSRNLGKDI
WNIF--------LEKNAPLR---VKIPEMLQAEIDLRLR---------------------
----------------------------------NSEDPRSALYEAQEAVM---------
---------------PEIQEQINDYRSKRTLGLGSLYGENDLLDLDGDPLRE--------
----------RQMAEKQLAALGDIF-----------APMDFAVNTYMSHTGIR-----LR
ESRPSSTAEKTQSAPDKD--KWLPFFPKTKKQSSNSKKEKDALEDKK-------------
----------RNPILRYIGKPKSSSQSIKPGNVRNIIQHFENSHQYDVPEPG-TQRLSTG
SFPEDLLESDS--SRSEIRLGRSESL----KGREEMKRSRKAENVPRSRSDVDMDAAAEA
TRLHQSASSSASSLSTRSLENPTPPF-TP------------------------------K
MGRRSIESPNLGFCTDVILPHLLEDDLGQLSDLEPE-PEVQNWQHTVGKDVVANLTQREI
DRQEVINELFVTEASHLRT-LRVLDLIF---YQRMKKENLMPREELARLFPNLPELIEI-
-HNSWCEAMK---------KLREEGP------IIRDISDLMLARFDGPAREELQQVAAQF
CSYQSVALELIRTK--QRKESRFQLFMQEAESHPQCRRLQLR---DLIISEMQRLTKYPL
LLENIIKHTAGGTSEHEK--LCRARDQCREILKFVNEAVKQTENRHRLEGYQKRLDATAL
ERASN------PLAAEFKS-LDLTT-----------RKMIHEGPLTWRI-SKDKTLDLQV
LLLEDLVVLLQRQEEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII
CTSELGPPQIYELVALTSSDKNIPVFVPSNRWMELLEEAVQNATKHPGDAPVLNHPSPPG
SQ-----------EPAYQGSTSSRVEVNDSEVYPTEREPKKPSEGPGPEQRGQDKQ---L
LAQEGPEQEEDAEELRALPC-------------------PPPSLDGENRGIRTRDPVLLA
LT---GPLLMEGLADAALEDVENLRHLILWSLLPGHTVKTQAAGEPEDDLTPTPSVVSIT
SHPWDPGSPGQAPAISDNTQFPRPEGSQPEGEDVALCSLAHLPPRTRNSGIWDSPELDRN
PAEEASSSEPAGSYK---------VVRKVSLLPGGGVGAAKVAGSNVTPALPE-------
-----SGQSESELSEVEGGAQATGN-CFYVSMPAEPLDSSTEPPGTP--P-------SLS
QCHSLPAWPTEPPQHRGVTGGQRSSLVLRDMGV-IFHTIEQLTVKLHRLKDMELAHRELL
NSLGGESSGGTTPVGSFHTEAARWTDYSLSPPAKEALTSDPQNNQEQGSYPEEGSDTPLE
DSATDTASSPGP
>gi|73956781|ref|XP_536728.2|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MFLYWKKRGAYELEALPGALTELDLGAVERFSWSSTLD------------
------------------------------------------------------------
------------------------------------------------------------
----------IIEDLGDDQSLAEEK-------GLHCQNPGCMDRGRAA------------
------KVCHHADCQQLHRRG---PLNL--------CEACDSKFHSAMHYDGHVRFDLPP
QGSI--------LARNVSTR----SCP---------------------------------
----------------------------------PRTSPAVDLEEEEESSM---------
----------------------DGKGDRKSTGLKL-----------SKKARRRHTDDPS-
----------KECFTLKFDLNVDI--ETEIVPAMKKKSLGEVLLPVFERKGIA-----LG
KVDIYLDQSNTPLSLTFEAYRFGGHYLRVKA--KPGDEGKVEQGVKD-------------
----------SKSLSLPILRP-----ARAGTPSLERVDPQSRRESLDILAPG-RRRKNMS
EFLGETSI-----PGQEASTPSSCSL--------------PSGSSGGSDSWKNRAASRFS
GFFSSGPSTSTFGREVDKMEQLEAKL-HT------------------------------Y
GLFGLPRLPRRLRFDHDSWEEEGDEEEEE-DDACL--WLEDSWRELIDGH--EKLTRRQC
HQQEAVWELLHTEVSYIKK-LRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPELARL-
-HRGLWAGTMA-----PVLEKARRTR------ALLQPGDFLRGFKMFGS---LFRPYIRY
CMEEEGCMEYMRGL--LRDNELFRAYVTWAEKHQQCQRLKLS---DMLAKPHQRLTKYPL
LLKSVLRKTDE-PRAKEA--VVTMIDSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV
VEGSN--DEVDKLLKEFLH-LDLTAPIPGAS-PEETRQLLLEGSLRMKE-GKDSKMDVYC
FLFTDLLLVTKAV--------------KKAERTKVIRPPLLVDKIVCRELR-DPGSFLLI
YLNEFH-SAVGAYTFQASGQALCRG------WVEAIYNAQNQLQQLRVQEHPGSQQPLQS
LE------------EEDDEQEEEDEEDEDEEEEEGGGS---------STSAASSPT---I
LRKSSNSLNS------------------------------QHCASDGSTETLAMVVVEPG
ET----LSSPEFEGGPFGSQSDETSLS-----------------------------TTAS
SVTPISELLPLGPVDGRSCSMDSAYGTLSPTSLQDFMAPA----------PVAEPLPRPP
ELPQAPSPLSSPRLR---------RRSPVQLLPRLPHLLKSKSEASLLQLLSG-------
-----ATTS--------------------GAPPAPSRSLSELCLAVAGRG-------TRT
QGSSR----EPGPSWVRQGTPSPSSGPEPSELE-GRTSCLAGEPERPTRRSRD-------
---------------LPLGASPR---VQPEPPPGISAQHRKLTLAQLYRIRTTLLLNSTL
TAS---------
>gi|148223173|ref|NP_001082763.	Xenopus laevis
MSGTQSAASDRFHSRKPTRHGSILYRESSTDKKQKVERSVSSSHDFDATESVSRKAKSTW
DESRQETYGLVQRCVVIQRDENGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVN
GTLVTHSNHLEVVKLIKSGSYVALTVQGRPLGSPT-IPLTDSEAD-----NFVPIM-PPH
SPVP----QGHGKGITSPILMEEENNIVHTQKLDILMKMLQKEQDQLHQFQEEFHTTPSQ
RLSKEIQDSKKHIAQLQDGLSKARGLSQG----------SESLQISELDADSSDILGQTD
CSSGDGSRPNSDIVDSPRSGQRDKSFLEESLEKSE-I--------------QDTDSQSSM
GSPSIRFTHNIIGAEDDDFDAEPEQSPQI---NGQCSCFQNMDLLKSH------------
-PAHLAVFIHHVVSQF--DPA---ALLC--------YLHADLYQQT--NSKETRRVFMEF
NQFF--------LERAANLK---VPVPDDVALELEKRRPELI------------------
----------------------------------PEELHRQYIQTVQERLS---------
---------------EDVKKNLEDFKQKRSMGLTL--AEGELSKLDTERFRDRNTIDKE-
----------RACAEQIVQKIEEILFTSQTPEDEKSNTIQYVILTYMKHLGVK-----VK
EPRSLEQKRGRI-----------GFLPKIKQSMKKDREGEEKVKRRG-------------
----------FPSILAPQRKP-SRQDSNAIGKAMELQRQRHPKHLSTSSSSS-PEPADGS
RLRTSGGSI----EGSDTPFSPSSNL-----GAAYTFQEVGREVEGVSRCGGENMSSVDT
LDGGTRTSGPIFDFPSPSLDHLHEEI-GE------------------------------A
DRLTDLGTPKLLRKLDSVALSDIQSEDEH-HEIDQE-EHPPNWQQLVSKDTLQKLKPHEI
KQQEVINELFCTERAHVQK-LSVLDQVF---HQRVIRENLLTPAETRNIFSNLEEILQL-
-HGALNEQMKA-------VKKRYETS------VVEEIGDYVLNWFSGAEEEKLKQAVATF
CSNQPFALEMIKSR--QKKDLKFLAFVQDAESNPLCKRLQLK---DIIPTEMQRLTKYPL
LLDNIARYSDQ-EDEKEK--VNKAANHCRNILDYVNQAVKEAENKQRLEDYQRRLDLSCL
KPGEY------PMIDELRN-LDLTK-----------RKLIHEGPLTWKV-NKDKSIDLYS
LLLEDILVLLQRQDDKFNSEMRKQDLAATSESKHIFSPVIKLNTVLVRQVATDNKAFFVI
SMSENG-AQIYELMANSVSEKNG--------WQDLITSMAATSKTENSQPAQLQQTDPDL
DS-----------EEEHEDQLKLSNDKEDERLLHRHRTDKDTESLVQPKSFSPSPTHGSI
LPHHAGILKDQNQQDFRCSTS------------------PSSCHPSTEHHLAVHALRNLG
LL---KQLLEQQLKFLQKEEEENFQRF----------------CSHKTKEQNLTRVSSLN
KQNRGSRESDLNKDLHALHRAIDKGSEHGNTGP-DCVAEI----------LEESGEQFFD
AQEPHSDIYVDGSRR---------EKHIEEAQFRSSENYLILDGYENVP-----------
-----ESSTDDDL--------------------SASHYSNQGDPNDSLHG----------
---------EERLAFNALEPASSSEAFDQ-----MLHYIETIESDLQQLKGLE-------
-----------------DHYITY---RNRVALSGVLEEDPDKAMLPTDKG----------
------------
>gi|156537856|ref|XP_001608097.	Nasonia vitripennis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------M------------
------------------EPA---PT----------------------------------
------------IGKSSSAS----------------------------------------
------------------------------------------------------------
---------------------VDEPTDQEAAGLLV-------------------------
-------------------------------PERRTRS----------------------
------------------------------------------------------------
--------------------------------------------ESDCDASG-AFPGNSA
GS-SSNSSLST--RSLDSPSTSLEQV-----------------------------HPATA
GANASASWD---------------------------------------------------
------------------------------SDVDVE-PDPPDWSQGVAEEVLARLGNAEK
KRQEVINELFHTERSHVRA-LKVLSQVF---HKPLLETQVLPPDQIHLLFSNLDEMVTL-
-HSQFNQAMK---------RRKKENP------CVGDIGDLLLEMFDGEAGEIFERAASKY
CAKQQVALRALRDQ--RRKDPKLNSFLNEVEANPLCRRLQLK---DHILTGMLRLTKYPL
LFDNLAKYTSE-QNEKEKAAVLRSLERSREILSRVNQAVREAEDYHRLAEIQHTIDRSAF
DKFEH------PTVQEFKN-LDITK-----------RRLIYEGPLQWRVVAKAKPVDLHV
VLLDDTILLLHRQDE----KYALKFINQTNQSNAVLSPIVRVSTVLVRHNAVDKNSLYLV
NTSQNG-AQIYDLVASSSEERKL--------WCKHISEAAEVHKSRDREGRRPMPPSSSS
TDLVESSEEQLLPEPSSAQTQENSNETRAAEKLEQDKRKDSPVATIDSPTVATAPT---Q
SSPRPQPQPTETTDAAAVTTEDDE---------------AAAATAASEEGAAGADPVKPG
LKIEGRRKLPEPEEGVAGGASPVAGLA-------GIAGTTSTGEPLRLLTCTQSSLIDPI
EVHVEERPVHVAEPVLTPIESLRRKDEVIKQALLEKQSIV----------ENILNIPKTE
VQPVTETVSELPAVE---------KEPSELILAAIGQANQLIELLN-----SA-------
-----LTVSETETVLATQTESASDG-CKATGCPTPRVHPRTLEPAIPVST-------LQP
FCNSLTSQLSQLLTKRENDCEKNYGEVVNVCMQ-LMPRLNAEKLQKYLLRQLKLKHKPNT
VSFTIPAVTTDDEVNQPTSYDGP---NKEIFVDAQSEPEASTVTTEPVEEVKVASDNEVM
GDSVG-------
>gi|157018350|gb|EAA07135.4|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
-------------------GYSTK------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------LGGTSSTSSLKKKSSS------------
-------FLHRERK----KPV---------------------------------------
------------LTRSQVSS----------------------------------------
---------------------------------------SEYFSVCFE------------
-------------------------SDQNDPGVLI-------------------------
-------------------------------PATKGVRLAECLRASLSRRSLS-----FS
QIYVTDNGFNNP------------------------------------------------
-------------------HETGLRYTEPLDANMDISALAGRTLIVSERDGA-PNRRTGG
HLTLQKAAS----VGNQPSIMSSNSK-------------LFTSTSTDDNYDQSPKASSAS
GKQSKQKWTIPFGSKGPQKSKLCELL-DS------------------------------Y
NKEIPKSTSSSSNFNNPEYVD---------ALVGLR-NLPQCWTDIVNCA---GMSEAET
KIQSAIWELVTTEVYYILA-LQTVTDLFLACLEDIQSQNILTDVDQNKLFSNIRDIWEA-
-NLRFWTLYLH-----PMVKHSQRTK------DPMSIYYFQRGFVDFAT---IFTPYTKY
CAEQSTCQFYCKEM--YHNNALFMTYCAWCESQKMCNRLRLA---DILVRPMQRLTKYGL
LLAAIKKHIND-EAEGEA--IDAMIHSVEEFVAGVNSHLTTRQESERLKGINARIDCYEV
VDSNN--ETLDRLVKQHSIMFDLCQPMRGI---DHGRKVFVEGDLKYK--DGTGKMDVHC
FLFTDFLLVCKKNKN------------DKLKVSCIVRQPYMTDRLMVQL---KDQSIYCC
YVNELN-MVVAAFTLQSAKAQH---------WYDSITKVKHIYNRMKQGTFGDVRHDEGA
GV-----------VNAVTGSGLVMMHSKYGA----------------VSSRKPKNT---V
CTMQTKSSNS----------------------------------------LTVQPYIDLN
ES---KQVSIDFEKTNSLSSDEGAGVV---------------------------------
----------NAVTGSGLVMMHSKYGAVSSRKPKNTVCTM--------------------
------QTKSSNSLT---------VQPYSGLGQSMPNLNLNSIQN---------------
--------------------------------RATLRRGFAFSTSIKNPP----------
-----------LIKTRNVSSQQSF------------------------------------
------------------------------------------------------------
------------
>gi|118404950|ref|NP_001072496.	Xenopus tropicalis
MSGTQSAASDRFHSRKPTRHGSILYRESSTDKKQKVERSVSSSHDFDAT-----------
--------GLVQRCVVIQRDENGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVN
GTLVTHSNHIEVVKLIKSGSYVALTVQGRPPGSPT-IPLTDSEAD---VHNLGPIM-PPH
SPVT----QGHGKGITSPILMEEENNIVHTQKLDILKKMLQKEQDQLQQFQEEYNSTPSP
RLSKEIQDSKKHIAQLQERLLKARGLSQG----------SESLQISELDADSSDILGRTD
YSSGDGSRPNSDIADSPRSGQREKSFLEESPEKSE-I--------------QDTDSQSSM
GSPSIRFTHNIIGAEDDDFDAEPEQ--QM---NGQCSCFQSMDLLKSH------------
-PAHLAVFIHHVVSQF--DPA---AMLC--------YLYTDLYQQT--NSKETRRVFLEF
NQFF--------LEKAGNLR---VSVPDDVALELEKRRPELI------------------
----------------------------------PEELHRQYIQTMQERLS---------
---------------EDVKKNLEDFKQKRSMGLTL--AEGELSKLDADRLRDRNTMEKE-
----------RVCAEQILQKIDEILFSSQTPEDEKSNTIQYVILTYMKHLGVK-----VK
EPRSLEQKRGRI-----------GFLPKIKQSMKKDREGEEKVKRRG-------------
----------FPSILAPQRKP-SRQDSNAIGRAMELQRPRHPKHLSTSSSSS-PEPADGS
RLRTSGGSI----EGSDTPFSPSSNL-----GAAYTFQEVGREVEGNFRC-GENMSSADT
LDGGTRTSGPIFDFPSPPLDHLHEET-GE------------------------------A
DRFTDLGTPKPFRKLDSLVVGDTQSEDEH-HEIDKE-QDPPNWQQLVSKEILQKLKPHEI
KQQEVIHELFYTERAHVQK-LGVLDQVF---HQRVIRENLLTPAETRNVFSNLEEILQL-
-HVALNEQMKA-------VKKRYETS------VVEQIGDDVLNWFSGAEEEKLKQAVATF
CSNQPFALEMIKSR--QKKDLKFLTFVQDAESNPLCKRLQLK---DIIPTEMQRLTKYPL
LLDNIARYSDR-EDEKEK--VNRAANHCRNILDYVNQAVKEAENKQRLEDYQRRLDLSYL
KPGEY------PMIDELRN-LDLTK-----------RKLIHEGPLTWKV-NRDKSIDLYS
LLLEDILVLLQRQDDKLILRCHSKILASTSDSKHIFSPVIKLNTVLVRQVATDNKAFFVI
SMSKNG-AQIYELIANSVSEKNG--------WQDLITKMAATSKTEYPQPTQLQQTAPEM
VS-----------EEEHEDVEQQKVSHDQQEDRLIYRHS--------TDKDSDTES---L
VQSKSPSSPS-----------------------------PSSCLSSTEHHLAVNALRNLG
LL---KQLLVQQLKLLQKEEAENFQRF-----------CSRKTKEQMRESEKLTKFSSLD
KQNWGSRESDLNKELHAQQRATDRRSEHSNTGP-DCVAEV----------LEEGGEQYFD
AQEPQIDMNVDGSKR---------EKNIEEAQFRLSENYLILDGYENVQ-----------
-----ESSTDDDL----------------SASQYPTQCPAVSDPADPLHV----------
---------EERLTFSALDPTPSSEAFNH-----MLQYIANIESDLQQLRGLE-------
-----------------EFYNTY---RNRVATSGVLEEDPDKAMLPTDKG----------
------------
>gi|125978529|ref|XP_001353297.	Drosophila pseudoobscura
--------------------------------------------------------MHEK
LLEKEETRKEKTERATSLLGGKVKEKPPKDKPPKQSKFAERLRRSFRRGDHRSLEIKRQE
PTPEELQAKSRATPPLPLSSENNNLVGGRPPSAFALSQLHLPGVGLGGHINPALLLDSPD
ECTPPEYAYRHLSSVATTNSSTSLESNCELGDLSGSQTSVFYWACGQQTTTASMGGEVST
A------NGAGASASAGAGAGAATGTGLDAQERSKRRLETQSSNRSDQQPISITTTTSSA
PASGSRSCSLTSESSSVRLTRLQNFLFKSSNESSRSCQGHSNEGFTASSHNSSSGEWEQM
GAHGPLSSSSGVGFHGGSFPEESTPDETDATDAGSTLPVESGEAGGGYYQYTLTSPNNPF
LPEITARTYHSTYEEDGLEPMEELQLDG--------NVTSVKYNASAAGTRSAQLPTPAY
SRAGSQESTHSESGRGSPLKQSAVTSPGAVTPDLGTKREEFLRATMKICLVVSPPSSKLQ
LKSKSLTHLDGLDTVVACQHGPGGTAATTSVVQAPGASGAPGVSSGHQHQHHHQAAATTP
TALGRQPHAYPGGEAQAAATSLSPYSSTPTSGPPLTSPSGLSATTSATVKKKSSFLQRKK
PLLTRSEVSSSEFFSVSFCMDSSQHPDEEFIPATKGVTLLNALSHALRRRNLT-----FS
QITITDNNPT--------------------------------------------------
--------------------P-SFLDAGPSPATSSVDEQTDVENLAGHHLCI-TERGSNR
KPLQKAASFGS--RQPPPRLLPSAST------------------------EETSDAAVAA
GKQIKQRWSSLFGIKNPQQSQLCELL-NS------------------------------Y
SRSGVPQRAEGLSFEHPDLDN---------SLAYLQ-NMHKSWRDFVESE---AMPESEV
KIQTAIWELVTTEVYYIHA-LQTVTDLFLACLEAVQTERLLIDVDQARLFSNVRAVCEA-
-NIKFWTMWLY-----PMVAHSVMTH------EPLRCAFFQEGFIAFAS---IFAPYKIY
CAEQSTCQFYCKEL--NQNNPLFTSYLAWCESQKMCNRLRLA---DIVVRPMQRLTKYSL
LLAAIKKHMGD-VEEIEA--IDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDV
VDTNN--EGLDKLIKQHSQMFDLCAPMRGCP-AYHVRHLFMEGDHKFK--DNLGKSDVHC
FLLTDLLLVCKTMAK------------RGLGALKVIRQPYLTDQLIVNMA--PNNTINCV
YLNEFQ-VATTAFTLQCTEAKNC-------------------------------------
--------------------------------FRFGGS---------GTSGGTADS---L
GVRKSPMNSS-------------------------------ICSHVSSANNSHSGSVEWN
DS---RNISVDFEKTNSVSSDEGSGMM---------------------------------
-TVPNLSSKDDLSLTGNHGMAGKGKQQLISGLHKAKIGMI--------------------
---GAIGSKSANTLT---------VQPLNHLGQSLPNLNMHHSHTNNTLLVPG-------
-----TTTSHSGNMLLSPSHRGISY-PPPSPTRVPLRRGMAFSTSTKNPP-------LRK
TRNVTS---QNSINWHQIPATPTPTPPSPRSQHTTTPASIALQKSLPVLDPS--------
--------------------------LPPLLHKQLSHQAPLTTSSTETDV----------
------------
>gi|71891653|dbj|BAA20836.2|	Homo sapiens
------------------------------------------------------------
-------------------------------------------AAMRAGVQTGDRIIKVN
GTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQ-IPLADSEVEPSVIGHMSPIMTSPH
SPGA----SGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQ
RLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTD
CSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETI--------------QDTDTQSLV
GSPSTRIAPHIIGAEDDDFGTEHEQI------NGQCSCFQSIELLKSR------------
-PAHLAVFLHHVVSQF--DPA---TLLC--------YLYSDLYKHT--NSKETRRIFLEF
HQFF--------LDRSAHLK---VSVPDEMSADLEKRRPELI------------------
----------------------------------PEDLHRHYIQTMQERVH---------
---------------PEVQRHLEDFRQKRSMGLTL--AESELTKLDAERDKDRLTLEKE-
----------RTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVK-----VK
EPRNLEHKRGRI-----------GFLPKIKQSMKKDKEGEEKGKRRG-------------
----------FPSILGPPRRP-SRHDNSAIGRAMELQKARHPKHLSTPSSVS-PEPQDSA
KLRQSGLAN----EGTDAGYLPANSM-SSVASGASFSQEGGKENDTGSKQVGETSAPGDT
LDGTPRTLNTVFDFPPPPLDQVQEEE-CE------------------------------V
ERVTEHGTPKPFRKFDSVAFGESQSEDEQ-FENDLE-TDPPNWQQLVSREVLLGLKPCEI
KRQEVINELFYTERAHVRT-LKVLDQVF---YQRVSREGILSPSELRKIFSNLEDILQL-
-HIGLNEQMKA-------VRKRNETS------VIDQIGEDLLTWFSGPGEEKLKHAAATF
CSNQPFALEMIKSR--QKKDSRFQTFVQDAESNPLCRRLQLK---DIIPTQMQRLTKYPL
LLDNIAKYTEW-PTEREK--VKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSL
KLSEY------PNVEELRN-LDLTK-----------RKMIHEGPLVWKV-NRDKTIDLYT
LLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVI
SMSDNG-AQIYELVAQTVSEKTV--------WQDLICRMAASVKEQSTKPIPLPQSTPGE
GD-----------NDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHS---L
STSGKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLG
LL---KQLLVQQLGLTEKSVQEDWQHF----------PRYRTASQGPQTDSVIQNSENIK
AYHSGEGHMPFRTGTGDIATCYSPRTSTESFAPRDSVGLA----PQDSQASNILVMDHMI
MTPEMPTMEPEGGLDDSGEHFFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDG
YDPVQESSTDEEVASSLTLQPMTGI-PAVESTHQQQHSPQNTHSDGAISP-------FTP
EFLVQQRW--GAMEYSCFEIQSPSSCADSQSQ--IMEYIHKIEADLEHLKKVE-------
-----------------ESYTIL---CQRLAGSALTDKHSDKS-----------------
------------
>gi|125855735|ref|XP_684640.2|	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
---------------MASVNFGRKSIQSGRRCVPH-------------------------
----------------SQPILTKSVSMVAISQKDLDAMGRLRPKRRISF-----------
------------------------------------------------------------
-------------------------------------------------------SFSIS
PMLPKSKTLFSLGSSSSD--------------EEEAVRLSSFTGTSGS------------
--------LEYSISEE--DPG---PLRSDSEGKIGGTKVSRTFSYLKSKMSKKNKVDQQT
HNLV--------YRTLGPVH----------------------------------------
----------------------------------AHWLPTSGMSTLCRRFL---------
-------------------PQGRSLKIKNTVGVVE-------QEKEKEKNKERERDAK--
-------------------------------DKERRASNGHLFTTVMTVPTIP-----CH
QCNKLINTKDSI------------------------------------------------
----------LCTNCNAQVHKGCKESLPVCAKVKMKQQKQQQTVTDSASTPSVTLRSKTL
PARDRPWSTISIPDDQPAPLAPPRKS-------------PSSIMSFNSNPLSKSMSINNI
AGYGKIELSNKYKFLSQSTDSLHKTSKVT------------------------------E
STESLTDEGKSTEMMDSQLMGE--------FEADAKELEADSYSFTVDKKFLKQLKKDVI
KRQDVIYELIQTEMHHVRT-LKIMADVY---SKGLLREVQLEAQTVEKMFPMLDDVLDL-
-HTQFFSHLLE--------RKKESGSQEEGGFVIQRIGDVLVSQFSGSSAERMKKVYGKF
CGRHNEAVNFYKEL--HTKDKRFQAFIKKKMSSPVVRRLSIP---ECILLVTQRITKYPV
LLQRILQHTKENEEDHAD--VSQGLKLVKEVIAAVDNKVNEHEKKKRLKEVYSRTDNKSI
MRMKS--------GQMFAR-EDLLR----------GRKLIHDGPLQLKN-SAGRLKDVQA
LLLRDVIVFLQEKDQ--------KYIFASLDQR---STVISLQKLIVREVANEEKALFLI
TAGIEK-PEMVEVYTSSKEERNT--------WMQLIQEAMQSMERDDDEGVPSENEEDRR
LQ-------------EIKVKEFRDQLHKRDEQILTLLEEKVKLFRDMCDCGAPDET---G
LRNRMLFRAT-------------------------------------TDDVTRGEPIMKE
ALKEVETLQVLVNDSLGGAVQEGVCAA---------------------------------
------GHVTLPRRAETFGGFDSHQMNISKNGDREELEES--------------------
-----------AELR---------RTESDSVLKKTSKTNPLLLVR---------------
---------------------------------------------------------RNN
ELKRCRFWLMTVLAVRFQEGVCAAGHVTLPRRAETFGGFDSHQMNISKSKGSY-------
---------------------GD---REELEESAELRRTESDSVLKK-------------
------------
>gi|119908422|ref|XP_872939.2|	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSGRSSSPLP-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------LALQAGREDRSLEEEK-------GLRCQNPDCMDKGRAA------------
------KVCHHADCQQLHHRG---PLNL--------CEACDSKFHSAMHYDGHVRFDLPP
QGSV--------LARNVSTR----SCP---------------------------------
----------------------------------PRTSPAVDLEEEEESCM---------
----------------------DGKGDRKSTGLKL----------SKKKARRRHTDDPS-
----------KECFTLKFDLNVDI--ETEIVPAMKKKSLGEVLLPVFERKGIA-----LG
KVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGVKD-------------
----------SKSLSLPILRQ-----AGAGPPAQERVDLQSRRESLDILAPG-RRRKNMS
EFLGEASI-----PGQEPPTPSSCSL-------PSSSSSGSSSSSSGSDSWKNRAASRFS
GFFSSGPSTSTYGREIDKMEQLEGKL-HA------------------------------Y
GLFGLPRLPRRLRFDHDSWEEEGDEEEDE-DDAGLR--LEDSWRELIDGH--EKLTRRQC
HQQEAVWELLHTEASYIKK-LRVITNLFLCCLLNLQESGLLCEVEADRLFSNIPEIARK-
-HRGLWGSVMA-----PVLEKARRTR------ALLQPGDFLKGFKMFGS---LFKPYVRY
CMEEEGCMEYMRGL--LRDNDLFRTYITWAEKHQQCQRLKLS---DMLAKPHQRLTKYPL
LLKSVLRKTDE-PRAKEA--VVTMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEV
VEGSN--DEVDKLLKEFLH-LDLTAPIPGAS-PEETRQLLLEGSLRMKE-GKDSKMDVYC
FLFTDLLLVTKPV--------------KKAERTKVIRPPLLVDKIVCRELR-DPGSFLLI
YLNEFH-SAVGAYTFQASGQALCRG------WVDAIYNAQNQLQQLRVQEHPGDQQHLQS
LE-----------EEEDEREEEEEEEEGGGS----------------STSAASSPT---I
LRKSSHSLDS------------------------------QHCASDGSTETLAMVVVEPG
EL----LSSPEFRGDPFSSQSDETSLS-----------------------------TTAS
SVTPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFMAPA----------PTVESAPRPP
ELPPAPSPPPSPRLR---------RRTPVQLLPCLPHLLKSKSEASILQLLSG-------
-----ATTR--------------------RVPPAPSRSLSEVCLAATVPG--------TR
TRGSCQ---EAGPSWYCQGAPGPGHQLAELE---GRAHCPGGEPEGPTRRSRE-------
---------------LSSGASTR---VQPEPPPGISAQHRKLTLAQLYRIRTTLLLNSTL
TAS---------
>gi|149722348|ref|XP_001499586.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
-----------------MATALLWTQAPGPPAPPQ-------------------------
--------HGSLSLGSRPGWPLKGSLSPHRGPIELWRPGPSSSPSPAEPMEAE-------
------------------------------------------------------------
---------------------------------------------------DVARGAAPG
PPRPGPVPVSIIGAEDEDFENELETNT-----EEQNSQFQSLEQVKRR------------
-PVHLMALLQHVALQF--DPG---PLLC--------CLHADMLGSL--GPKEAKKAFIDF
YHSF--------LDKTAVLR---VVVPPTVSFELDRTRPDLL------------------
----------------------------------SEDVQRQFVQEVVQSQQ---------
---------------EAVSRQLEDFRSKRLMGMTP--SEQELSQLEAWVGRDRASFEARE
----------RHVAEQLLNHLEEIQHTIST-DEEKSAAVVSAISLYMRHLGVR-------
-TKSGDKKSGRN-----------FFRKKVMGNKRSDEPTK---TKKG-------------
----------LSSFLDAARWN---------RVEPQVPDMRHLKNETNVEKLGLTERKGGL
GAPSRDRNVGA--PGQDTPGVSVHPL-----------------SGDSPNRESGVDGPLEL
GDPPSQGPAS-LELPAPPESTEEGAD-TE------------------------------S
PEPGDEGEPGR-------------------SGLELEPEEPPGWRELILPDTLHSLPKSQV
KRQEVISELLVTEAAHVRM-LRVLHDLF---YQPMVDGGFFPVEELQNIFPSLDELIEV-
-HSLFLDCLMK--------RRQDSGP------VIEEIGDVLLARFDGAEGSWFQKISSRF
CSRQSFALEQLKAK--QRKEPRFSAFVQEAESRPRCRRLQLK---DMIPTEMQRLTKYPL
LLQSIGQNTEE-PAEREK--VELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHL
RQSSD------PMLSEFKN-LDITK-----------KRLIHEGPLTWRV-TKDKAVEVHV
LLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVI
FTWEQE-AQIYELVAQTVSERKN--------WCNLITETAGSLKVPAPASRHKPRPSPIS
TR-----------EPLLSS----------SEKGNCGREM--------PPADGPHPF---W
VWALRP-------------------------------------AGGGEDGPARGIGGTIG
RE---APCGGRKLKLSEPRFGDPISKL---------------------------------
--------PFVSVGLLVESCSGFPLGSCVASGNQRRMASA--------QLAQSVNE----
--------GAAPEFR---------VMGAAEVTPEEPPKGRQILGS---------------
---------------------------------------RELEAGAPLPP-------PWP
TLKTW----GLTFAVRAVGFPYRNSVKAVLLHN-LPGLVLSRGHNGQRPGGVK-------
-----------QHGPWVVGRQGR---CGEGPSEQDMGGALNQGFWGGGTLAQGIVGVTP-
------------
>gi|149048200|gb|EDM00776.1|	Rattus norvegicus
------------------------------------------------------------
---------------------------------------------MKAGVKEGDRIIKVN
GTMVTNSSHLEVVKLIKSGAYAALTLLGSSPPSVG-VSGLQQNPSVAGVPRVNPIIPPPP
PPPP----LPPPQHITGPKPLQDPE--VQKHATQILRNMLRQEEKELQDILPPCGETSQR
TCEGRLSVDSQEAD-------------------------------SGLDSGTERFPSISE
SLMNRNSVLSDPGLDSPQTSPVILARVAQHHRRQG----------------SDAALLPLN
HQGIDQSPKPLIIGPEEDYDPGYFN-------NESDIIFQDLEKLKSH------------
-PAYLVVFLRYIFSQA--DPG---PLLF--------YLCSEVYQQT--NPKDSRSLGKDI
WNIF--------LEKNAPLR---VKIPEMLQAEIDLRLR---------------------
----------------------------------NNEDPRNVLCEAQEAVM---------
---------------LEIQEQINDYRSKRTLGLGSLYGENDLLGLDGDPLRE--------
----------RQMAEKQLAALGDILSKY---EEDRSAPMDFAVNTFMSHAGIR-----LR
ESRSSCTAEKTQSAPDKD--KWLPFFPKTKKQSSNSKKEKDALEDKK-------------
----------RNPILRYIGKPKSSSQSIKPGNVRNIIQHFENSHQYDVPEPG-TQRLSTG
SFPEDLLESDS--SRSEIRLGRSESL----KGREEMKRSRKAENVPRSRSDVDMDAAAEA
ARLHQSASSSASSLSTRSLENPTPPF-TP------------------------------K
MGRRSIESPNLGFCTDVILPHLLEDDLGQLSDLEPE-PEVQNWQHTVGKDVVANLTQREI
DRQEVINELFVTEASHLRT-LRVLDLIF---YQRMRKENLMPREELARLFPNLPELIEI-
-HNSWCEAMK---------KLREEGP------IIRDISDLMLARFDGPAREELQQVAAQF
CSYQSVALELIRTK--QRKESRFQLFMQEAESHPQCRRLQLR---DLIVSEMQRLTKYPL
LLENIIKHTEGGTSEHEK--LCRARDQCREILKFVNEAVKQTENRHRLEGYQKRLDATAL
ERASN------PLAAEFKS-LDLTT-----------RKMIHEGPLTWRI-SKDKTLDLQV
LLLEDLVVLLQRQEERLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFII
CTSELGPPQIYELVALTSSDKNI--------WMELLEEAVQNATKHPGAAPIPIHPSPPG
SQ-----------EPAYQGSTSSRVEINDSEVYHTEKEPKKLPEGPGPEQRVQDKQ---L
IAQGEPVQEEDEEELRTLPR-------------------APPSLDGENRGIRTRDPVLLA
LT---GPLLMEGLADAALEDVENLRHLILWSLLPGHTVKTQAAGEPEDDLTPTPSVVSIT
SHPWDPGSPGQAPTISDSTRLARPEGSQPEGEDVAVSSLAHLPPRTRSSGVWDSPELDRN
PAAEAASTEPAASYK---------VVRKVSLLPGGGVGAAKVAGSN---AIPD-------
-----SGQSESELSEVEGGAQATGN-CFYVSMPAGPLDSSTEPTGTPPSP---------S
QCHSLPAWPTEPQPYRGVRGGQCSSLVRRDVDV-IFHTIEQLTIKLHRLKDMELAHRELL
KSLGGESSGGTTPVGSFHTEAARWTDYSLSPPAKEALASDSQNGQEQGSCPEEGSDIALE
DSATDTAVSPGP
>gi|47225083|emb|CAF97498.1|	Tetraodon nigroviridis
------------------------------------------------------------
--------GLVQRCVIIQKDENGFGLTVSGDNPVFVQLVKEDGAAMRAGVQTGDRIIKVN
GTLVTHSNHIEVVKLIKSGSYVALTVLGRPPGLTQ-IPLSEAESE-----MLGVSISSPN
SPATERPYSPQDRFSAQPSW--DENNSACNQKVDYSVKMLSREQQELQEPFHSIDADDGS
IFETEFFPTSKGGDNNTDLSLFSTPMSRG-----------------------------FG
CGSPESLYPKESSFPSPKSTPRNSLNSCHSPDAEDATDLVAADISPQKCANDSLSPITVG
SPSVTRVISQIIGAEDDYFDSDQEQS------NGQCNSFNSIEQLKSR------------
-PAHLAAFLHHVISQF--DPA---PVLC--------YLYADFYKQT--NSKETRRVFMDL
HNFF--------IDRGANLK---VPVPDSISADLDRRRTELI------------------
----------------------------------PEEINRQLVQTLQDSLL---------
---------------PDIQKNLEDFRQKRSMGLTV--AEGELSRLDQERIRDRVTLERE-
----------RSYAENIISKIEDILLTTQTTEEEKCTTMQYVIYTYMKHLGVR-----VK
EPRSLESKRVRI-----------NFLPKIKKSIKTEKEG-EEKKKPR-------------
----------FPSILGPQRRP-SRIEAAPVGKALD-GRPRPQKRQSQPTLGA-SEHMEAG
RLRGSHSS-----EGPELIHGTSVNISSSNSAAVNLDSSRDADTSGSLTSVPSRMSDGLQ
ADLLEGLPYPPTHFDLYSLDQLQEDD-RE------------------------------S
DRAHE-GTPKAIRRLEAIGAADVQSEDDQGTDSEHD---PPYWQQLVGREVLAGLMPQEI
KRQEVINELFYTERAHVRM-LRVLDHLF---YQRLSKDAILPPADIKNIFPNLEEISQL-
-HVSILEQMAA-------VRKRNESS------VIDQIGDDLLSWFSEGEEEKIKQAAGTF
CSNQPFALEIIKTK--QKKDSRFASFVQEAESNRLCRRLQLK---DIIPIEMQRLTKYPL
LLDNIAKYTDN-AAEKDK--VKQAADCCRKILNHVNQAVKESENKQRLEDYQRRLDLSSL
KQTDN------PMILELKN-LDLTK-----------RTMVHEGPLSWKM-NKEKTIELYT
LLLEDILVLLQKQDERLILKCHSKNLASTADTKHIFSPIIKLNTVLVRSVATDNKSFFVL
CTSENG-PQIYELMAPTVSDQRT--------WQRLITQRADAMKVKPHSVIPLPQTDCNT
FV--------------EVKAEGEEEEGGFADSELPYR----------VTEDGKKRD---L
YEGVPCRADE--------------------------------------------ALKTLA
AL---KQVLVTQLMSQEATQQNKRSTG---------------------------------
--PRLLRTTSLRTPVESCARVMVHNGSEKITSKLEEAAQD--------------------
-----LGSRDKGFFD----------------TPEDYAGYLVLEGYS----GPG-------
-----ESSTDDDIL---------------ASAAGKLLRSTRGCAVDSSSN----------
---------------SRFSLMSQAGSLSSFSRQ-VLSHLRSLQADLSYLKAYE-------
--------------------------TPRGIIVTPNGQ----------------------
------------
>gi|126329530|ref|XP_001377260.	Monodelphis domestica
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MFLYWRKRGAYELESLPPSLTQLEYGAVERFSWNSPLDIIEDLEGRCWGL
RVGTDGPGD---------------------------------------------------
---------------------------------------------------KEEAVGSPQ
SEHFSSPQEWLALCSADDRSLTEEK-------GLRCQNPECIDKRRAS------------
------KVCHHADCQQLHRRG---PLNL--------CEVCDGKFHSTMHFDGHIRFDLPP
QGSV--------LSRNVSTR----SCP---------------------------------
----------------------------------PRTSPASDLEEDDEGLM---------
----------------------DSKGEKKGSSLKL----------SKKKARRRHTDDPS-
----------KECFTLKFDLNVDI--ETEIVPAMKKKSLGEVLLPVFERKGIE-----LS
KVDIYLDQSNTPLSLPFEAYRFGGHYLRVKA--KPGDEVKVELAVKD-------------
----------FKSLSLPIPGP----------PASDRADQQARRESLDILAPG-RRRKNMT
EFLGDASI-----PGLEPSMPSSSSL-----------------PSNGIDTWKNRAASRFS
GLFSSGPSVSSFGREVDKMEQLESKL-HS------------------------------Y
SLFGLPKLPQQLRFDHDSWEEEEEEED---ADLVLE----DSWQELIDGT--EDLTRRQC
HQQEAVWELLHTEASYIKK-LRVITDLFMCCLLNLQESGLLCEVDIERLFSNTQEIIQL-
-HKGLWSSVMA-----PILDKARRTR------TLLQPADLLKGFKMFGS---LFKPYIRY
CMEEEGCMEYMRSL--LRDSDLFRVYVTWAEKHQQCQRLKLS---DMLAKPHQRLTKYPL
LLKSVLKKTDD-PPTKEA--IVTMISSVERFISHINSRMRQRQEQQRLVAIISRIDSYEV
VESST--DEVDKLLKEFLR-FDLTAPIPGTS-PDDTRQLLLEGSLKMKE-GKDSKMDVYC
FLFTDLFLVTKPV--------------KKAERTKVIRQPLMVDKIVCRELR-DPGSFLLI
YLNEFR-SAVGAFTFQASGQALCRG------WVEAIFNAQNLLQRMRLQEHQGSHQQHLQ
SL-----------EEEEDEEEEEEEGES-------------------STSGASSPT---I
LRKSNNSLNS------------------------------QCCPSDGSTETLAVVVVEPG
ES----PSSPDFEGGPFSSRSDETSIS--------------------------TTASSTT
PTSEADGLLHSAPAECRSCSIDSAYGTLSPTSLKDFVAPA-------ELAPVPAPRPPDP
PDPPAPALPLSPRLR---------RRTPVQLLP-WPRLLKSKSEASLLQLLSG-------
-----ASGR--------------------VPPSAPSRSLSELCLTTPLLPNGF----PRT
QMGPCQPPPEARASWDCGGASPSGASGPPEAEDSGCSPGRGDESPLSRECKKPV------
--------------------------SKTTFRAQPSGQHRKLTLAQLYRIRTTLLLNSTL
TAS---------
>gi|39777606|ref|NP_945353.1|	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MASLSTWSSPAEPREMEDFAR-------------------------------
------------------------------------------------------------
------------------------------------------------------GAASPG
PSRPGLVPVSIIGAEDEDFENELETNS-----EEQNSQFQSLEQVKRR------------
-PAHLMALLQHVALQF--EPG---PLLC--------CLHADMLGSL--GPKEAKKAFLDF
YHSF--------LEKTAVLR---VPVPPNVAFELDRTRADLI------------------
----------------------------------SEDVQRRFVQEVVQSQQ---------
---------------VAVGRQLEDFRSKRLMGMTP--WEQELAQLEAWVGRDRASYEARE
----------RHVAERLLMHLEEMQHTIST-DEEKSAAVVNAIGLYMRHLGVR-------
-TKSGDKKSGRN-----------FFRKKVMGNRRSDEPAK---TKKG-------------
----------LSSILDAARWN---------RGEPQVPDFRHLKAEVDAEKPGATDRKGGV
GMPSRDRNIGA--PGQDTPGVSLHPL-----------------SLDSPDREPGADAPLEL
GDSSPQGPMSLESLAPPE-STDEGAE-TE------------------------------S
PEPGDEGEPGR-------------------SGLELEPEEPPGWRELVPPDTLHSLPKSQV
KRQEVISELLVTEAAHVRM-LRVLHDLF---FQPMAECLFFPLEELQNIFPSLDELIEV-
-HSLFLDRLMK--------RRQESGY------LIEEIGDVLLARFDGAEGSWFQKISSRF
CSRQSFALEQLKAK--QRKDPRFCAFVQEAESRPRCRRLQLK---DMIPTEMQRLTKYPL
LLQSIGQNTEE-PTEREK--VELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHL
RQSSD------PMLSEFKN-LDITK-----------KKLVHEGPLTWRV-TKDKAVEVHV
LLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVL
FTWDQE-AQIYELVAQTVSERKN--------WCALITETAGSLKVPAPASRPKPRPSPSS
TR----------------------------------------------------------
----EPLLSS--------------------------------------------------
------------------------------------------------------------
------------SENGNGGRETSPADARTERILSDLLPFC--------------------
------RPGPEGQL----------AATALRKVLSLKQLLFPAEEDN--------------
-------------------------------GAGPPRDGDGVPGGGPLSP----------
--------------ARTQEIQENLLSLEE-----TMKQLEELEEEFCRLRPLL-------
-------------------SQLG---GNSVPQPGCT------------------------
------------
