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Function & Expression : proteomics

 News
[Aug.7.2017]   
A Postdoctoral Research Associate position is avaiable in the Mitreva Lab! Follow the link for details!

[June.7.2017]   
Bioinformatics Workshop for Helminth Genomics (2015) class materials now freely available!

[May.11.2017]   
NTDs get some well deserved coverage outside the usual channels: Financial Times Special Report: Neglected Tropical Diseases





Nematode Proteomics

This page pulls together the nematode protein expression work we've accomplished within the past few years. Please refer to the papers themselves for full details on this work.

 Project information:

Citations & Datafiles:

McNulty SN, Rosa BA, Fischer PU, et al. An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis. Molecular & Cellular Proteomics : MCP. 2015;14(12):3224-3233. doi:10.1074/mcp.M115.051953.

Datafiles: Protein & spectra data
Dataset_S1.xlsx
Dataset_S2.xlsx


Jasmer DP, Rosa BA, Mitreva M (2015) Peptidases Compartmentalized to the Ascaris suum Intestinal Lumen and Apical Intestinal Membrane. PLOS Neglected Tropical Diseases 9(1): e3375. https://doi.org/10.1371/journal.pntd.0003375

Datafiles: Protein & spectra data
journal.pntd.0003375.s002.XLSX
journal.pntd.0003375.s003.DOCX


Tang YT, Gao X, Rosa BA, et al. Genome of the human hookworm Necator americanus. Nature genetics. 2014;46(3):261-269. doi:10.1038/ng.2875.

Datafiles: Protein array data
ng.2875-S14.xlsx


Ondrovics M, Silbermayr K, Mitreva M, Young ND, Gasser RB, Joachim A. Proteomics elucidates key molecules involved in exsheathment in vitro in Oesophagostomum dentatum. International journal for parasitology. 2014;44(11):759-764. doi:10.1016/j.ijpara.2014.06.003.


Sotillo J, Sanchez-Flores A, Cantacessi C, et al. Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis. Molecular & Cellular Proteomics : MCP. 2014;13(10):2736-2751. doi:10.1074/mcp.M114.038950.


Borloo J, De Graef J, Peelaers I, et al. In-Depth Proteomic and Glycomic Analysis of the Adult-Stage Cooperia oncophora Excretome/Secretome. Journal of proteome research. 2013;12(9):10.1021/pr400114y. doi:10.1021/pr400114y.


Ondrovics M, Silbermayr K, Mitreva M, et al. Proteomic Analysis of Oesophagostomum dentatum (Nematoda) during Larval Transition, and the Effects of Hydrolase Inhibitors on Development. Hofmann A, ed. PLoS ONE. 2013;8(5):e63955. doi:10.1371/journal.pone.0063955.



 
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