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Our Mission:
Parasitic roundworms (nematodes) of humans, livestock and other animals cause diseases of major socio-economic importance globally. They have a major, long-term impact (directly and indirectly) on human health and cause substantial suffering, particularly in children. The World Health Organization (WHO) estimates that 2.9 billion people are infected with nematodes. Furthermore, the current financial losses caused by parasites to agriculture worldwide (domesticated animals and crops) have a major impact on farm profitability and exacerbate the global food shortage.
Methods available for the control of the parasitic nematode infections are mainly based on chemical treatment (anthelmintics), non-chemical management practices, immune modulation and biological control. However, the incomplete protective response of the host and acquisition of anthelmintic resistance by an increasing number of parasitic nematodes hampered what use to be effective and long-lasting control strategies. Moreover, the use of such drugs poses major risks of residue problems in meat, milk and the environment.
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Therefore, the challenges to improve control of parasitic nematode infections are multi-fold and no single category of information will meet them all. However, new information, such as nematode genomics, functional genomics and proteomics, can strengthen basic and applied biological research aimed at developing improvements. Our MISSION is through integrated approaches to accelerate progress towards developing more efficient and sustainable parasitic nematode control programs.
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Citation:
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To cite Nematode.net please use:
Martin J, Rosa BA, Ozersky P, Hallsworth-Pepin K, Zhang X, Bhonagiri-Palsikar V, Tyagi R, Wang Q, Choi Y, Gao X, McNulty S, Brindley PJ and Mitreva M (2014) Helminth.net: expansions to Nematode.net and an introduction to Trematode.net Nucleic Acids Research first published online November 12, 2014 doi: 10.1093/nar/gku1128
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Ancylostoma caninum |
MGI |
PRJNA72585 |
29170 |
unpublished (assembled and annotated as part of the Helminth Genome Initiative) |
Ancylostoma ceylanicum |
MGI |
PRJNA72583 |
53326 |
unpublished (assembled and annotated as part of the Helminth Genome Initiative) |
Ancylostoma ceylanicum |
Cornell, Cal. Inst. of Technology & Univ. of Massachusetts Medical School |
PRJNA231479 |
53326 |
The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families |
Ancylostoma duodenale |
MGI |
PRJNA72581 |
51022 |
unpublished (assembled and annotated as part of the Helminth Genome Initiative) |
Ascaris suum |
University of Melbourne |
PRJNA80881 |
6253 |
Ascaris suum draft genome |
Ascaris suum |
University of Colorado/WUGI |
PRJNA62057 |
6253 |
Silencing of germline-expressed genes by DNA elimination in somatic cells |
Brugia malayi |
University of Pittsburgh |
PRJNA10729 |
6279 |
Draft Genome of the Filarial Nematode Parasite Brugia malayi |
Caenorhabditis briggsae |
WTSI |
PRJNA10731 |
6238 |
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics |
Caenorhabditis elegans |
The C. elegans Sequencing Consortium |
PRJNA158 |
6239 |
Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology |
Cooperia oncophora |
MGI |
PRJNA72571 |
27828 |
unpublished |
Dictyocaulus viviparus |
MGI |
PRJNA72587 |
29172 |
Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention |
Dirofilaria immitis |
University of Edinburgh |
PRJEB1797 |
6287 |
The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets |
Globodera pallida |
WTSI |
PRJEB123 |
36090 |
The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode |
Haemonchus contortus |
WTSI |
PRJEB506 |
6289 |
The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery |
Haemonchus contortus |
University of Melbourne |
PRJNA205202 |
6289 |
The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus |
Heterorhabditis bacteriophora |
MGI |
PRJNA13977 |
37862 |
A Lover and a Fighter: The Genome Sequence of an Entomopathogenic Nematode Heterorhabditis bacteriophora |
Loa loa |
Broad Institute |
PRJNA60051 |
7209 |
Genomics of Loa loa, a Wolbachia-free filarial parasite of humans |
Meloidogyne hapla |
NCSU |
PRJNA29083 |
6305 |
Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism |
Meloidogyne incognita |
INRA |
PRJEA28837 |
6306 |
Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. |
Necator americanus |
MGI |
PRJNA72135 |
51031 |
Genome of the human hookworm Necator americanus. |
Nematodirus battus |
MGI |
PRJNA86621 |
28839 |
unpublished |
Oesophagostomum dentatum |
MGI |
PRJNA72579 |
61180 |
Cracking the nodule worm code advances knowledge of parasite biology and biotechnology to tackle major diseases of livestock |
Onchocerca flexuosa |
MGI |
PRJNA230512 |
387005 |
unpublished |
Onchocerca flexuosa |
WTSI |
PRJEB512 |
387005 |
50 Helminth Genomes Initiative (Helminth Genomes Consortium, unpublished) |
Ostertagia ostertagi |
MGI |
PRJNA72577 |
6317 |
unpublished |
Pristionchus pacificus |
Max Planck Institute/MGI |
PRJNA12644 |
54126 |
The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism. |
Romanomermis culicivorax |
Universitat zu Koln, Cologne, NRW, Germany |
PRJEB516 |
13658 |
The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda |
Teladorsagia circumcincta |
MGI |
PRJNA72569 |
45464 |
In press (PLOS Genetics) |
Trichinella nativa |
MGI |
PRJNA179527 |
6335 |
unpublished (assembled and annotated as part of the Helminth Genome Initiative) |
Trichinella spiralis |
MGI |
PRJNA12603 |
6334 |
The draft genome of the parasitic nematode Trichinella spiralis |
Trichuris muris |
WTSI |
PRJEB2108 |
70415 |
Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction |
Trichuris suis |
University of Melbourne |
PRJNA208415 PRJNA208416 |
68888 |
Genome and transcriptome of the porcine whipworm Trichuris suis. |
Trichuris trichiura |
WTSI |
PRJEB535 |
36087 |
Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction |
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Please note that our lab is a sequencing and analysis facility; we are not clinicians, and as such we are not qualified to provide medical advice regarding parasitic nematode afflictions. If you are in need of such assistance, please instead contact a qualified physician, preferably one with a specialty in parasitic diseases.
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