>gi|115497582|ref|NP_001068591.	Bos taurus
--------MLGSSAHGPAAREAGSA-VTLQQTAFQ---EDQENVNP---EKAAPA-----
-QQPRTRAGLAVLRA---GNSR-GPAP-QRPKTRRVAPLKDLP--INDEYVP-VP-----
-PWK----ANNK-QPAFTIHVDEA------------------E-EEIQK--RPTESKKSE
SE--DVLAFNSA--VTLPGPRKPLAPLDYP-----MDGSFESPHTMEMSVVLEDE-----
KPVS----VNEVPDYHEDIHTYLREMEVKCKPKVGYM--KKQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCK-----VES----
--LAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTG--QS-------WPESLVQKT
GYTLET---------------------LKPCLLDLHQ------TYLRA-----------P
QHAQQS-------------------------------IREKYKNS-KYHGVS---LL---
--------------------------------------NP---PETLNV-----------
-------------
>gi|584909|sp|P37881|CCNA2_MESA	Mesocricetus auratus
--------MPGSSRQ--SGREAGSALLSLQ----Q---EDQENVNP---EKAAPD-----
-Q--RARA---ALKT---GNAR-GNAPQQRLKARRVAPLKDLS--INDEHVASGP-----
-SWK----AASK-QPAFTIHVDEE------------------E--DTQK--IPPEHKEMR
CE--DALAFNAA--VSLPGARKPLVPLDYP-----MDGSFESPHAMDMSIVLEEE-----
KPVS----VNEVPDYHEDIHTYLREMEIKCKPKVGYM--KKQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYSKKQVLRMEHLVLKVLAFDLAAPTVNQFLNQYFLHQQPANCK-----VES----
--LAMFLGELSLIDADPYLKYLPSLIAGAAFHLALYTVTG--QS-------WPESLVQKT
GYTLES---------------------LKPCLMDLHQ------TYLRA-----------A
QHTQQS-------------------------------IREKYKHS-KYHGVS---LL---
--------------------------------------NP---PETLNV-----------
-------------
>gi|148222643|ref|NP_001080527.	Xenopus laevis
------------------------------------------------------------
-----------------------MSRRSGRLQARHGSAETGND--CQLAVATKKR-----
--------KSEETSTTFECHQDAKR-----------------------------------
----HNYEIQGCWSEITTGTVTPCILIETP--------HKEMPVSTDLSQFSRYR--FKN
LFISRSPLPELSWGNSKDVWMKMISKESRYVHSSRLL--QNHPTLNPDMRSILLDWLIEV
SEVYTLHRETFYLAQDFFDRFMLTQTCVNKSMLQLIGVTALFIASKLEEIYPPKLYEFAY
VTDGACTEDDILQMELIILKALKWELCPVTAISWLNLYLQV-SSLKDHPKLLLPQYSQEQ
FIHVAQLLDMCILHHT-SLEFQYRILAAAALYHCTSI----------------EVVTKAT
GLDMDS---------------------ISECVHWMTP------FASVVKKSFPLKLKVFK
RISPED-------------------------------MHNIQTHT-NYIDMLDDVKIPDR
VLGESPVFI-----------------------------GGILTPPKSTEKTF--------
-------------
>gi|73983960|ref|XP_540965.2|	Canis familiaris
--------MLGSSEPGPEAREAGSSLLTLQHTALQ---EDQENINP---EKAAPA-----
-QQPRTRAGLAVLKA---GNQR-VPAPQQRPKTRRVAPLKDLP--INDEQVT-IP-----
-PWK----ANSK-QPAFTIHVDET------------------E-EETQK--RPAESKKTE
HE--NVLAFNSA--ITLPGPRKPLVPLDYP-----MDGSFESPHTMDISIVLEDE-----
KPLS----VNEVPDYHEDIHTYLREMEVKCKPKVGYM--KKQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLKVLAFDLAAPTVNQFLTQYFLHQQSANCK-----VES----
--LAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTG--QS-------WPESLVQKT
GYTLES---------------------LKPCLMDLHQ------TYLRA-----------P
QHAQQS-------------------------------IREKYKSS-KYHGVS---LL---
--------------------------------------NP---PETLNV-----------
-------------
>gi|150864310|ref|XP_001383074.	Pichia stipitis
------------------------------------------------------------
------------------------------------------------------------
--------MSPE-DAAEP------------------------------------------
----VANTRHSS--EDGHVAMEPIWTRNVA---EELHYVIQKYSRSTLDENDEDT-----
------FDVTMVAEYAPEIFNYMRELENKLVPDPNYM--DNQDELKWEMRSVLIDWVVQV
HSRFNLLPETLYLTVNYIDRF-LSKRKVSLSRFQLVGAVALFIAAKYEEINCPTVQEVAY
MADNAYSIDDFLKAERFMIDVLEFDMGWPGPMSFLRRTSKA-DDYDYE-----TRT----
--LAKYFLEITIMDSK-FVASSPSWLAAGAHYLSRKLLNR--GG-------WTELHVFYS
GYTESQ---------------------LRPLAEVLLQ------NCRDA------------
ETNHRA-------------------------------IFEKYQER-RYRRSS---SF---
--------------------------------------VQEYLETVEQ------------
-------------
>gi|47115321|emb|CAG28620.1|	Homo sapiens
--------MLGNSAPGPATREAGSALLALQQTALQ---EDQENINP---EKAAPV-----
-QQPRTRAALAVLKS---GNPR-GLAQQQRPKTRRVAPLKDLP--VNDEHVT-VP-----
-PWK----ANSK-QPAFTIHVDEA------------------E-KEAQK--KPAESQKIE
RE--DALAFNSA--ISLPGPRKPLVPLDYP-----MDGSFESPRTMDMSIVLEDE-----
KPVS----VNEVPDYHEDIHTYLREMEVKCKPKVGYM--KKQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCK-----VES----
--LAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTG--QS-------WPESLIRKT
GYTLES---------------------LKPCLMDLHQ------TYLKA-----------P
QHAQQS-------------------------------IREKYKNS-KYHGVS---LL---
--------------------------------------NP---PETLNL-----------
-------------
>gi|25012581|gb|AAN71390.1|	Drosophila melanogaster
------------------------------------------------------------
------------------------------------------------------------
---------MSVTDVQSPMSVDRS------------------------------------
----ILGVIQSS--DISVGTETGVSPTGRV---------------KELPPRNDRQ-----
-------RFLEVVQYQMDILEYFRESEKKHRAKPLYM--RRQKDISHNMRSILIDWLVEV
SEEYKLDTETLYLSVFYLDRF-LSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVF
LTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVL-CDMPEK-----LKY----
--MTLYISELSLMEGETYLQYLPSLMSSASVALARHILGM--EM-------WTPRLEEIT
TYKLED---------------------LKTVVLHLCH------THKTA-----------K
ELNTQA-------------------------------MREKYNRD-TYKKVA---MMESV
EMSKDDFDQLCEAYNCKQKE------------------DEHQQPDINTKSNVNLFYKF--
-------------
>gi|9082245|gb|AAF82778.1|	Carassius auratus
MSSVGQTQRSAVQDPGADIHNQENMLSRLRGAA-KNRIENRENVNP---K----P-----
----GNRTVLGALEN---NQRR----PPVLRAAKQVSGPQITA--CKSEEHG-SF-----
-GEK----PSTR-PPAFQIHVDEP------------------DGACSKK--QCTQRATMA
C---SPLTLNPT--VTRL--RQPLATIDLP-----VEASFDSP--MDMSIIDSEE-----
RPTN----VNEVSDYAAEIHAHLREMEIKSKPKAGYM--KKQPDITNSMRAILVDWLVEV
GEEYKLQNETLYLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLTVLSFDLAAPTINQFLTQYFLH-QPVSSK-----VES----
--LSMFLGELSLIDCDPFLKYLPSQTAAAAFILANHTIAG--GS-------WSKAFVEMT
GYTLED---------------------LMPCIQDLHQ------TYLGA-----------A
QHTQQA-------------------------------VREKYKGS-KYHEVS---LI---
--------------------------------------EP---PEKLMLN----------
-------------
>gi|413909|dbj|BAA03115.1|	Rattus rattus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MEHQLLCC--------EVETIRRAYP----------------DTNLLNRPG-----
-------------------LRAMLKTEETCAPSVSYF-KCVQREIVPSMRKIVATWMLEV
CEEQKCEEEVFPLAMNYLDRF-LSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCI
YTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSK-MPEADE-NKQIIRK----
--HAQTFVALCATDVK-FISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVI
KCDPDC---------------------LRACQEQIEA------LLESS-----------L
RQAQQN-------------------------------IDPKATEE-EGEVEE---EA---
--------------------------------------GLACTPTDVRDVDI--------
-------------
>gi|6320046|ref|NP_010126.1|	Saccharomyces cerevisiae
-----------------------MHHNSQSLSSGHIRSPEDENVAP-IGNLKHRTGSLSH
ISSAHPRVALSDVTNIVATNS--SNNSISKPKVAPIKERLDSAAIIEEERLD--------
--------ANSVAQRKEADHNDLL----------------------------------TD
REQEEPVEDDGESEEDEEEDQEPLLLQHYASDTLVWEHAFRTYYRTTLDPNDDDV-----
------YDVVMVAELSNEIFEYMRKLEDLYKPNPYYM--DKQPELRWSFRSTLIDWIVQV
HEKFQLLPETLYLCINIIDRY-LCKEVVPVNKFQLVGAASLFIAAKYEEINCPTIKDFVY
MSENCYSRNDLLDAERTILNGLEFELGWPGPMSFLRRISKA-DDYEHD-----TRT----
--LAKYLLESTIMDHR-LVSAQPSWLAAGAYFLSKIILGQ--NQ-------WSLAHVYYS
NYTQEQ---------------------ILPLATIILE------NCRYA------------
SKRHNA-------------------------------IWRKYSSR-RYLHSS---QI---
--------------------------------------VAKWIALAEHRVERSN------
-------------
>gi|50291319|ref|XP_448092.1|	Candida glabrata
------------------MNNTEDMFRDVENASQNMASTVNTSRMDQRQRRALTDLTSQK
VNRIHTSKTIKDIPAYLSNYTADGENKNIDQAFNHSNDQDIGLVNQINSGYANV------
--------ENEPGKETDHIFIDQD---------------------DLSDLDIVQEDSLRE
QLEEFEHDFENF-----VEPLSPIFNDEIQ---DTLDRAFKEYYRATPDMEDDDT-----
------FDAVMVTEYGSDIFRYMRKLELKYRPNPYYM--AGQPELKWEYRKTVIDWIVQV
HERFQLLPETLYLTINIIDRF-LSRKNITLNRFQLVSATALLIASKYEEINCPTIKDIVY
MVDNTYSRDDIIEAEKYMIDALDFEVSWPGPMSFLRRISKA-DDYEYR-----TRN----
--LAKYLLETTLMESS-LISALPSWLAAGAYFLSRIILGY--EE-------WTLKHVYYS
GYTHEQ---------------------LYPLATLILD------NCQN------------Y
EESHQA-------------------------------IWTKYSQP-QYHQVS---ILVTK
F-------------------------------------LGRVSSDDMSEIY---------
-------------
>gi|116171|sp|P04962|CCNA_SPISO	Spisula solidissima
------------------------------MSQPFALHHDGENQMQRRGKMNTRS----N
GLSGQKRAALGVITN--------QVNQQVRIQPSRAAKPKSSEFNIQDENAFTKK-----
-NAK----TFGQQPSQFSVFVDPT-------------------------PAAPVQKAPTS
HVTDIPAALTTL--QRVPLTEVPGSPDIIS-----LEDSMESPMILDLP--EEEK-----
-PLDREAVILTVPEYEEDIYNYLRQAEMKNRAKPGYM--KRQTDITTSMRCILVDWLVEV
SEEDKLHRETLFLGVNYIDRF-LSKISVLRGKLQLVGAASMFLAAKYEEIYPPDVKEFAY
ITDDTYTSQQVLRMEHLILKVLTFDVAVPTTNWFCEDFLKS-CDADDK-----LKS----
--LTMFLTELTLIDMDAYLKYLPSITAAAALCLARYSLGI--EP-------WPQNLVKKT
GYEIGH---------------------FVDCLKDLHK------TSLGA-----------E
SHQQQA-------------------------------VQEKYKQD-KYHQVS---DF---
--------------------------------------SKNPVPHNLALLAL--------
-------------
>gi|50305949|ref|XP_452935.1|	Kluyveromyces lactis
---------------------MMQMQQRVALGDVTSQINNRANRFSVDGDSKKAFVDAGF
LKEKRVKNAKENDLFSGHDDDLVVARAQKLREQTLVSSVSTES--IRSQQLSSNS-----
--------NETVQHHLIEVEADDE-----------------DDAETDSEALAFKEDEEAE
TGGDISEEMEDV--DESFTPLVPVVTEHSE---RLYQYVYERLHREEPDPNDEDT-----
------WDPVMVSEYTIEIFEHLKFLERKFSPNPRYI--EHQPELTWKYRSTLIDWIVQV
HDRFQLLPETLFLTVNIIDRF-LSKKQVTLNRLQLVGAAALFIASKYEEINCPTLKDMLY
MLDNAYTREEILRAERFMINTLNFEFGWPGPMSFLRRVSKA-DDYEYD-----TRT----
--VAKYLLETSIMEPE-IIAAPPSWLAAGAYYLSKIIIGL--TG-------WSDEHIYYS
GYTEEQ---------------------LIPLATMILD------SCRHA------------
TERHKA-------------------------------IFDKYSRS-RHRKSA---FV---
--------------------------------------VAKWISMAESRLEQK-------
-------------
>gi|118150676|ref|NP_446154.3|	Rattus norvegicus
--------MPGNSRQ------AGSALLS-Q----Q---EDQENVNP---EKVAPA-----
-QQPRAQA---VLKA---GKVR-GPAPQQRLKTRRVAPLKDLP--INDEHVPTVP-----
-SWK----AVSK-QPAFTIHVDEA------------------E--ETQK--RPAEQKETQ
CE--DALAFSAA--VSLPGARKPLVPLDYP-----MDGSFESPHAMDISIVLEDE-----
KPVN----VNEVPDYHEDIHTYLREMEVKCKPKVSYM--KRQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYSKKQVLRMEHLVLKVLAFDLAAPTVNQFLTQYFLHLQPANCK-----VES----
--LAMFLGELSLIDADPYLKYLPSLIAGAAFHLALYTVTG--QS-------WPESLVQKT
GYTLES---------------------LKPCLMDLHQ------TYLKA-----------P
QHAQQS-------------------------------IREKYKHS-KYHSVS---LL---
--------------------------------------NP---PETLNV-----------
-------------
>gi|126309863|ref|XP_001370590.	Monodelphis domestica
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MELLCS-------EGARRTPRAGP----------------DPRLLGDQR-----
------------------VLQSLLRLEERYVPRASYF-QCVQRELKPHMRKMLAYWMLEV
CEEQRCEEEVFPLAMNYLDRY-LSCVPTRKCHLQLLGAVCMLLASKLRETTPLTMEKLCI
YTDHSVTPHQLRDWEVIVLGRLKWDLAAVIAHDFLALILHR-LPVPMD-RRALVKK----
--HAQTFLALCATDYT-FAMYPPSMIATGSIGAAVQGLAACPLS----SDELTELLAGIT
GTDVDC---------------------LRACQEQIEA------ALRESL----------R
EATQDT-------------------------------VATIPKAP-EYSGSQ---EP---
--------------------------------------SQTSTPTEVTAVHL--------
-------------
>gi|23308637|ref|NP_694481.1|	Danio rerio
----MSTQGSAVHD--SDIHNQENMLSRLRGAAAKNRVENRENVNP---N----P-----
-KAANNRTVLGELEN---SQRR----QLGLRGAKQGSGPQIIA--CKPEENARSF-----
-GER----PSNRQPAAFQIHVDEP------------------DGACSKK--APLQRSTMD
C---SPLTLNPT--VTRL--RQPLATIDLP-----LEASFDSP--MDMSVIDCEE-----
RPTN----VNEVSDYAAEIHTHLREMEVKSKPKAGYM--RKQPDITNSMRAILVDWLVEV
GEEYKLQNETLYLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLTVLSFDLAAPTINQFLTQYFLH-QPVSSK-----VES----
--LSMFLGELSLIDCDPFLKYLPSQMAAAAFILANHTLAS--GS-------WSKSLVDLT
GYSLED---------------------LLPCVQDLHQ------TYLAA-----------S
QHAQQA-------------------------------VREKYKGS-KYHEVS---LI---
--------------------------------------EP---PEKLMLN----------
-------------
>gi|3608420|gb|AAC35953.1|	Dreissena polymorpha
-------------------------------MSQFAIHQDVENQVPRRGKAANTR----T
VTQGQKRAVLGVITN--------QANQPNRVQPSRAAKPKVPE-TVQDENAFAKE-----
-NWK----ILGQT-GQFSVFVD-E-------------------------QTKPVSKAPKS
--TELPSVLTAVPHTRLPLDQVPCSPEIIC-----LDDSVESPMVLDIQ--EDEK-----
KPFDREAVILTAPEYEEDIYSYLREAEAKNRAKPGYM--KRQQDITSSMRSILVDWLVEV
AEEYKLHRETLFLAVNYIDRF-LSKISVLRGKLQLVGAASMFLAAKYEEIYPPDVTEFAY
ITDDTYDKKQILRMEHLILKVLAFDVAIPTTNWFCESFLKS-IDAEEK-----LKS----
--LTMFLSELTLIEMDSYLKYVPSITASACICLARYSLGL--EP-------WPQSLVKKT
GYEVGH---------------------FVDCLKELHK------TYQAA-----------E
SHPQQA-------------------------------VQEKYKQD-KFQQVS---DF---
--------------------------------------TKNPVPHSLTLLAV--------
-------------
>gi|118403824|ref|NP_001072146.	Sus scrofa
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MELLCC-------EGTRHAPRAGP----------------DPRVGGDQR-----
------------------VLQSLLRLEERYVPRASYF-QCVQREIKPHMRKMLAYWMLEV
CEEQRCEEEVFPLAMNYLDRY-LSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCI
YTDHSVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLALILHR-LALPRD-RQALVKK----
--HAQTFLALCATDYT-FAMYPPSMIATGSIGAAVQGLGACSTS----GDELTELLAGIT
GTEVDC---------------------LRACQEQIEA------ALRESL----------R
EAAQTS-------------------------------PSPAPKAP-RGSSSQ---GP---
--------------------------------------SQTSTPTDVTAIHL--------
-------------
>gi|54114982|ref|NP_001005757.1	Canis lupus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MAHQLLCC--------EVETIRRAYP----------------DANLLNDR------
------------------VLRAMLKAEETCAPSVSYF-KCVQKEILPSMRKIVATWMLEV
CEEQKCEEEVFPLAMNYLNRF-LSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCI
YTDNSIRPDELLQMELLLVNKLKWNLAAMTPHDFIEHFLSK-MPVAEE-NKQIIRK----
--HAQTFVALCATDVK-FISNPPSMVAAGSVVAAVQGLHLGSSNSFLSYHRLTRFLSKVI
KCDADC---------------------LRACQEQIEA------LLESSL----------R
QAQQQS-------------------------------LDPKAAEE-EEEEEE---A----
--------------------------------------DLACTPTDVRDVNI--------
-------------
>gi|109075534|ref|XP_001100860.	Macaca mulatta
--------MLGNSAPGPATREAGSALLALQQTALQ---EDQENINP---EKAAPV-----
-QQPRTRAALAVLKA---GNPR-GLAQQQRPKTRRVAPLKDLP--VNDEHVT-VP-----
-PWK----ANSK-QPAFTIHVDEA------------------E-KETQK--KPAESQKTE
RE--DALAFNSA--ISLPGPRKPLVPLDYP-----MDGSFESPHTMDMSIVLEDE-----
KPVS----VNEVPDYHEDIHTYLREMEVKCKPKVGYM--KKQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANSK-----VES----
--LAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTG--QS-------WPESLIRKT
GYTLES---------------------LKPCLMDLHQ------TYLKA-----------P
QHAQQS-------------------------------IREKYKNS-KYHGVS---LL---
--------------------------------------NP---PETLNL-----------
-------------
>gi|55741972|ref|NP_001006768.1	Xenopus tropicalis
---------------------MADHLLR------D---ENQENVQP---RK--PL-----
-APVGGRTVLGVLQENHRGRQT-LKASKPALQQAQALSVNHLG--VNDENYGKVP-----
-AGK----AASK-QPTFTIHVDEP------------------DCTNNRR--KPVHKKTVQ
DE--NLRQLNSV--LGSIGTRKPLEPIHIA-----METSFGSP--MDVSLVDEEQ-----
KVVG----CSNVPDYAKEIHTYLREMEVKCKPKSGYM--QKQPDITGNMRAILVDWLVEV
GEEYKLQNETLYLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLKMEHLVLKVLSFDLAAPTILQYLNQYFQI-QPVSPK-----VES----
--LSMFLGELSLVDADPFLRYLPSVVAAAAFVIANYTVNE--RT-------WSDSLVQYT
GYALET---------------------LKPCILDLYQ------TYLSA-----------A
SHQQQA-------------------------------VREKYKTQ-KNHCVS---LI---
--------------------------------------DP---PESLSIFL---------
-------------
>gi|1752809|dbj|BAA14010.1|	Asterina pectinifera
------------------------MSFAFSENPLTYDVENSQNAGPQTRKTKREDAGRGN
GPQACKRAALGTLST--------NVTRKQPSRAAKQSGFADGFYNYQDENAFARPAAGKS
TGSCGFALPPTASQPSFSIHIDPV------------------EPAPSRARFLKEQKPTEL
PL--DPIGYFVT--RSRKTALRTVFTLDES----------ASPMVLDTSLSEENTAQATI
EDIDNSDGVFGVPEYAEDIYEYLREAELRNRPKPGYM--RKQPDITSGMRSILVDWLIEV
GEEYRLHNETLYLAVSYIDRF-LSQMSVLRSKLQLVGAASMFLAAKFEEIYPPEVNEFVY
ITDDTYTVKQVLRMEHLILKVLSFDVAVPTANAFLSRYLKA-AKADSR-----NGT----
--SSQYLAELTLPDCE-YIKYIPSTIAAAAVCLANYTLSG--TA-------WTPMLEKHS
GYNLED---------------------IAPCVRDLLK------TFTNA-----------P
SQSQQA-------------------------------AQEKYKSQ-RYNSVS---MI---
--------------------------------------AA---PTTLPSWL---------
-------------
>gi|414062|emb|CAA53212.1|	Mus musculus
--------MPGTSRH--SGRDAGSALLSLH----Q---EDQENVNP---EKLAPA-----
-QQPRAQA---VLKA---GNVR-GPAPQQKLKTRRVAPLKDLP--INDEHVTAGP-----
-SWK----AVSK-QPAFTIHVDEA------------------E--ETQK--RPAELKETE
CE--DALAFNAA--VSLPAARKPLTPLDYP-----MDGSFESPHAMDMSIVLED------
KPVN----VNEVPDYQEDIHTYLREMEVKCKPKVGYM--KRQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYSKKQVLRMEHLVLKVLAFDLAAPTVNQFLTQYFLHLQPANCK-----VES----
--LAMFLGELSLIDADPYLKYLPSLIAGAAFHLALYTVTG--QS-------WPESLAQQT
GYTLES---------------------LKPCLVDLHQ------TYLKP-----------P
QHAQQS-------------------------------IREKYKHS-KYHSVS---LL---
--------------------------------------NP---PETLSV-----------
-------------
>gi|91081399|ref|XP_972623.1|	Tribolium castaneum
-----------------------MASIRIH--------QDQENRVP---ELRRKP----G
TTAQQKRGVLGEIDS--------NKVNNAALKGKQTKKPTVLG--NRVENGQKNE-----
-NKKNVVVPVAQ-FEAFTVYEDDEYRARIDERLKLISKSNVYKGTAEDRFITKTELAEIE
RKK-NLEKLKEI--TAPQLKRKSEIPMSI------EKSDVENIELKEQTVSTSTN-----
ARDV----FFEMEEYRDSIFAYLKEHELRHRPKPGYI--VKQPDVTENMRAVLIDWLVEV
TEEYGMQTETLYLAVNFIDRF-LSYMSVVRAKLQLVGTAAMFIASKYEEIFPPEVSEFVY
ITDDTYDKHQMIRMEQLILRVLGFDLSVPTPLTFLNAICIS-TKQTEK-----VKN----
--LAMYLSESALLEVEPYLQFLPSVVASSAIALSRHTLGE--EA-------WPGDLQKYT
GYNLKK---------------------LESCIGFLYK------MFAKA-----------P
SNPQHA-------------------------------IRDKYKAP-KYMQVS---KI---
--------------------------------------SP---SGEMISFD---------
-------------
>gi|157013014|gb|EAA00183.3|	Anopheles gambiae
------------------------------------------------------------
----------------------------------RSAPLQELK-----------------
-------------------HAELL------------------E--------TPMSVGENF
----SPMSIDKS--TSIIVEEGPIPRND-------RERFF--------------------
----------EVEEYQEDILLYLKEAEKRNRPKPGYM--LKQTDITHSMRTILVDWLVEV
SEEYKLQGETLALAVSYIDRF-LSFMSVVRAKLQLVGTAAMFIAAKYEEIYPPDVSEFVY
ITDDTYTKTQVLRMEQLILKVLSFDLTVPTSLVFTNTYCVM-NDVPDK-----VKY----
--LTMYLCELSLLEADPFLTYMPSKIAAGALALARRTLDL--PM-------WSKMLENNT
GYKLVD---------------------MRDIILDLNK------THVDA-----------V
TMQQQA-------------------------------IQEKYKSK-TYHEVA---SLPAT
EITKESFDKICATLCNSSAATLLLSNTDSELLKE----MGRENPSNLLFV----------
-------------
>gi|45382585|ref|NP_990575.1|	Gallus gallus
--------MLAE----------------------Q---ENQENVPP---AAKAPP-----
-PAAGTRVALGLLRG---GPARPGPAAQAARNGE-------------------GR-----
-GAA----AGQQ-QQPFSVYVDEP------------------D--EERR--RPQRKKERD
EEAADAPGLRAA--LGTVGERRPLAPLGNA-----MELSLDSPSIMDISITSEAE-----
ERPN----VNNVPDYVSDIHTYLREMEVKCKPKIGYM--KKQPDITNNMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYNKKQVLRMEHLILKVLSFDLAAPTINQFLTQYFLH-QQTNAK-----VES----
--LSMYLGELTLIDADPYLKYLPSVIAAAAFHLASYTITG--QT-------WPESLCKVT
GYTLEH---------------------IKPCLMDLHR------TYLKA-----------A
QHTQQS-------------------------------IREKYKST-KYHAVS---LI---
--------------------------------------DA---PETLDL-----------
-------------
>gi|116172|sp|P18606|CCNA1_XENL	Xenopus laevis
----------MRRSMASNGHILTASSVVGASSAFQNPCLAKVEVQP---NL---------
----PQRTVLGVI----------GDNEQRRRSVSRGGVPAKSLPGIENVLAFPGK-----
-ILSANPAPVAP-KPSFTVYVDEP---------------------------TETYSVEID
C-------------PSLGDEDSNIVKQNIH---LLLDISEASPMVVDTSPQTSPE-----
DDSVTDPDAVAVSEYIHEIHQYLREAELKHRPKAYYM--RKQPDITSAMRTILVDWLVEV
GEEYKLHTETLYLAMNYLDRF-LSCMSVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVY
ITDDTYSKKQLLRMEHVLLKVLAFDLTVPTVNQFLLQYLQR-HAVSVK-----MEH----
--LAMYMAELTLLEVEPFLKYVPSLTAAAAYCLANYALNK--VF-------WPDTLEAFT
GYALSD---------------------IAPCLSDLHQ------FCLGA-----------P
YQAQQA-------------------------------IREKYKTT-KYMQVS---LL---
--------------------------------------EM---PSILPLN----------
-------------
>gi|55623156|ref|XP_517420.1|	Pan troglodytes
--------MLGNSAPGPATREAGSALLALQQTALQ---EDQENINP---EKAAPV-----
-QQPRTRAALAVLKS---GNPR-GLAQQQRPKTRRVAPLKDLP--VNDEHVT-VP-----
-PWK----ANSK-QPAFTIHVDEA------------------V-KEAQK--KPAESQKTE
RE--DALAFNSA--ISLPGPRKPLVPLDYP-----MDGSFESPHTMDMSIVLEDE-----
KPVS----VNEVPDYHEDIHTYLREMEVKCKPKVGYM--KKQPDITNSMRAILVDWLVEV
GEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCK-----VES----
--LAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTG--QS-------WPESLIRKT
GYTLES---------------------LKPCLMDLHQ------TYLKA-----------P
QHAQQS-------------------------------IREKYKNS-KYHGVS---LL---
--------------------------------------NP---PETLNL-----------
-------------
>gi|145558686|gb|ABP73256.1|	Cricetulus griseus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MEHQLLCC--------EVETIRRAYP----------------DTNLLNDR------
------------------VLRAMLKTEETCAPSVSYF-KCVQREIVPSMRKIVATWMLEV
CEEQKCEEEVFPLAMNYLDRF-LSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCI
YTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSK-MPEADE-NKQIIRK----
--HAQTFVALCATDVK-FISNPPSMVAAGSVVAAMQGLNLGSPNNYLSCYRTTHFLSRVI
KCDPDC---------------------LRACQEQIEA------LLESS-----------L
RQAQQN-------------------------------INPKATEE-EGEAEG---ET---
--------------------------------------DLACTPTDVRDVDI--------
-------------
>gi|116170|sp|P24861|CCNA_PATVU	Patella vulgata
--------------------------MSMVHGSSFQIAQDGENENQGVQRVKKAGLTARG
NVAVAKRSALGTITN-----------QNIRVQPSRAAKSGNAD--CQDENVF--------
-AKQKSFGSSNNENKGFKIHVDEP----------------------TVQVLTTATLKTTR
QSEDEDIKLNDQ--VTSLPSLQALEDIQ-------VDNENGSPMVLDVTIEDAEK-----
KPIDREAIILSVPEYAEDIYKHLREAESRHRSKPGYM--KKQPDITNSMRSILVDWMVEV
SEEYKLHRETLFLAINYIDRF-LSQMSVLRGKLQLVGAASMFIASKYEEIYPPEVSEFVY
ITDDTYEQKQVLRMEHLILKVLSFDVAQPTINWFTDTYAKM-ADTDET-----TKS----
--LSMYLSELTLVDADPYLKYLPSTIAAASLCLANITLGS--EP-------WPSSLAKES
KYEISE---------------------FSECLQEMYQ------TYLNA-----------P
NHPQQA-------------------------------IREKYKSS-KYQQVS---SI---
--------------------------------------SP---PSSLSFTM---------
-------------
>gi|47227508|emb|CAG04656.1|	Tetraodon nigroviridis
------------------------------------------------------------
------------------------------------------------------------
---K----QADK-PATFQIHVDEP------------------DTKKPPQVVQPVKAKSST
EE--SPLAISNA--VTRL--RQPLARIDVP---LAMDVSFDSP--MDMSVVEGED-----
KPAP----VNEVPEYAAEIHAYLREMELKTRPKAAYM--KKQPDITVSMRAILVDWLVEV
GEEYKLQNETLYLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY
ITDDTYTKKQVLRMEHLVLKVLSFDLAAPTVNQFLTQYFLH-QSVGKQ-----VEN----
--LAMVSSQCCA-----WSVYTEQSLTPICLSVSRRAQSGGFGS-------LPEVPAVPD
GRC--S---------------------LRPGQQHGDR------WLVVQVPGRGDWI---H
PGRFAA-------------------------------LHRRFAQTLPQRSSA--------
--------------------------------------CPASRTGKVQGFEVS-------
-------------
>gi|149421960|ref|XP_001518484.	Ornithorhynchus anatinus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----GAWNWGAG--------RTPLASPPHP-----------------PRPLCSNE-----
--------------------TVVFSLSASASGR------TPVPPCPPS----------QV
CEEQKCEEEVFPLAMNYLDRF-LAGVPTPKHHLQLLGAVCMFLASKLKETAPLTAEKLCI
YTDNSIKPRELLEWELVVLGKLKWNLAAVTPHDFIEHILRK-LCQPRD-KLLLIRK----
--HAQTFIALCATDFT-FAMYPPSMIATGSVGAAICGLQLDVEESALSGDGLTDLLAKIT
NTDVDC---------------------LKACQEQIEA------VLVHN-----------L
RRVQQR---------------------------------EPPPSQ-PSKMVD---EV---
--------------------------------------DQAGTPTDVRDINL--------
-------------
>gi|48128757|ref|XP_396634.1|	Apis mellifera
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MDLLCC-------ETTETECRAYA----------------DPALLGDDR-----
------------------VLQNLLKTEERYAPSSSYF-ECVQRDISPLMRKIVAEWMLEV
CEEQKCQDEVFPLSMNYVDRF-LSICPIRKSQLQLLGTACLLLASKLREPSPLTAEVLVF
YTDNSITMDDLWRWEQLVVSKLKWELSAVTPGDFLMHILSR-LPVPRTWDPVMVRR----
--HAQTFIALSAREYK-FSMYTPSMIAAASVAAALHGLDWTGKSGYG-LAGLLDELTRIT
AIEQQCQGIDLISTWFAPGLPQVSEDYLQGCLEQIEE------MVSQAVGADGAGGNGHQ
MTGSSG-------------------------------ASQRPLGD-EITSQEKILEH---
--------------------------------------EKAGTPTDVRDVHF--------
-------------
>gi|108872030|gb|EAT36255.1|	Aedes aegypti
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MAHNVDLV--------CKEIIYDE-------VDSQFAEP---DPTMIADVR-----
------------------VIQNLIGLERLTIPSCNYF-GSVQQDIKPNMRKIVTTWMLEV
CDEQKCEEQTFPLAVNFFDRF-LCACPIDRYHLQLLGCCALLLASKIRQCHPLTVDVLSA
YTDHAVSPDQIRSWELLMISKLEWNITAVTAFDYVDQILER-VKWGSD--DSRLRE----
--HAHTLIHVCSTETI-FMQLEPSLLAAACIASASRGLNVSTKM------ATGFDLCRLT
FHDIAK---------------------IDFIVKIIEE------IVAKEIADKQ------L
QQQQQQMGANGAAGGS---------------------CKEQYQQAPQKVGGA---TVEQT
TSQ-----------------------------------QQPETPTDVQFIYF--------
-------------
>gi|63054436|ref|NP_588110.2|	Schizosaccharomyces pombe
------------------------------------------------------------
-MDVSTQTRHATYFQDENQLQKDHIYVKKKSHIKLNTGVRAPFKAVDNINQQDEPTLIEG
NNESSISSSTGDTFEEDFAYQDKV------------------EIEERSIRSTPKSIGDDD
LENREGSFDAPEGILTHGKHRLPTIPEWTK---EDLAALSEAAARLQANPSPEDI-----
-----ETDPSMVPDYDPEIFHYMQSLERKLAPPPNYM--SVQQEIDWVTRHMLVDWIVQV
QIHFRLLPETLFLAVNLIDRF-LSIKVVSLQKVQLVGLSALLIACKYEEIHPPSIYNFAH
VVQGIFTVDEIIRAERYMLMLLDFDISWPGPMSFLRRISRA-DSYDHD-----IRM----
--LAKYLQEVTLMDEI-FIGAHISFIAATAYYLSMQMLGH--LD-------WTPCHVYYS
GYTARQ---------------------LKPCAIIIME------CLVDA-----------P
NH-HNA-------------------------------IYRKYSEN-RMKRVS---AF---
--------------------------------------AHNWVLSVI-------------
-------------
>gi|47550981|ref|NP_999664.1|	Strongylocentrotus purpuratus
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MDNLLCF---EQEYFDHAKSPMSYV----------------DQVLLRDKN-----
-------------------LDNLLAVEEQYVLSADYFGNHFQRELRPSMRKLVVDWMFEV
CEEQQREEDVFPLSVNYLDRF-LSIERISRDKFQLLGATCMFLASKLLETIPLTSEKLII
YTDNSITLEQLLKFEQLVLTKLKWDLMAITPNAFLEHIFHR-LPVDKE-QAALLRK----
--HAQTFIVLCATDYN-FAMQPPSLIAASGVAAAANGLRMHIPK-------VIDLLHRIT
KIETDY---------------------LILVRDRMEN------LLSKNL----------V
PGSPTK-------------------------------TAGHTTVQ-KTRSMD---ES---
--------------------------------------DKPCTPTGVDEVEIITMPSGLC
-------------
