Comparative genomics : Dictyocaulus viviparus genome

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Bioinformatics Workshop for Helminth Genomics (2015) class materials now freely available!

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The genome of Dictyocaulus viviparus

The bovine lungworm, Dictyocaulus viviparus (order Strongylida), is an important parasite of livestock that causes substantial economic and production losses worldwide. Here we report the draft genome, variome and developmental transcriptome of D. viviparus. The genome (161 Mb) is smaller than those of related bursate nematodes and encodes fewer (14,171) proteins. In the first genome-wide assessment of genomic variation in any parasitic nematode, we found a high degree of sequence variability in proteins predicted to be involved host-parasite interactions. Next, we used extensive RNA sequence data to track gene transcription across the life cycle of D. viviparus, and identified genes that are likely important in nematode development and parasitism. Finally, we predicted genes that could be vital in host-parasite interactions, genes that could serve as drug targets, and putative RNAi effectors with a view to developing functional genomic tools. This extensive curated dataset should provide a basis for developing new anthelmintics, vaccines, and improved diagnostic tests rrrand serve as a platform for future investigations of drug resistance and the epidemiology of this lungworm.


Pending Publication:
Samantha N. McNulty, Christina Strube, Bruce A. Rosa, John C. Martin, Rahul Tyagi, Young-Jun Choi, Qi Wang, Kymberlie Hallsworth-Pepin, Xu Zhang, Philip Ozersky, Richard K. Wilson, Paul W. Sternberg, Robin B. Gasser, Makedonka Mitreva (2015) Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention (TBA)

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