>gi|4585283|gb|AAD25360.1|AF117	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
---------------------------MDSPTQGTHWSALALCVLLLWSSVCG-------
----------------------------------------------------R--EHVCQ
EIS------VPLCR------------GIGYNYTYMPNQFNHDNQDEAGLEVH--------
-QFWPLVEIQCSPDLRFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFPW
PDRMRCDLLPVQG-D---PNTLCMDYNR--------------------------------
------------------TDATSSPAAPKTTSRPGK---------------------PFK
RKNKSSPGS-------SSCEPECYCRAPMVPVHSDH--------------HPLYNRVKTG
---QIPNCAMPCHN------PYLSQEERTFATFWIGIWSVLCFLSTFATVATFLIDIERF
KYPERPIIFLSACYMFVSLGYIIRLIAGHERVACNQNH-----EVDHIHYETTG--PALC
TLVFLLIYFFGMASAIWWVILSFTWFLAAGLKWGNEAIARYSQYFHMAAWLIPSVKSITV
LALSSVDGXSIAGICYVGNQNLDNLRGFVLAPLVIYLFIGTIFLFAGFVSMFRIRSVIKQ
-----GGTKTDKLERLMVRIGVFTVLYTVVAIMIVACYVYEHHNREAWEIAHAC-N----
--CS-SDKKAP---------------KPDYAVFMLKYFMCLLIGITSGAWTWSSKTLDSW
RALCTRCCCC---------------RWATK------GTSGSVYSDASS---------GLT
WRS---------------------------------------------------------
------------------------------------------------------------
-GTASSVLCPP-------------------------------------------KQMPLS
-RV----------------------
>gi|157114296|ref|XP_001658030.	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MTRTHRFSLLSACLLLLLCS-------
---------------------------TRVNSSYYSGGGASPAPHLPAIPKDP--HSRCE
EIT------IPMCR------------GIGYNLTSFPNEMNHETQEEAGLEVH--------
-QFWPLVEIKCSPDLKFFLCSMYTPICIEDYHKPLPVCRSVCERARAGCAPIMQQYSFQW
PERMACEILPVSG-D---SDNLCMEQPSEDDGSHSSGGG---------------------
----------------GGGGSSGGSHSKPTRKSHGSSAGGASG----QNNKCK-G--KNS
KNCQNPPGE---RT--KECM--CRCREPLVTLGKEN---------LLH-------NQSVE
RVGDVINCAIPCRG------AFFSQEEKDFAGVWIALWSGLCGISTLMTLTTFLIDTERF
KYPERPIVFLSACYFIVSCGYLTKLFLGHDEIACDGKA---------IKYPSMG--QSSC
TMIFIMIYFFGMASSIWWVILSFTWFLAAGLKWGNEAISKHSQYFHLAAWLIPTVQSVSV
LLRPAVDGDPIAGICYVGNTSVENLKNFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQ
QGGIGAGSKADKLEKLMIRIGIFSVLYTVPATIVIGCHLYEANFTEDWMTGLTC-P----
--CKAGTGIRQ---------------KPLYSVLMLKYFMALAVGITSGVWIWSGKTVESW
RRLWRRLFGS-----------------PDP------TGAGQVLIKPRP---------PLP
QPYATSGIGVP------------------------------GSAAASLLATPYTQTV---
---------------------G-------------------------------SVASTSH
HHLHHHVLKQT----------------------------------------------PLS
-HV----------------------
>gi|125977796|ref|XP_001352931.	Drosophila pseudoobscura
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VLGLGLVLCL-------
-----SSGGRALPDSPQHSPDHGMGMGMGMGSHGMDVSPAPGGYGVPAIPKDP--NSRCE
EIT------IPMCR------------GIGYNMTSFPNEMNHETQDEAGLEVH--------
-QFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEW
PERMACEHLPLHG-D---PDNLCMEQPS--------------------------------
----------------KCRGRNSKNCQNPQGEKASG------------------------
----------------KECA--CSCQSPLISLGKEQLLQQS---PMRH--HHWYMNLTVQ
RIAGVPNCAIPCKG------PFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERF
KYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGHL---------LKESSTG--PHSC
TLVFLLTYFFGMASSIWWVILSLTWFLAAGLKWGNEAITKHSQYFHLAAWLFPTVQSVAV
LLLSAVDGDPILGICYVGNLNPDHLKKFVLGPLFVYLVIGTTFLMAGFVSLFRIRSVIKQ
QGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALAC-P----
--CAQVKGPGR---------------KPLYSVLMLKYFMALAVGITSGVWIWSGKTLESW
RRFWRRLFGA-----------------PDR------TGANQALIKQRP---------PIP
HPYAGSGMGMP-----------------------------VGSAAGSLLATPYTQAG---
---------------------GA------------------------------SVASTSH
HHLHHHVLKQP----------------------------------------------AAS
-HV----------------------
>gi|47217199|emb|CAG11035.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MESTESHS--EFSCE
PIR------LRMCQ------------DLPYNTTFMPNLLNHYDQQTAALAMGGIREHPGL
LPFHPMVNLECSPDLRMFLCALYAPVCVV-YGQVSMPCRSLCQRAKNQCHKLMEIFGVAW
PEDMECSRFPDCD-E---PYPRPEDLLT--------------------------------
-------------------GSDPANQSSMTVQREYG------------------------
----------------FWCP-------RELKVEADL-------------------GYSFM
---GRRDCSAPCPS------MFFHPQELTLIRYFIGVTSVVCLSATLFTFLTFLIDVTRF
RYPERPIIFYAVCYVMVSLVFFLGFLLE-DRVACNAAS----PAHFRAATVTQGSHNKVC
TLFFMVLYFFTMAGSLWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVAL
LALNKIEGDGISGVCFIGLYDIDALRWFVLAPLGLNVTVGVSLLFVGIVALNKVRMEIPL
-----EKENQTKLVKFMIRMGVFSALYLVPLLVVLGCYLYEHTFRSVWERTWMEEN----
--CRRYHIPCPY-------EVKQTG-RPAAVLFLMKYLMMLVVGIPSVFWVGSKKTCFEW
ADFMQGRRRK------DSGVNESRQVLQEQP-----DFAQSLLREPNT---------PII
RKSRGTSTQGTSTHASSTNLAVMDGLEDPAPAHQRHAAS-TRSKASSVHSKASCHGSLRR
PREDRPNKDSSSQGRHCGLQRHGGARFPWQPVTAEPPTLRSQQPPSAGRPVEAQQPARCT
RGPAGADHPRN---------------------------DSQPQPGWRRRRHQRLTGRPWT
-------------------------
>gi|115903813|ref|XP_790565.2|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MATWSLILRVFLMWGWCCG-------
------------------------------------------SYGLGVRHGNT--QGHCE
RIT------IDFCQ------------GIGYNMTKMPNLFGHVTQSEAAPSIH--------
-EFHPLVVVGCAEHLRLFLCSMYAPMCSEHIDIRIPSCQSMCDDVRRKCEPVMARFSFSW
PESMNCDKLPRGK-D------LCMVAPD-----------T--------------------
-----------------ADVGDTIPTYEPNFNFGGPDDN--------IPSGPSAG-----
DGQRESNAS-------SSAPPTCTNPQKFVFVSQTN------------------------
------SCAPRCDVD-----VYFQRSDKEFTEMWMGVWAILCFVCTSITVLTFLIDRGRF
KYPERPIIFLSMCYNIYSITYIVRLIVGPQAVACEKTS------SGVPYLIQEGLDSTGC
TIVFLVQYYFFMASSIWWVILTLTWFLAAGMKWGYEAIAAYSSYYHVVAWALPALKAVIA
LFKRRLDADELTGMCYIGNHDPDVLTYYVLVPLFIYFAIGTLFILAGFFYLFRIRKVMKN
-----GGTNIDKLERLMVRIGIFSVLYTVPATAVIACYFYQRSNMEYWRIVAEHAP----
--CR----PLPPEQGGGCAPMDYS--IPSVPVLSVKLFMLLVVGITSGMWIWSSKTVQSW
QKWLGGCALF--------------SPAQKS------SFQQQQLKQQQQ---------QQQ
FPNGGTPNKEN-----------------------------RPTTPRGKYPTINGN-----
-----------------------------------------------------NRSTGIV
YSSVNAGSAIV-------------------------------------------------
-------------------------
>gi|17737633|ref|NP_524155.1|	Drosophila melanogaster
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MRHNRLKVLILGLVLLLTSCR-------
--ADGPLHSADHGMGGMGMGGHGLDASP------------APGYGVPVIPKDP--NLRCE
EIT------IPMCR------------GIGYNMTSFPNEMNHETQDEAGLEVH--------
-QFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEW
PERMACEHLPLHG-D---PDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSG
SGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASG------------------------
----------------KECS--CSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQ
RIAGVPNCGIPCKG------PFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERF
KYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLL---------LRESSTG--PHSC
TLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAV
LLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQ
QGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKALAC-P----
--CAQVKGPGK---------------KPLYSVLMLKYFMALAVGITSGVWIWSGKTLESW
RRFWRRLLGA-----------------PDR------TGANQALIKQRP---------PIP
HPYAGSGMGMP-----------------------------VGSAAGSLLATPYTQAG---
---------------------GA------------------------------SVASTSH
HHLHHHVLKQP----------------------------------------------AAS
-HV----------------------
>gi|121582126|dbj|BAF44470.1|	Hydra magnipapillata
------------------------------------------------------------
------------------------------------------------------------
---------------------------MRRNLYLHILKSVIIHLLCLNLIFCE-------
--------------------------------------------PRGIRERYE--TRKCE
KLS------ITMCE------------KVGYNLTFMPNKHGHVNQIDAGQLIR--------
-QFAPLVAINCSPLLAHFVCSLYAPMCDPVYNKDIVPCQSLCENIRNSCEKFMKQNGYTW
PDNLQCSQFPTRE-----KDPICMKPDF--------------------------------
--------------------DFPEPSIPTHLNLPDE----------------------NK
KTSLIQTKDVFKIRDFSGCG--CLCKYPFVSVNSSS-------------------NTDLF
-----PPCVLPCGQ------YFFSNTQNIFMKFWLSLWSILSLITTAVTLLTFLIDRTKF
KFVEQPIILISFCYFIVSFGYIIRLIYGFKAIACNDHT-------GFLHYASTG--PASC
TAVFILTYFFTNVSWIWWVVLSINWFLSSGLKWTNGTISSYSQYFHFVAWLIPTIQTMAI
LAMSAIDGDPVSGLCTVGNHDSNTLTIFVIGPLLIYTMLSLSFFIAGVVAKLRIEQTIRN
-----EAKNNLKSGRFLSRVGMFTLILFVPAVSLLGCYFYEHSYKEIWEKSTNCD-----
--CMPIKK------------------QPIFYIFLFKYLMSLVIGIAIGLGTLNSDALGAW
RR----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------
>gi|114619513|ref|XP_001166266.	Pan troglodytes
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MAMTWIVFSLWPLTVF-------
---------------------------------------------MGHIGGHS--LFSCE
PIT------LRMCQ------------DLPYNTTFMPNLLNHYDQQTAALAME--------
-PFHPMVNLDCSRDFRPFLCALYAPICME-YGRVTLPCRRLCQRAYSECSKLMEMFGVPW
PEDMECSRFPDCD-E---PYPRLVDLNL--------------------------------
-------------------AGEPTEGAPVAVQRDYG------------------------
----------------FWCP-------RELKIDPDL-------------------GYSFL
---HVRDCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRF
RYPERPIIFYAVCYMMVSLIFFIGFLLE-DRVACNASI----PAQYKASTVTQGSHNKAC
TMLFMILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIIL
LAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPL
-----EKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQER----
--CREYHIPCPLLPSFHSLPCHTPL-RPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEW
ASFFHGRRKK-------EIVNESRQVLQEP------DFAQSLLRDPNT---------PII
RKSRGTSTQGTSTHASSTQLAMVDD---------------QRSKAGSIHSKVSSYHGSLH
RSRDGRYTPCSYRGMEERLPHGS----------------------------MSRLTDHSR
HSSSHRLNEQS---------------------------RH--------SSIRDLSNNPMT
-HITHGTSMNRVIEEDGTSA-----
>gi|50978730|ref|NP_001003065.1	Canis lupus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MEMFTFLLTCV-------
--------------------------------------------FLPFVRGHS--LFTCE
PIT------VPRCM------------KMAYNMTFFPNLMRHYDQSTAAVKME--------
-PFLPLANLECSPNIETFLCKAFVPACTD-QINVVPPCRKFCEKVYSDCKKLIDTFGMRW
PEELECDRLQYCD-E---TVPVTFDPHT--------------------------------
-------------------QFLGPQKNTEQVQRDIG------------------------
----------------FWCP-------RHLKTSGGQ-------------------GYKFL
---GIDQCAPPCPN------MYFKSDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVKRF
RYPERPIIYYSVCYSIVSLMYFIGFLLG-DRTACNKAD----EKLELGDTVVLGSQNKAC
TVLFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGIPGFLTVML
LAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQH
-----DGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDH----
--CRQYHIPCPY-------QAKTET-RPELALFMIKYLMTLIVGISAVFWVGSKKTCTEW
AGFFKRNRKR-------DPISESRRVLQESCEFF--LKHNSKVKHKKKHYKPSSHKLKVI
SKSMGTSTGATANHGTSAVAITNHDYLG-QETLTE-----IQTSPETSVREVRADGASTP
RSREQDCGEPASPAASSSRLCEEQADRK--GRAGNGTDKISISESTRSEGRVTPKSDVTE
TGPMQSSSLQV---------------------------PGSSEPGSLKGSTSLLVHSASG
GRKEHGTGSHSDT------------
>gi|83657477|gb|ABC40387.1|	Polyodon spathula
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MPNQFNHDTQDEAGLEVH--------
-QFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERARAGCAPLMRQYGFAW
PDRMRCDRLPVQG-S---PDTLCMDYNR--------------------------------
-----------------TDLTTASPIFPKPTVHPGKPS---------SPHKNKNGIRPPV
PGSKHRPPV-------TPCEPGCQCRAPMVKITSER--------------HPLYNRISTG
---QMPNCAMPCHS------PYFTHEERTFTAFWIGLWSVLCFVSTFATVATFLIDMERF
KYPERPIIFLSACYMFVSVGYIVRLIAGHEKVACNREY-----EVEHIHYETTG--PALC
TVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSIKSIAV
LALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQ
-----GGTKTDKLEKLMIRIGIFTVLYTVPATIVVACYFYEQHNRQSWEITHNC-S----
--CLVEQDIK----------------KPEYAVFMLKYFMCLLMG----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------
>gi|148235925|ref|NP_001083918.	Xenopus laevis
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MAAYLISFIWVSVIL-------
---------------------------------------------AQKSMGHS--LFACE
PIT------LRMCQ------------DLPYNSTFMPNLLNHYDQQTAALAME--------
-PFHPMVNLECSRDLRPFLCALYTPVCME-YGRMTLPCRKLCQRAYNECFKLMEMFGVPW
PEEMECSRFPDCD-E---PYPRIVDISL--------------------------------
-------------------SGEPSEETPLAVQRDYG------------------------
----------------FWCP-------RELKIDPDL-------------------RSSFL
---GVRDCSPPCPH------MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRF
RYPERPIIFYAVCYMMVSLIFFIGFLLE-DKVACNGAN----PSQYKASTVTQGSHNKAC
TMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIIL
LAMNKIEGDNISGVCFVGLYDVHALRYFVLAPLCLDVVVGVSLLLAGIISLNRVRIEIPL
-----EKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGVWETTWVQER----
--CREYHIPCPY-------KVTQTS-RPDLILFLMKYLMLLVVGIPSVFWVGSKKTCFEW
ASFFHGRKKK-------AGVNESRQVLQEP------DFAQSLLRDPNT---------PIV
RKSRGTSTQGTSTHASSTQLAMLDD---------------QRSKAGSVQSKVSSYHGSLH
RSRDGRYTPCSYRGIEERLPHGS----------------------------MSHLTDHSR
HSSTHRLNEQS---------------------------HQ--------GSIRDLS-NPLA
-HISHGTSMNRVIEADATSA-----
>gi|37719656|gb|AAR01940.1|	Oreochromis niloticus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------DTQDEAGLEVH--------
-QFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERARAGCAPLMRQYGFPW
PDRMRCDLLPVQG-N---PDTLCMDYNR--------------------------------
-----------------TDSTTASPVLSKPTNHPGKGY---------NPPKNKPG--RPG
TPGKYKPPA-------APCEPGCTCLEPMVPVNTER--------------HPLYNRVKTG
---QITNCAMPCHN------PYFTHDERAFTAFWIGLWSVLCFVSTFATVATFLIDMERF
KYPERPIIFLSACYMFVSVGYIVRLIAGHEKVACNREF-----DVDHIHYETTG--PALC
TVVFLLIYFFGMGSSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSMKSIAV
LALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQ
-----GGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFFEQHNRQSWEITHNCFN----
--CLLERDRR----------------TPDYAVFMLKYFMCLLVGITSGVWIWSGKTLDSW
RTFCTRCC------------------WGSK------GTSGSMYSDVST---------GLT
WRS---------------------------------------------------------
------------------------------------------------------------
-GTASSVSCPK--------------------------------------------QMPLS
-------------------------
>gi|83318899|emb|CAJ29888.1|	Paracentrotus lividus
------------------------------------------------------------
------------------------------------------------------------
--------------------------MAASRVTSSQFPAVTMIFFITVLSSCF-------
----------------------------------------------SIALSIR--DAKCE
PIT------VPMCR------------DIGYNMTYMPNHFNHDSQEEAGLEVH--------
-QFYPLVEIQCSPDLKFFLCSMYTPICLADYHKPLMACRSVCERAKAGCAPLMRQYGFAW
PDRMQCENLPEFG-D---PDNLCMDSNH--------------------------------
------------------TNAGTSAPTNPPMTRPGG------------------------
RRPRPRPTD-------KPCD--CSCNEPLISIPESH---------------PYYNRVSTG
---GISNCATPCKS------AFFSEDEHTFATFWIGLWSILCFVSTLMTVATFLIDCGRF
KYPERPIIFLSACYFMVSLGFIIRLVVGHDQVACSGDY---------VRVGSTG--PALC
TIVFLLIYFFSMASSIWWVILAFTWFLAAGMKWGSEAISSYSQYFHLAAWLLPSIQSIAV
LALSSVDGDPIAGICYVGNHDLAKLRGFVLAPLFMYLIIGCSFLLAGFVSLFRIRNVIKQ
-----GGRKTDKLEKLMIRIGIFSVLYTVPATMVVAIYIYEQHSRSDWERGVTC-P----
--CQADHLP-----------------KPEYSVFMLKYFMCLVVGITSGVWIWTGKTLSSW
RGFVNRLLGR----------------KAYP------KRERTFNCK------------PVI
LKTL--------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------PNA
-QV----------------------
>gi|126327746|ref|XP_001376661.	Monodelphis domestica
---MVSLKYLQDPFQNVQEAVEVYDYSLGDNIWLHTKLEDLKINCTEMIIKPMGTGESSG
KIQAGCAFLLELPAVHQVPATASRKQRLAKAPSWESRVELGPGQGRRSATRSSPASAEKR
SGAREPKSPEPGWLRLAAMTPGVPPSAGGRVTPDFLARQLVLQTGGVWASGRSRRRSLRR
RLPLPLALAMARWVLGLRVPGASGGVYFSLSPPPPLLLLLLLLGQTRAFGDEE--ERRCD
PIR------ISMCQ------------NLGYNVTKMPNLVGHELQTDAELQLT--------
-TFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAW
PDSLNCSKFPPQN-D---HNHMCMEGPG--------------------------------
-------------------DEEVPLPHKTPIQPG--------------------------
----------------EECHTMGAHSDQYIWVKRSL------------------------
------NCVLKCGYDA----GLYNRSAKEFTDIWMAMWASLCFISTAFTVLTFLIDSSRF
SYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEE------AAEPVLIQEGLKNTGC
AIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVI
LIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQK
-----DGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWTLFLYS--AD-----
--------------------------DSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTW
QKCSNRL-----------------------------VNSGKVKREKRGD--------GWI
KPGKGNETVV--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------
>gi|70569750|dbj|BAE06469.1|	Ciona intestinalis
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------VYTPICIPGYPGFLPPCRFICEAAKAGCEPILKKYDRTW
PNLFDCKQFPDSQ-G---KNPPCLHFNR--------------------------------
-------------------SATEEPAVPRTITKKGG-------------SKTTPG--GPV
ASVTHHPYK-----PINGCP--CACARRMVKITNKK--------------DPLYGKVTTG
---GVPNCAMPCKS------PYFSEEKRKFAESWITVWSVVCFAITMLTVGTYLIDTQRF
AYPERPIIFLSACYMFVSIGFIIRVVAGHEAVACAWHS-------DRVLYQTTG--PFLC
SIVFLLLYFFGMAGALWWVILSLTWFLAAGLKWGSEAIASYSQYFHAAAWLIPALKSITV
LAMSSVDGDVLSGICFVGNQSTKTLRGFVLAPLVVYLALGGLFLFLGFVNLFRIRTSIKK
-----VGKKTDTLEKLMGRIGLFSLLYMVPSAALVACYFYEQQNRELWAKAYNCRSFHGR
DRCS--HGNAN---------------GPEFAVFIVKYSMTLLIGITNGVWILSGKTITSW
RKFYRRCYGCLCGKYGLKAKQEGEPLAADDMSKASDNSSGKRTKSDKASDKTSPEEIPLT
NSVATSSFTGNPHSVGGSDSKESRSSSA-RKKSKTQSNGVQHNRNDMYYECNEVDRNDVN
QIRHVACDCDIAPCPLPSEVRGNPAKQL--SFPEGFETLPDPLDVSTTELEAANRVQHIH
HHHHHHVTQPPCSCGCHASRVTTRRPTPRRHSHHDPGACYEANHRKLVLTPPAYRTSPTT
HHSLRR-------------------
>gi|149721598|ref|XP_001494331.	Equus caballus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MEMFPFLLTCI-------
--------------------------------------------FLPLIRGHS--LFTCE
PIT------VPRCM------------KMAYNMTFFPNLMGHYDQSTAAVEME--------
-LFLPLANLECSPNVETFLCKAFVPTCTE-QIHVVPPCRKFCEKVYSDCKKLIDTFGIQW
PEELECDRLQYCD-E---TVPVTFDPHS--------------------------------
-------------------EFLNPQKKTEQVQRDIG------------------------
----------------FWCP-------RHLKTSGGQ-------------------GYKFL
---GIDQCAPPCPN------MYFKSDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVKRF
RYPERPIIYYSVCYSIVSLMYFIGFLLG-NSTACNKAD----EKLELGDTVVLGSQNKAC
TVLFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGIPGFLTVML
LAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQH
-----DGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDH----
--CRQYHIPCPY-------QAKTET-RPELALFMIKYLMTLIVGISAVFWVGSKKTCTEW
AGFFKRNRKK-------DPISESRRVLQESCEFF--LKHNSKVKHKKKHYKPSSHKLKVI
SKSMGTSTGATANHGTSAVAITNHDFLG-QDTLTE-----IQTSPEMSVREVRADGASTP
KSREQDCGEPASPAASTSKLCGEQADRK--GRAGLANDKSSVSESARSEGRLTPKSDVTE
TGPVQSSNLQV---------------------------PSSPERSSLKGSTSLLVHSASG
VRKEQGAGSHSDA------------
>gi|109480714|ref|XP_343231.3|	Rattus norvegicus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MEASPFLSACI-------
--------------------------------------------LLPLIRGHS--LFTCE
PIT------VPRCM------------KMAYNMTFFPNLMGHYDQGIAAVEME--------
-HFLPLANLECSPNIEMFLCQAFVPTCTE-QIDVVSPCRKLCEKILSDCQKLMDTFGIRW
PEELECHRLPYCD-G---AVPVTSDPHT--------------------------------
-------------------ELFGPQKKTDQVPRDIG------------------------
----------------FWCP-------KHLRTSGDQ-------------------GYRFL
---GIDQCAPPCPN------MYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRF
RYPERPIIYYSVCYSIVSLMYFVGFLLG-NSTACNKAD----EKLELGNTVVLGSKNKAC
SVVFMFLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGMPGFLTVML
LAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQH
-----DGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYELVNRVTWEMTWFSDH----
--CHQYRIPCPY-------QANPKA-RPELALFMIKYLMTLIVGISAVFWVGSKKTCTEW
AGFCKRNRKR-------DPISESRRVLQESCEFF--LKHNSKVRHKKKHGKPGSHKLKVI
SKSMGTSTGVTTDHGTSAVAIADHDYLG-QETSAE-----VQTSPEASLKEGRADRANTP
RAKGPDCGEPASTAASNSKFSGDQIDRK--SRAGSVKEKSSVSEGAPSEGRVSPKG-VPG
TGLMEC-TLQI---------------------------PSSPEPNSLKGSTSLLVRSASG
TRKEQGAGGHSDT------------
>gi|118089114|ref|XP_420029.2|	Gallus gallus
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MAVSWMFCCFWLLDVL-------
---------------------------------------------VGCTRGHS--LFSCE
PII------LRMCQ------------DLPYNTTFMPNLLNHYDQQTAALAME--------
-PFHPMVNLECSRDFRPFLCALYAPVCME-YGRVTLPCRRLCQRAYSECSKLMEMFGVSW
PEDMECTRFPDCD-E---PYPRLVDLSL--------------------------------
-------------------GGEPTEEAPMAVQRDYG------------------------
----------------FWCP-------RELKIDPDL-------------------GYSFL
---RVRDCSPPCPN------MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRF
RYPERPIIFYAVCYMMVSLIFFIGFLLE-DRVACNASS----PAQYKASTVTQGSHNKAC
TMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIVL
LAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPL
-----EKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQER----
--CREYHIPCPY-------QVTQMS-RPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEW
ASFFHGRRKK-------EVVNESRQVLQEP------DFAQSLLRDPNT---------PII
RKSRGTSTQGTSTHASSTQLAMLDD---------------QRSKAGSVHSKVSSYHGSLH
RSRDGRYTPCSYRGIEERLPHGS----------------------------MSRLTDHSR
HSSSHRLNEQS---------------------------RH--------SSIRDLSSNPLT
-HITHGTSMNRVIEEDGTSA-----
>gi|119906679|ref|XP_868973.2|	Bos taurus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------METFTFLWTCI-------
--------------------------------------------FLPLVRGHS--LFTCE
PIT------VPRCM------------KMAYNMTFFPNLMGHYDQSIAAVEME--------
-IFLPLANLECSPNVETFLCKAFVPTCTE-QIHVVPPCRKFCEKVYSDCKKLMDTFGIRW
PEELECDRLQYCD-E---SVPATFNPHT--------------------------------
-------------------ELLGPHKKSEQIRRDIG------------------------
----------------FWCP-------RHLKTSGGQ-------------------GYKFL
---GIDQCAPPCPN------MYFKSDELEFAKSFIGIVSIFCLCATLFTFLTFLIDVRRF
RYPERPIIYYSVCYSIVSLMYFIGFLLG-NSTACNKAD----EKLELGDTVVLGSQNKAC
TILFMFLYFFTMAGTVWWVMLTITWFLAAGRKWSCEAIEQNAVWFHAVAWGIPGFLTIML
LAMSKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQH
-----DGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDH----
--CRQYHIPCPY-------QANTET-RPELALFMIKYLMTLIVGISAVFWVGSKKTCTEW
AGFFKRNRKK-------DPISESRRVLQESCEFF--LKHNSKVKHKKKHYKPSSHKLKVI
SKSMGTSTGATANHGTSAVAITNHDYLG-QETLTE-----IQTSPETSVREVRGDGASTP
KLRERDCEEPASSAAPSSKLCREQMDKKGHGRAGKVNDKSSVSESARSEGRVTPKSDVPE
SGPVQSNSMQA---------------------------SSSPEPSSLKGSTSLLVHSASG
VGKEQGAGGRSDT------------
>gi|149603629|ref|XP_001516249.	Ornithorhynchus anatinus
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MAGSWLLFSLWPWVLL-------
---------------------------------------------VAQAGGHS--LFSCE
PIT------LRMCQ------------DLPYNSTFMPNLLNHYDQQTAALAME--------
-PFHPVVNLECSRDFRPFLCALYAPVCME-YGRVSLPCRRLCQRAFGECAKLMEVFGLSW
PEDMECSRFPDCD-E---PYPRPADLNA--------------------------------
-------------------AAEPTAATPAAVQRDYG------------------------
----------------FWCP-------RELKTEPAL-------------------GYSFL
---RVRDCSPPCPN------MYFRREELAFARYFIGLISIVCLSATLFTFLTFLIDVRRF
RYPERPIIFYAVCYMMVSLIFFVGFLLE-DRVACNAAR----PAQYRAATVTQGSHNKAC
TLLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIVL
LAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLDVAVGVSLLLAGIVSLNRVRIEIPL
-----EKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAHRGVWETTWVRER----
--CRDYHIPCPY-------QMPQMS-RPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEW
ASFFHGRRKK-------EAVNESRQVLQEP------DFAQSLLRDPNT---------PVI
RKSRGTSTQGTSTHASSTQLAVVDE---------------QRSKAGSVHSKMSSYHGSLH
RSRDGRYTPCNYRLSEERLADGHTSRLTDLSLPGSSHRLNEXXXXXPESGRAVDEKKVLD
HPPPPPHPTGS----LVPRRLSRGRGLFPGRSVTVPSRPQIRGRGKDEGSGGRAGSPEGE
LRGGRGLAGGLVARADARGHHPTPA
>gi|31205113|ref|XP_311505.1|	Anopheles gambiae
------------------------------------------------------------
------------------------------------------------------------
---------------MALARSKHRRHTVRSTLQQTVGVRCAVSVLPILLLMIS-------
-----------------------------GVAECSYHSGVSPMPHVPAVPKDP--NSRCE
EIT------IPMCR------------GIGYNLTSFPNEMNHETQEEAGLEVH--------
-QFWPLVEIKCSPDLKFFLCSMYTPICIEDYHKPLPVCRSVCERARAGCAPIMESYSFNW
PERMACENLPVSG-D---SDNLCMEMPREEEHGEDRGAGGSS------------------
----------------GGGSGSSGHSGKPTRKSHGGSGGQSSGGGNQQNNKCK-G--KNS
KNCQNPPGE---RT--KECM--CRCREPLVTLGRESSTT-----TLLHHHGSLSSNQSVE
RVGDVQNCAIPCRG------AFFTQEEKDFAGIWIALWSGLCGISTLMTLTTFLIDTERF
KYPERPIVFLSACYFIVSCGYLTRIFLGHDEIACDGKS---------IKYPSTG--QSSC
TMIFIMIYFFGMASSIWWVILSFTWFLAAGLKWGNEAISKHSQYFHLAAWLIPTVQTVSV
LLRPAVDGDPVAGICYVGNTSVENLKNFVLAPLFMYLVVGTTFLMAGFVSLFRIRSVIKQ
QGGIGAGSKADKLEKLMIRIGIFSVLYTVPATIVIGCHLYEASYFEDWMTGLTC-P----
--CKVAPGLRQ---------------KPLYSVLMLKYFMALAVGITSGVWIWSGKTVDSW
RRLWRRLFGS-----------------PDP------TGAGQVLIKPRP---------PLP
QPYATSGIGVP------------------------------GSAAASLLATPYTQTV---
---------------------G-------------------------------SVASTSH
HHLHHHVLKQA----------------------------------------------PLS
-HV----------------------
>gi|156539957|ref|XP_001599448.	Nasonia vitripennis
------------------------------------------------------------
------------------------------------------------------------
---------------------MHKANDIDSQFGSSSTSSMTLTSSVSGIVMNV-------
-----------------------------GSNSAPISTDIDYSISRSDLSSPT--GSRCE
EIT------IPMCK------------GIGYNLTTMPNELNHDTQDEAGLEVH--------
-QFWPLVEIKCSLDLKFFLCSMYTPICLPEYSKPLPACRSVCERARMGCAPLMHQYGFSW
PERMACERLPNQG-D---PENLCMEQDN----------RTTL------------------
----------------VSTEILTPIALPKPTKTPKG----------FQATKCKPG--KNQ
KNCHHSIEE-------KDCT--CRCRPPLIPLISSS-------------SIQEKDAAESL
---GSLNCVLPCQG------AFLTNEQKNFATIWLTLWSGLCAASTLATVTTFLIDTQRF
KYPERPIVFLSACYFLVSIGYLSRSIIGHEQIACDGNM---------LRYGTQG--PGIC
ITVFLLIYFFGMASSVWWVILSFTWFLAAGLKWGNEAISSYSQYFHLAAWLAPTAQTLWA
LLAGGVAGDPIAGVCTVA---PEGIRIFILAPLLMYLLLGTTFLFAGFVSLFRIRSVIKR
Q----PGAKADKLEKLMIRIGVFSVLYTVPASAVLACHLYETTLRSEWLSSLAC-P----
--CK----PRI---------------KPLYSVLMLKYFMALAVGITSGVWIWSGKTIGSW
KRLWRRLFGR--------------------------NLNVSSNVQGAT---------GTG
ILSNVSGSKGI-----------------------------VARSIAPQYSTASGPGSTLL
H--------------------------------------------------QSSITSASQ
HHIHHHVLKQP----------------------------------------------PLS
-HV----------------------
>gi|76556424|emb|CAJ32309.1|	Hydractinia echinata
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------MEIIFTKLFFFVIVLLAT-------
---------------------------------------------VNLSHAGQ--KTTCV
SLKHR---GLRLCQ------------NLGYNATMFPNSLEHRNMENASTELD--------
-NFLPLVKIRCAKEIEFFLCSVYLPVCLD--SGPLPPCREVCERAQRGCIKLMTQYGFPW
PEYLRCSRFPKKV-----EDRLCVDKPF--------------------------------
-----------------KEPGTNGNNGNNGINTGGIPV-------------------NPS
HNTTHATYDD------YRCP---------AKQQKET------------------KHYKFM
---GTEKCASLCTP------IYFTHKEKDFARNWVLFWSVVCMLSTAFTLLAFIVDMPRF
RYPERPIIFLSGCYFIVAIAFISGPVSD-NAIACHKTD-------DGTQLLNQGTDNASC
TIVFMLIYFFLMSASIWWVILTLTWFLAAGLKWGHEAIEGSSQYFHAAAWAIPAAKTIAV
LAMNQTDGDILAGVCFVGGKNVNALRGFVLAPLFVYLVVESFFLFAGFISLIQIRKVLKD
D----SSLRAEKLTRLMVRIGIFSILYSLPAIIVIACLFYEQTYRIEWDSSWISAWLTML
GKCD--EKVCF--------EFSGKS-RPDFAVFMIKYLMLLMVGITSGFWIWSGKTIQSW
RRFYYNKILH--------------------------QRVPRQYYESKD---------GSV
FTARTNLT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------
>gi|112363134|ref|NP_001036226.	Danio rerio
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MVLLWALCSMLTVCM-------
------------------------------------------AINMEATGSHS--MFSCE
PIT------LRMCQ------------GLAYNTTFMPNLLNHYDQQTAALAME--------
-PFHPMVNLECSTEIRPFLCALYAPVCTE-YGRVTLPCRRLCQRAKSDCYKLMEMFGVSW
PDEMECSRFPECE-E---SYPRAIDLLP--------------------------------
-------------------SSDSTEESPSAVQRDYG------------------------
----------------FWCP-------RELKIEPDL-------------------GYSFM
---GVRDCSPPCPN------MYFRKDELIFARYFIGVISIVCLSATLFTFLTFLIDVGRF
RYPERPIIFYAVCYMMVSLVFFLGFLLE-DRVSCNTAS----PGRFRASTITQGSHNKAC
TLLFMTLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGVPGALTITL
MAMNKIEGDSMSGVCFVGLYDLMALRWFLLVPLVLDVIVGVVLLLAGIAALNRVRMEIPL
-----EKENQDKLVKFMIRIGVFSVLYLVPLLTVIGCYLYEQSHRSVWETTWVQER----
--CREYHIPCPF-------KVEKTS-RPDIALFLIKYLMMLVVGIPSVFWVGSKKTCFEW
ASFFSGHRRK-------DAVHESRQVLQEP------DFTQLLLRDPNT---------PVV
RKSRGTSTQGTSTHASSTHLAMLDEPPS-A----------STSRAGSTRSKSSSFHGSLH
RSRDGRYTASSFRGVEERVSHGSSLRL----------------NEPLQHCAINRLDSQSR
HGSLQRLESQS---------------------------RH--------SSVRDLSITAQA
IQSSPGNGIHRVMEEDATKA-----
>gi|15706324|dbj|BAB68350.1|	Ciona savignyi
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MDVKSGIYLLCCL-------
--------------------------------------------IIEVSSLNV--HPKCR
PVM------LPMCSVGQSRDGDNDVVKWIYNSTTFPNFNNDANEQEVEISMS--------
-AIHPLISTSCSRFLELFLCSVFSPACTG--NGVVPPCRSLCLKVKEDCEAVTQMFGVAW
PPRLDCDNFPLQD-DMTGNGNDAGDAIL-VNSIIWSEALLSD------------------
----------------VCIPLSGDDVITPALSRGEE-----------------------E
ENVTRYPADYE-----VRCP-------AHMRAPPDQ------------------PGYTFL
---GLEECAAPCPN------MYLDPVELSIVRYIIIVLASLCVVVTSFVLFTFAIDTNRF
RYPERPIVFYATSYLVISCIFIVGFILG-PEVACNEQVTNEENKIEQGFVVTEGFHRRFC
TVVFMVLYFFTVNGTIWWLILTVTWLLAAGLKWGSEAIEKYSHYYHGLAWGIPAIQTMIV
VTSGKIEGDNIAGVCFVGLYDSEGLRYLLLLPMSLYLIVGIIVLLTGFICLNRVRKSLD-
-----DEANQKNLAKFMLRIGVFSILYILPQVVLIAIYAIEDSNRKYWESAWFMVN----
--CGNYGIPCPAEQHPVVILAEGNP-HPGIIIFCLKYVMTLVVALPPLFWVASKKTVISW
QNFVTKPPCG---NHGNKLNLTQTQLLNDS------NGPHARDVKRKQQSRDNDVIFGAF
GNLWGSSASVAAAVTSPRARTQQELWDDVTSTLTSESESTLAKVLEFESRKNRGRRVVGR
RRRKGDCASTEVAEICKVPIVGTNHKVPESKERNNRFDDAVKAKTVNGADDKAQVPDVVD
KKVEVTSPCVP---------------------DVIKTSEPTSSLTRPNRPERNRKTPPVP
PTRVDSARILEI-------------
>gi|110759904|ref|XP_397259.3|	Apis mellifera
------------------------------------------------------------
------------------------------------------------------------
-------------------MAPLLSLLVLAVLPNARLESAINPVSNVGSVSSGSSSSSSS
SSSSSSSSMVGGVPGSGSSSGSMAGSGNSVVGGGGSSGVGHSSLGGGGAGVNG--NGRCE
EIT------IPMCR------------GIGYNLTAMPNELNHDNQEEAGLEVH--------
-QFWPLVEIKCSPDLKFFLCSMYTPICLPEYTKPLPACRSVCERARAGCAPLMQQYGFSW
PERMACERLPAHG-D---PENLCMEQDNHTSSTGHGGSGNGG------------------
----------------AASSAPLPAAQPRPTRPSKTT----------QPPRCRPG--KNQ
KNCQHPPGE---RA--RDCV--CRCRPPLVPLGAGGTVIPGPISGSST--GSIGSGAGLA
GMAVIPNCALPCHG------AFLTSEERGFAAVWLALWSGLCAASTLVTVTTFLIDTQRF
KYPERPIVFLSACYFAVSIGYLSRSVFGHEEIACDGSA---------LKSRAQG--PEAC
VAVFLMIYFFGMASSVWWVILAFTWFLAAGLKWGNEAIASYSQYFHLAAWLAPAVQTFSA
YLAGGVAGDPVAGVCTVA---PDGVRSFILVPLFVYLLLGTSFLLAGFVSLFRIRSVIKR
Q----PGAKADKLEKLMIRIGVFSVLYTLPAGVVLACHMYETSLRNEWLDSLAC-P----
--CR----PRA---------------RPLYSVLMLKYFMALAVGITSGVWIWSGKTVDSW
KRLWRRLFSG--------------------------GGGGGGHGGGGA---------GMV
AGVTGVSGGIGSTSIKG-----------------------VVGRVGVPYPPAPGPGSALL
P--------------------------------------------------PGSVASASQ
HHLHHHVLKQP----------------------------------------------PLS
-HV----------------------
>gi|109067553|ref|XP_001092281.	Macaca mulatta
-------------------------------------MTSVAQPVEPKWPRSQEFPSEPW
ASPGFRKAPQGPRLPASAAPAGATSAVWSGEDDPREAPPPPRSSGGGGGEGGGGAGGSRA
RWAAESCALYGAAATSAAPPAGSQRAEDQEGGTRPRRTRATRLLLLLWLLEAP-------
----LLLGVRAQAAGQGPGQGPGPGQQPPPPPPPQQQQSGQQYNGERGISIPD--HGYCQ
PIS------IPLCT------------DIAYNQTIMPNLLGHTNQEDAGLEVH--------
-QFYPLVKVQCSAELKFFLCSMYAPVCTV-LEQALPPCRSLCERARQGCEALMNKFGFQW
PDTLKCEKFPVHG-----AGELCVGQNT----------SDKG------------------
----------------TPTPSLLPEFWTSNPQHGGG-----------------------G
HRGGFPGGASASERGKFSCP-------RALKVPSYL-------------------NYHFL
---GEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRF
SYPERPIIFLSGCYTAVAVAYIAGFLLE-DRVVCNDKF-----TEDGARTVAQGTKKEGC
TILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITI
LALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH
-----DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQS----
--CKSYAIPCPHLQAGGGAPPHPPM-SPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSW
RKFYTRLTNS--------------------------KQGETTV-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------
>gi|73993657|ref|XP_857180.1|	Canis familiaris
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MAMSWIVFYFWPLTMF-------
---------------------------------------------VGHIGGHS--LFSCE
PIT------LRMCQ------------DLPYNTTFMPNLLNHYDQQTAALAMESLRSHPGL
QPFHPMVNLDCSRDFRPFLCALYAPICME-YGRVTLPCRRLCQRAYSECSELMEMFGVPW
PEDMECSRFPDCD-E---PYPRLVDLNL--------------------------------
-------------------AGDPTEGAPVAVQRDYG------------------------
----------------FWCP-------RELKIDPDL-------------------GYSFL
---HVRDCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRF
RYPERPIIFYAVCYMMVSLIFFIGFLLE-DRVACNASS----PAQYKASTVTQGSHNKAC
TMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIIL
LAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPL
-----EKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQER----
--CREYHIPCPY-------QVRETF-RPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEW
ASFFHGRRKK-------EIVNESRQVLQEP------DFAQSLLRDPNT---------PII
RKSRGTSTQGTSTHASSTQLAMVDD---------------QRSKAGSVHSKVSSYHGSLH
RSRDGRYTPCSYRGMEERLPHGS----------------------------MSRLTDHSR
HSSSHRLNEQS---------------------------RH--------SSIRDLSSNPMT
-HITHGTSMNRVIEEDGTSA-----
>gi|17432985|sp|O60353|FZD6_HUM	Homo sapiens
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MEMFTFLLTCI-------
--------------------------------------------FLPLLRGHS--LFTCE
PIT------VPRCM------------KMAYNMTFFPNLMGHYDQSIAAVEME--------
-HFLPLANLECSPNIETFLCKAFVPTCIE-QIHVVPPCRKLCEKVYSDCKKLIDTFGIRW
PEELECDRLQYCD-E---TVPVTFDPHT--------------------------------
-------------------EFLGPQKKTEQVQRDIG------------------------
----------------FWCP-------RHLKTSGGQ-------------------GYKFL
---GIDQCAPPCPN------MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRF
RYPERPIIYYSVCYSIVSLMYFIGFLLG-DSTACNKAD----EKLELGDTVVLGSQNKAC
TVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVML
LALNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQH
-----DGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDH----
--CRQYHIPCPY-------QAKAKA-RPELALFMIKYLMTLIVGISAVFWVGSKKTCTEW
AGFFKRNRKR-------DPISESRRVLQESCEFF--LKHNSKVKHKKKHYKPSSHKLKVI
SKSMGTSTGATANHGTSAVAITSHDYLG-QETLTE-----IQTSPETSMREVKADGASTP
RLREQDCGEPASPAASISRLSGEQVDGK--GQAG------SVSESARSEGRISPKSDITD
TGLAQSNNLQV---------------------------PSSSEPSSLKGSTSLLVHPVSG
VRKEQGGGCHSDT------------
>gi|29437351|gb|AAH49781.1|	Mus musculus
RLQWPAGPQGEKAEQHHRGDGRGEQAGTQGAGLAEAWLGLGDVRIGVRPGLEKLGQTLKG
NRRSLLLVAAEKAAPLRLGGEGKATPLPSIPHSRPRSLNLRRLRECHAEAAAAPPRLAAS
PPLCRHPSTLGSAPPTARPRRREDSHAPGAAAPPCIQASPQRLVFFLQLRTPL-------
---HSRPAMRGPGTAASHSPLGLCALVLALLGALPTDTRAQPYHGEKGISVPD--HGFCQ
PIS------IPLCT------------DIAYNQTILPNLLGHTNQEDAGLEVH--------
-QFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCRSLCERARQGCEALMNKFGFQW
PERLRCENFPVHG-----AGEICVGQNT-----------SDG------------------
----------------SGGAGGSPTAYPTAPYLPDPPF---------TAMSPSDG-----
RGRLSFP---------FSCP-------RQLKVPPYL-------------------GYRFL
---GERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRF
SYPERPIIFLSGCYFMVAVAHVAGFLLE-DRAVCVERF-----SDDGYRTVAQGTKKEGC
TILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITI
LAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH
-----DGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQT----
--CKSYAVPCP--------PGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSW
RRFYHRLSHS--------------------------SKGETAV-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------
>gi|37719620|gb|AAR01922.1|	Acipenser baerii
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------NQFNHDTQDEAGLEVH--------
-QFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERARAGCSPLMRQYGFAW
PDRMRCDRLPVQG-N---PDTLCMDYNR--------------------------------
-----------------TDLTTASPFFPKPTVHPGKPS---------SPHKNKDGIRPQV
PGSKHRPPV-------TPCEPGCQCRAPMVKITIER--------------HPLYNRINTG
---QMPNCAMPCHN------PYFTHDERTFTAFWIGLWSVLCFVSTFATVATFLIDMERF
KYPERPIIFLSACYMFVSVGYIVRLIAGHEKVACNREY-----EVEHIHYETTG--PALC
TVVFLMVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSIKSIAV
LALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQ
-----GGTKTDKLEKLMIRIGIFTVLYTVPATIVVACYFYEQHNRQSWEITHNC-S----
--CLVEQDIK----------------KPEYAVFMLKYFMCLLVGITSGVWIWSGKTLESW
RAFTTRCC------------------WGSK------GTSGSLYSDAST------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------
>gi|91078748|ref|XP_968118.1|	Tribolium castaneum
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MMGYTRLSILVILLVNTATG-------
-----------------------------------------GSLISHLDGSDQ--EERCE
DIT------IPMCM------------GIGYNQTRMPNELNHETQEEAGLEVH--------
-QFWPLVEIKCSPDLKFFLCSMYAPICLPGYKKPLPPCRGLCKRAREGCEPIMTQYGFKW
PERMDCEQFPVYGAS---PDQLCMDENN--------------------------------
--------------------GSSTTAKPPPRAK--------------APKQCR-G----S
KNCTNPPGDGRKSSVAKGCK--CQCQHPLVSLGKDPSLL----------------NLSVL
---DPATCAAPCRA------TYFNSEEKEFTTVWITLWSSLCAASTLMTLTTFFIETERF
KYPERPIVFLSACYFLVSVGYLIRVGVGHEEVACEGPV---------IRYSSTG--ANPC
SLVFLLVYFFGMASSIWWVVLSFTWFLAAGLKWGNEAIASYAEYFHVAAWLIPTLQTVAV
FVSGAVDGDPVAGICYVGNMNMENLRTFVLAPLFIYLLLGTTFLIAGFVSLFRIRNVIKK
QGGAGAGSKADKLEKLMIRIGIFSVLYTVPASIVIACHLYENAFHNEWMLSAACT-----
--CPSAKV------------------RPIYSVLMLKYFMALAVGITSGVWIWSGKTLDSW
RRLWRRLFGR-----------------PDP------TGANAVLIKNRP------------
-----KGLGGPP----------------------------QYVVAGAGSASLLGPAG---
-----------------------------------------------------SVASASQ
HHLHHHVLKQP----------------------------------------------PLS
-HV----------------------
>gi|54020847|ref|NP_001005669.1	Xenopus tropicalis
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MDLSGTGLLRRTALLLVLAAALCS-------
--------------------------------------------GISSINPDRSGDGRCQ
PIE------IPMCK------------DIGYNMTRMPNLMGHENQKEAAIQLH--------
-EFAPLVEYGCHSHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKW
PDSLDCSKLPNKN-D---PNYLCMEAPN--------------------------------
-------------------NGSEEAPRGSSMLPPIF------------------------
RPQRPNSGH-------EIYP-----KDPTGRTTCEN-------------------SGKFH
HVEKSASCAPLCSSAVD---VYWSKDDKKFAFIWIAIWSILCFFSSAFTVLTFLVDPLRF
KYPERPIIFLSMCYCVYSVGYIIRLFAGADSIACDRDS-------GQLYVIQEGLESTGC
TIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMI
LVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKT
-----GGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDFWKILATQDK----
--CKMDSQTKTL-------DCTMTSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTVQSW
QNVFSKRLKK-----------RNRSKPASV------ITSAGIYKKPQH------------
------------------------------------------------------------
-------------------------------------------------------PPKIH
HGKYESALQSP----------------------------------------------TCV
-------------------------
