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A Postdoctoral Research Associate position is avaiable in the Mitreva Lab! Follow the link for details!

Bioinformatics Workshop for Helminth Genomics (2015) class materials now freely available!

NTDs get some well deserved coverage outside the usual channels: Financial Times Special Report: Neglected Tropical Diseases

Our Mission:

Parasitic roundworms (nematodes) of humans, livestock and other animals cause diseases of major socio-economic importance globally. They have a major, long-term impact (directly and indirectly) on human health and cause substantial suffering, particularly in children. The World Health Organization (WHO) estimates that 2.9 billion people are infected with nematodes. Furthermore, the current financial losses caused by parasites to agriculture worldwide (domesticated animals and crops) have a major impact on farm profitability and exacerbate the global food shortage.

Methods available for the control of the parasitic nematode infections are mainly based on chemical treatment (anthelmintics), non-chemical management practices, immune modulation and biological control. However, the incomplete protective response of the host and acquisition of anthelmintic resistance by an increasing number of parasitic nematodes hampered what use to be effective and long-lasting control strategies. Moreover, the use of such drugs poses major risks of residue problems in meat, milk and the environment.

Therefore, the challenges to improve control of parasitic nematode infections are multi-fold and no single category of information will meet them all. However, new information, such as nematode genomics, functional genomics and proteomics, can strengthen basic and applied biological research aimed at developing improvements. Our MISSION is through integrated approaches to accelerate progress towards developing more efficient and sustainable parasitic nematode control programs.


To cite please use:

Martin J, Rosa BA, Ozersky P, Hallsworth-Pepin K, Zhang X, Bhonagiri-Palsikar V, Tyagi R, Wang Q, Choi Y, Gao X, McNulty S, Brindley PJ and Mitreva M (2014) expansions to and an introduction to Nucleic Acids Research first published online November 12, 2014 doi: 10.1093/nar/gku1128

Genome information:

Genome Source BioProject id NCBI taxon id Publication link
Ancylostoma caninum MGI PRJNA72585 29170 unpublished (assembled and annotated as part of the Helminth Genome Initiative)
Ancylostoma ceylanicum MGI PRJNA72583 53326 unpublished (assembled and annotated as part of the Helminth Genome Initiative)
Ancylostoma ceylanicum Cornell, Cal. Inst. of Technology & Univ. of Massachusetts Medical School PRJNA231479 53326 The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families
Ancylostoma duodenale MGI PRJNA72581 51022 unpublished (assembled and annotated as part of the Helminth Genome Initiative)
Ascaris suum University of Melbourne PRJNA80881 6253 Ascaris suum draft genome
Ascaris suum University of Colorado/WUGI PRJNA62057 6253 Silencing of germline-expressed genes by DNA elimination in somatic cells
Brugia malayi University of Pittsburgh PRJNA10729 6279 Draft Genome of the Filarial Nematode Parasite Brugia malayi
Caenorhabditis briggsae WTSI PRJNA10731 6238 The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
Caenorhabditis elegans The C. elegans Sequencing Consortium PRJNA158 6239 Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology
Cooperia oncophora MGI PRJNA72571 27828 unpublished
Dictyocaulus viviparus MGI PRJNA72587 29172 Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention
Dirofilaria immitis University of Edinburgh PRJEB1797 6287 The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets
Globodera pallida WTSI PRJEB123 36090 The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode
Haemonchus contortus WTSI PRJEB506 6289 The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery
Haemonchus contortus University of Melbourne PRJNA205202 6289 The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus
Heterorhabditis bacteriophora MGI PRJNA13977 37862 A Lover and a Fighter: The Genome Sequence of an Entomopathogenic Nematode Heterorhabditis bacteriophora
Loa loa Broad Institute PRJNA60051 7209 Genomics of Loa loa, a Wolbachia-free filarial parasite of humans
Meloidogyne hapla NCSU PRJNA29083 6305 Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism
Meloidogyne incognita INRA PRJEA28837 6306 Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita.
Necator americanus MGI PRJNA72135 51031 Genome of the human hookworm Necator americanus.
Nematodirus battus MGI PRJNA86621 28839 unpublished
Oesophagostomum dentatum MGI PRJNA72579 61180 Cracking the nodule worm code advances knowledge of parasite biology and biotechnology to tackle major diseases of livestock
Onchocerca flexuosa MGI PRJNA230512 387005 unpublished
Onchocerca flexuosa WTSI PRJEB512 387005 50 Helminth Genomes Initiative (Helminth Genomes Consortium, unpublished)
Ostertagia ostertagi MGI PRJNA72577 6317 unpublished
Pristionchus pacificus Max Planck Institute/MGI PRJNA12644 54126 The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism.
Romanomermis culicivorax Universitat zu Koln, Cologne, NRW, Germany PRJEB516 13658 The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda
Teladorsagia circumcincta MGI PRJNA72569 45464 In press (PLOS Genetics)
Trichinella nativa MGI PRJNA179527 6335 unpublished (assembled and annotated as part of the Helminth Genome Initiative)
Trichinella spiralis MGI PRJNA12603 6334 The draft genome of the parasitic nematode Trichinella spiralis
Trichuris muris WTSI PRJEB2108 70415 Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction
Trichuris suis University of Melbourne PRJNA208415
68888 Genome and transcriptome of the porcine whipworm Trichuris suis.
Trichuris trichiura WTSI PRJEB535 36087 Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction

Please note that our lab is a sequencing and analysis facility; we are not clinicians, and as such we are not qualified to provide medical advice regarding parasitic nematode afflictions. If you are in need of such assistance, please instead contact a qualified physician, preferably one with a specialty in parasitic diseases. v4.0           Copyright Statement
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